ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling.
The Journal Of Cell Biology
Hancock-Cerutti, William W; Wu, Zheng Z; Xu, Peng P; Yadavalli, Narayana N; Leonzino, Marianna M; Tharkeshwar, Arun Kumar AK; Ferguson, Shawn M SM; Shadel, Gerald S GS; De Camilli, Pietro P
Pyronaridine Protects against SARS-CoV-2 Infection in Mouse.
Acs Infectious Diseases
Puhl, Ana C AC; Gomes, Giovanni F GF; Damasceno, Samara S; Godoy, Andre S AS; Noske, Gabriela D GD; Nakamura, Aline M AM; Gawriljuk, Victor O VO; Fernandes, Rafaela S RS; Monakhova, Natalia N; Riabova, Olga O; Lane, Thomas R TR; Makarov, Vadim V; Veras, Flavio P FP; Batah, Sabrina S SS; Fabro, Alexandre T AT; Oliva, Glaucius G; Cunha, Fernando Q FQ; Alves-Filho, José C JC; Cunha, Thiago M TM; Ekins, Sean S
Proteomic Alterations and Novel Markers of Neurotoxic Reactive Astrocytes in Human Induced Pluripotent Stem Cell Models.
Frontiers In Molecular Neuroscience
Labib, David D; Wang, Zhen Z; Prakash, Priya P; Zimmer, Matthew M; Smith, Matthew D MD; Frazel, Paul W PW; Barbar, Lilianne L; Sapar, Maria L ML; Calabresi, Peter A PA; Peng, Junmin J; Liddelow, Shane A SA; Fossati, Valentina V
Vocal changes in a zebra finch model of Parkinson's disease characterized by alpha-synuclein overexpression in the song-dedicated anterior forebrain pathway.
Plos One
Medina, Cesar A CA; Vargas, Eddie E; Munger, Stephanie J SJ; Miller, Julie E JE
Predictive Modeling of Alzheimer's and Parkinson's Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid.
Metabolites
Hwangbo, Nathan N; Zhang, Xinyu X; Raftery, Daniel D; Gu, Haiwei H; Hu, Shu-Ching SC; Montine, Thomas J TJ; Quinn, Joseph F JF; Chung, Kathryn A KA; Hiller, Amie L AL; Wang, Dongfang D; Fei, Qiang Q; Bettcher, Lisa L; Zabetian, Cyrus P CP; Peskind, Elaine R ER; Li, Ge G; Promislow, Daniel E L DEL; Davis, Marie Y MY; Franks, Alexander A
Defects of Nutrient Signaling and Autophagy in Neurodegeneration.
Frontiers In Cell And Developmental Biology
Ondaro, Jon J; Hernandez-Eguiazu, Haizea H; Garciandia-Arcelus, Maddi M; Loera-Valencia, Raúl R; Rodriguez-Gómez, Laura L; Jiménez-Zúñiga, Andrés A; Goikolea, Julen J; Rodriguez-Rodriguez, Patricia P; Ruiz-Martinez, Javier J; Moreno, Fermín F; Lopez de Munain, Adolfo A; Holt, Ian James IJ; Gil-Bea, Francisco Javier FJ; Gereñu, Gorka G
DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion.
The Embo Journal
Long, Maeve M; Sanchez-Martinez, Alvaro A; Longo, Marianna M; Suomi, Fumi F; Stenlund, Hans H; Johansson, Annika I AI; Ehsan, Homa H; Salo, Veijo T VT; Montava-Garriga, Lambert L; Naddafi, Seyedehshima S; Ikonen, Elina E; Ganley, Ian G IG; Whitworth, Alexander J AJ; McWilliams, Thomas G TG
Best practices for the interpretation and reporting of clinical whole genome sequencing.
Npj Genomic Medicine
Austin-Tse, Christina A CA; Jobanputra, Vaidehi V; Perry, Denise L DL; Bick, David D; Taft, Ryan J RJ; Venner, Eric E; Gibbs, Richard A RA; Young, Ted T; Barnett, Sarah S; Belmont, John W JW; Boczek, Nicole N; Chowdhury, Shimul S; Ellsworth, Katarzyna A KA; Guha, Saurav S; Kulkarni, Shashikant S; Marcou, Cherisse C; Meng, Linyan L; Murdock, David R DR; Rehman, Atteeq U AU; Spiteri, Elizabeth E; Thomas-Wilson, Amanda A; Kearney, Hutton M HM; Rehm, Heidi L HL; ,
Publication Date: 2022-04-08
Variant appearance in text: LRRK2: 6055G>A; Gly2019Ser
Whole Exome Sequencing Study in Isolated South-Eastern Moravia (Czechia) Population Indicates Heterogenous Genetic Background for Parkinsonism Development.
Frontiers In Neuroscience
Kolarikova, Kristyna K; Vodicka, Radek R; Vrtel, Radek R; Stellmachova, Julia J; Prochazka, Martin M; Mensikova, Katerina K; Kanovsky, Petr P
Identification of Novel Noninvasive Diagnostics Biomarkers in the Parkinson's Diseases and Improving the Disease Classification Using Support Vector Machine.
Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts.
Nature Communications
Schiff, Lauren L; Migliori, Bianca B; Chen, Ye Y; Carter, Deidre D; Bonilla, Caitlyn C; Hall, Jenna J; Fan, Minjie M; Tam, Edmund E; Ahadi, Sara S; Fischbacher, Brodie B; Geraschenko, Anton A; Hunter, Christopher J CJ; Venugopalan, Subhashini S; DesMarteau, Sean S; Narayanaswamy, Arunachalam A; Jacob, Selwyn S; Armstrong, Zan Z; Ferrarotto, Peter P; Williams, Brian B; Buckley-Herd, Geoff G; Hazard, Jon J; Goldberg, Jordan J; Coram, Marc M; Otto, Reid R; Baltz, Edward A EA; Andres-Martin, Laura L; Pritchard, Orion O; Duren-Lubanski, Alyssa A; Daigavane, Ameya A; Reggio, Kathryn K; , ; Nelson, Phillip C PC; Frumkin, Michael M; Solomon, Susan L SL; Bauer, Lauren L; Aiyar, Raeka S RS; Schwarzbach, Elizabeth E; Noggle, Scott A SA; Monsma, Frederick J FJ; Paull, Daniel D; Berndl, Marc M; Yang, Samuel J SJ; Johannesson, Bjarki B
Optimized Protocol for Proportionate CNS Cell Retrieval as a Versatile Platform for Cellular and Molecular Phenomapping in Aging and Neurodegeneration.
International Journal Of Molecular Sciences
Ain, Quratul Q; Schmeer, Christian W CW; Wengerodt, Diane D; Hofmann, Yvonne Y; Witte, Otto W OW; Kretz, Alexandra A
A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively.
Cells
Marchand, Antoine A; Sarchione, Alessia A; Athanasopoulos, Panagiotis S PS; Roy, Hélène Bauderlique-Le HB; Goveas, Liesel L; Magnez, Romain R; Drouyer, Matthieu M; Emanuele, Marco M; Ho, Franz Y FY; Liberelle, Maxime M; Melnyk, Patricia P; Lebègue, Nicolas N; Thuru, Xavier X; Nichols, R Jeremy RJ; Greggio, Elisa E; Kortholt, Arjan A; Galli, Thierry T; Chartier-Harlin, Marie-Christine MC; Taymans, Jean-Marc JM
Principal Component Analysis versus Subject's Residual Profile Analysis for Neuroinflammation Investigation in Parkinson Patients: A PET Brain Imaging Study.
Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures.
Npj Parkinson'S Disease
Dhanwani, Rekha R; Lima-Junior, João Rodrigues JR; Sethi, Ashu A; Pham, John J; Williams, Gregory G; Frazier, April A; Xu, Yaqian Y; Amara, Amy W AW; Standaert, David G DG; Goldman, Jennifer G JG; Litvan, Irene I; Alcalay, Roy N RN; Peters, Bjoern B; Sulzer, David D; Arlehamn, Cecilia S Lindestam CSL; Sette, Alessandro A
The emerging postural instability phenotype in idiopathic Parkinson disease.
Npj Parkinson'S Disease
Skidmore, Frank M FM; Monroe, William S WS; Hurt, Christopher P CP; Nicholas, Anthony P AP; Gerstenecker, Adam A; Anthony, Thomas T; Jololian, Leon L; Cutter, Gary G; Bashir, Adil A; Denny, Thomas T; Standaert, David D; Disbrow, Elizabeth A EA
Publication Date: 2022-03-18
Variant appearance in text: LRRK2: G2019s; rs34637584
Altered expression of the immunoregulatory ligand-receptor pair CD200-CD200R1 in the brain of Parkinson's disease patients.
Npj Parkinson'S Disease
Rabaneda-Lombarte, Neus N; Vidal-Taboada, José Manuel JM; Valente, Tony T; Ezquerra, Mario M; Fernández-Santiago, Rubén R; Martí, María José MJ; Compta, Yaroslau Y; Saura, Josep J; Solà, Carme C