Variant ID: 12-25398285-C-G

NM_004985.3(KRAS):c.34G>C;(p.G12R)

This variant was identified in 981 publications

View GRCh38 version.




Publications:


Molecular Landscape and Prognostic Biomarker Analysis of Advanced Pancreatic Cancer and Predictors of Treatment Efficacy of AG Chemotherapy.

Frontiers In Oncology
Du, Juan J; Qiu, Xin X; Lu, Changchang C; Zhu, Yahui Y; Kong, Weiwei W; Xu, Mian M; Zhang, Xin X; Tang, Min M; Chen, Jun J; Li, Qi Q; Li, Aimei A; He, Jian J; Gu, Qing Q; Wang, Lei L; Qiu, Yudong Y; Liu, Baorui B
Publication Date: 2022

Variant appearance in text: KRAS: G12R
PubMed Link: 35664782
Variant Present in the following documents:
  • Main text
  • fonc-12-844527.pdf
View BVdb publication page



Molecular Signatures of KRAS-Mutated Lung Adenocarcinoma: Analysis of Concomitant EGFR, ALK, STK11, and PD-L1 Status.

Clinical Pathology (Thousand Oaks, Ventura County, Calif.)
Hsu, Jim J; Annunziata, Joseph F JF; Burns, Ethan E; Bernicker, Eric H EH; Olsen, Randall J RJ; Thomas, Jessica S JS
Publication Date: 2022

Variant appearance in text: KRAS: G12R
PubMed Link: 35634237
Variant Present in the following documents:
  • Main text
  • 10.1177_2632010X221102054.pdf
View BVdb publication page



KRAS/NRAS/BRAF Mutation Rate in Saudi Academic Hospital Patients With Colorectal Cancer.

Cureus
Saharti, Samah S
Publication Date: 2022-04

Variant appearance in text: KRAS: G12R
PubMed Link: 35619874
Variant Present in the following documents:
  • Main text
  • cureus-0014-00000024392.pdf
View BVdb publication page



Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q.

Ebiomedicine
Adema, Vera V; Palomo, Laura L; Walter, Wencke W; Mallo, Mar M; Hutter, Stephan S; La Framboise, Thomas T; Arenillas, Leonor L; Meggendorfer, Manja M; Radivoyevitch, Tomas T; Xicoy, Blanca B; Pellagatti, Andrea A; Haferlach, Claudia C; Boultwood, Jacqueline J; Kern, Wolfgang W; Visconte, Valeria V; Sekeres, Mikkael M; Barnard, John J; Haferlach, Torsten T; Solé, Francesc F; Maciejewski, Jaroslaw P JP
Publication Date: 2022-05-23

Variant appearance in text: KRAS: 34G>C; Gly12Arg
PubMed Link: 35617825
Variant Present in the following documents:
  • mmc3.xlsx
View BVdb publication page



Free Energy Profiles Relating With Conformational Transition of the Switch Domains Induced by G12 Mutations in GTP-Bound KRAS.

Frontiers In Molecular Biosciences
Chen, Jianzhong J; Zhang, Shaolong S; Zeng, Qingkai Q; Wang, Wei W; Zhang, Qinggang Q; Liu, Xinguo X
Publication Date: 2022

Variant appearance in text: KRAS: G12R
PubMed Link: 35586192
Variant Present in the following documents:
  • fmolb-09-912518.pdf
View BVdb publication page



The implication of liquid biopsies to predict chemoresistance in pancreatic cancer.

Cancer Drug Resistance (Alhambra, Calif.)
Pietri, Elisabetta E; Balsano, Rita R; Coriano, Matilde M; Gelsomino, Fabio F; Leonardi, Francesco F; Bui, Simona S; Gnetti, Letizia L; Valle, Raffaele Dalla RD; Garajová, Ingrid I
Publication Date: 2021

Variant appearance in text: KRAS: G12R
PubMed Link: 35582309
Variant Present in the following documents:
  • cdr-4-559.pdf
View BVdb publication page



Prognostic and Immunotherapeutic Roles of KRAS in Pan-Cancer.

Cells
Yang, Kaixin K; Li, Chengyun C; Liu, Yang Y; Gu, Xueyan X; Jiang, Longchang L; Shi, Lei L
Publication Date: 2022-04-22

Variant appearance in text: KRAS: G12R
PubMed Link: 35563733
Variant Present in the following documents:
  • cells-11-01427.pdf
View BVdb publication page



PD-L1 Expression in Non-Small Cell Lung Cancer Specimens: Association with Clinicopathological Factors and Molecular Alterations.

International Journal Of Molecular Sciences
Mansour, Mohammed S I MSI; Malmros, Karina K; Mager, Ulrich U; Ericson Lindquist, Kajsa K; Hejny, Kim K; Holmgren, Benjamin B; Seidal, Tomas T; Dejmek, Annika A; Dobra, Katalin K; Planck, Maria M; Brunnström, Hans H
Publication Date: 2022-04-19

Variant appearance in text: KRAS: G12R
PubMed Link: 35562908
Variant Present in the following documents:
  • ijms-23-04517.pdf
View BVdb publication page



Clinicopathological and Gene Mutation Analysis of 27 Cases with Extranodal Rosai-Dorfman Disease.

Journal Of Inflammation Research
Tang, Ming M; Gu, Xue-Zhong XZ; Wu, Peng-Chun PC; Yang, Xuan-Tao XT
Publication Date: 2022

Variant appearance in text: KRAS: 34G>C; G12R
PubMed Link: 35518839
Variant Present in the following documents:
  • jir-15-2775.pdf
View BVdb publication page



Establishment of patient-derived organoids and a characterization-based drug discovery platform for treatment of pancreatic cancer.

Bmc Cancer
Watanabe, Sadanori S; Yogo, Akitada A; Otsubo, Tsuguteru T; Umehara, Hiroki H; Oishi, Jun J; Kodo, Toru T; Masui, Toshihiko T; Takaishi, Shigeo S; Seno, Hiroshi H; Uemoto, Shinji S; Hatano, Etsuro E
Publication Date: 2022-05-03

Variant appearance in text: rs121913530
PubMed Link: 35505283
Variant Present in the following documents:
  • 12885_2022_9619_MOESM1_ESM.xlsx
View BVdb publication page



Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Sun, Na N; Tran, Benjamin V BV; Peng, Zishan Z; Wang, Jing J; Zhang, Ceng C; Yang, Peng P; Zhang, Tiffany X TX; Widjaja, Josephine J; Zhang, Ryan Y RY; Xia, Wenxi W; Keir, Alexandra A; She, Jia-Wei JW; Yu, Hsiao-Hua HH; Shyue, Jing-Jong JJ; Zhu, Hongguang H; Agopian, Vatche G VG; Pei, Renjun R; Tomlinson, James S JS; Toretsky, Jeffrey A JA; Jonas, Steven J SJ; Federman, Noah N; Lu, Shaohua S; Tseng, Hsian-Rong HR; Zhu, Yazhen Y
Publication Date: 2022-03-09

Variant appearance in text: KRAS: G12R
PubMed Link: 35486030
Variant Present in the following documents:
  • ADVS-9-2105853-s001.pdf
  • ADVS-9-2105853.pdf
View BVdb publication page



Systematic discovery and validation of T cell targets directed against oncogenic KRAS mutations.

Cell Reports Methods
Choi, Jaewon J; Goulding, Scott P SP; Conn, Brandon P BP; McGann, Christopher D CD; Dietze, Jared L JL; Kohler, Jessica J; Lenkala, Divya D; Boudot, Antoine A; Rothenberg, Daniel A DA; Turcott, Paul J PJ; Srouji, John R JR; Foley, Kendra C KC; Rooney, Michael S MS; van Buuren, Marit M MM; Gaynor, Richard B RB; Abelin, Jennifer G JG; Addona, Terri A TA; Juneja, Vikram R VR
Publication Date: 2021-09-27

Variant appearance in text: KRAS: G12R
PubMed Link: 35474673
Variant Present in the following documents:
  • mmc3.pdf
  • mmc1.pdf
  • main.pdf
View BVdb publication page



Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors.

Plos Computational Biology
Poorebrahim, Mansour M; Abazari, Mohammad Foad MF; Moradi, Leila L; Shahbazi, Behzad B; Mahmoudi, Reza R; Kalhor, Hourieh H; Askari, Hassan H; Teimoori-Toolabi, Ladan L
Publication Date: 2022-04

Variant appearance in text: K-Ras4B: G12R
PubMed Link: 35472201
Variant Present in the following documents:
  • pcbi.1009962.pdf
View BVdb publication page



Identification of BRAF V600E mutation in odontogenic tumors by high-performance MALDI-TOF analysis.

International Journal Of Oral Science
Togni, Lucrezia L; Zizzi, Antonio A; Mazzucchelli, Roberta R; Santarelli, Andrea A; Rubini, Corrado C; Mascitti, Marco M
Publication Date: 2022-04-25

Variant appearance in text: KRAS: G12R
PubMed Link: 35468886
Variant Present in the following documents:
  • 41368_2022_170_MOESM3_ESM.pdf
  • 41368_2022_Article_170.pdf
View BVdb publication page



Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Bmc Medical Genomics
Sobahy, Turki M TM; Tashkandi, Ghassan G; Bahussain, Donya D; Al-Harbi, Raneem R
Publication Date: 2022-04-25

Variant appearance in text: KRAS: G12R
PubMed Link: 35468810
Variant Present in the following documents:
  • 12920_2022_1235_MOESM3_ESM.xlsx
  • 12920_2022_1235_MOESM2_ESM.xlsx
View BVdb publication page



Synergistic blocking of RAS downstream signaling and epigenetic pathway in KRAS mutant pancreatic cancer.

Aging
Zhang, Xiaofei X; Mao, Tiebo T; Xu, Haiyan H; Li, Shumin S; Yue, Ming M; Ma, Jingyu J; Yao, Jiayu J; Wang, Yongchao Y; Zhang, Xiao X; Ge, Weiyu W; Wang, Yanling Y; Shentu, Daiyuan D; Wang, Liwei L
Publication Date: 2022-04-25

Variant appearance in text: KRAS: G12R
PubMed Link: 35468095
Variant Present in the following documents:
  • aging-14-204031.pdf
View BVdb publication page



Clinicopathological Significance of PTEN Expression and Its Prognostic Effect in Colorectal Adenocarcinoma Patients.

Iranian Journal Of Pathology
Mirzapour Abbas Abadi, Zohreh Z; Samiee Rad, Fatemeh F; Hamedi Asl, Dariush D; Rahmani, Babak B; Soleimani Dodaran, Mahmood M; Peimani, Amir A
Publication Date: 2022

Variant appearance in text: KRAS: G12R
PubMed Link: 35463728
Variant Present in the following documents:
  • ijp-17-150.pdf
View BVdb publication page



Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer.

Science Advances
Ferguson, Scott S; Yang, Katherine S KS; Zelga, Piotr P; Liss, Andrew S AS; Carlson, Jonathan C T JCT; Del Castillo, Carlos Fernandez CF; Weissleder, Ralph R
Publication Date: 2022-04-22

Variant appearance in text: KRAS: G12R
PubMed Link: 35452280
Variant Present in the following documents:
  • sciadv.abm3453_sm.pdf
View BVdb publication page



Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity.

Nature Communications
Shi, Xiaohan X; Li, Yunguang Y; Yuan, Qiuyue Q; Tang, Shijie S; Guo, Shiwei S; Zhang, Yehan Y; He, Juan J; Zhang, Xiaoyu X; Han, Ming M; Liu, Zhuang Z; Zhu, Yiqin Y; Gao, Suizhi S; Wang, Huan H; Xu, Xiongfei X; Zheng, Kailian K; Jing, Wei W; Chen, Luonan L; Wang, Yong Y; Jin, Gang G; Gao, Dong D
Publication Date: 2022-04-21

Variant appearance in text: KRAS: G12R
PubMed Link: 35449156
Variant Present in the following documents:
  • 41467_2022_29857_MOESM5_ESM.xlsx
View BVdb publication page



Longitudinal Study of Circulating Biomarkers in Patients with Resectable Pancreatic Ductal Adenocarcinoma.

Biosensors
Dopico, Pablo J PJ; Le, Minh-Chau N MN; Burgess, Benjamin B; Yang, Zhijie Z; Zhao, Yu Y; Wang, Youxiang Y; George, Thomas J TJ; Fan, Z Hugh ZH
Publication Date: 2022-03-30

Variant appearance in text: KRAS: G12R
PubMed Link: 35448266
Variant Present in the following documents:
  • biosensors-12-00206.pdf
View BVdb publication page



An alternative CYB5A transcript is expressed in aneuploid ALL and enriched in relapse.

Bmc Genomic Data
Bartsch, Lorenz L; Schroeder, Michael P MP; Hänzelmann, Sonja S; Bastian, Lorenz L; Lázaro-Navarro, Juan J; Schlee, Cornelia C; Tanchez, Jutta Ortiz JO; Schulze, Veronika V; Isaakidis, Konstandina K; Rieger, Michael A MA; Gökbuget, Nicola N; Eckert, Cornelia C; Serve, Hubert H; Horstmann, Martin M; Schrappe, Martin M; Brüggemann, Monika M; Baldus, Claudia D CD; Neumann, Martin M
Publication Date: 2022-04-18

Variant appearance in text: KRAS: G12R; rs121913530
PubMed Link: 35436854
Variant Present in the following documents:
  • 12863_2022_1041_MOESM15_ESM.xlsx
View BVdb publication page



Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer.

World Journal Of Gastroenterology
Okamoto, Takeshi T
Publication Date: 2022-03-14

Variant appearance in text: KRAS: G12R
PubMed Link: 35431494
Variant Present in the following documents:
  • WJG-28-985.pdf
View BVdb publication page



A Liquid Biopsy-Based Approach for Monitoring Treatment Response in Post-Operative Colorectal Cancer Patients.

International Journal Of Molecular Sciences
Barták, Barbara Kinga BK; Fodor, Tamás T; Kalmár, Alexandra A; Nagy, Zsófia Brigitta ZB; Zsigrai, Sára S; Szigeti, Krisztina Andrea KA; Valcz, Gábor G; Igaz, Péter P; Dank, Magdolna M; Takács, István I; Molnár, Béla B
Publication Date: 2022-03-29

Variant appearance in text: KRAS: G12R
PubMed Link: 35409133
Variant Present in the following documents:
  • ijms-23-03774.pdf
View BVdb publication page



Exosomes in the Treatment of Pancreatic Cancer: A Moonshot to PDAC Treatment?

International Journal Of Molecular Sciences
Papadakos, Stavros P SP; Dedes, Nikolaos N; Pergaris, Alexandros A; Gazouli, Maria M; Theocharis, Stamatios S
Publication Date: 2022-03-25

Variant appearance in text: KRAS: G12R
PubMed Link: 35408980
Variant Present in the following documents:
  • ijms-23-03620.pdf
View BVdb publication page



Daily Practice Assessment of KRAS Status in NSCLC Patients: A New Challenge for the Thoracic Pathologist Is Right around the Corner.

Cancers
Bontoux, Christophe C; Hofman, Véronique V; Brest, Patrick P; Ilié, Marius M; Mograbi, Baharia B; Hofman, Paul P
Publication Date: 2022-03-23

Variant appearance in text: KRAS: G12R
PubMed Link: 35406400
Variant Present in the following documents:
  • cancers-14-01628.pdf
View BVdb publication page



Genetic Characteristics Associated With Drug Resistance in Lung Cancer and Colorectal Cancer Using Whole Exome Sequencing of Cell-Free DNA.

Frontiers In Oncology
Lee, Jong Won JW; Park, Young Soo YS; Choi, Jung Yoon JY; Chang, Won Jin WJ; Lee, Soohyeon S; Sung, Jae Sook JS; Kim, Boyeon B; Lee, Saet Byeol SB; Lee, Sung Yong SY; Choi, Jungmin J; Kim, Yeul Hong YH
Publication Date: 2022

Variant appearance in text: KRAS: G12R
PubMed Link: 35402275
Variant Present in the following documents:
  • fonc-12-843561.pdf
View BVdb publication page



Adjuvant therapy for periampullary carcinoma and the significance of histopathological typing: A systematic review.

Translational Oncology
Duan, Zhiqing Z; Zhang, Yinuo Y; Tang, Yajie Y; Gao, Ruqing R; Bao, Jing J; Liang, Bo B
Publication Date: 2022-04-06

Variant appearance in text: KRAS: G12R
PubMed Link: 35397420
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Partial response to dabrafenib and trametinib in relapsed BRAF V600E-Mutated multiple myeloma and possible mechanisms of resistance.

Bmj Case Reports
Ernst, Tina T; Aebi, Stefan S; Zander, Andrea A; Zander, Thilo T
Publication Date: 2022-04-08

Variant appearance in text: KRAS: 34G>C; G12R
PubMed Link: 35396243
Variant Present in the following documents:
  • bcr-2021-246264.pdf
View BVdb publication page



KRAS Mutation in Rare Tumors: A Landscape Analysis of 3453 Chinese Patients.

Frontiers In Molecular Biosciences
Wang, Shuhang S; Li, Qin Q; Ma, Peiwen P; Fang, Yuan Y; Yu, Yue Y; Jiang, Ning N; Miao, Huilei H; Tang, Qiyu Q; Yang, Yuqi Y; Xing, Shujun S; Chen, Rongrong R; Yi, Xin X; Li, Ning N
Publication Date: 2022

Variant appearance in text: KRAS: G12R
PubMed Link: 35359599
Variant Present in the following documents:
  • fmolb-09-831382.pdf
View BVdb publication page



Clinical utility of comprehensive genomic profiling in Japan: Result of PROFILE-F study.

Plos One
Aoyagi, Yasuko Y; Kano, Yoshihito Y; Tohyama, Kohki K; Matsudera, Shotaro S; Kumaki, Yuichi Y; Takahashi, Kenta K; Mitsumura, Takahiro T; Harada, Yohei Y; Sato, Akemi A; Nakamura, Hideaki H; Sueoka, Eisaburo E; Aragane, Naoko N; Kimura, Koichiro K; Onishi, Iichiro I; Takemoto, Akira A; Akahoshi, Keiichi K; Ono, Hiroaki H; Ishikawa, Toshiaki T; Tokunaga, Masanori M; Nakagawa, Tsuyoshi T; Oshima, Noriko N; Nakamura, Reiko R; Takagi, Masatoshi M; Asakage, Takahiro T; Uetake, Hiroyuki H; Tanabe, Minoru M; Miyake, Satoshi S; Kinugasa, Yusuke Y; Ikeda, Sadakatsu S
Publication Date: 2022

Variant appearance in text: KRAS: G12R
PubMed Link: 35358259
Variant Present in the following documents:
  • pone.0266112.s001.xlsx
View BVdb publication page



Diagnostic and prognostic values of KRAS mutations on EUS-FNA specimens and circulating tumor DNA in patients with pancreatic cancer.

Clinical And Translational Gastroenterology
Wang, Ronghua R; Zhao, Yuchong Y; Wang, Yun Y; Zhao, Zhenxiong Z; Chen, Qian Q; Duan, Yaqi Y; Xiong, Si S; Luan, Zhou Z; Wang, Jinlin J; Cheng, Bin B
Publication Date: 2022-03-30

Variant appearance in text: KRAS: G12R
PubMed Link: 35351843
Variant Present in the following documents:
  • Main text
  • ct9-13-e00487.pdf
View BVdb publication page



Landscape of KRASG12C, Associated Genomic Alterations, and Interrelation With Immuno-Oncology Biomarkers in KRAS-Mutated Cancers.

Jco Precision Oncology
Salem, Mohamed E ME; El-Refai, Sherif M SM; Sha, Wei W; Puccini, Alberto A; Grothey, Axel A; George, Thomas J TJ; Hwang, Jimmy J JJ; O'Neil, Bert B; Barrett, Alexander S AS; Kadakia, Kunal C KC; Musselwhite, Laura W LW; Raghavan, Derek D; Van Cutsem, Eric E; Tabernero, Josep J; Tie, Jeanne J
Publication Date: 2022-03

Variant appearance in text: KRAS: G12R
PubMed Link: 35319967
Variant Present in the following documents:
  • po-6-e2100245.pdf
View BVdb publication page



Dynamic changes in gene alterations during chemotherapy in metastatic castrate resistant prostate cancer.

Scientific Reports
Tan, Winston W; Zheng, Tiantian T; Wang, Amy A; Roacho, Joanna J; Thao, Seng S; Du, Pan P; Jia, Shidong S; Yu, Jianjun J; King, Bonnie L BL; Kohli, Manish M
Publication Date: 2022-03-18

Variant appearance in text: KRAS: 34G>C; Gly12Arg
PubMed Link: 35304525
Variant Present in the following documents:
  • 41598_2022_8520_MOESM2_ESM.xlsx
View BVdb publication page



The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers.

Nature Communications
Rosen, Ezra Y EY; Won, Helen H HH; Zheng, Youyun Y; Cocco, Emiliano E; Selcuklu, Duygu D; Gong, Yixiao Y; Friedman, Noah D ND; de Bruijn, Ino I; Sumer, Onur O; Bielski, Craig M CM; Savin, Casey C; Bourque, Caitlin C; Falcon, Christina C; Clarke, Nikeysha N; Jing, Xiaohong X; Meng, Fanli F; Zimel, Catherine C; Shifman, Sophie S; Kittane, Srusthi S; Wu, Fan F; Ladanyi, Marc M; Ebata, Kevin K; Kherani, Jennifer J; Brandhuber, Barbara J BJ; Fagin, James J; Sherman, Eric J EJ; Rekhtman, Natasha N; Berger, Michael F MF; Scaltriti, Maurizio M; Hyman, David M DM; Taylor, Barry S BS; Drilon, Alexander A
Publication Date: 2022-03-18

Variant appearance in text: KRAS: G12R
PubMed Link: 35304457
Variant Present in the following documents:
  • 41467_2022_Article_28848.pdf
View BVdb publication page



Clinical and genomic features of Chinese lung cancer patients with germline mutations.

Nature Communications
Peng, Wenying W; Li, Bin B; Li, Jin J; Chang, Lianpeng L; Bai, Jing J; Yi, Yuting Y; Chen, Rongrong R; Zhang, Yanyan Y; Chen, Chen C; Pu, Xingxiang X; Jiang, Meilin M; Li, Jia J; Zhong, Rui R; Xu, Fang F; Chen, Bolin B; Xu, Li L; Wang, Ning N; Huan, Jiaojiao J; Dai, Pingping P; Guan, Yanfang Y; Yang, Ling L; Xia, Xuefeng X; Yi, Xin X; Wang, Jiayin J; Yu, Fenglei F; Wu, Lin L
Publication Date: 2022-03-10

Variant appearance in text: KRAS: 34G>C; G12R
PubMed Link: 35273153
Variant Present in the following documents:
  • 41467_2022_28840_MOESM7_ESM.xlsx
View BVdb publication page



Tumors carrying BRAF-mutations over-express NAMPT that is genetically amplified and possesses oncogenic properties.

Journal Of Translational Medicine
Audrito, Valentina V; Moiso, Enrico E; Ugolini, Filippo F; Messana, Vincenzo Gianluca VG; Brandimarte, Lorenzo L; Manfredonia, Ilaria I; Bianchi, Simonetta S; De Logu, Francesco F; Nassini, Romina R; Szumera-Ciećkiewicz, Anna A; Taverna, Daniela D; Massi, Daniela D; Deaglio, Silvia S
Publication Date: 2022-03-10

Variant appearance in text: KRAS: 34G>C; G12R
PubMed Link: 35272691
Variant Present in the following documents:
  • 12967_2022_Article_3315.pdf
View BVdb publication page



Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance.

Cancers
Reita, Damien D; Pabst, Lucile L; Pencreach, Erwan E; Guérin, Eric E; Dano, Laurent L; Rimelen, Valérie V; Voegeli, Anne-Claire AC; Vallat, Laurent L; Mascaux, Céline C; Beau-Faller, Michèle M
Publication Date: 2022-03-04

Variant appearance in text: KRAS: G12R
PubMed Link: 35267628
Variant Present in the following documents:
  • cancers-14-01321.pdf
View BVdb publication page



Characterization of disease-propagating stem cells responsible for myeloproliferative neoplasm-blast phase.

Jci Insight
Wang, Xiaoli X; Rampal, Raajit K RK; Hu, Cing Siang CS; Tripodi, Joseph J; Farnoud, Noushin N; Petersen, Bruce B; Rossi, Michael R MR; Patel, Minal M; McGovern, Erin E; Najfeld, Vesna V; Iancu-Rubin, Camelia C; Lu, Min M; Davis, Andrew A; Kremyanskaya, Marina M; Weinberg, Rona Singer RS; Mascarenhas, John J; Hoffman, Ronald R
Publication Date: 2022-03-08

Variant appearance in text: KRAS: G12R
PubMed Link: 35259128
Variant Present in the following documents:
  • jciinsight-7-156534-s067.xlsx
View BVdb publication page



Genetic diagnosis of pseudomyxoma peritonei originating from mucinous borderline tumor inside an ovarian teratoma.

Bmc Medical Genomics
Taguchi, Ayumi A; Rokutan, Hirofumi H; Oda, Katsutoshi K; Tanikawa, Michihiro M; Tanimoto, Saki S; Sone, Kenbun K; Mori, Mayuyo M; Tsuruga, Tetsushi T; Kohsaka, Shinji S; Tatsuno, Kenji K; Shinozaki-Ushiku, Aya A; Miyagawa, Kiyoshi K; Mano, Hiroyuki H; Aburatani, Hiroyuki H; Ushiku, Tetsuo T; Osuga, Yutaka Y
Publication Date: 2022-03-07

Variant appearance in text: KRAS: G12R
PubMed Link: 35255903
Variant Present in the following documents:
  • 12920_2022_Article_1188.pdf
View BVdb publication page



Characterization of the genomic landscape in large-scale Chinese patients with pancreatic cancer.

Ebiomedicine
Zhang, Xiaofei X; Mao, Tiebo T; Zhang, Bei B; Xu, Haiyan H; Cui, Jiujie J; Jiao, Feng F; Chen, Dongqin D; Wang, Yu Y; Hu, Jiong J; Xia, Qing Q; Ge, Weiyu W; Li, Shumin S; Yue, Ming M; Ma, Jingyu J; Yao, Jiayu J; Wang, Yongchao Y; Wang, Yanling Y; Shentu, Daiyuan D; Zhang, Xiao X; Chen, Shiqing S; Bai, Yuezong Y; Wang, Yuexiang Y; Zhang, Xuebin X; Liu, Qiang Q; Sun, Yongwei Y; Fu, Deliang D; Liu, Yingbin Y; Xiong, Lei L; Wang, Liwei L
Publication Date: 2022-02-26

Variant appearance in text: KRAS: G12R
PubMed Link: 35231699
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors.

Genome Medicine
Simon, Tincy T; Riemer, Pamela P; Jarosch, Armin A; Detjen, Katharina K; Di Domenico, Annunziata A; Bormann, Felix F; Menne, Andrea A; Khouja, Slim S; Monjé, Nanna N; Childs, Liam H LH; Lenze, Dido D; Leser, Ulf U; Rossner, Florian F; Morkel, Markus M; Blüthgen, Nils N; Pavel, Marianne M; Horst, David D; Capper, David D; Marinoni, Ilaria I; Perren, Aurel A; Mamlouk, Soulafa S; Sers, Christine C
Publication Date: 2022-03-01

Variant appearance in text: KRAS: G12R
PubMed Link: 35227293
Variant Present in the following documents:
  • 13073_2022_1018_MOESM1_ESM.xlsx
  • 13073_2022_Article_1018.pdf
View BVdb publication page



The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: KRAS: Gly12Arg
PubMed Link: 35221333
Variant Present in the following documents:
  • 43018_2022_332_MOESM3_ESM.xlsx
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Dynamics of RAS/BRAF Mutations in cfDNA from Metastatic Colorectal Carcinoma Patients Treated with Polychemotherapy and Anti-EGFR Monoclonal Antibodies.

Cancers
Rachiglio, Anna Maria AM; Forgione, Laura L; Pasquale, Raffaella R; Barone, Carlo Antonio CA; Maiello, Evaristo E; Antonuzzo, Lorenzo L; Cassata, Antonino A; Tonini, Giuseppe G; Bordonaro, Roberto R; Rosati, Gerardo G; Zaniboni, Alberto A; Lonardi, Sara S; Ferrari, Daris D; Frassineti, Giovanni Luca GL; Tamberi, Stefano S; Pisconti, Salvatore S; Di Fabio, Francesca F; Roma, Cristin C; Orlandi, Armando A; Latiano, Tiziana T; Damato, Angela A; Tortora, Giampaolo G; Pinto, Carmine C; Normanno, Nicola N
Publication Date: 2022-02-18

Variant appearance in text: KRAS: G12R
PubMed Link: 35205799
Variant Present in the following documents:
  • cancers-14-01052.pdf
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The genetic landscape of pancreatic head ductal adenocarcinoma in China and prognosis stratification.

Bmc Cancer
Yang, Yefan Y; Ding, Ying Y; Gong, Yuxi Y; Zhao, Sha S; Li, Mingna M; Li, Xiao X; Song, Guoxin G; Zhai, Boya B; Liu, Jin J; Shao, Yang Y; Zhu, Liuqing L; Pang, Jiaohui J; Ma, Yutong Y; Ou, Qiuxiang Q; Wu, Xue X; Zhang, Zhihong Z
Publication Date: 2022-02-18

Variant appearance in text: KRAS: G12R
PubMed Link: 35180847
Variant Present in the following documents:
  • 12885_2022_9279_MOESM3_ESM.xlsx
  • 12885_2022_Article_9279.pdf
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Transcriptomic Mapping of Non-Small Cell Lung Cancer K-RAS p.G12C Mutated Tumors: Identification of Surfaceome Targets and Immunologic Correlates.

Frontiers In Immunology
Alcaraz-Sanabria, Ana A; Cabañas Morafraile, Esther E; Fernández-Hinojal, Gonzalo G; Velasco, Guillermo G; Pérez-Segura, Pedro P; Pandiella, Atanasio A; Győrffy, Balázs B; Ocaña, Alberto A
Publication Date: 2021

Variant appearance in text: KRAS: G12R
PubMed Link: 35178045
Variant Present in the following documents:
  • DataSheet_2.pdf
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Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition.

Scientific Reports
Vaclova, Tereza T; Chakraborty, Atanu A; Sherwood, James J; Ross, Sarah S; Carroll, Danielle D; Barrett, J Carl JC; Downward, Julian J; de Bruin, Elza C EC
Publication Date: 2022-02-17

Variant appearance in text: KRAS: G12R
PubMed Link: 35177674
Variant Present in the following documents:
  • 41598_2022_6369_MOESM1_ESM.pdf
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Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition.

Scientific Reports
Jiri, Jungwirth J; Marketa, Urbanova U; Arnoud, Boot B; Petr, Hosek H; Petra, Bendova B; Anna, Siskova S; Jiri, Svec S; Milan, Kment K; Daniela, Tumova T; Sandra, Summerova S; Zdenek, Benes B; Tomas, Buchler B; Pavel, Kohout K; Tomas, Hucl H; Radoslav, Matej M; Ludmila, Vodickova V; Tom, van Wezel VW; Pavel, Vodicka V; Veronika, Vymetalkova V
Publication Date: 2022-02-16

Variant appearance in text: KRAS: 34G>C
PubMed Link: 35173208
Variant Present in the following documents:
  • 41598_2022_Article_6498.pdf
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Deciphering Genetic Alterations of Taiwanese Patients with Pancreatic Adenocarcinoma through Targeted Sequencing.

International Journal Of Molecular Sciences
Huang, Chi-Cheng CC; Liu, Chih-Yi CY; Huang, Chi-Jung CJ; Hsu, Yao-Chun YC; Lien, Heng-Hui HH; Wong, Jia-Uei JU; Tai, Feng-Chuan FC; Ku, Wen-Hui WH; Hung, Chi-Feng CF; Lin, Jaw-Town JT; Huang, Ching-Shui CS; Chiang, Han-Sun HS
Publication Date: 2022-01-29

Variant appearance in text: KRAS: G12R
PubMed Link: 35163506
Variant Present in the following documents:
  • Main text
  • ijms-23-01579.pdf
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Identification of New KRAS G12D Inhibitors through Computer-Aided Drug Discovery Methods.

International Journal Of Molecular Sciences
Kulkarni, Apoorva M AM; Kumar, Vikas V; Parate, Shraddha S; Lee, Gihwan G; Yoon, Sanghwa S; Lee, Keun Woo KW
Publication Date: 2022-01-24

Variant appearance in text: KRAS: G12R
PubMed Link: 35163234
Variant Present in the following documents:
  • Main text
  • ijms-23-01309.pdf
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KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications.

Cells
Pereira, Flávia F; Ferreira, Anabela A; Reis, Celso Albuquerque CA; Sousa, Maria João MJ; Oliveira, Maria José MJ; Preto, Ana A
Publication Date: 2022-01-24

Variant appearance in text: KRAS: G12R
PubMed Link: 35159208
Variant Present in the following documents:
  • Main text
  • cells-11-00398.pdf
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Genetic Alterations Predict Long-Term Survival in Ductal Adenocarcinoma of the Pancreatic Head.

Cancers
Safi, Sami-Alexander SA; Haeberle, Lena L; Goering, Wolfgang W; Keitel, Verena V; Fluegen, Georg G; Stoecklein, Nikolas N; Rehders, Alexander A; Knoefel, Wolfram Trudo WT; Esposito, Irene I
Publication Date: 2022-02-08

Variant appearance in text: KRAS: G12R
PubMed Link: 35159117
Variant Present in the following documents:
  • Main text
  • cancers-14-00850.pdf
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RAS Mutation Conversion in Bevacizumab-Treated Metastatic Colorectal Cancer Patients: A Liquid Biopsy Based Study.

Cancers
Nicolazzo, Chiara C; Belardinilli, Francesca F; Vestri, Annarita A; Magri, Valentina V; De Renzi, Gianluigi G; De Meo, Michela M; Caponnetto, Salvatore S; Di Nicolantonio, Federica F; Cortesi, Enrico E; Giannini, Giuseppe G; Gazzaniga, Paola P
Publication Date: 2022-02-04

Variant appearance in text: KRAS: G12R
PubMed Link: 35159069
Variant Present in the following documents:
  • Main text
  • cancers-14-00802.pdf
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Pancreatic Cancer Organoids in the Field of Precision Medicine: A Review of Literature and Experience on Drug Sensitivity Testing with Multiple Readouts and Synergy Scoring.

Cancers
Mäkinen, Lotta L; Vähä-Koskela, Markus M; Juusola, Matilda M; Mustonen, Harri H; Wennerberg, Krister K; Hagström, Jaana J; Puolakkainen, Pauli P; Seppänen, Hanna H
Publication Date: 2022-01-21

Variant appearance in text: KRAS: G12R
PubMed Link: 35158794
Variant Present in the following documents:
  • Main text
  • cancers-14-00525.pdf
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Exploiting macropinocytosis for drug delivery into KRAS mutant cancer.

Theranostics
Liu, Huiqin H; Qian, Feng F
Publication Date: 2022

Variant appearance in text: KRAS: G12R
PubMed Link: 35154489
Variant Present in the following documents:
  • Main text
  • thnov12p1321.pdf
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Macropinocytic dextran facilitates KRAS-targeted delivery while reducing drug-induced tumor immunity depletion in pancreatic cancer.

Theranostics
Yuan, Fang F; Sun, Mengnan M; Liu, Zhengsheng Z; Liu, Huiqin H; Kong, Weijian W; Wang, Rui R; Qian, Feng F
Publication Date: 2022

Variant appearance in text: KRAS: G12R
PubMed Link: 35154474
Variant Present in the following documents:
  • Main text
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RAS-mediated tumor stress adaptation and the targeting opportunities it presents.

Disease Models & Mechanisms
Redding, Alexandra A; Aplin, Andrew E AE; Grabocka, Elda E
Publication Date: 2022-02-01

Variant appearance in text: KRAS: G12R
PubMed Link: 35147163
Variant Present in the following documents:
  • Main text
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Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants.

Cell Reports
Khan, Imran I; Koide, Akiko A; Zuberi, Mariyam M; Ketavarapu, Gayatri G; Denbaum, Eric E; Teng, Kai Wen KW; Rhett, J Matthew JM; Spencer-Smith, Russell R; Hobbs, G Aaron GA; Camp, Ernest Ramsay ER; Koide, Shohei S; O'Bryan, John P JP
Publication Date: 2022-02-08

Variant appearance in text: KRAS: G12R
PubMed Link: 35139380
Variant Present in the following documents:
  • nihms-1778820.pdf
  • NIHMS1778820-supplement-1.pdf
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Discovery of novel KRAS‒PDEδ inhibitors with potent activity in patient-derived human pancreatic tumor xenograft models.

Acta Pharmaceutica Sinica. B
Chen, Long L; Zhang, Jing J; Wang, Xinjing X; Li, Yu Y; Zhou, Lu L; Lu, Xiongxiong X; Dong, Guoqiang G; Sheng, Chunquan C
Publication Date: 2022-01

Variant appearance in text: KRAS: G12R
PubMed Link: 35127385
Variant Present in the following documents:
  • Main text
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The clinicopathological study of lung cancer concealed in end-stage of interstitial lung disease.

Translational Cancer Research
Wang, Bei B; Zhang, Xiaoyan X; Chen, Huang H; Yang, Lei L; Li, Jie J; Xiao, Fei F; Liang, Chaoyang C; Zhong, Dingrong D
Publication Date: 2020-02

Variant appearance in text: KRAS: G12R
PubMed Link: 35117398
Variant Present in the following documents:
  • Main text
  • tcr-09-02-536.pdf
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Case Report: Effectiveness of Targeted Treatment in a Patient With Pancreatic Cancer Harboring PALB2 Germline Mutation and KRAS Somatic Mutation.

Frontiers In Medicine
Wu, Wei W; Liu, Yu Y; Jin, Yuzhi Y; Liu, Lulu L; Guo, Yixuan Y; Xu, Mian M; Hao, Qing Q; Li, Dazhi D; Fang, Weijia W; Zhang, Aibin A; Zhao, Peng P
Publication Date: 2021

Variant appearance in text: KRAS: G12R
PubMed Link: 35096857
Variant Present in the following documents:
  • fmed-08-746637.pdf
  • Data_Sheet_1.pdf
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Mutational landscape of circulating tumor DNA identifies distinct molecular features associated with therapeutic response in patients with metastatic colorectal cancer.

Therapeutic Advances In Medical Oncology
Shi, Min M; Yuan, Hong H; Ji, Jun J; Zhang, Shouwei S; Li, Qingyuan Q; Chen, Yawei Y; Gong, Xiaoli X; Zhu, Zhenggang Z; Zhang, Jun J
Publication Date: 2022

Variant appearance in text: rs121913530
PubMed Link: 35096147
Variant Present in the following documents:
  • sj-xls-4-tam-10.1177_17588359211070643.xls
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Multiple ETS Factors Participate in the Transcriptional Control of TERT Mutant Promoter in Thyroid Cancers.

Cancers
Thornton, Caitlin E M CEM; Hao, Jingzhu J; Tamarapu, Prasanna P PP; Landa, Iñigo I
Publication Date: 2022-01-12

Variant appearance in text: KRAS: G12R
PubMed Link: 35053525
Variant Present in the following documents:
  • Main text
  • cancers-14-00357.pdf
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Genetic Profile of Adenomatoid Odontogenic Tumor and Ameloblastoma. A Systematic Review.

Frontiers In Oral Health
Marín, Constanza C; Niklander, Sven E SE; Martínez-Flores, René R
Publication Date: 2021

Variant appearance in text: KRAS: G12R
PubMed Link: 35048068
Variant Present in the following documents:
  • Main text
  • froh-02-767474.pdf
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The Molecular Pathology of Odontogenic Tumors: Expanding the Spectrum of MAPK Pathway Driven Tumors.

Frontiers In Oral Health
Guimarães, Letícia Martins LM; Coura, Bruna Pizziolo BP; Gomez, Ricardo Santiago RS; Gomes, Carolina Cavalieri CC
Publication Date: 2021

Variant appearance in text: KRAS: G12R
PubMed Link: 35048058
Variant Present in the following documents:
  • Main text
  • froh-02-740788.pdf
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The path to the clinic: a comprehensive review on direct KRASG12C inhibitors.

Journal Of Experimental & Clinical Cancer Research : Cr
Kwan, Albert K AK; Piazza, Gary A GA; Keeton, Adam B AB; Leite, Caio A CA
Publication Date: 2022-01-19

Variant appearance in text: KRAS: G12R
PubMed Link: 35045886
Variant Present in the following documents:
  • Main text
  • 13046_2021_Article_2225.pdf
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Analysis of genetic variants in myeloproliferative neoplasms using a 22-gene next-generation sequencing panel.

Bmc Medical Genomics
Tan, Jaymi J; Chow, Yock Ping YP; Zainul Abidin, Norziha N; Chang, Kian Meng KM; Selvaratnam, Veena V; Tumian, Nor Rafeah NR; Poh, Yang Ming YM; Veerakumarasivam, Abhi A; Laffan, Michael Arthur MA; Wong, Chieh Lee CL
Publication Date: 2022-01-15

Variant appearance in text: KRAS: G12R
PubMed Link: 35033063
Variant Present in the following documents:
  • 12920_2021_1145_MOESM3_ESM.pdf
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Combined large cell neuroendocrine carcinoma of the lung associated with low-grade fetal adenocarcinoma without β-catenin mutation: a case report.

International Journal Of Clinical And Experimental Pathology
Xiong, Xiaoming X; Ruan, Sibei S; Zhang, Cuiwei C; Xiao, Xiuli X; Long, Hanan H
Publication Date: 2021

Variant appearance in text: KRAS: g12r
PubMed Link: 35027997
Variant Present in the following documents:
  • Main text
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Resistance to KRASG12C Inhibitors in Non-Small Cell Lung Cancer.

Frontiers In Oncology
Blaquier, Juan Bautista JB; Cardona, Andrés Felipe AF; Recondo, Gonzalo G
Publication Date: 2021

Variant appearance in text: KRAS: G12R
PubMed Link: 35004309
Variant Present in the following documents:
  • Main text
  • fonc-11-787585.pdf
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Impact of somatic mutations on clinical and pathologic outcomes in borderline resectable and locally advanced pancreatic cancer treated with neoadjuvant chemotherapy and stereotactic body radiotherapy followed by surgical resection.

Radiation Oncology Journal
Reddy, Abhinav V AV; Hill, Colin S CS; Sehgal, Shuchi S; Ding, Ding D; Hacker-Prietz, Amy A; He, Jin J; Zheng, Lei L; Herman, Joseph M JM; Meyer, Jeffrey J; Narang, Amol K AK
Publication Date: 2021-12

Variant appearance in text: KRAS: G12R
PubMed Link: 34986552
Variant Present in the following documents:
  • Main text
  • roj-2021-00815.pdf
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KRAS Mutations in Squamous Cell Carcinomas of the Lung.

Frontiers In Oncology
Acker, Fabian F; Stratmann, Jan J; Aspacher, Lukas L; Nguyen, Ngoc Thien Thu NTT; Wagner, Sebastian S; Serve, Hubert H; Wild, Peter J PJ; Sebastian, Martin M
Publication Date: 2021

Variant appearance in text: KRAS: G12R
PubMed Link: 34976827
Variant Present in the following documents:
  • Main text
  • fonc-11-788084.pdf
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The Advance and Correlation of KRAS Mutation With the Fertility-Preservation Treatment of Endometrial Cancer in the Background of Molecular Classification Application.

Pathology Oncology Research : Por
Yu, KeXuan K; Wang, Yiqin Y
Publication Date: 2021

Variant appearance in text: KRAS: G12R
PubMed Link: 34975345
Variant Present in the following documents:
  • Main text
View BVdb publication page