Publications:

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Overview of the Impact of Pathogenic LRRK2 Mutations in Parkinson's Disease.

Biomolecules

Ito, Genta G; Utsunomiya-Tate, Naoko N

Publication Date: 2023-05-16

Variant appearance in text: LRRK2: N1437H

PubMed Link: 37238714

Variant Present in the following documents:

• Main text
• biomolecules-13-00845.pdf

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Immunological Features of LRRK2 Function and Its Role in the Gut-Brain Axis Governing Parkinson's Disease.

Journal Of Parkinson'S Disease

Peter, Inga I; Strober, Warren W

Publication Date: 2023-04-10

Variant appearance in text: LRRK2: N1437H

PubMed Link: 37066923

Variant Present in the following documents:

• Main text
• jpd-13-jpd230021.pdf

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LRRK2 and Parkinson's disease: from genetics to targeted therapy.

Annals Of Clinical And Translational Neurology

Sosero, Yuri L YL; Gan-Or, Ziv Z

Publication Date: 2023-04-06

Variant appearance in text: LRRK2: N1437H

PubMed Link: 37021623

Variant Present in the following documents:

• Main text
• ACN3-10-850.pdf

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Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation.

Biochemical Society Transactions

Fasiczka, Rachel R; Naaldijk, Yahaira Y; Brahmia, Besma B; Hilfiker, Sabine S

Publication Date: 2023-03-17

Variant appearance in text: LRRK2: N1437H

PubMed Link: 36929701

Variant Present in the following documents:

• Main text
• BST-51-587.pdf

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Changes in Liver Lipidomic Profile in G2019S-LRRK2 Mouse Model of Parkinson's Disease.

Cells

Corral Nieto, Yaiza Y; Yakhine-Diop, Sokhna M S SMS; Moreno-Cruz, Paula P; Manrique García, Laura L; Gabrielly Pereira, Amanda A; Morales-García, José A JA; Niso-Santano, Mireia M; González-Polo, Rosa A RA; Uribe-Carretero, Elisabet E; Durand, Sylvère S; Maiuri, Maria Chiara MC; Paredes-Barquero, Marta M; Alegre-Cortés, Eva E; Canales-Cortés, Saray S; López de Munain, Adolfo A; Pérez-Tur, Jordi J; Pérez-Castillo, Ana A; Kroemer, Guido G; Fuentes, José M JM; Bravo-San Pedro, José M JM

Publication Date: 2023-03-04

Variant appearance in text: PARK8: N1437H

PubMed Link: 36899942

Variant Present in the following documents:

• Main text
• cells-12-00806.pdf

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The function of Golgi apparatus in LRRK2-associated Parkinson's disease.

Frontiers In Molecular Neuroscience

Wei, Yonghang Y; Awan, Maher Un Nisa MUN; Bai, Liping L; Bai, Jie J

Publication Date: 2023

Variant appearance in text: LRRK2: N1437H

PubMed Link: 36896008

Variant Present in the following documents:

• Main text
• fnmol-16-1097633.pdf

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Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective.

International Journal Of Molecular Sciences

Yi, Shuanglong S; Wang, Linfang L; Wang, Honglei H; Ho, Margaret S MS; Zhang, Shiping S

Publication Date: 2022-11-25

Variant appearance in text: LRRK2: N1437H

PubMed Link: 36499080

Variant Present in the following documents:

• Main text
• ijms-23-14753.pdf

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Development of mutation-selective LRRK2 kinase inhibitors as precision medicine for Parkinson's disease and other diseases for which carriers are at increased risk.

Frontiers In Neurology

Lesniak, Robert K RK; Nichols, R Jeremy RJ; Montine, Thomas J TJ

Publication Date: 2022

Variant appearance in text: LRRK2: N1437H

PubMed Link: 36388213

Variant Present in the following documents:

• Main text
• fneur-13-1016040.pdf

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Human Induced Pluripotent Stem Cell Phenotyping and Preclinical Modeling of Familial Parkinson's Disease.

Genes

Kim, Jeffrey J; Daadi, Etienne W EW; Oh, Thomas T; Daadi, Elyas S ES; Daadi, Marcel M MM

Publication Date: 2022-10-25

Variant appearance in text: LRRK2: N1437H

PubMed Link: 36360174

Variant Present in the following documents:

• Main text
• genes-13-01937.pdf

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Precision Medicine in Parkinson's Disease: From Genetic Risk Signals to Personalized Therapy.

Brain Sciences

Straccia, Giulia G; Colucci, Fabiana F; Eleopra, Roberto R; Cilia, Roberto R

Publication Date: 2022-09-28

Variant appearance in text: LRRK2: N1437H

PubMed Link: 36291241

Variant Present in the following documents:

• Main text
• brainsci-12-01308.pdf

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Structural Insights and Development of LRRK2 Inhibitors for Parkinson's Disease in the Last Decade.

Genes

Thakur, Gunjan G; Kumar, Vikas V; Lee, Keun Woo KW; Won, Chungkil C

Publication Date: 2022-08-11

Variant appearance in text: LRRK2: N1437H

PubMed Link: 36011337

Variant Present in the following documents:

• Main text
• genes-13-01426.pdf

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Effect Modification between Genes and Environment and Parkinson's Disease Risk.

Annals Of Neurology

Periñán, Maria Teresa MT; Brolin, Kajsa K; Bandres-Ciga, Sara S; Blauwendraat, Cornelis C; Klein, Christine C; Gan-Or, Ziv Z; Singleton, Andrew A; Gomez-Garre, Pilar P; Swanberg, Maria M; Mir, Pablo P; Noyce, Alastair A

Publication Date: 2022-11

Variant appearance in text: LRRK2: Asn1437His

PubMed Link: 35913124

Variant Present in the following documents:

• Main text
• ANA-92-715.pdf

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The emerging role of LRRK2 in tauopathies.

Clinical Science (London, England : 1979)

Herbst, Susanne S; Lewis, Patrick A PA; Morris, Huw R HR

Publication Date: 2022-07-15

Variant appearance in text: PARK8: N1437H

PubMed Link: 35815712

Variant Present in the following documents:

• Main text
• cs-136-cs20220067.pdf

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Mitochondrial Dysfunction in Parkinson's Disease: From Mechanistic Insights to Therapy.

Frontiers In Aging Neuroscience

Gao, Xiao-Yan XY; Yang, Tuo T; Gu, Ying Y; Sun, Xiao-Hong XH

Publication Date: 2022

Variant appearance in text: LRRK2: N1437H

PubMed Link: 35795234

Variant Present in the following documents:

• Main text
• fnagi-14-885500.pdf

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The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization.

Biology Open

Lara Ordóñez, Antonio Jesús AJ; Fasiczka, Rachel R; Fernández, Belén B; Naaldijk, Yahaira Y; Fdez, Elena E; Blanca Ramírez, Marian M; Phan, Sébastien S; Boassa, Daniela D; Hilfiker, Sabine S

Publication Date: 2022-08-15

Variant appearance in text: LRRK2: N1437H

PubMed Link: 35776681

Variant Present in the following documents:

• Main text
• biolopen-11-059468.pdf

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LRRK2 and Proteostasis in Parkinson's Disease.

International Journal Of Molecular Sciences

Pérez-Carrión, María Dolores MD; Posadas, Inmaculada I; Solera, Javier J; Ceña, Valentín V

Publication Date: 2022-06-18

Variant appearance in text: LRRK2: N1437H

PubMed Link: 35743250

Variant Present in the following documents:

• Main text
• ijms-23-06808.pdf

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A Review on Response to Device-Aided Therapies Used in Monogenic Parkinsonism and GBA Variants Carriers: A Need for Guidelines and Comparative Studies.

Journal Of Parkinson'S Disease

Salles, Philippe A PA; Liao, James J; Shuaib, Umar U; Mata, Ignacio F IF; Fernandez, Hubert H HH

Publication Date: 2022

Variant appearance in text: LRRK2: N1437H

PubMed Link: 35662127

Variant Present in the following documents:

• Main text
• jpd-12-jpd212986.pdf

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Monogenic Parkinson's Disease: Genotype, Phenotype, Pathophysiology, and Genetic Testing.

Genes

Jia, Fangzhi F; Fellner, Avi A; Kumar, Kishore Raj KR

Publication Date: 2022-03-07

Variant appearance in text: LRRK2: N1437H

PubMed Link: 35328025

Variant Present in the following documents:

• Main text
• genes-13-00471.pdf

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LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.

Plos Biology

Weng, Jui-Hung JH; Aoto, Phillip C PC; Lorenz, Robin R; Wu, Jian J; Schmidt, Sven H SH; Manschwetus, Jascha T JT; Kaila-Sharma, Pallavi P; Silletti, Steve S; Mathea, Sebastian S; Chatterjee, Deep D; Knapp, Stefan S; Herberg, Friedrich W FW; Taylor, Susan S SS

Publication Date: 2022-02

Variant appearance in text: LRRK2: N1437H

PubMed Link: 35192607

Variant Present in the following documents:

• Main text
• pbio.3001427.pdf

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LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson's disease.

Translational Neurodegeneration

Chang, Eunice Eun Seo EES; Ho, Philip Wing-Lok PW; Liu, Hui-Fang HF; Pang, Shirley Yin-Yu SY; Leung, Chi-Ting CT; Malki, Yasine Y; Choi, Zoe Yuen-Kiu ZY; Ramsden, David Boyer DB; Ho, Shu-Leong SL

Publication Date: 2022-02-14

Variant appearance in text: LRRK2: N1437H

PubMed Link: 35152914

Variant Present in the following documents:

• Main text

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Cognitive Impairment in Genetic Parkinson's Disease.

Parkinson'S Disease

Planas-Ballvé, A A; Vilas, D D

Publication Date: 2021

Variant appearance in text: LRRK2: N1437H

PubMed Link: 35003622

Variant Present in the following documents:

• Main text
• PD2021-8610285.pdf

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Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson's Disease.

Frontiers In Pharmacology

Wang, Yumin Y; Gao, Luyan L; Chen, Jichao J; Li, Qiang Q; Huo, Liang L; Wang, Yanchao Y; Wang, Hongquan H; Du, Jichen J

Publication Date: 2021

Variant appearance in text: LRRK2: N1437H

PubMed Link: 34887759

Variant Present in the following documents:

• Main text
• fphar-12-757161.pdf

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The Regulation of Rab GTPases by Phosphorylation.

Biomolecules

Xu, Lejia L; Nagai, Yuki Y; Kajihara, Yotaro Y; Ito, Genta G; Tomita, Taisuke T

Publication Date: 2021-09-10

Variant appearance in text: LRRK2: N1437H

PubMed Link: 34572553

Variant Present in the following documents:

• Main text

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A Conserved Role for LRRK2 and Roco Proteins in the Regulation of Mitochondrial Activity.

Frontiers In Cell And Developmental Biology

Rosenbusch, Katharina E KE; Oun, Asmaa A; Sanislav, Oana O; Lay, Sui T ST; Keizer-Gunnink, Ineke I; Annesley, Sarah J SJ; Fisher, Paul R PR; Dolga, Amalia M AM; Kortholt, Arjan A

Publication Date: 2021

Variant appearance in text: LRRK2: Asn1437His

PubMed Link: 34568343

Variant Present in the following documents:

• fcell-09-734554.pdf

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Pathways to Parkinson's disease: a spotlight on 14-3-3 proteins.

Npj Parkinson'S Disease

Giusto, E E; Yacoubian, T A TA; Greggio, E E; Civiero, L L

Publication Date: 2021-09-21

Variant appearance in text: LRRK2: N1437H

PubMed Link: 34548498

Variant Present in the following documents:

• Main text

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Impact of Type II LRRK2 inhibitors on signaling and mitophagy.

The Biochemical Journal

Tasegian, Anna A; Singh, Francois F; Ganley, Ian G IG; Reith, Alastair D AD; Alessi, Dario R DR

Publication Date: 2021-10-15

Variant appearance in text: LRRK2: N1437H

PubMed Link: 34515301

Variant Present in the following documents:

• Main text

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LIPAD (LRRK2/Luebeck International Parkinson's Disease) Study Protocol: Deep Phenotyping of an International Genetic Cohort.

Frontiers In Neurology

Usnich, Tatiana T; Vollstedt, Eva-Juliane EJ; Schell, Nathalie N; Skrahina, Volha V; Bogdanovic, Xenia X; Gaber, Hanaa H; Förster, Toni M TM; Heuer, Andreas A; Koleva-Alazeh, Natalia N; Csoti, Ilona I; Basak, Ayse Nazli AN; Ertan, Sibel S; Genc, Gencer G; Bauer, Peter P; Lohmann, Katja K; Grünewald, Anne A; Schymanski, Emma L EL; Trinh, Joanne J; Schaake, Susen S; Berg, Daniela D; Gruber, Doreen D; Isaacson, Stuart H SH; Kühn, Andrea A AA; Mollenhauer, Brit B; Pedrosa, David J DJ; Reetz, Kathrin K; Sammler, Esther M EM; Valente, Enza Maria EM; Valzania, Franco F; Volkmann, Jens J; Zittel, Simone S; Brüggemann, Norbert N; Kasten, Meike M; Rolfs, Arndt A; Klein, Christine C; ,

Publication Date: 2021

Variant appearance in text: LRRK2: 4309A>C; Asn1437His

PubMed Link: 34475849

Variant Present in the following documents:

• Main text

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Nanomedicine for Neurodegenerative Disorders: Focus on Alzheimer's and Parkinson's Diseases.

International Journal Of Molecular Sciences

Jagaran, Keelan K; Singh, Moganavelli M

Publication Date: 2021-08-23

Variant appearance in text: LRRK2: Asn1437His

PubMed Link: 34445784

Variant Present in the following documents:

• Main text
• ijms-22-09082.pdf

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Targeting of Lysosomal Pathway Genes for Parkinson's Disease Modification: Insights From Cellular and Animal Models.

Frontiers In Neurology

Abe, Tetsuro T; Kuwahara, Tomoki T

Publication Date: 2021

Variant appearance in text: LRRK2: N1437H

PubMed Link: 34194386

Variant Present in the following documents:

• Main text
• fneur-12-681369.pdf

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R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils.

Acta Neuropathologica

Fan, Ying Y; Nirujogi, Raja S RS; Garrido, Alicia A; Ruiz-Martínez, Javier J; Bergareche-Yarza, Alberto A; Mondragón-Rezola, Elisabet E; Vinagre-Aragón, Ana A; Croitoru, Ioana I; Gorostidi Pagola, Ana A; Paternain Markinez, Laura L; Alcalay, Roy R; Hickman, Richard A RA; Düring, Jonas J; Gomes, Sara S; Pratuseviciute, Neringa N; Padmanabhan, Shalini S; Valldeoriola, Francesc F; Pérez Sisqués, Leticia L; Malagelada, Cristina C; Ximelis, Teresa T; Molina Porcel, Laura L; Martí, Maria José MJ; Tolosa, Eduardo E; Alessi, Dario R DR; Sammler, Esther M EM

Publication Date: 2021-09

Variant appearance in text: LRRK2: N1437H

PubMed Link: 34125248

Variant Present in the following documents:

• Main text

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Generation of fourteen isogenic cell lines for Parkinson's disease-associated leucine-rich repeat kinase (LRRK2).

Stem Cell Research

Beylina, Aleksandra A; Langston, Rebekah G RG; Rosen, Dorien D; Reed, Xylena X; Cookson, Mark R MR

Publication Date: 2021-05

Variant appearance in text: LRRK2: N1437H

PubMed Link: 34087985

Variant Present in the following documents:

• Main text
• nihms-1717181.pdf

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The Contribution of Microglia to Neuroinflammation in Parkinson's Disease.

International Journal Of Molecular Sciences

Badanjak, Katja K; Fixemer, Sonja S; Smajić, Semra S; Skupin, Alexander A; Grünewald, Anne A

Publication Date: 2021-04-28

Variant appearance in text: LRRK2: N1437H

PubMed Link: 33925154

Variant Present in the following documents:

• Main text

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Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells.

Cells

Goveas, Liesel L; Mutez, Eugénie E; Chartier-Harlin, Marie-Christine MC; Taymans, Jean-Marc JM

Publication Date: 2021-04-22

Variant appearance in text: LRRK2: N1437H

PubMed Link: 33922322

Variant Present in the following documents:

• Main text

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Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence.

Journal Of Personalized Medicine

Cesario, Alfredo A; D'Oria, Marika M; Bove, Francesco F; Privitera, Giuseppe G; Boškoski, Ivo I; Pedicino, Daniela D; Boldrini, Luca L; Erra, Carmen C; Loreti, Claudia C; Liuzzo, Giovanna G; Crea, Filippo F; Armuzzi, Alessandro A; Gasbarrini, Antonio A; Calabresi, Paolo P; Padua, Luca L; Costamagna, Guido G; Antonelli, Massimo M; Valentini, Vincenzo V; Auffray, Charles C; Scambia, Giovanni G

Publication Date: 2021-04-02

Variant appearance in text: LRRK2: N1437H

PubMed Link: 33918214

Variant Present in the following documents:

• Main text

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LRRK2 at the Crossroad of Aging and Parkinson's Disease.

Genes

Hur, Eun-Mi EM; Lee, Byoung Dae BD

Publication Date: 2021-03-29

Variant appearance in text: LRRK2: N1437H

PubMed Link: 33805527

Variant Present in the following documents:

• Main text

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A More Homogeneous Phenotype in Parkinson's Disease Related to R1441G Mutation in the LRRK2 Gene.

Frontiers In Neurology

Vinagre-Aragón, Ana A; Campo-Caballero, David D; Mondragón-Rezola, Elisabet E; Pardina-Vilella, Lara L; Hernandez Eguiazu, Haizea H; Gorostidi, Ana A; Croitoru, Ioana I; Bergareche, Alberto A; Ruiz-Martinez, Javier J

Publication Date: 2021

Variant appearance in text: LRRK2: N1437H

PubMed Link: 33763016

Variant Present in the following documents:

• Main text
• fneur-12-635396.pdf

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Is LRRK2 the missing link between inflammatory bowel disease and Parkinson's disease?

Npj Parkinson'S Disease

Herrick, Mary K MK; Tansey, Malú G MG

Publication Date: 2021-03-09

Variant appearance in text: LRRK2: N1437H

PubMed Link: 33750819

Variant Present in the following documents:

• Main text
• 41531_2021_Article_170.pdf

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Parkinson's Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance.

Molecular Neurobiology

Streubel-Gallasch, Linn L; Giusti, Veronica V; Sandre, Michele M; Tessari, Isabella I; Plotegher, Nicoletta N; Giusto, Elena E; Masato, Anna A; Iovino, Ludovica L; Battisti, Ilaria I; Arrigoni, Giorgio G; Shimshek, Derya D; Greggio, Elisa E; Tremblay, Marie-Eve ME; Bubacco, Luigi L; Erlandsson, Anna A; Civiero, Laura L

Publication Date: 2021-07

Variant appearance in text: LRRK2: N1437H

PubMed Link: 33629273

Variant Present in the following documents:

• Main text

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