Variant ID: 12-40734202-G-A

NM_198578.3(LRRK2):c.6055G>A;(p.G2019S)

This variant was identified in 2236 publications

View GRCh38 version.




Publications:


Genetic Variants Associated With Resilience in Human and Animal Studies.

Frontiers In Psychiatry
Cahill, Stephanie S; Chandola, Tarani T; Hager, Reinmar R
Publication Date: 2022

Variant appearance in text: LRRK2: g2019s
PubMed Link: 35669264
Variant Present in the following documents:
  • Main text
  • fpsyt-13-840120.pdf
View BVdb publication page



Alterations in Immune-Related Defensin Alpha 4 (DEFA4) Gene Expression in Health and Disease.

International Journal Of Inflammation
Basingab, Fatemah F; Alsaiary, Abeer A; Almontashri, Shahad S; Alrofaidi, Aisha A; Alharbi, Mona M; Azhari, Sheren S; Algothmi, Khloud K; Alhazmi, Safiah S
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35668817
Variant Present in the following documents:
  • Main text
  • IJI2022-9099136.pdf
View BVdb publication page



Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy.

Signal Transduction And Targeted Therapy
Pan, Jie J; Zhou, Lisha L; Zhang, Chenyang C; Xu, Qiang Q; Sun, Yang Y
Publication Date: 2022-06-04

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35665742
Variant Present in the following documents:
  • Main text
  • 41392_2022_Article_1038.pdf
View BVdb publication page



From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer's and Parkinson's diseases.

Neural Regeneration Research
Wakhloo, Debia D; Oberhauser, Jane J; Madira, Angela A; Mahajani, Sameehan S
Publication Date: 2022-12

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35662189
Variant Present in the following documents:
  • Main text
  • NRR-17-2606.pdf
View BVdb publication page



ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling.

The Journal Of Cell Biology
Hancock-Cerutti, William W; Wu, Zheng Z; Xu, Peng P; Yadavalli, Narayana N; Leonzino, Marianna M; Tharkeshwar, Arun Kumar AK; Ferguson, Shawn M SM; Shadel, Gerald S GS; De Camilli, Pietro P
Publication Date: 2022-07-04

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35657605
Variant Present in the following documents:
  • Main text
  • JCB_202106046.pdf
View BVdb publication page



Human Brain-Based Models Provide a Powerful Tool for the Advancement of Parkinson's Disease Research and Therapeutic Development.

Frontiers In Neuroscience
McComish, Sarah F SF; MacMahon Copas, Adina N AN; Caldwell, Maeve A MA
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35651633
Variant Present in the following documents:
  • Main text
  • fnins-16-851058.pdf
View BVdb publication page



Altered neural cell junctions and ion-channels leading to disrupted neuron communication in Parkinson's disease.

Npj Parkinson'S Disease
Choudhury, Saptamita Paul SP; Bano, Sarika S; Sen, Srijon S; Suchal, Kapil K; Kumar, Saroj S; Nikolajeff, Fredrik F; Dey, Sanjay Kumar SK; Sharma, Vaibhav V
Publication Date: 2022-06-01

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35650269
Variant Present in the following documents:
  • Main text
  • 41531_2022_Article_324.pdf
View BVdb publication page



RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration.

Frontiers In Genetics
Castelli, Lydia M LM; Benson, Bridget C BC; Huang, Wan-Ping WP; Lin, Ya-Hui YH; Hautbergue, Guillaume M GM
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35646086
Variant Present in the following documents:
  • Main text
  • fgene-13-886563.pdf
View BVdb publication page



The Double-Faceted Role of Leucine-Rich Repeat Kinase 2 in the Immunopathogenesis of Parkinson's Disease.

Frontiers In Aging Neuroscience
Zhang, Mengfei M; Li, Chaoyi C; Ren, Jie J; Wang, Huakun H; Yi, Fang F; Wu, Junjiao J; Tang, Yu Y
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35645775
Variant Present in the following documents:
  • Main text
  • fnagi-14-909303.pdf
View BVdb publication page



Genetic Analysis of Patients With Early-Onset Parkinson's Disease in Eastern China.

Frontiers In Aging Neuroscience
Hua, Ping P; Zhao, Yuwen Y; Zeng, Qian Q; Li, Lanting L; Ren, Jingru J; Guo, Jifeng J; Tang, Beisha B; Liu, Weiguo W
Publication Date: 2022

Variant appearance in text: LRRK2: 6055G>A; G2019S
PubMed Link: 35645773
Variant Present in the following documents:
  • Main text
  • fnagi-14-849462.pdf
View BVdb publication page



Neuropathological Features of Gaucher Disease and Gaucher Disease with Parkinsonism.

International Journal Of Molecular Sciences
Furderer, Makaila L ML; Hertz, Ellen E; Lopez, Grisel J GJ; Sidransky, Ellen E
Publication Date: 2022-05-23

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35628652
Variant Present in the following documents:
  • Main text
  • ijms-23-05842.pdf
View BVdb publication page



Plasma microRNAs as a Potential Biomarker for Identification of Progressive Supranuclear Palsy.

Diagnostics (Basel, Switzerland)
Ramaswamy, Palaniswamy P; Christopher, Rita R; Kumar Pal, Pramod P; Debnath, Monojit M; Yadav, Ravi R
Publication Date: 2022-05-11

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35626359
Variant Present in the following documents:
  • diagnostics-12-01204.pdf
View BVdb publication page



TGF-β as a Key Modulator of Astrocyte Reactivity: Disease Relevance and Therapeutic Implications.

Biomedicines
Luo, Jian J
Publication Date: 2022-05-23

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35625943
Variant Present in the following documents:
  • Main text
  • biomedicines-10-01206.pdf
View BVdb publication page



Adeno-Associated Viruses for Modeling Neurological Diseases in Animals: Achievements and Prospects.

Biomedicines
Lunev, Evgenii E; Karan, Anna A; Egorova, Tatiana T; Bardina, Maryana M
Publication Date: 2022-05-15

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35625877
Variant Present in the following documents:
  • Main text
  • biomedicines-10-01140.pdf
View BVdb publication page



Kinases on Double Duty: A Review of UniProtKB Annotated Bifunctionality within the Kinome.

Biomolecules
Rangwala, Aziz M AM; Mingione, Victoria R VR; Georghiou, George G; Seeliger, Markus A MA
Publication Date: 2022-05-11

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35625613
Variant Present in the following documents:
  • Main text
  • biomolecules-12-00685.pdf
View BVdb publication page



PepNN: a deep attention model for the identification of peptide binding sites.

Communications Biology
Abdin, Osama O; Nim, Satra S; Wen, Han H; Kim, Philip M PM
Publication Date: 2022-05-26

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35618814
Variant Present in the following documents:
  • 42003_2022_3445_MOESM3_ESM.xlsx
View BVdb publication page



Human organoids in basic research and clinical applications.

Signal Transduction And Targeted Therapy
Tang, Xiao-Yan XY; Wu, Shanshan S; Wang, Da D; Chu, Chu C; Hong, Yuan Y; Tao, Mengdan M; Hu, Hao H; Xu, Min M; Guo, Xing X; Liu, Yan Y
Publication Date: 2022-05-24

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35610212
Variant Present in the following documents:
  • 41392_2022_Article_1024.pdf
View BVdb publication page



Pyronaridine Protects against SARS-CoV-2 Infection in Mouse.

Acs Infectious Diseases
Puhl, Ana C AC; Gomes, Giovanni F GF; Damasceno, Samara S; Godoy, Andre S AS; Noske, Gabriela D GD; Nakamura, Aline M AM; Gawriljuk, Victor O VO; Fernandes, Rafaela S RS; Monakhova, Natalia N; Riabova, Olga O; Lane, Thomas R TR; Makarov, Vadim V; Veras, Flavio P FP; Batah, Sabrina S SS; Fabro, Alexandre T AT; Oliva, Glaucius G; Cunha, Fernando Q FQ; Alves-Filho, José C JC; Cunha, Thiago M TM; Ekins, Sean S
Publication Date: 2022-05-24

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35609344
Variant Present in the following documents:
  • id2c00091_si_001.pdf
View BVdb publication page



Association of p53 with Neurodegeneration in Parkinson's Disease.

Parkinson'S Disease
Luo, Qiang Q; Sun, Wei W; Wang, Yi-Fan YF; Li, Ji J; Li, Da-Wei DW
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35601652
Variant Present in the following documents:
  • PD2022-6600944.pdf
View BVdb publication page



Loss of PTEN-Induced Kinase 1 Regulates Oncogenic Ras-Driven Tumor Growth By Inhibiting Mitochondrial Fission.

Frontiers In Oncology
Zhu, Dantong D; Han, Fengtong F; Sun, Liuke L; Agnihotri, Sandeep K SK; Hu, Ying Y; Büeler, Hansruedi H
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35600352
Variant Present in the following documents:
  • fonc-12-893396.pdf
View BVdb publication page



Proteomic Alterations and Novel Markers of Neurotoxic Reactive Astrocytes in Human Induced Pluripotent Stem Cell Models.

Frontiers In Molecular Neuroscience
Labib, David D; Wang, Zhen Z; Prakash, Priya P; Zimmer, Matthew M; Smith, Matthew D MD; Frazel, Paul W PW; Barbar, Lilianne L; Sapar, Maria L ML; Calabresi, Peter A PA; Peng, Junmin J; Liddelow, Shane A SA; Fossati, Valentina V
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35592112
Variant Present in the following documents:
  • fnmol-15-870085.pdf
View BVdb publication page



Modeling the blood-brain barrier for treatment of central nervous system (CNS) diseases.

Journal Of Tissue Engineering
Rice, Olivia O; Surian, Allison A; Chen, Yupeng Y
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35586265
Variant Present in the following documents:
  • 10.1177_20417314221095997.pdf
View BVdb publication page



Neuropsychiatric Symptoms in Clinically Defined Parkinson's Disease: An Updated Review of Literature.

Behavioural Neurology
Macías-García, Paloma P; Rashid-López, Raúl R; Cruz-Gómez, Álvaro J ÁJ; Lozano-Soto, Elena E; Sanmartino, Florencia F; Espinosa-Rosso, Raúl R; González-Rosa, Javier J JJ
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35586201
Variant Present in the following documents:
  • BN2022-1213393.pdf
View BVdb publication page



Mechanotransduction: Exploring New Therapeutic Avenues in Central Nervous System Pathology.

Frontiers In Neuroscience
Rocha, Daniela Nogueira DN; Carvalho, Eva Daniela ED; Relvas, João Bettencourt JB; Oliveira, Maria José MJ; Pêgo, Ana Paula AP
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35573316
Variant Present in the following documents:
  • fnins-16-861613.pdf
View BVdb publication page



Functional Screening of Parkinson's Disease Susceptibility Genes to Identify Novel Modulators of α-Synuclein Neurotoxicity in Caenorhabditis elegans.

Frontiers In Aging Neuroscience
Vozdek, Roman R; Pramstaller, Peter P PP; Hicks, Andrew A AA
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35572147
Variant Present in the following documents:
  • fnagi-14-806000.pdf
View BVdb publication page



Altered Mitochondrial Protein Homeostasis and Proteinopathies.

Frontiers In Molecular Neuroscience
Jishi, Aya A; Qi, Xin X
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35571369
Variant Present in the following documents:
  • fnmol-15-867935.pdf
View BVdb publication page



Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders.

Journal Of Tissue Engineering
Fanizza, Francesca F; Campanile, Marzia M; Forloni, Gianluigi G; Giordano, Carmen C; Albani, Diego D
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35570845
Variant Present in the following documents:
  • 10.1177_20417314221095339.pdf
View BVdb publication page



Pathophysiological Features of Nigral Dopaminergic Neurons in Animal Models of Parkinson's Disease.

International Journal Of Molecular Sciences
Guatteo, Ezia E; Berretta, Nicola N; Monda, Vincenzo V; Ledonne, Ada A; Mercuri, Nicola Biagio NB
Publication Date: 2022-04-19

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35562898
Variant Present in the following documents:
  • ijms-23-04508.pdf
View BVdb publication page



Latest perspectives of orally bioavailable 2,4-diarylaminopyrimidine analogues (DAAPalogues) as anaplastic lymphoma kinase inhibitors: discovery and clinical developments.

Rsc Advances
Latif, Muhammad M; Ashraf, Zaman Z; Basit, Sulman S; Ghaffar, Abdul A; Zafar, Muhammad Sohail MS; Saeed, Aamer A; Meo, Sultan Ayoub SA
Publication Date: 2018-05-03

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35540549
Variant Present in the following documents:
  • RA-008-C8RA01934G.pdf
View BVdb publication page



Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination.

Molecular Neurodegeneration
Zirngibl, Martin M; Assinck, Peggy P; Sizov, Anastasia A; Caprariello, Andrew V AV; Plemel, Jason R JR
Publication Date: 2022-05-07

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35526004
Variant Present in the following documents:
  • 13024_2022_Article_538.pdf
View BVdb publication page



Synthesis of some new acylhydrazone compounds containing the 1,2,4-triazole structure and their neuritogenic activities in Neuro-2a cells.

Rsc Advances
Jiang, Xia X; Tang, Genyun G; Yang, Jie J; Ding, Jiacheng J; Lin, Hongwei H; Xiang, Xiaoliang X
Publication Date: 2020-05-14

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35518339
Variant Present in the following documents:
  • RA-010-D0RA02880K.pdf
View BVdb publication page



A genome on shaky ground: exploring the impact of mitochondrial DNA integrity on Parkinson's disease by highlighting the use of cybrid models.

Cellular And Molecular Life Sciences : Cmls
Lang, Martin M; Grünewald, Anne A; Pramstaller, Peter P PP; Hicks, Andrew A AA; Pichler, Irene I
Publication Date: 2022-05-05

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35513611
Variant Present in the following documents:
  • 18_2022_Article_4304.pdf
View BVdb publication page



Vocal changes in a zebra finch model of Parkinson's disease characterized by alpha-synuclein overexpression in the song-dedicated anterior forebrain pathway.

Plos One
Medina, Cesar A CA; Vargas, Eddie E; Munger, Stephanie J SJ; Miller, Julie E JE
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35507553
Variant Present in the following documents:
  • pone.0265604.pdf
View BVdb publication page



Leucine-rich repeat kinase-2 deficiency protected against cardiac remodelling in mice via regulating autophagy formation and degradation.

Journal Of Advanced Research
Liu, Yuan Y; Hao, Congqing C; Zhang, Wei W; Liu, Yuzhou Y; Guo, Sen S; Li, Ran R; Peng, Meng M; Xu, Yawei Y; Pei, Xiaoxin X; Yang, Haibo H; Zhao, Yintao Y
Publication Date: 2022-03

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35499056
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Ca2+ Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson's Disease.

Frontiers In Cellular Neuroscience
Xu, Jianjun J; Minobe, Etsuko E; Kameyama, Masaki M
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35496903
Variant Present in the following documents:
  • fncel-16-867385.pdf
View BVdb publication page



Editorial: LRRK2-Fifteen Years From Cloning to the Clinic.

Frontiers In Neuroscience
Rideout, Hardy H; Greggio, Elisa E; Kortholt, Arjan A; Nichols, R Jeremy RJ
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35478845
Variant Present in the following documents:
  • fnins-16-880914.pdf
View BVdb publication page



Epidemiology of atypical parkinsonian syndromes.

Tzu Chi Medical Journal
Lo, Raymond Y RY
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35465274
Variant Present in the following documents:
  • TCMJ-34-169.pdf
View BVdb publication page



Biomarker of Neuroinflammation in Parkinson's Disease.

International Journal Of Molecular Sciences
Liu, Tsai-Wei TW; Chen, Chiung-Mei CM; Chang, Kuo-Hsuan KH
Publication Date: 2022-04-08

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35456966
Variant Present in the following documents:
  • ijms-23-04148.pdf
View BVdb publication page



Squalene-Based Nano-Assemblies Improve the Pro-Autophagic Activity of Trehalose.

Pharmaceutics
Frapporti, Giulia G; Colombo, Eleonora E; Ahmed, Hazem H; Assoni, Giulia G; Polito, Laura L; Randazzo, Pietro P; Arosio, Daniela D; Seneci, Pierfausto P; Piccoli, Giovanni G
Publication Date: 2022-04-14

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35456696
Variant Present in the following documents:
  • pharmaceutics-14-00862.pdf
View BVdb publication page



Levetiracetam Mechanisms of Action: From Molecules to Systems.

Pharmaceuticals (Basel, Switzerland)
Contreras-García, Itzel Jatziri IJ; Cárdenas-Rodríguez, Noemí N; Romo-Mancillas, Antonio A; Bandala, Cindy C; Zamudio, Sergio R SR; Gómez-Manzo, Saúl S; Hernández-Ochoa, Beatriz B; Mendoza-Torreblanca, Julieta Griselda JG; Pichardo-Macías, Luz Adriana LA
Publication Date: 2022-04-13

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35455472
Variant Present in the following documents:
  • pharmaceuticals-15-00475.pdf
View BVdb publication page



α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword.

Biomolecules
Tan, Li Yang LY; Tang, Kwan Hou KH; Lim, Lynette Yu You LYY; Ong, Jia Xin JX; Park, Hyokeun H; Jung, Sangyong S
Publication Date: 2022-03-27

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35454096
Variant Present in the following documents:
  • biomolecules-12-00507.pdf
View BVdb publication page



Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice.

Biomedicines
Domenicale, Chiara C; Mercatelli, Daniela D; Albanese, Federica F; Novello, Salvatore S; Vincenzi, Fabrizio F; Varani, Katia K; Morari, Michele M
Publication Date: 2022-04-12

Variant appearance in text: LRRK2: 6055G>A; G2019S
PubMed Link: 35453631
Variant Present in the following documents:
  • biomedicines-10-00881.pdf
View BVdb publication page



Mitochondria and Other Organelles in Neural Development and Their Potential as Therapeutic Targets in Neurodegenerative Diseases.

Frontiers In Neuroscience
Zhang, Shuyuan S; Zhao, Juan J; Quan, Zhenzhen Z; Li, Hui H; Qing, Hong H
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35450015
Variant Present in the following documents:
  • fnins-16-853911.pdf
View BVdb publication page



Predictive Modeling of Alzheimer's and Parkinson's Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid.

Metabolites
Hwangbo, Nathan N; Zhang, Xinyu X; Raftery, Daniel D; Gu, Haiwei H; Hu, Shu-Ching SC; Montine, Thomas J TJ; Quinn, Joseph F JF; Chung, Kathryn A KA; Hiller, Amie L AL; Wang, Dongfang D; Fei, Qiang Q; Bettcher, Lisa L; Zabetian, Cyrus P CP; Peskind, Elaine R ER; Li, Ge G; Promislow, Daniel E L DEL; Davis, Marie Y MY; Franks, Alexander A
Publication Date: 2022-03-22

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35448464
Variant Present in the following documents:
  • metabolites-12-00277.pdf
View BVdb publication page



Defects of Nutrient Signaling and Autophagy in Neurodegeneration.

Frontiers In Cell And Developmental Biology
Ondaro, Jon J; Hernandez-Eguiazu, Haizea H; Garciandia-Arcelus, Maddi M; Loera-Valencia, Raúl R; Rodriguez-Gómez, Laura L; Jiménez-Zúñiga, Andrés A; Goikolea, Julen J; Rodriguez-Rodriguez, Patricia P; Ruiz-Martinez, Javier J; Moreno, Fermín F; Lopez de Munain, Adolfo A; Holt, Ian James IJ; Gil-Bea, Francisco Javier FJ; Gereñu, Gorka G
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35419363
Variant Present in the following documents:
  • fcell-10-836196.pdf
View BVdb publication page



DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion.

The Embo Journal
Long, Maeve M; Sanchez-Martinez, Alvaro A; Longo, Marianna M; Suomi, Fumi F; Stenlund, Hans H; Johansson, Annika I AI; Ehsan, Homa H; Salo, Veijo T VT; Montava-Garriga, Lambert L; Naddafi, Seyedehshima S; Ikonen, Elina E; Ganley, Ian G IG; Whitworth, Alexander J AJ; McWilliams, Thomas G TG
Publication Date: 2022-04-12

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35411952
Variant Present in the following documents:
  • EMBJ-41-e109390.pdf
View BVdb publication page



Atypical Ubiquitination and Parkinson's Disease.

International Journal Of Molecular Sciences
Buneeva, Olga O; Medvedev, Alexei A
Publication Date: 2022-03-28

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35409068
Variant Present in the following documents:
  • ijms-23-03705.pdf
View BVdb publication page



Autophagy Alteration in ApoA-I Related Systemic Amyloidosis.

International Journal Of Molecular Sciences
Del Giudice, Rita R; Imbimbo, Paola P; Pietrocola, Federico F; Martins, Isabelle I; De Palma, Fatima Domenica Elisa FDE; Bravo-San Pedro, José Manuel JM; Kroemer, Guido G; Maiuri, Maria Chiara MC; Monti, Daria Maria DM
Publication Date: 2022-03-23

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35408859
Variant Present in the following documents:
  • ijms-23-03498.pdf
View BVdb publication page



Immune Response Modifications in the Genetic Forms of Parkinson's Disease: What Do We Know?

International Journal Of Molecular Sciences
Magistrelli, Luca L; Contaldi, Elena E; Vignaroli, Francesca F; Gallo, Silvia S; Colombatto, Federico F; Cantello, Roberto R; Comi, Cristoforo C
Publication Date: 2022-03-23

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35408836
Variant Present in the following documents:
  • ijms-23-03476.pdf
View BVdb publication page



The Pharmacological Potential of Adenosine A2A Receptor Antagonists for Treating Parkinson's Disease.

Molecules (Basel, Switzerland)
Mori, Akihisa A; Chen, Jiang-Fan JF; Uchida, Shinichi S; Durlach, Cecile C; King, Shelby M SM; Jenner, Peter P
Publication Date: 2022-04-06

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35408767
Variant Present in the following documents:
  • molecules-27-02366.pdf
View BVdb publication page



Chaperone-Mediated Autophagy in Neurodegenerative Diseases and Acute Neurological Insults in the Central Nervous System.

Cells
Kanno, Haruo H; Handa, Kyoichi K; Murakami, Taishi T; Aizawa, Toshimi T; Ozawa, Hiroshi H
Publication Date: 2022-04-02

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35406769
Variant Present in the following documents:
  • cells-11-01205.pdf
View BVdb publication page



Are transient protein-protein interactions more dispensable?

Plos Computational Biology
Ghadie, Mohamed Ali MA; Xia, Yu Y
Publication Date: 2022-04

Variant appearance in text: LRRK2: 6055G>A; Gly2019Ser
PubMed Link: 35404956
Variant Present in the following documents:
  • pcbi.1010013.s002.xlsx
View BVdb publication page



Best practices for the interpretation and reporting of clinical whole genome sequencing.

Npj Genomic Medicine
Austin-Tse, Christina A CA; Jobanputra, Vaidehi V; Perry, Denise L DL; Bick, David D; Taft, Ryan J RJ; Venner, Eric E; Gibbs, Richard A RA; Young, Ted T; Barnett, Sarah S; Belmont, John W JW; Boczek, Nicole N; Chowdhury, Shimul S; Ellsworth, Katarzyna A KA; Guha, Saurav S; Kulkarni, Shashikant S; Marcou, Cherisse C; Meng, Linyan L; Murdock, David R DR; Rehman, Atteeq U AU; Spiteri, Elizabeth E; Thomas-Wilson, Amanda A; Kearney, Hutton M HM; Rehm, Heidi L HL; ,
Publication Date: 2022-04-08

Variant appearance in text: LRRK2: 6055G>A; Gly2019Ser
PubMed Link: 35395838
Variant Present in the following documents:
  • 41525_2022_295_MOESM5_ESM.xlsx
View BVdb publication page



Genetic heterogeneity on sleep disorders in Parkinson's disease: a systematic review and meta-analysis.

Translational Neurodegeneration
Huang, Jingxuan J; Cheng, Yangfan Y; Li, Chunyu C; Shang, Huifang H
Publication Date: 2022-04-08

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35395825
Variant Present in the following documents:
  • 40035_2022_Article_294.pdf
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Mitophagy and Neurodegeneration: Between the Knowns and the Unknowns.

Frontiers In Cell And Developmental Biology
Jetto, Cuckoo Teresa CT; Nambiar, Akshaya A; Manjithaya, Ravi R
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35392168
Variant Present in the following documents:
  • fcell-10-837337.pdf
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DRD2 Taq1A Polymorphism-Related Brain Volume Changes in Parkinson's Disease: Voxel-Based Morphometry.

Parkinson'S Disease
Ohira, Kenji K; Yokota, Hajime H; Hirano, Shigeki S; Nishimura, Motoi M; Mukai, Hiroki H; Horikoshi, Takuro T; Sawai, Setsu S; Yamanaka, Yoshitaka Y; Yamamoto, Tatsuya T; Kakeda, Shingo S; Kuwabara, Satoshi S; Tanaka, Tomoaki T; Uno, Takashi T
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35386951
Variant Present in the following documents:
  • PD2022-8649195.pdf
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KLF5 inhibition overcomes oxaliplatin resistance in patient-derived colorectal cancer organoids by restoring apoptotic response.

Cell Death & Disease
Shen, Xiaohui X; Zhang, Yuchen Y; Xu, Zhuoqing Z; Gao, Han H; Feng, Wenqing W; Li, Wenchang W; Miao, Yiming Y; Xu, Zifeng Z; Zong, Yaping Y; Zhao, Jingkun J; Lu, Aiguo A
Publication Date: 2022-04-05

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35379798
Variant Present in the following documents:
  • 41419_2022_4773_MOESM9_ESM.xlsx
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Whole Exome Sequencing in 16p13.11 Microdeletion Patients Reveals New Variants Through Deductive and Systems Medicine Approaches.

Frontiers In Genetics
Granata, Paola P; Cocciadiferro, Dario D; Zito, Alessandra A; Pessina, Chiara C; Bassani, Alessandro A; Zambonin, Fabio F; Novelli, Antonio A; Fasano, Mauro M; Casalone, Rosario R
Publication Date: 2022

Variant appearance in text: PARK8: 6055G>A
PubMed Link: 35368691
Variant Present in the following documents:
  • fgene-13-798607.pdf
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Age-Dependent Neuropsychiatric Symptoms in the NF-κB/c-Rel Knockout Mouse Model of Parkinson's Disease.

Frontiers In Behavioral Neuroscience
Parrella, Edoardo E; Del Gallo, Federico F; Porrini, Vanessa V; Gussago, Cristina C; Benarese, Marina M; Fabene, Paolo Francesco PF; Pizzi, Marina M
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35368305
Variant Present in the following documents:
  • fnbeh-16-831664.pdf
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Whole Exome Sequencing Study in Isolated South-Eastern Moravia (Czechia) Population Indicates Heterogenous Genetic Background for Parkinsonism Development.

Frontiers In Neuroscience
Kolarikova, Kristyna K; Vodicka, Radek R; Vrtel, Radek R; Stellmachova, Julia J; Prochazka, Martin M; Mensikova, Katerina K; Kanovsky, Petr P
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35368288
Variant Present in the following documents:
  • fnins-16-817713.pdf
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Emerging Potential of Exosomal Non-coding RNA in Parkinson's Disease: A Review.

Frontiers In Aging Neuroscience
Zhang, Peng P; Rasheed, Madiha M; Liang, Junhan J; Wang, Chaolei C; Feng, Lin L; Chen, Zixuan Z
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35360206
Variant Present in the following documents:
  • fnagi-14-819836.pdf
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Effect of LRRK2 protein and activity on stimulated cytokines in human monocytes and macrophages.

Npj Parkinson'S Disease
Ahmadi Rastegar, Diba D; Hughes, Laura P LP; Perera, Gayathri G; Keshiya, Shikara S; Zhong, Siying S; Gao, Jianqun J; Halliday, Glenda M GM; Schüle, Birgitt B; Dzamko, Nicolas N
Publication Date: 2022-03-28

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35347144
Variant Present in the following documents:
  • 41531_2022_Article_297.pdf
  • 41531_2022_297_MOESM1_ESM.pdf
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F-Actin Dysplasia Involved in Organ of Corti Deformity in Gjb2 Knockdown Mouse Model.

Frontiers In Molecular Neuroscience
Liu, Xiao-Zhou XZ; Jin, Yuan Y; Chen, Sen S; Xu, Kai K; Xie, Le L; Qiu, Yue Y; Wang, Xiao-Hui XH; Sun, Yu Y; Kong, Wei-Jia WJ
Publication Date: 2021

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35345836
Variant Present in the following documents:
  • fnmol-14-808553.pdf
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Identification of Novel Noninvasive Diagnostics Biomarkers in the Parkinson's Diseases and Improving the Disease Classification Using Support Vector Machine.

Biomed Research International
Moradi, Shadi S; Tapak, Leili L; Afshar, Saeid S
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35342758
Variant Present in the following documents:
  • BMRI2022-5009892.pdf
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Role of JAK/STAT in the Neuroinflammation and its Association with Neurological Disorders.

Annals Of Neurosciences
Jain, Mayank M; Singh, Mukul Kumar MK; Shyam, Hari H; Mishra, Archana A; Kumar, Shailendra S; Kumar, Ambrish A; Kushwaha, Jitendra J
Publication Date: 2021-07

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35341232
Variant Present in the following documents:
  • 10.1177_09727531211070532.pdf
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Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts.

Nature Communications
Schiff, Lauren L; Migliori, Bianca B; Chen, Ye Y; Carter, Deidre D; Bonilla, Caitlyn C; Hall, Jenna J; Fan, Minjie M; Tam, Edmund E; Ahadi, Sara S; Fischbacher, Brodie B; Geraschenko, Anton A; Hunter, Christopher J CJ; Venugopalan, Subhashini S; DesMarteau, Sean S; Narayanaswamy, Arunachalam A; Jacob, Selwyn S; Armstrong, Zan Z; Ferrarotto, Peter P; Williams, Brian B; Buckley-Herd, Geoff G; Hazard, Jon J; Goldberg, Jordan J; Coram, Marc M; Otto, Reid R; Baltz, Edward A EA; Andres-Martin, Laura L; Pritchard, Orion O; Duren-Lubanski, Alyssa A; Daigavane, Ameya A; Reggio, Kathryn K; , ; Nelson, Phillip C PC; Frumkin, Michael M; Solomon, Susan L SL; Bauer, Lauren L; Aiyar, Raeka S RS; Schwarzbach, Elizabeth E; Noggle, Scott A SA; Monsma, Frederick J FJ; Paull, Daniel D; Berndl, Marc M; Yang, Samuel J SJ; Johannesson, Bjarki B
Publication Date: 2022-03-25

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35338121
Variant Present in the following documents:
  • 41467_2022_Article_28423.pdf
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Small but Mighty-Exosomes, Novel Intercellular Messengers in Neurodegeneration.

Biology
Kumari, Meena M; Anji, Antje A
Publication Date: 2022-03-08

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35336787
Variant Present in the following documents:
  • biology-11-00413.pdf
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Non-Motor Symptoms in PLA2G6-Associated Dystonia-Parkinsonism: A Case Report and Literature Review.

Journal Of Clinical Medicine
Vela-Desojo, Lydia L; Urso, Daniele D; Osuna-López, Mireia M; Hoenicka, Janet J
Publication Date: 2022-03-13

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35329915
Variant Present in the following documents:
  • jcm-11-01590.pdf
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Structural Plasticity of the Hippocampus in Neurodegenerative Diseases.

International Journal Of Molecular Sciences
Weerasinghe-Mudiyanselage, Poornima D E PDE; Ang, Mary Jasmin MJ; Kang, Sohi S; Kim, Joong-Sun JS; Moon, Changjong C
Publication Date: 2022-03-20

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35328770
Variant Present in the following documents:
  • ijms-23-03349.pdf
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Optimized Protocol for Proportionate CNS Cell Retrieval as a Versatile Platform for Cellular and Molecular Phenomapping in Aging and Neurodegeneration.

International Journal Of Molecular Sciences
Ain, Quratul Q; Schmeer, Christian W CW; Wengerodt, Diane D; Hofmann, Yvonne Y; Witte, Otto W OW; Kretz, Alexandra A
Publication Date: 2022-03-10

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35328432
Variant Present in the following documents:
  • ijms-23-03000.pdf
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Does the Expression and Epigenetics of Genes Involved in Monogenic Forms of Parkinson's Disease Influence Sporadic Forms?

Genes
Lanore, Aymeric A; Lesage, Suzanne S; Mariani, Louise-Laure LL; Menon, Poornima Jayadev PJ; Ravassard, Philippe P; Cheval, Helene H; Corti, Olga O; Brice, Alexis A; Corvol, Jean-Christophe JC
Publication Date: 2022-03-08

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35328033
Variant Present in the following documents:
  • genes-13-00479.pdf
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Monogenic Parkinson's Disease: Genotype, Phenotype, Pathophysiology, and Genetic Testing.

Genes
Jia, Fangzhi F; Fellner, Avi A; Kumar, Kishore Raj KR
Publication Date: 2022-03-07

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35328025
Variant Present in the following documents:
  • genes-13-00471.pdf
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Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders.

Biomolecules
Kumar, Mandeep M; Nguyen, Nhung Thi Phuong NTP; Milanese, Marco M; Bonanno, Giambattista G
Publication Date: 2022-02-23

Variant appearance in text: LRRK2: Gly2019Ser
PubMed Link: 35327542
Variant Present in the following documents:
  • biomolecules-12-00344.pdf
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Mitochondrial Phenotypes in Genetically Diverse Neurodegenerative Diseases and Their Response to Mitofusin Activation.

Cells
Dang, Xiawei X; Walton, Emily K EK; Zablocka, Barbara B; Baloh, Robert H RH; Shy, Michael E ME; Dorn, Gerald W GW
Publication Date: 2022-03-21

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35326504
Variant Present in the following documents:
  • cells-11-01053.pdf
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A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively.

Cells
Marchand, Antoine A; Sarchione, Alessia A; Athanasopoulos, Panagiotis S PS; Roy, Hélène Bauderlique-Le HB; Goveas, Liesel L; Magnez, Romain R; Drouyer, Matthieu M; Emanuele, Marco M; Ho, Franz Y FY; Liberelle, Maxime M; Melnyk, Patricia P; Lebègue, Nicolas N; Thuru, Xavier X; Nichols, R Jeremy RJ; Greggio, Elisa E; Kortholt, Arjan A; Galli, Thierry T; Chartier-Harlin, Marie-Christine MC; Taymans, Jean-Marc JM
Publication Date: 2022-03-17

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35326469
Variant Present in the following documents:
  • cells-11-01018.pdf
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Principal Component Analysis versus Subject's Residual Profile Analysis for Neuroinflammation Investigation in Parkinson Patients: A PET Brain Imaging Study.

Journal Of Imaging
Mabrouk, Rostom R
Publication Date: 2022-02-25

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35324611
Variant Present in the following documents:
  • jimaging-08-00056.pdf
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Mitochondria Related Cell Death Modalities and Disease.

Frontiers In Cell And Developmental Biology
Tian, Chuwen C; Liu, Yifan Y; Li, Zhuoshu Z; Zhu, Ping P; Zhao, Mingyi M
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35321239
Variant Present in the following documents:
  • fcell-10-832356.pdf
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Monogenetic Forms of Parkinson's Disease - Bridging the Gap Between Genetics and Biomarkers.

Frontiers In Aging Neuroscience
Tönges, Lars L; Kwon, Eun Hae EH; Klebe, Stephan S
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35317530
Variant Present in the following documents:
  • fnagi-14-822949.pdf
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Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures.

Npj Parkinson'S Disease
Dhanwani, Rekha R; Lima-Junior, João Rodrigues JR; Sethi, Ashu A; Pham, John J; Williams, Gregory G; Frazier, April A; Xu, Yaqian Y; Amara, Amy W AW; Standaert, David G DG; Goldman, Jennifer G JG; Litvan, Irene I; Alcalay, Roy N RN; Peters, Bjoern B; Sulzer, David D; Arlehamn, Cecilia S Lindestam CSL; Sette, Alessandro A
Publication Date: 2022-03-21

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35314697
Variant Present in the following documents:
  • 41531_2022_Article_282.pdf
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The emerging postural instability phenotype in idiopathic Parkinson disease.

Npj Parkinson'S Disease
Skidmore, Frank M FM; Monroe, William S WS; Hurt, Christopher P CP; Nicholas, Anthony P AP; Gerstenecker, Adam A; Anthony, Thomas T; Jololian, Leon L; Cutter, Gary G; Bashir, Adil A; Denny, Thomas T; Standaert, David D; Disbrow, Elizabeth A EA
Publication Date: 2022-03-18

Variant appearance in text: LRRK2: G2019s; rs34637584
PubMed Link: 35304493
Variant Present in the following documents:
  • 41531_2022_Article_287.pdf
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Current Status of Next-Generation Sequencing Approaches for Candidate Gene Discovery in Familial Parkinson´s Disease.

Frontiers In Genetics
Pillay, Nikita Simone NS; Ross, Owen A OA; Christoffels, Alan A; Bardien, Soraya S
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35299952
Variant Present in the following documents:
  • fgene-13-781816.pdf
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Altered expression of the immunoregulatory ligand-receptor pair CD200-CD200R1 in the brain of Parkinson's disease patients.

Npj Parkinson'S Disease
Rabaneda-Lombarte, Neus N; Vidal-Taboada, José Manuel JM; Valente, Tony T; Ezquerra, Mario M; Fernández-Santiago, Rubén R; Martí, María José MJ; Compta, Yaroslau Y; Saura, Josep J; Solà, Carme C
Publication Date: 2022-03-16

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35296683
Variant Present in the following documents:
  • 41531_2022_Article_290.pdf
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Mutant LRRK2 in lymphocytes regulates neurodegeneration via IL-6 in an inflammatory model of Parkinson's disease.

Npj Parkinson'S Disease
Kozina, Elena E; Byrne, Matthew M; Smeyne, Richard Jay RJ
Publication Date: 2022-03-15

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35292674
Variant Present in the following documents:
  • 41531_2022_289_MOESM1_ESM.pdf
  • 41531_2022_Article_289.pdf
View BVdb publication page



Neuronal induction and bioenergetics characterization of human forearm adipose stem cells from Parkinson's disease patients and healthy controls.

Plos One
González-Casacuberta, Ingrid I; Vilas, Dolores D; Pont-Sunyer, Claustre C; Tobías, Ester E; Cantó-Santos, Judith J; Valls-Roca, Laura L; García-García, Francesc Josep FJ; Garrabou, Glòria G; Grau-Junyent, Josep Maria JM; Martí, Maria Josep MJ; Cardellach, Francesc F; Morén, Constanza C
Publication Date: 2022

Variant appearance in text: LRRK2: G2019S
PubMed Link: 35290400
Variant Present in the following documents:
  • pone.0265256.pdf
View BVdb publication page