Publications:

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LRRK2 Structure-Based Activation Mechanism and Pathogenesis.

Biomolecules

Zhang, Xiaojuan X; Kortholt, Arjan A

Publication Date: 2023-03-28

Variant appearance in text: LRRK2: E193K

PubMed Link: 37189360

Variant Present in the following documents:

• biomolecules-13-00612.pdf

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LRRK2 and Proteostasis in Parkinson's Disease.

International Journal Of Molecular Sciences

Pérez-Carrión, María Dolores MD; Posadas, Inmaculada I; Solera, Javier J; Ceña, Valentín V

Publication Date: 2022-06-18

Variant appearance in text: LRRK2: E193K

PubMed Link: 35743250

Variant Present in the following documents:

• Main text
• ijms-23-06808.pdf

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Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress.

International Journal Of Molecular Sciences

Jurcau, Anamaria A

Publication Date: 2021-10-31

Variant appearance in text: LRRK2: E193K

PubMed Link: 34769277

Variant Present in the following documents:

• Main text
• ijms-22-11847.pdf

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A Conserved Role for LRRK2 and Roco Proteins in the Regulation of Mitochondrial Activity.

Frontiers In Cell And Developmental Biology

Rosenbusch, Katharina E KE; Oun, Asmaa A; Sanislav, Oana O; Lay, Sui T ST; Keizer-Gunnink, Ineke I; Annesley, Sarah J SJ; Fisher, Paul R PR; Dolga, Amalia M AM; Kortholt, Arjan A

Publication Date: 2021

Variant appearance in text: LRRK2: E193K

PubMed Link: 34568343

Variant Present in the following documents:

• Main text
• fcell-09-734554.pdf

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Selective Neuron Vulnerability in Common and Rare Diseases-Mitochondria in the Focus.

Frontiers In Molecular Biosciences

Paß, Thomas T; Wiesner, Rudolf J RJ; Pla-Martín, David D

Publication Date: 2021

Variant appearance in text: LRRK2: E193K

PubMed Link: 34295920

Variant Present in the following documents:

• fmolb-08-676187.pdf

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Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Schmidt, Sven H SH; Weng, Jui-Hung JH; Aoto, Phillip C PC; Boassa, Daniela D; Mathea, Sebastian S; Silletti, Steve S; Hu, Junru J; Wallbott, Maximilian M; Komives, Elizabeth A EA; Knapp, Stefan S; Herberg, Friedrich W FW; Taylor, Susan S SS

Publication Date: 2021-06-08

Variant appearance in text: LRRK2: E193K

PubMed Link: 34088839

Variant Present in the following documents:

• pnas.202100844.pdf

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LRRK2 at the Crossroad of Aging and Parkinson's Disease.

Genes

Hur, Eun-Mi EM; Lee, Byoung Dae BD

Publication Date: 2021-03-29

Variant appearance in text: LRRK2: E193K

PubMed Link: 33805527

Variant Present in the following documents:

• genes-12-00505.pdf

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LncRNA XIST sponges miR-199a-3p to modulate the Sp1/LRRK2 signal pathway to accelerate Parkinson's disease progression.

Aging

Zhou, Qian Q; Zhang, Ming-Ming MM; Liu, Min M; Tan, Zhi-Gang ZG; Qin, Qi-Lin QL; Jiang, Yu-Gang YG

Publication Date: 2021-01-20

Variant appearance in text: LRRK2: E193K

PubMed Link: 33494069

Variant Present in the following documents:

• aging-13-202378.pdf

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A Critical LRRK at the Synapse? The Neurobiological Function and Pathophysiological Dysfunction of LRRK2.

Frontiers In Molecular Neuroscience

Kuhlmann, Naila N; Milnerwood, Austen J AJ

Publication Date: 2020

Variant appearance in text: LRRK2: E193K

PubMed Link: 32973447

Variant Present in the following documents:

• fnmol-13-00153.pdf

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From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson's Disease: Lessons From LRRK2.

Frontiers In Cellular Neuroscience

Mancini, Andrea A; Mazzocchetti, Petra P; Sciaccaluga, Miriam M; Megaro, Alfredo A; Bellingacci, Laura L; Beccano-Kelly, Dayne A DA; Di Filippo, Massimiliano M; Tozzi, Alessandro A; Calabresi, Paolo P

Publication Date: 2020

Variant appearance in text: LRRK2: E193K

PubMed Link: 32848606

Variant Present in the following documents:

• Main text
• fncel-14-00158.pdf

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LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson's Disease?

Frontiers In Neuroscience

O'Hara, Darren M DM; Pawar, Grishma G; Kalia, Suneil K SK; Kalia, Lorraine V LV

Publication Date: 2020

Variant appearance in text: LRRK2: E193K

PubMed Link: 32625052

Variant Present in the following documents:

• Main text

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Guilt-by-Association - Functional Insights Gained From Studying the LRRK2 Interactome.

Frontiers In Neuroscience

Gloeckner, Christian Johannes CJ; Porras, Pablo P

Publication Date: 2020

Variant appearance in text: LRRK2: E193K

PubMed Link: 32508578

Variant Present in the following documents:

• Main text
• fnins-14-00485.pdf

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The LRRK2 N-terminal domain influences vesicle trafficking: impact of the E193K variant.

Scientific Reports

Marku, Algerta A; Carrion, Maria Dolores Perez MDP; Pischedda, Francesca F; Marte, Antonella A; Casiraghi, Zeila Z; Marciani, Paola P; von Zweydorf, Felix F; Gloeckner, Christian Johannes CJ; Onofri, Franco F; Perego, Carla C; Piccoli, Giovanni G

Publication Date: 2020-03-02

Variant appearance in text: LRRK2: E193K

PubMed Link: 32123243

Variant Present in the following documents:

• Main text
• 41598_2020_60834_MOESM1_ESM.pdf
• 41598_2020_Article_60834.pdf

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GSK-3β Inhibitor Alsterpaullone Attenuates MPP+-Induced Cell Damage in a c-Myc-Dependent Manner in SH-SY5Y Cells.

Frontiers In Cellular Neuroscience

Wang, Jiancai J; Li, Yuqian Y; Gao, Li L; Yan, Fengqi F; Gao, Guodong G; Li, Lihong L

Publication Date: 2018

Variant appearance in text: LRRK2: E193K

PubMed Link: 30233322

Variant Present in the following documents:

• fncel-12-00283.pdf

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LRRK2 and mitochondria: Recent advances and current views.

Brain Research

Singh, Alpana A; Zhi, Lianteng L; Zhang, Hui H

Publication Date: 2019-01-01

Variant appearance in text: LRRK2: E193K

PubMed Link: 29894679

Variant Present in the following documents:

• Main text

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The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.

Frontiers In Molecular Neuroscience

Perez Carrion, Maria M; Pischedda, Francesca F; Biosa, Alice A; Russo, Isabella I; Straniero, Letizia L; Civiero, Laura L; Guida, Marianna M; Gloeckner, Christian J CJ; Ticozzi, Nicola N; Tiloca, Cinzia C; Mariani, Claudio C; Pezzoli, Gianni G; Duga, Stefano S; Pichler, Irene I; Pan, Lifeng L; Landers, John E JE; Greggio, Elisa E; Hess, Michael W MW; Goldwurm, Stefano S; Piccoli, Giovanni G

Publication Date: 2018

Variant appearance in text: LRRK2: E193K

PubMed Link: 29541021

Variant Present in the following documents:

• Main text
• Image_1.pdf
• fnmol-11-00064.pdf

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Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One

Holehouse, Alex S AS; Naegle, Kristen M KM

Publication Date: 2015

Variant appearance in text: PARK8: E193K

PubMed Link: 26659599

Variant Present in the following documents:

• pone.0144692.s002.xlsx, sheet 1

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