Publications:

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PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

The Biochemical Journal

Malik, Asad U AU; Karapetsas, Athanasios A; Nirujogi, Raja S RS; Chatterjee, Deep D; Phung, Toan K TK; Wightman, Melanie M; Gourlay, Robert R; Morrice, Nick N; Mathea, Sebastian S; Knapp, Stefan S; Alessi, Dario R DR

Publication Date: 2022-09-30

Variant appearance in text: LRRK2: D2017A

PubMed Link: 36040231

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• Main text
• BCJ-479-1941.pdf

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Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding.

The Biochemical Journal

Kalogeropulou, Alexia F AF; Purlyte, Elena E; Tonelli, Francesca F; Lange, Sven M SM; Wightman, Melanie M; Prescott, Alan R AR; Padmanabhan, Shalini S; Sammler, Esther E; Alessi, Dario R DR

Publication Date: 2022-09-16

Variant appearance in text: LRRK2: D2017A

PubMed Link: 35950872

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• BCJ-479-1759.pdf
• BCJ-479-1759-s1.pdf

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Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Schmidt, Sven H SH; Weng, Jui-Hung JH; Aoto, Phillip C PC; Boassa, Daniela D; Mathea, Sebastian S; Silletti, Steve S; Hu, Junru J; Wallbott, Maximilian M; Komives, Elizabeth A EA; Knapp, Stefan S; Herberg, Friedrich W FW; Taylor, Susan S SS

Publication Date: 2021-06-08

Variant appearance in text: LRRK2: D2017A

PubMed Link: 34088839

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• pnas.202100844.pdf
• pnas.2100844118.sapp.pdf

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Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.

The Biochemical Journal

Malik, Asad U AU; Karapetsas, Athanasios A; Nirujogi, Raja S RS; Mathea, Sebastian S; Chatterjee, Deep D; Pal, Prosenjit P; Lis, Pawel P; Taylor, Matthew M; Purlyte, Elena E; Gourlay, Robert R; Dorward, Mark M; Weidlich, Simone S; Toth, Rachel R; Polinski, Nicole K NK; Knapp, Stefan S; Tonelli, Francesca F; Alessi, Dario R DR

Publication Date: 2021-02-12

Variant appearance in text: LRRK2: D2017A

PubMed Link: 33459343

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• Main text
• BCJ-478-553.pdf

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LRRK2 Phosphorylation, More Than an Epiphenomenon.

Frontiers In Neuroscience

Marchand, Antoine A; Drouyer, Matthieu M; Sarchione, Alessia A; Chartier-Harlin, Marie-Christine MC; Taymans, Jean-Marc JM

Publication Date: 2020

Variant appearance in text: LRRK2: D2017A

PubMed Link: 32612495

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• Main text
• fnins-14-00527.pdf

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Origins of Parkinson's Disease in Brain Development: Insights From Early and Persistent Effects of LRRK2-G2019S on Striatal Circuits.

Frontiers In Neuroscience

Huntley, George W GW; Benson, Deanna L DL

Publication Date: 2020

Variant appearance in text: LRRK2: D2017A

PubMed Link: 32273839

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Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases.

The Journal Of Cell Biology

Gomez, Rachel C RC; Wawro, Paulina P; Lis, Pawel P; Alessi, Dario R DR; Pfeffer, Suzanne R SR

Publication Date: 2019-12-02

Variant appearance in text: LRRK2: D2017A

PubMed Link: 31624137

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• Main text
• JCB_201902184_review_history.pdf
• JCB_201902184.pdf

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The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Schmidt, Sven H SH; Knape, Matthias J MJ; Boassa, Daniela D; Mumdey, Natascha N; Kornev, Alexandr P AP; Ellisman, Mark H MH; Taylor, Susan S SS; Herberg, Friedrich W FW

Publication Date: 2019-07-23

Variant appearance in text: LRRK2: D2017A

PubMed Link: 31292254

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Leucine-rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes.

Pharmacology Research & Perspectives

Mercatelli, Daniela D; Bolognesi, Paolo P; Frassineti, Martina M; Pisanò, Clarissa A CA; Longo, Francesco F; Shimshek, Derya R DR; Morari, Michele M

Publication Date: 2019-06

Variant appearance in text: LRRK2: D2017A

PubMed Link: 31149340

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• Main text
• PRP2-7-e00484.pdf

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Crystal structure of the WD40 domain dimer of LRRK2.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Zhang, Pengfei P; Fan, Ying Y; Ru, Heng H; Wang, Li L; Magupalli, Venkat Giri VG; Taylor, Susan S SS; Alessi, Dario R DR; Wu, Hao H

Publication Date: 2019-01-29

Variant appearance in text: LRRK2: D2017A

PubMed Link: 30635421

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• Main text
• pnas.201817889.pdf
• pnas.1817889116.sapp.pdf

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Functional and behavioral consequences of Parkinson's disease-associated LRRK2-G2019S mutation.

Biochemical Society Transactions

Benson, Deanna L DL; Matikainen-Ankney, Bridget A BA; Hussein, Ayan A; Huntley, George W GW

Publication Date: 2018-12-17

Variant appearance in text: LRRK2: D2017A

PubMed Link: 30514770

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Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

The Embo Journal

Purlyte, Elena E; Dhekne, Herschel S HS; Sarhan, Adil R AR; Gomez, Rachel R; Lis, Pawel P; Wightman, Melanie M; Martinez, Terina N TN; Tonelli, Francesca F; Pfeffer, Suzanne R SR; Alessi, Dario R DR

Publication Date: 2018-01-04

Variant appearance in text: LRRK2: D2017A

PubMed Link: 29212815

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Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

Elife

Steger, Martin M; Diez, Federico F; Dhekne, Herschel S HS; Lis, Pawel P; Nirujogi, Raja S RS; Karayel, Ozge O; Tonelli, Francesca F; Martinez, Terina N TN; Lorentzen, Esben E; Pfeffer, Suzanne R SR; Alessi, Dario R DR; Mann, Matthias M

Publication Date: 2017-11-10

Variant appearance in text: LRRK2: D2017A

PubMed Link: 29125462

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• Main text
• elife-31012.pdf

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LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.

The Journal Of Experimental Medicine

Liu, Weiwei W; Liu, Xia'nan X; Li, Yu Y; Zhao, Junjie J; Liu, Zhenshan Z; Hu, Zhuqin Z; Wang, Ying Y; Yao, Yufeng Y; Miller, Aaron W AW; Su, Bing B; Cookson, Mark R MR; Li, Xiaoxia X; Kang, Zizhen Z

Publication Date: 2017-10-02

Variant appearance in text: LRRK2: D2017A

PubMed Link: 28821568

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• Main text
• JEM_20170014.pdf

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Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling.

Molecular Neurodegeneration

Berwick, Daniel C DC; Javaheri, Behzad B; Wetzel, Andrea A; Hopkinson, Mark M; Nixon-Abell, Jonathon J; Grannò, Simone S; Pitsillides, Andrew A AA; Harvey, Kirsten K

Publication Date: 2017-01-19

Variant appearance in text: LRRK2: D2017A

PubMed Link: 28103901

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• Main text
• 13024_2017_Article_153.pdf

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'Up with the LRRK': a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement.

The Biochemical Journal

Eyers, Patrick A PA

Publication Date: 2016-09-15

Variant appearance in text: LRRK2: D2017A

PubMed Link: 27621483

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• Main text
• BCJ-2016-0671C.pdf

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Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.

The Biochemical Journal

Ito, Genta G; Katsemonova, Kristina K; Tonelli, Francesca F; Lis, Pawel P; Baptista, Marco A S MA; Shpiro, Natalia N; Duddy, Graham G; Wilson, Steve S; Ho, Philip Wing-Lok PW; Ho, Shu-Leong SL; Reith, Alastair D AD; Alessi, Dario R DR

Publication Date: 2016-09-01

Variant appearance in text: LRRK2: D2017A

PubMed Link: 27474410

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• Main text
• bj4732671.pdf

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Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Matikainen-Ankney, Bridget A BA; Kezunovic, Nebojsa N; Mesias, Roxana E RE; Tian, Yuan Y; Williams, Frances M FM; Huntley, George W GW; Benson, Deanna L DL

Publication Date: 2016-07-06

Variant appearance in text: LRRK2: D2017A

PubMed Link: 27383589

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Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution.

The Journal Of Biological Chemistry

Mamais, Adamantios A; Chia, Ruth R; Beilina, Alexandra A; Hauser, David N DN; Hall, Christine C; Lewis, Patrick A PA; Cookson, Mark R MR; Bandopadhyay, Rina R

Publication Date: 2014-08-01

Variant appearance in text: LRRK2: D2017A

PubMed Link: 24942733

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In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.

Frontiers In Molecular Neuroscience

Vancraenenbroeck, Renée R; De Raeymaecker, Joren J; Lobbestael, Evy E; Gao, Fangye F; De Maeyer, Marc M; Voet, Arnout A; Baekelandt, Veerle V; Taymans, Jean-Marc JM

Publication Date: 2014

Variant appearance in text: LRRK2: D2017A

PubMed Link: 24917786

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Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955.

Plos One

Ito, Genta G; Fujimoto, Tetta T; Kamikawaji, Shogo S; Kuwahara, Tomoki T; Iwatsubo, Takeshi T

Publication Date: 2014

Variant appearance in text: LRRK2: D2017A

PubMed Link: 24836358

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• Main text
• pone.0097988.pdf

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LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.

Human Molecular Genetics

Berwick, Daniel C DC; Harvey, Kirsten K

Publication Date: 2012-11-15

Variant appearance in text: LRRK2: D2017A

PubMed Link: 22899650

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• Main text
• dds342.pdf

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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.

Open Biology

Kondapalli, Chandana C; Kazlauskaite, Agne A; Zhang, Ning N; Woodroof, Helen I HI; Campbell, David G DG; Gourlay, Robert R; Burchell, Lynn L; Walden, Helen H; Macartney, Thomas J TJ; Deak, Maria M; Knebel, Axel A; Alessi, Dario R DR; Muqit, Miratul M K MM

Publication Date: 2012-05

Variant appearance in text: LRRK2: D2017A

PubMed Link: 22724072

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• rsob-2-120080.pdf

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The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation.

The Biochemical Journal

Rudenko, Iakov N IN; Kaganovich, Alice A; Hauser, David N DN; Beylina, Aleksandra A; Chia, Ruth R; Ding, Jinhui J; Maric, Dragan D; Jaffe, Howard H; Cookson, Mark R MR

Publication Date: 2012-08-15

Variant appearance in text: LRRK2: D2017A

PubMed Link: 22612223

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Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression.

Nature

Gehrke, Stephan S; Imai, Yuzuru Y; Sokol, Nicholas N; Lu, Bingwei B

Publication Date: 2010-07-29

Variant appearance in text: LRRK2: D2017A

PubMed Link: 20671708

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Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.

The Biochemical Journal

Dzamko, Nicolas N; Deak, Maria M; Hentati, Faycal F; Reith, Alastair D AD; Prescott, Alan R AR; Alessi, Dario R DR; Nichols, R Jeremy RJ

Publication Date: 2010-09-15

Variant appearance in text: LRRK2: D2017A

PubMed Link: 20659021

Variant Present in the following documents:

• bj4300405add.pdf
• bj4300405.pdf

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Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.

The Biochemical Journal

Nichols, R Jeremy RJ; Dzamko, Nicolas N; Hutti, Jessica E JE; Cantley, Lewis C LC; Deak, Maria M; Moran, Jennifer J; Bamborough, Paul P; Reith, Alastair D AD; Alessi, Dario R DR

Publication Date: 2009-10-23

Variant appearance in text: LRRK2: D2017A

PubMed Link: 19740074

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The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.

Biochemical And Biophysical Research Communications

Greggio, Elisa E; Taymans, Jean-Marc JM; Zhen, Eugene Yuejun EY; Ryder, John J; Vancraenenbroeck, Renée R; Beilina, Alexandra A; Sun, Peng P; Deng, Junpeng J; Jaffe, Howard H; Baekelandt, Veerle V; Merchant, Kalpana K; Cookson, Mark R MR

Publication Date: 2009-11-20

Variant appearance in text: LRRK2: D2017A

PubMed Link: 19733152

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The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation.

The Journal Of Biological Chemistry

Greggio, Elisa E; Zambrano, Ibardo I; Kaganovich, Alice A; Beilina, Alexandra A; Taymans, Jean-Marc JM; Daniëls, Veronique V; Lewis, Patrick P; Jain, Shushant S; Ding, Jinhui J; Syed, Ali A; Thomas, Kelly J KJ; Baekelandt, Veerle V; Cookson, Mark R MR

Publication Date: 2008-06-13

Variant appearance in text: LRRK2: D2017A

PubMed Link: 18397888

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.

The Biochemical Journal

Jaleel, Mahaboobi M; Nichols, R Jeremy RJ; Deak, Maria M; Campbell, David G DG; Gillardon, Frank F; Knebel, Axel A; Alessi, Dario R DR

Publication Date: 2007-07-15

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PubMed Link: 17447891

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