Publications:

---

LRRK2 Structure-Based Activation Mechanism and Pathogenesis.

Biomolecules

Zhang, Xiaojuan X; Kortholt, Arjan A

Publication Date: 2023-03-28

Variant appearance in text: LRRK2: L1165P

PubMed Link: 37189360

Variant Present in the following documents:

• Main text
• biomolecules-13-00612.pdf

View BVdb publication page

---

LRRK2 and Parkinson's disease: from genetics to targeted therapy.

Annals Of Clinical And Translational Neurology

Sosero, Yuri L YL; Gan-Or, Ziv Z

Publication Date: 2023-04-06

Variant appearance in text: LRRK2: L1165P

PubMed Link: 37021623

Variant Present in the following documents:

• Main text
• ACN3-10-850.pdf

View BVdb publication page

---

Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells.

Cells

Goveas, Liesel L; Mutez, Eugénie E; Chartier-Harlin, Marie-Christine MC; Taymans, Jean-Marc JM

Publication Date: 2021-04-22

Variant appearance in text: LRRK2: L1165P

PubMed Link: 33922322

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Genetic and Environmental Factors Influence the Pleomorphy of LRRK2 Parkinsonism.

International Journal Of Molecular Sciences

Chittoor-Vinod, Vinita G VG; Nichols, R Jeremy RJ; Schüle, Birgitt B

Publication Date: 2021-01-21

Variant appearance in text: LRRK2: 3494T>C; L1165P

PubMed Link: 33494262

Variant Present in the following documents:

• Main text
• ijms-22-01045.pdf

View BVdb publication page

---

Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease.

Acta Neuropathologica Communications

Henderson, Michael X MX; Sengupta, Medha M; Trojanowski, John Q JQ; Lee, Virginia M Y VMY

Publication Date: 2019-11-16

Variant appearance in text: LRRK2: L1165P

PubMed Link: 31733655

Variant Present in the following documents:

• Main text
• 40478_2019_Article_836.pdf

View BVdb publication page

---

Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature.

Movement Disorders : Official Journal Of The Movement Disorder Society

Schneider, Susanne A SA; Alcalay, Roy N RN

Publication Date: 2017-11

Variant appearance in text: LRRK2: L1165P

PubMed Link: 29124790

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Evaluating LRRK2 genetic variants with unclear pathogenicity.

Biomed Research International

Refai, Fathima Shaffra FS; Ng, Shin Hui SH; Tan, Eng-King EK

Publication Date: 2015

Variant appearance in text: LRRK2: L1165P

PubMed Link: 25821816

Variant Present in the following documents:

• Main text
• BMRI2015-678701.pdf

View BVdb publication page

---

TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT.

Neurobiology Of Aging

Ling, Helen H; Kara, Eleanna E; Bandopadhyay, Rina R; Hardy, John J; Holton, Janice J; Xiromerisiou, Georgia G; Lees, Andrew A; Houlden, Henry H; Revesz, Tamas T

Publication Date: 2013-12

Variant appearance in text: LRRK2: L1165P

PubMed Link: 23664753

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The neuropathology of genetic Parkinson's disease.

Movement Disorders : Official Journal Of The Movement Disorder Society

Poulopoulos, Markos M; Levy, Oren A OA; Alcalay, Roy N RN

Publication Date: 2012-06

Variant appearance in text: LRRK2: L1165P

PubMed Link: 22451330

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.

The Lancet. Neurology

Ross, Owen A OA; Soto-Ortolaza, Alexandra I AI; Heckman, Michael G MG; Aasly, Jan O JO; Abahuni, Nadine N; Annesi, Grazia G; Bacon, Justin A JA; Bardien, Soraya S; Bozi, Maria M; Brice, Alexis A; Brighina, Laura L; Van Broeckhoven, Christine C; Carr, Jonathan J; Chartier-Harlin, Marie-Christine MC; Dardiotis, Efthimios E; Dickson, Dennis W DW; Diehl, Nancy N NN; Elbaz, Alexis A; Ferrarese, Carlo C; Ferraris, Alessandro A; Fiske, Brian B; Gibson, J Mark JM; Gibson, Rachel R; Hadjigeorgiou, Georgios M GM; Hattori, Nobutaka N; Ioannidis, John P A JP; Jasinska-Myga, Barbara B; Jeon, Beom S BS; Kim, Yun Joong YJ; Klein, Christine C; Kruger, Rejko R; Kyratzi, Elli E; Lesage, Suzanne S; Lin, Chin-Hsien CH; Lynch, Timothy T; Maraganore, Demetrius M DM; Mellick, George D GD; Mutez, Eugénie E; Nilsson, Christer C; Opala, Grzegorz G; Park, Sung Sup SS; Puschmann, Andreas A; Quattrone, Aldo A; Sharma, Manu M; Silburn, Peter A PA; Sohn, Young Ho YH; Stefanis, Leonidas L; Tadic, Vera V; Theuns, Jessie J; Tomiyama, Hiroyuki H; Uitti, Ryan J RJ; Valente, Enza Maria EM; van de Loo, Simone S; Vassilatis, Demetrios K DK; Vilariño-Güell, Carles C; White, Linda R LR; Wirdefeldt, Karin K; Wszolek, Zbigniew K ZK; Wu, Ruey-Meei RM; Farrer, Matthew J MJ; ,

Publication Date: 2011-10

Variant appearance in text: LRRK2: L1165P

PubMed Link: 21885347

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.

Human Mutation

Nuytemans, Karen K; Theuns, Jessie J; Cruts, Marc M; Van Broeckhoven, Christine C

Publication Date: 2010-07

Variant appearance in text: LRRK2: 3494T>C; L1165P

PubMed Link: 20506312

Variant Present in the following documents:

• humu0031-0763-SD1.pdf

View BVdb publication page

---

Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions.

Journal Of Neuropathology And Experimental Neurology

Waxman, Elisa A EA; Covy, Jason P JP; Bukh, Irene I; Li, Xiaojie X; Dawson, Ted M TM; Giasson, Benoit I BI

Publication Date: 2009-07

Variant appearance in text: LRRK2: L1165P

PubMed Link: 19535993

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.

Movement Disorders : Official Journal Of The Movement Disorder Society

Covy, Jason P JP; Yuan, Wuxing W; Waxman, Elisa A EA; Hurtig, Howard I HI; Van Deerlin, Vivianna M VM; Giasson, Benoit I BI

Publication Date: 2009-01-15

Variant appearance in text: LRRK2: 3494T>C

PubMed Link: 19006185

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease.

Biochimica Et Biophysica Acta

Biskup, Saskia S; West, Andrew B AB

Publication Date: 2009-07

Variant appearance in text: LRRK2: L1165P

PubMed Link: 18973807

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations.

Neurology

Chen-Plotkin, A S AS; Yuan, W W; Anderson, C C; McCarty Wood, E E; Hurtig, H I HI; Clark, C M CM; Miller, B L BL; Lee, V M-Y VM; Trojanowski, J Q JQ; Grossman, M M; Van Deerlin, V M VM

Publication Date: 2008-02-12

Variant appearance in text: LRRK2: 3494T>C; L1165P

PubMed Link: 17914064

Variant Present in the following documents:

• Main text

View BVdb publication page

---