CD4 c.166T>G ;(p.S56A)

Variant ID: 12-6909589-T-G

NM_000616.4(CD4):c.166T>G;(p.S56A)

This variant was identified in 4 publications

View GRCh38 version.




Publications:


Monoclonal antibody m18 paratope leading to dual receptor antagonism of HIV-1 gp120.

Biochemistry
Gift, Syna Kuriakose SK; McFadden, Karyn K; Zentner, Isaac J IJ; Rajagopal, Srivats S; Zhang, Mei-Yun MY; Dimitrov, Dimiter S DS; Chaiken, Irwin M IM
Publication Date: 2011-04-12

Variant appearance in text: CD4: S56A
PubMed Link: 21417283
Variant Present in the following documents:
  • Main text
View BVdb publication page



β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release.

Retrovirology
Tervo, Hanna-Mari HM; Homann, Stefanie S; Ambiel, Ina I; Fritz, Joëlle V JV; Fackler, Oliver T OT; Keppler, Oliver T OT
Publication Date: 2011-02-10

Variant appearance in text: CD4: S56A
PubMed Link: 21310048
Variant Present in the following documents:
  • Main text
  • 1742-4690-8-9.pdf
View BVdb publication page



HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.

Plos Pathogens
Mangeat, Bastien B; Gers-Huber, Gustavo G; Lehmann, Martin M; Zufferey, Madeleine M; Luban, Jeremy J; Piguet, Vincent V
Publication Date: 2009-09

Variant appearance in text: CD4: S56A
PubMed Link: 19730691
Variant Present in the following documents:
  • Main text
View BVdb publication page



Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particles.

Plos Pathogens
Estrabaud, Emilie E; Le Rouzic, Erwann E; Lopez-Vergès, Sandra S; Morel, Marina M; Belaïdouni, Nadia N; Benarous, Richard R; Transy, Catherine C; Berlioz-Torrent, Clarisse C; Margottin-Goguet, Florence F
Publication Date: 2007-07-27

Variant appearance in text: CD4: S56A
PubMed Link: 17676996
Variant Present in the following documents:
  • Main text
  • ppat.0030104.pdf
View BVdb publication page