Publications:

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Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Schmidt, Sven H SH; Weng, Jui-Hung JH; Aoto, Phillip C PC; Boassa, Daniela D; Mathea, Sebastian S; Silletti, Steve S; Hu, Junru J; Wallbott, Maximilian M; Komives, Elizabeth A EA; Knapp, Stefan S; Herberg, Friedrich W FW; Taylor, Susan S SS

Publication Date: 2021-06-08

Variant appearance in text: LRRK2: Y2018F

PubMed Link: 34088839

Variant Present in the following documents:

• Main text
• pnas.2100844118.sapp.pdf
• pnas.202100844.pdf

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The Cell Biology of LRRK2 in Parkinson's Disease.

Molecular And Cellular Biology

Usmani, Ahsan A; Shavarebi, Farbod F; Hiniker, Annie A

Publication Date: 2021-04-22

Variant appearance in text: LRRK2: Y2018F

PubMed Link: 33526455

Variant Present in the following documents:

• Main text

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Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery.

Frontiers In Molecular Neuroscience

Taylor, Susan S SS; Kaila-Sharma, Pallavi P; Weng, Jui-Hung JH; Aoto, Phillip P; Schmidt, Sven H SH; Knapp, Stefan S; Mathea, Sebastian S; Herberg, Friedrich W FW

Publication Date: 2020

Variant appearance in text: LRRK2: Y2018F

PubMed Link: 33122997

Variant Present in the following documents:

• Main text
• fnmol-13-538219.pdf

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Structure of LRRK2 in Parkinson's disease and model for microtubule interaction.

Nature

Deniston, C K CK; Salogiannis, J J; Mathea, S S; Snead, D M DM; Lahiri, I I; Matyszewski, M M; Donosa, O O; Watanabe, R R; Böhning, J J; Shiau, A K AK; Knapp, S S; Villa, E E; Reck-Peterson, S L SL; Leschziner, A E AE

Publication Date: 2020-12

Variant appearance in text: LRRK2: Y2018F

PubMed Link: 32814344

Variant Present in the following documents:

• Main text
• nihms-1620036.pdf

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LRRK2 Phosphorylation, More Than an Epiphenomenon.

Frontiers In Neuroscience

Marchand, Antoine A; Drouyer, Matthieu M; Sarchione, Alessia A; Chartier-Harlin, Marie-Christine MC; Taymans, Jean-Marc JM

Publication Date: 2020

Variant appearance in text: LRRK2: Y2018F

PubMed Link: 32612495

Variant Present in the following documents:

• Main text
• fnins-14-00527.pdf

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The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Schmidt, Sven H SH; Knape, Matthias J MJ; Boassa, Daniela D; Mumdey, Natascha N; Kornev, Alexandr P AP; Ellisman, Mark H MH; Taylor, Susan S SS; Herberg, Friedrich W FW

Publication Date: 2019-07-23

Variant appearance in text: LRRK2: Y2018F

PubMed Link: 31292254

Variant Present in the following documents:

• Main text
• pnas.1900289116.sapp.pdf
• pnas.201900289.pdf

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