Publications:

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Precision Medicine in Parkinson's Disease: From Genetic Risk Signals to Personalized Therapy.

Brain Sciences

Straccia, Giulia G; Colucci, Fabiana F; Eleopra, Roberto R; Cilia, Roberto R

Publication Date: 2022-09-28

Variant appearance in text: LRRK2: D1994A

PubMed Link: 36291241

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• brainsci-12-01308.pdf

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Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration.

Science Signaling

Liu, Qinfang Q; Bautista-Gomez, Judith J; Higgins, Daniel A DA; Yu, Jianzhong J; Xiong, Yulan Y

Publication Date: 2021-07-27

Variant appearance in text: LRRK2: D1994A

PubMed Link: 34315807

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LRRK2 Kinase Inhibitor Rejuvenates Oxidative Stress-Induced Cellular Senescence in Neuronal Cells.

Oxidative Medicine And Cellular Longevity

Ho, Dong Hwan DH; Nam, Daleum D; Seo, Mi Kyoung MK; Park, Sung Woo SW; Seol, Wongi W; Son, Ilhong I

Publication Date: 2021

Variant appearance in text: LRRK2: D1994A

PubMed Link: 34306319

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• OMCL2021-9969842.pdf

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The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.

International Journal Of Molecular Sciences

Cresto, Noémie N; Gardier, Camille C; Gaillard, Marie-Claude MC; Gubinelli, Francesco F; Roost, Pauline P; Molina, Daniela D; Josephine, Charlène C; Dufour, Noëlle N; Auregan, Gwenaëlle G; Guillermier, Martine M; Bernier, Suéva S; Jan, Caroline C; Gipchtein, Pauline P; Hantraye, Philippe P; Chartier-Harlin, Marie-Christine MC; Bonvento, Gilles G; Van Camp, Nadja N; Taymans, Jean-Marc JM; Cambon, Karine K; Liot, Géraldine G; Bemelmans, Alexis-Pierre AP; Brouillet, Emmanuel E

Publication Date: 2021-06-23

Variant appearance in text: LRRK2: D1994A

PubMed Link: 34201785

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• ijms-22-06760.pdf

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Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo.

Molecular Neurodegeneration

Sarkar, Souvarish S; Bardai, Farah F; Olsen, Abby L AL; Lohr, Kelly M KM; Zhang, Ying-Yi YY; Feany, Mel B MB

Publication Date: 2021-05-24

Variant appearance in text: LRRK2: D1994A

PubMed Link: 34030727

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LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair.

Clinical And Translational Medicine

Chen, Lifeng L; Hou, Jing J; Zeng, Xiangyu X; Guo, Qiang Q; Deng, Min M; Kloeber, Jake A JA; Tu, Xinyi X; Zhao, Fei F; Wu, Zheming Z; Huang, Jinzhou J; Luo, Kuntian K; Kim, Wootae W; Lou, Zhenkun Z

Publication Date: 2021-03

Variant appearance in text: LRRK2: D1994A

PubMed Link: 33784003

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• CTM2-11-e341.pdf

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Pathological Functions of LRRK2 in Parkinson's Disease.

Cells

Jeong, Ga Ram GR; Lee, Byoung Dae BD

Publication Date: 2020-11-30

Variant appearance in text: LRRK2: D1994A

PubMed Link: 33266247

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• Main text
• cells-09-02565.pdf

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LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies.

Science Translational Medicine

Kim, Changyoun C; Beilina, Alexandria A; Smith, Nathan N; Li, Yan Y; Kim, Minhyung M; Kumaran, Ravindran R; Kaganovich, Alice A; Mamais, Adamantios A; Adame, Anthony A; Iba, Michiyo M; Kwon, Somin S; Lee, Won-Jae WJ; Shin, Soo-Jean SJ; Rissman, Robert A RA; You, Sungyong S; Lee, Seung-Jae SJ; Singleton, Andrew B AB; Cookson, Mark R MR; Masliah, Eliezer E

Publication Date: 2020-10-14

Variant appearance in text: LRRK2: D1994A

PubMed Link: 33055242

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The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease.

Frontiers In Neuroscience

Rideout, Hardy J HJ; Chartier-Harlin, Marie-Christine MC; Fell, Matthew J MJ; Hirst, Warren D WD; Huntwork-Rodriguez, Sarah S; Leyns, Cheryl E G CEG; Mabrouk, Omar S OS; Taymans, Jean-Marc JM

Publication Date: 2020

Variant appearance in text: LRRK2: D1994A

PubMed Link: 33013290

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Chetomin rescues pathogenic phenotype of LRRK2 mutation in drosophila.

Aging

Chua, Ling Ling LL; Ho, Patrick P; Toh, Joanne J; Tan, Eng-King EK

Publication Date: 2020-09-24

Variant appearance in text: LRRK2: D1994A

PubMed Link: 32990658

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Mitochondrial Mechanisms of LRRK2 G2019S Penetrance.

Frontiers In Neurology

Delcambre, Sylvie S; Ghelfi, Jenny J; Ouzren, Nassima N; Grandmougin, Léa L; Delbrouck, Catherine C; Seibler, Philip P; Wasner, Kobi K; Aasly, Jan O JO; Klein, Christine C; Trinh, Joanne J; Pereira, Sandro L SL; Grünewald, Anne A

Publication Date: 2020

Variant appearance in text: LRRK2: D1994A

PubMed Link: 32982917

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• fneur-11-00881.pdf

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Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis.

Cell Stem Cell

Kim, Jungwoo Wren JW; Yin, Xiling X; Jhaldiyal, Aanishaa A; Khan, Mohammed Repon MR; Martin, Ian I; Xie, Zhong Z; Perez-Rosello, Tamara T; Kumar, Manoj M; Abalde-Atristain, Leire L; Xu, Jinchong J; Chen, Li L; Eacker, Stephen M SM; Surmeier, D James DJ; Ingolia, Nicholas T NT; Dawson, Ted M TM; Dawson, Valina L VL

Publication Date: 2020-10-01

Variant appearance in text: LRRK2: D1994A

PubMed Link: 32846140

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Progress in LRRK2-Associated Parkinson's Disease Animal Models.

Frontiers In Neuroscience

Seegobin, Steven P SP; Heaton, George R GR; Liang, Dongxiao D; Choi, Insup I; Blanca Ramirez, Marian M; Tang, Beisha B; Yue, Zhenyu Z

Publication Date: 2020

Variant appearance in text: LRRK2: D1994A

PubMed Link: 32765209

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LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Onishi, Keisuke K; Tian, Runyi R; Feng, Bo B; Liu, Yiqiong Y; Wang, Junkai J; Li, Yinan Y; Zou, Yimin Y

Publication Date: 2020-07-28

Variant appearance in text: LRRK2: D1994A

PubMed Link: 32641508

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Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Nguyen, An Phu Tran APT; Tsika, Elpida E; Kelly, Kaela K; Levine, Nathan N; Chen, Xi X; West, Andrew B AB; Boularand, Sylviane S; Barneoud, Pascal P; Moore, Darren J DJ

Publication Date: 2020-07-21

Variant appearance in text: LRRK2: D1994A

PubMed Link: 32631998

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LRRK2 Phosphorylation, More Than an Epiphenomenon.

Frontiers In Neuroscience

Marchand, Antoine A; Drouyer, Matthieu M; Sarchione, Alessia A; Chartier-Harlin, Marie-Christine MC; Taymans, Jean-Marc JM

Publication Date: 2020

Variant appearance in text: LRRK2: D1994A

PubMed Link: 32612495

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• fnins-14-00527.pdf

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Dietary Amino Acids Impact LRRK2-Induced Neurodegeneration in Parkinson's Disease Models.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Chittoor-Vinod, Vinita G VG; Villalobos-Cantor, Steffany S; Roshak, Hanna H; Shea, Kelsey K; Abalde-Atristain, Leire L; Martin, Ian I

Publication Date: 2020-08-05

Variant appearance in text: LRRK2: D1994A

PubMed Link: 32605938

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Autophagy and LRRK2 in the Aging Brain.

Frontiers In Neuroscience

Albanese, Federica F; Novello, Salvatore S; Morari, Michele M

Publication Date: 2019

Variant appearance in text: LRRK2: D1994A

PubMed Link: 31920513

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LRRK2 regulates endoplasmic reticulum-mitochondrial tethering through the PERK-mediated ubiquitination pathway.

The Embo Journal

Toyofuku, Toshihiko T; Okamoto, Yuki Y; Ishikawa, Takako T; Sasawatari, Shigemi S; Kumanogoh, Atsushi A

Publication Date: 2020-01-15

Variant appearance in text: LRRK2: D1994A

PubMed Link: 31821596

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LRRK2 regulation of immune-pathways and inflammatory disease.

Biochemical Society Transactions

Wallings, Rebecca L RL; Tansey, Malú G MG

Publication Date: 2019-12-20

Variant appearance in text: LRRK2: D1994A

PubMed Link: 31769472

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Role of endolysosomes and inter-organellar signaling in brain disease.

Neurobiology Of Disease

Afghah, Zahra Z; Chen, Xuesong X; Geiger, Jonathan D JD

Publication Date: 2020-02

Variant appearance in text: LRRK2: D1994A

PubMed Link: 31707116

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Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity.

Neuromolecular Medicine

Sim, Joan Poh Ling JPL; Ziyin, Wang W; Basil, Adeline Henry AH; Lin, Shuping S; Chen, Zhongcan Z; Zhang, Chengwu C; Zeng, Li L; Cai, Yu Y; Lim, Kah-Leong KL

Publication Date: 2020-06

Variant appearance in text: LRRK2: D1994A

PubMed Link: 31664682

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• Main text
• 12017_2019_Article_8577.pdf

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Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.

Acta Neuropathologica Communications

Lee, Jee Hoon JH; Han, Ji-Hye JH; Kim, Hyunmi H; Park, Sang Myun SM; Joe, Eun-Hye EH; Jou, Ilo I

Publication Date: 2019-05-02

Variant appearance in text: LRRK2: D1994A

PubMed Link: 31046837

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• Main text
• 40478_2019_Article_716.pdf

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Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set.

Nature Communications

, ; Del-Toro, N N; Duesbury, M M; Koch, M M; Perfetto, L L; Shrivastava, A A; Ochoa, D D; Wagih, O O; Piñero, J J; Kotlyar, M M; Pastrello, C C; Beltrao, P P; Furlong, L I LI; Jurisica, I I; Hermjakob, H H; Orchard, S S; Porras, P P

Publication Date: 2019-01-02

Variant appearance in text: PARK8: D1994A

PubMed Link: 30602777

Variant Present in the following documents:

• 41467_2018_7709_MOESM6_ESM.xlsx, sheet 1

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LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation.

Nature Communications

Bae, Eun-Jin EJ; Kim, Dong-Kyu DK; Kim, Changyoun C; Mante, Michael M; Adame, Anthony A; Rockenstein, Edward E; Ulusoy, Ayse A; Klinkenberg, Michael M; Jeong, Ga Ram GR; Bae, Jae Ryul JR; Lee, Cheolsoon C; Lee, He-Jin HJ; Lee, Byung-Dae BD; Di Monte, Donato A DA; Masliah, Eliezer E; Lee, Seung-Jae SJ

Publication Date: 2018-08-27

Variant appearance in text: LRRK2: D1994A

PubMed Link: 30150626

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• Main text
• 41467_2018_Article_5958.pdf

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Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Kim, Kwang Soo KS; Marcogliese, Paul C PC; Yang, Jungwoo J; Callaghan, Steve M SM; Resende, Virginia V; Abdel-Messih, Elizabeth E; Marras, Connie C; Visanji, Naomi P NP; Huang, Jana J; Schlossmacher, Michael G MG; Trinkle-Mulcahy, Laura L; Slack, Ruth S RS; Lang, Anthony E AE; , ; Park, David S DS

Publication Date: 2018-05-29

Variant appearance in text: LRRK2: D1994A

PubMed Link: 29760073

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Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.

Molecular Neurodegeneration

Jeong, Ga Ram GR; Jang, Eun-Hae EH; Bae, Jae Ryul JR; Jun, Soyoung S; Kang, Ho Chul HC; Park, Chi-Hu CH; Shin, Joo-Ho JH; Yamamoto, Yukio Y; Tanaka-Yamamoto, Keiko K; Dawson, Valina L VL; Dawson, Ted M TM; Hur, Eun-Mi EM; Lee, Byoung Dae BD

Publication Date: 2018-02-13

Variant appearance in text: LRRK2: D1994A

PubMed Link: 29439717

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• Main text
• 13024_2018_Article_240.pdf

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In Vitro Modeling of Leucine-Rich Repeat Kinase 2 G2019S-Mediated Parkinson's Disease Pathology.

Stem Cells And Development

Vermilyea, Scott C SC; Emborg, Marina E ME

Publication Date: 2018-07-15

Variant appearance in text: LRRK2: D1994A

PubMed Link: 29402177

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Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Xiong, Yulan Y; Neifert, Stewart S; Karuppagounder, Senthilkumar S SS; Liu, Qinfang Q; Stankowski, Jeannette N JN; Lee, Byoung Dae BD; Ko, Han Seok HS; Lee, Yunjong Y; Grima, Jonathan C JC; Mao, Xiaobo X; Jiang, Haisong H; Kang, Sung-Ung SU; Swing, Deborah A DA; Iacovitti, Lorraine L; Tessarollo, Lino L; Dawson, Ted M TM; Dawson, Valina L VL

Publication Date: 2018-02-13

Variant appearance in text: LRRK2: D1994A

PubMed Link: 29386392

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LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.

Human Molecular Genetics

Liu, Zhiyong Z; Bryant, Nicole N; Kumaran, Ravindran R; Beilina, Alexandra A; Abeliovich, Asa A; Cookson, Mark R MR; West, Andrew B AB

Publication Date: 2018-01-15

Variant appearance in text: LRRK2: D1994A

PubMed Link: 29177506

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Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Pan, Ping-Yue PY; Li, Xianting X; Wang, Jing J; Powell, James J; Wang, Qian Q; Zhang, Yuanxi Y; Chen, Zhaoyu Z; Wicinski, Bridget B; Hof, Patrick P; Ryan, Timothy A TA; Yue, Zhenyu Z

Publication Date: 2017-11-22

Variant appearance in text: LRRK2: D1994A

PubMed Link: 29054882

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LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease.

Human Molecular Genetics

Howlett, Evan H EH; Jensen, Nicholas N; Belmonte, Frances F; Zafar, Faria F; Hu, Xiaoping X; Kluss, Jillian J; Schüle, Birgitt B; Kaufman, Brett A BA; Greenamyre, J T JT; Sanders, Laurie H LH

Publication Date: 2017-11-15

Variant appearance in text: LRRK2: D1994A

PubMed Link: 28973664

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Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells.

Scientific Reports

Thirstrup, Kenneth K; Dächsel, Justus C JC; Oppermann, Felix S FS; Williamson, Douglas S DS; Smith, Garrick P GP; Fog, Karina K; Christensen, Kenneth V KV

Publication Date: 2017-08-31

Variant appearance in text: LRRK2: D1994A

PubMed Link: 28860483

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Role of LRRK2 in the regulation of dopamine receptor trafficking.

Plos One

Rassu, Mauro M; Del Giudice, Maria Grazia MG; Sanna, Simona S; Taymans, Jean Marc JM; Morari, Michele M; Brugnoli, Alberto A; Frassineti, Martina M; Masala, Alessandra A; Esposito, Sonia S; Galioto, Manuela M; Valle, Cristiana C; Carri, Maria Teresa MT; Biosa, Alice A; Greggio, Elisa E; Crosio, Claudia C; Iaccarino, Ciro C

Publication Date: 2017

Variant appearance in text: LRRK2: D1994A

PubMed Link: 28582422

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Leucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1.

Frontiers In Cellular Neuroscience

Han, Kyung A KA; Yoo, Lang L; Sung, Jee Y JY; Chung, Sun A SA; Um, Ji W JW; Kim, Hyeyoung H; Seol, Wongi W; Chung, Kwang C KC

Publication Date: 2017

Variant appearance in text: LRRK2: D1994A

PubMed Link: 28553204

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• fncel-11-00125.pdf

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Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology.

Eneuro

Xiong, Yulan Y; Neifert, Stewart S; Karuppagounder, Senthilkumar S SS; Stankowski, Jeannette N JN; Lee, Byoung Dae BD; Grima, Jonathan C JC; Chen, Guanxing G; Ko, Han Seok HS; Lee, Yunjong Y; Swing, Debbie D; Tessarollo, Lino L; Dawson, Ted M TM; Dawson, Valina L VL

Publication Date: 2017

Variant appearance in text: LRRK2: D1994A

PubMed Link: 28321439

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Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.

Biochemical Society Transactions

Islam, Md Shariful MS; Moore, Darren J DJ

Publication Date: 2017-02-08

Variant appearance in text: LRRK2: D1994A

PubMed Link: 28202670

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Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling.

Molecular Neurodegeneration

Berwick, Daniel C DC; Javaheri, Behzad B; Wetzel, Andrea A; Hopkinson, Mark M; Nixon-Abell, Jonathon J; Grannò, Simone S; Pitsillides, Andrew A AA; Harvey, Kirsten K

Publication Date: 2017-01-19

Variant appearance in text: LRRK2: D1994A

PubMed Link: 28103901

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• 13024_2017_Article_153.pdf

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The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro.

Biochimica Et Biophysica Acta. Proteins And Proteomics

Liu, Zhiyong Z; West, Andrew B AB

Publication Date: 2017-03

Variant appearance in text: LRRK2: D1994A

PubMed Link: 27939437

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Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity.

Neurobiology Of Disease

Ding, Xiaodong X; Barodia, Sandeep K SK; Ma, Lisha L; Goldberg, Matthew S MS

Publication Date: 2017-02

Variant appearance in text: LRRK2: D1994A

PubMed Link: 27890708

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Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations.

Plos One

Melachroinou, Katerina K; Leandrou, Emmanouela E; Valkimadi, Polytimi-Eleni PE; Memou, Anna A; Hadjigeorgiou, Georgios G; Stefanis, Leonidas L; Rideout, Hardy J HJ

Publication Date: 2016

Variant appearance in text: LRRK2: D1994A

PubMed Link: 27832104

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Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease.

Human Molecular Genetics

Islam, Md Shariful MS; Nolte, Hendrik H; Jacob, Wright W; Ziegler, Anna B AB; Pütz, Stefanie S; Grosjean, Yael Y; Szczepanowska, Karolina K; Trifunovic, Aleksandra A; Braun, Thomas T; Heumann, Hermann H; Heumann, Rolf R; Hovemann, Bernhard B; Moore, Darren J DJ; Krüger, Marcus M

Publication Date: 2016-12-15

Variant appearance in text: LRRK2: D1994A

PubMed Link: 27794539

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LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2.

Experimental Neurobiology

Choi, Insup I; Byun, Ji-Won JW; Park, Sang Myun SM; Jou, Ilo I; Joe, Eun-Hye EH

Publication Date: 2016-10

Variant appearance in text: LRRK2: D1994A

PubMed Link: 27790061

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Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy.

Plos One

Park, Sangwook S; Han, Seulki S; Choi, Insup I; Kim, Beomsue B; Park, Seung Pyo SP; Joe, Eun-Hye EH; Suh, Young Ho YH

Publication Date: 2016

Variant appearance in text: LRRK2: D1994A

PubMed Link: 27631370

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• pone.0163029.pdf

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G2385R and I2020T Mutations Increase LRRK2 GTPase Activity.

Biomed Research International

Ho, Dong Hwan DH; Jang, Jihoon J; Joe, Eun-Hye EH; Son, Ilhong I; Seo, Hyemyung H; Seol, Wongi W

Publication Date: 2016

Variant appearance in text: LRRK2: D1994A

PubMed Link: 27314038

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Antioxidants inhibit neuronal toxicity in Parkinson's disease-linked LRRK2.

Annals Of Clinical And Translational Neurology

Angeles, Dario C DC; Ho, Patrick P; Dymock, Brian W BW; Lim, Kah-Leong KL; Zhou, Zhi-Dong ZD; Tan, Eng-King EK

Publication Date: 2016-04

Variant appearance in text: LRRK2: D1994A

PubMed Link: 27081659

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Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

Elife

Steger, Martin M; Tonelli, Francesca F; Ito, Genta G; Davies, Paul P; Trost, Matthias M; Vetter, Melanie M; Wachter, Stefanie S; Lorentzen, Esben E; Duddy, Graham G; Wilson, Stephen S; Baptista, Marco As MA; Fiske, Brian K BK; Fell, Matthew J MJ; Morrow, John A JA; Reith, Alastair D AD; Alessi, Dario R DR; Mann, Matthias M

Publication Date: 2016-01-29

Variant appearance in text: LRRK2: D1994A

PubMed Link: 26824392

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• elife-12813.pdf

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Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression.

Molecular Brain

Ho, Dong Hwan DH; Kim, Hyejung H; Kim, Jisun J; Sim, Hyuna H; Ahn, Hyunjun H; Kim, Janghwan J; Seo, Hyemyung H; Chung, Kwang Chul KC; Park, Bum-Joon BJ; Son, Ilhong I; Seol, Wongi W

Publication Date: 2015-09-18

Variant appearance in text: LRRK2: D1994A

PubMed Link: 26384650

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LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.

Nature Communications

Choi, Insup I; Kim, Beomsue B; Byun, Ji-Won JW; Baik, Sung Hoon SH; Huh, Yun Hyun YH; Kim, Jong-Hyeon JH; Mook-Jung, Inhee I; Song, Woo Keun WK; Shin, Joo-Ho JH; Seo, Hyemyung H; Suh, Young Ho YH; Jou, Ilo I; Park, Sang Myun SM; Kang, Ho Chul HC; Joe, Eun-Hye EH

Publication Date: 2015-09-14

Variant appearance in text: LRRK2: D1994A

PubMed Link: 26365310

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Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy.

Biochimica Et Biophysica Acta

Su, Yu-Chin YC; Guo, Xing X; Qi, Xin X

Publication Date: 2015-01

Variant appearance in text: LRRK2: D1994A

PubMed Link: 25446991

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Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.

The Journal Of Biological Chemistry

Liu, Zhiyong Z; Galemmo, Robert A RA; Fraser, Kyle B KB; Moehle, Mark S MS; Sen, Saurabh S; Volpicelli-Daley, Laura A LA; DeLucas, Lawrence J LJ; Ross, Larry J LJ; Valiyaveettil, Jacob J; Moukha-Chafiq, Omar O; Pathak, Ashish K AK; Ananthan, Subramaniam S; Kezar, Hollis H; White, E Lucile EL; Gupta, Vandana V; Maddry, Joseph A JA; Suto, Mark J MJ; West, Andrew B AB

Publication Date: 2014-11-21

Variant appearance in text: LRRK2: D1994A

PubMed Link: 25228699

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LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status.

Frontiers In Molecular Neuroscience

Reynolds, April A; Doggett, Elizabeth A EA; Riddle, Steve M SM; Lebakken, Connie S CS; Nichols, R Jeremy RJ

Publication Date: 2014

Variant appearance in text: LRRK2: Asp1994Ala

PubMed Link: 25009464

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Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955.

Plos One

Ito, Genta G; Fujimoto, Tetta T; Kamikawaji, Shogo S; Kuwahara, Tomoki T; Iwatsubo, Takeshi T

Publication Date: 2014

Variant appearance in text: LRRK2: D1994A

PubMed Link: 24836358

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