Publications:

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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.

The Journal Of Cell Biology

Stormo, Adrienne E D AED; Shavarebi, Farbod F; FitzGibbon, Molly M; Earley, Elizabeth M EM; Ahrendt, Hannah H; Lum, Lotus S LS; Verschueren, Erik E; Swaney, Danielle L DL; Skibinski, Gaia G; Ravisankar, Abinaya A; van Haren, Jeffrey J; Davis, Emily J EJ; Johnson, Jeffrey R JR; Von Dollen, John J; Balen, Carson C; Porath, Jacob J; Crosio, Claudia C; Mirescu, Christian C; Iaccarino, Ciro C; Dauer, William T WT; Nichols, R Jeremy RJ; Wittmann, Torsten T; Cox, Timothy C TC; Finkbeiner, Steve S; Krogan, Nevan J NJ; Oakes, Scott A SA; Hiniker, Annie A

Publication Date: 2022-04-04

Variant appearance in text: LRRK2: Ser935Ala

PubMed Link: 35266954

Variant Present in the following documents:

• Main text
• JCB_202010065.pdf

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Physiological and pathological functions of LRRK2: implications from substrate proteins.

Neuronal Signaling

Araki, Miho M; Ito, Genta G; Tomita, Taisuke T

Publication Date: 2018-12

Variant appearance in text: LRRK2: S935A

PubMed Link: 32714591

Variant Present in the following documents:

• Main text
• ns-02-ns20180005.pdf

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Elevated In Vitro Kinase Activity in Peripheral Blood Mononuclear Cells of Leucine-Rich Repeat Kinase 2 G2019S Carriers: A Novel Enzyme-Linked Immunosorbent Assay-Based Method.

Movement Disorders : Official Journal Of The Movement Disorder Society

Melachroinou, Katerina K; Kang, Min Suk MS; Liong, Christopher C; Narayan, Sushma S; Levers, Najah N; Joshi, Neal N; Kopil, Katie K; Hutten, Samantha J SJ; Baptista, Marco A S MAS; Padmanabhan, Shalini S; Kang, Un Jung UJ; Stefanis, Leonidas L; Alcalay, Roy N RN; Rideout, Hardy J HJ

Publication Date: 2020-11

Variant appearance in text: LRRK2: S935A

PubMed Link: 32652692

Variant Present in the following documents:

• Main text

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LRRK2 Phosphorylation, More Than an Epiphenomenon.

Frontiers In Neuroscience

Marchand, Antoine A; Drouyer, Matthieu M; Sarchione, Alessia A; Chartier-Harlin, Marie-Christine MC; Taymans, Jean-Marc JM

Publication Date: 2020

Variant appearance in text: LRRK2: S935A

PubMed Link: 32612495

Variant Present in the following documents:

• Main text
• fnins-14-00527.pdf

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LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages.

Stem Cell Reports

Lee, Heyne H; Flynn, Rowan R; Sharma, Ishta I; Haberman, Emma E; Carling, Phillippa J PJ; Nicholls, Francesca J FJ; Stegmann, Monika M; Vowles, Jane J; Haenseler, Walther W; Wade-Martins, Richard R; James, William S WS; Cowley, Sally A SA

Publication Date: 2020-05-12

Variant appearance in text: LRRK2: S935A

PubMed Link: 32359446

Variant Present in the following documents:

• Main text

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Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization.

Molecular Neurobiology

De Wit, T T; Baekelandt, V V; Lobbestael, E E

Publication Date: 2019-08

Variant appearance in text: LRRK2: S935A

PubMed Link: 30592011

Variant Present in the following documents:

• Main text
• 12035_2018_Article_1449.pdf

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Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.

Neurobiology Of Disease

Zhao, Ye Y; Keshiya, Shikara S; Atashrazm, Farzaneh F; Gao, Jianqun J; Ittner, Lars M LM; Alessi, Dario R DR; Halliday, Glenda M GM; Fu, Yuhong Y; Dzamko, Nicolas N

Publication Date: 2018-12

Variant appearance in text: LRRK2: S935A

PubMed Link: 30194047

Variant Present in the following documents:

• Main text

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Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation.

Scientific Reports

Lobbestael, E E; Civiero, L L; De Wit, T T; Taymans, J-M JM; Greggio, E E; Baekelandt, V V

Publication Date: 2016-09-23

Variant appearance in text: LRRK2: S935A

PubMed Link: 27658356

Variant Present in the following documents:

• Main text
• srep33897.pdf

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Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.

The Biochemical Journal

Ito, Genta G; Katsemonova, Kristina K; Tonelli, Francesca F; Lis, Pawel P; Baptista, Marco A S MA; Shpiro, Natalia N; Duddy, Graham G; Wilson, Steve S; Ho, Philip Wing-Lok PW; Ho, Shu-Leong SL; Reith, Alastair D AD; Alessi, Dario R DR

Publication Date: 2016-09-01

Variant appearance in text: LRRK2: S935A

PubMed Link: 27474410

Variant Present in the following documents:

• Main text
• bj4732671.pdf

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14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.

Human Molecular Genetics

Lavalley, Nicholas J NJ; Slone, Sunny R SR; Ding, Huiping H; West, Andrew B AB; Yacoubian, Talene A TA

Publication Date: 2016-01-01

Variant appearance in text: LRRK2: S935A

PubMed Link: 26546614

Variant Present in the following documents:

• Main text

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Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.

Nature Communications

Chia, Ruth R; Haddock, Sara S; Beilina, Alexandra A; Rudenko, Iakov N IN; Mamais, Adamantios A; Kaganovich, Alice A; Li, Yan Y; Kumaran, Ravindran R; Nalls, Michael A MA; Cookson, Mark R MR

Publication Date: 2014-12-15

Variant appearance in text: LRRK2: S935A

PubMed Link: 25500533

Variant Present in the following documents:

• nihms641836.pdf

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Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation.

Plos One

Hermanson, Spencer B SB; Carlson, Coby B CB; Riddle, Steven M SM; Zhao, Jing J; Vogel, Kurt W KW; Nichols, R Jeremy RJ; Bi, Kun K

Publication Date: 2012

Variant appearance in text: LRRK2: Ser935Ala

PubMed Link: 22952710

Variant Present in the following documents:

• Main text
• pone.0043580.pdf

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Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease.

Plos One

Li, Xianting X; Wang, Qing Jun QJ; Pan, Nina N; Lee, Sangkyu S; Zhao, Yingming Y; Chait, Brian T BT; Yue, Zhenyu Z

Publication Date: 2011-03-01

Variant appearance in text: LRRK2: S935A

PubMed Link: 21390248

Variant Present in the following documents:

• Main text

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14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.

The Biochemical Journal

Nichols, R Jeremy RJ; Dzamko, Nicolas N; Morrice, Nicholas A NA; Campbell, David G DG; Deak, Maria M; Ordureau, Alban A; Macartney, Thomas T; Tong, Youren Y; Shen, Jie J; Prescott, Alan R AR; Alessi, Dario R DR

Publication Date: 2010-09-15

Variant appearance in text: LRRK2: S935A

PubMed Link: 20642453

Variant Present in the following documents:

• Main text
• bj4300393.pdf

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