Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.
Neurobiology Of Disease
Heaton, George R GR; Landeck, Natalie N; Mamais, Adamantios A; Nalls, Mike A MA; Nixon-Abell, Jonathon J; Kumaran, Ravindran R; Beilina, Alexandra A; Pellegrini, Laura L; Li, Yan Y; , ; Harvey, Kirsten K; Cookson, Mark R MR
Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2.
Neurochemical Research
Langston, Rebekah G RG; Rudenko, Iakov N IN; Kumaran, Ravindran R; Hauser, David N DN; Kaganovich, Alice A; Ponce, Luis Bonet LB; Mamais, Adamantios A; Ndukwe, Kelechi K; Dillman, Allissa A AA; Al-Saif, Amr M AM; Beilina, Aleksandra A; Cookson, Mark R MR
Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling.
Molecular Neurodegeneration
Berwick, Daniel C DC; Javaheri, Behzad B; Wetzel, Andrea A; Hopkinson, Mark M; Nixon-Abell, Jonathon J; Grannò, Simone S; Pitsillides, Andrew A AA; Harvey, Kirsten K
Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Nature Communications
Chia, Ruth R; Haddock, Sara S; Beilina, Alexandra A; Rudenko, Iakov N IN; Mamais, Adamantios A; Kaganovich, Alice A; Li, Yan Y; Kumaran, Ravindran R; Nalls, Michael A MA; Cookson, Mark R MR
Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution.
The Journal Of Biological Chemistry
Mamais, Adamantios A; Chia, Ruth R; Beilina, Alexandra A; Hauser, David N DN; Hall, Christine C; Lewis, Patrick A PA; Cookson, Mark R MR; Bandopadhyay, Rina R
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Human Molecular Genetics
Dusonchet, Julien J; Li, Hu H; Guillily, Maria M; Liu, Min M; Stafa, Klodjan K; Derada Troletti, Claudio C; Boon, Joon Y JY; Saha, Shamol S; Glauser, Liliane L; Mamais, Adamantios A; Citro, Allison A; Youmans, Katherine L KL; Liu, LiQun L; Schneider, Bernard L BL; Aebischer, Patrick P; Yue, Zhenyu Z; Bandopadhyay, Rina R; Glicksman, Marcie A MA; Moore, Darren J DJ; Collins, James J JJ; Wolozin, Benjamin B
A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation.
The Journal Of Biological Chemistry
Law, Bernard M H BM; Spain, Victoria A VA; Leinster, Veronica H L VH; Chia, Ruth R; Beilina, Alexandra A; Cho, Hyun J HJ; Taymans, Jean-Marc JM; Urban, Mary K MK; Sancho, Rosa M RM; Blanca Ramírez, Marian M; Biskup, Saskia S; Baekelandt, Veerle V; Cai, Huaibin H; Cookson, Mark R MR; Berwick, Daniel C DC; Harvey, Kirsten K
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.
Human Molecular Genetics
Wang, Xinglong X; Yan, Michael H MH; Fujioka, Hisashi H; Liu, Jun J; Wilson-Delfosse, Amy A; Chen, Shu G SG; Perry, George G; Casadesus, Gemma G; Zhu, Xiongwei X
LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding.
Plos One
Taymans, Jean-Marc JM; Vancraenenbroeck, Renée R; Ollikainen, Petri P; Beilina, Alexandra A; Lobbestael, Evy E; De Maeyer, Marc M; Baekelandt, Veerle V; Cookson, Mark R MR
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.
Journal Of Neurochemistry
Daniëls, Veronique V; Vancraenenbroeck, Renée R; Law, Bernard M H BM; Greggio, Elisa E; Lobbestael, Evy E; Gao, Fangye F; De Maeyer, Marc M; Cookson, Mark R MR; Harvey, Kirsten K; Baekelandt, Veerle V; Taymans, Jean-Marc JM
Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif.
Plos One
Pungaliya, Pooja P PP; Bai, Yuchen Y; Lipinski, Kerri K; Anand, Vasanti S VS; Sen, Saurabh S; Brown, Eugene L EL; Bates, Brian B; Reinhart, Peter H PH; West, Andrew B AB; Hirst, Warren D WD; Braithwaite, Steven P SP
GTPase activity plays a key role in the pathobiology of LRRK2.
Plos Genetics
Xiong, Yulan Y; Coombes, Candice E CE; Kilaru, Austin A; Li, Xiaojie X; Gitler, Aaron D AD; Bowers, William J WJ; Dawson, Valina L VL; Dawson, Ted M TM; Moore, Darren J DJ
LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease.
Neurobiology Of Disease
Yao, Chen C; El Khoury, Rabih R; Wang, Wen W; Byrd, Tara A TA; Pehek, Elizabeth A EA; Thacker, Colin C; Zhu, Xiongwei X; Smith, Mark A MA; Wilson-Delfosse, Amy L AL; Chen, Shu G SG