Publications:

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HIV reprograms host m6Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1.

Nature Communications

Zhang, Qiong Q; Kang, Yuqi Y; Wang, Shaobo S; Gonzalez, Gwendolyn Michelle GM; Li, Wanyu W; Hui, Hui H; Wang, Yinsheng Y; Rana, Tariq M TM

Publication Date: 2021-09-20

Variant appearance in text: CD4: Q65R

PubMed Link: 34545078

Variant Present in the following documents:

• Main text
• 41467_2021_Article_25683.pdf

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Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination.

Journal Of Translational Medicine

Eldin, Patrick P; Péron, Sophie S; Galashevskaya, Anastasia A; Denis-Lagache, Nicolas N; Cogné, Michel M; Slupphaug, Geir G; Briant, Laurence L

Publication Date: 2020-08-10

Variant appearance in text: CD4: Q65R

PubMed Link: 32778120

Variant Present in the following documents:

• Main text
• 12967_2020_Article_2478.pdf

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Delineation of Homeostatic Immune Signatures Defining Viremic Non-progression in HIV-1 Infection.

Frontiers In Immunology

Singh, Amit Kumar AK; Salwe, Sukeshani S; Padwal, Varsha V; Velhal, Shilpa S; Sutar, Jyoti J; Bhowmick, Shilpa S; Mukherjee, Srabani S; Nagar, Vidya V; Patil, Priya P; Patel, Vainav V

Publication Date: 2020

Variant appearance in text: CD4: Q65R

PubMed Link: 32194543

Variant Present in the following documents:

• Main text
• fimmu-11-00182.pdf

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HIV-1 Accessory Protein Vpr Interacts with REAF/RPRD2 To Mitigate Its Antiviral Activity.

Journal Of Virology

Gibbons, Joseph M JM; Marno, Kelly M KM; Pike, Rebecca R; Lee, Wing-Yiu Jason WJ; Jones, Christopher E CE; Ogunkolade, Babatunji W BW; Pardieu, Claire C; Bryan, Alexander A; Fu, Rebecca Menhua RM; Warnes, Gary G; Rowley, Paul A PA; Sloan, Richard D RD; McKnight, Áine Á

Publication Date: 2020-01-31

Variant appearance in text: CD4: Q65R

PubMed Link: 31776272

Variant Present in the following documents:

• Main text

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Vpr and Its Cellular Interaction Partners: R We There Yet?

Cells

Fabryova, Helena H; Strebel, Klaus K

Publication Date: 2019-10-24

Variant appearance in text: CD4: Q65R

PubMed Link: 31652959

Variant Present in the following documents:

• Main text

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HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing.

Scientific Reports

Forouzanfar, F F; Ali, S S; Wallet, C C; De Rovere, M M; Ducloy, C C; El Mekdad, H H; El Maassarani, M M; Aït-Ammar, A A; Van Assche, J J; Boutant, E E; Daouad, F F; Margottin-Goguet, F F; Moog, C C; Van Lint, C C; Schwartz, C C; Rohr, O O

Publication Date: 2019-09-11

Variant appearance in text: CD4: Q65R

PubMed Link: 31511615

Variant Present in the following documents:

• Main text
• 41598_2019_Article_48689.pdf

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Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection.

Cell Reports

Greenwood, Edward J D EJD; Williamson, James C JC; Sienkiewicz, Agata A; Naamati, Adi A; Matheson, Nicholas J NJ; Lehner, Paul J PJ

Publication Date: 2019-04-30

Variant appearance in text: CD4: Q65R

PubMed Link: 31042482

Variant Present in the following documents:

• Main text
• mmc3.pdf
• main.pdf

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HIV-1 Vpr counteracts HLTF-mediated restriction of HIV-1 infection in T cells.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Yan, Junpeng J; Shun, Ming-Chieh MC; Zhang, Yi Y; Hao, Caili C; Skowronski, Jacek J

Publication Date: 2019-05-07

Variant appearance in text: CD4: Q65R

PubMed Link: 31019079

Variant Present in the following documents:

• Main text

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HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis.

The Journal Of Biological Chemistry

Hossain, Delowar D; Ferreira Barbosa, Jérémy A JA; Cohen, Éric A ÉA; Tsang, William Y WY

Publication Date: 2018-06-15

Variant appearance in text: CD4: Q65R

PubMed Link: 29724823

Variant Present in the following documents:

• Main text

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Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells.

Journal Of Virology

Miller, Caitlin M CM; Akiyama, Hisashi H; Agosto, Luis M LM; Emery, Ann A; Ettinger, Chelsea R CR; Swanstrom, Ronald I RI; Henderson, Andrew J AJ; Gummuluru, Suryaram S

Publication Date: 2017-07-01

Variant appearance in text: CD4: Q65R

PubMed Link: 28424288

Variant Present in the following documents:

• Main text

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The HIV-1 Vpr Protein: A Multifaceted Target for Therapeutic Intervention.

International Journal Of Molecular Sciences

González, María Eugenia ME

Publication Date: 2017-01-10

Variant appearance in text: CD4: Q65R

PubMed Link: 28075409

Variant Present in the following documents:

• Main text
• ijms-18-00126.pdf

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HIV-1 Vpr reactivates latent HIV-1 provirus by inducing depletion of class I HDACs on chromatin.

Scientific Reports

Romani, Bizhan B; Kamali Jamil, Razieh R; Hamidi-Fard, Mojtaba M; Rahimi, Pooneh P; Momen, Seyed Bahman SB; Aghasadeghi, Mohammad Reza MR; Allahbakhshi, Elham E

Publication Date: 2016-08-23

Variant appearance in text: CD4: Q65R

PubMed Link: 27550312

Variant Present in the following documents:

• srep31924.pdf

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Transmitted/Founder HIV-1 Subtype C Viruses Show Distinctive Signature Patterns in Vif, Vpr, and Vpu That Are Under Subsequent Immune Pressure During Early Infection.

Aids Research And Human Retroviruses

Rossenkhan, Raabya R; MacLeod, Iain J IJ; Brumme, Zabrina L ZL; Magaret, Craig A CA; Sebunya, Theresa K TK; Musonda, Rosemary R; Gashe, Berhanu A BA; Edlefsen, Paul T PT; Novitsky, Vlad V; Essex, M M

Publication Date: 2016

Variant appearance in text: CD4: Q65R

PubMed Link: 27349335

Variant Present in the following documents:

• Main text

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Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells.

Journal Of Virology

Roesch, Ferdinand F; Richard, Léa L; Rua, Réjane R; Porrot, Françoise F; Casartelli, Nicoletta N; Schwartz, Olivier O

Publication Date: 2015-12

Variant appearance in text: CD4: Q65R

PubMed Link: 26401039

Variant Present in the following documents:

• Main text

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HIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complex.

The Journal Of Biological Chemistry

Wang, Xin X; Singh, Shailbala S; Jung, Hae-Yun HY; Yang, Guojun G; Jun, Sohee S; Sastry, K Jagannadha KJ; Park, Jae-Il JI

Publication Date: 2013-05-31

Variant appearance in text: CD4: Q65R

PubMed Link: 23612978

Variant Present in the following documents:

• Main text

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Evidence for Vpr-dependent HIV-1 replication in human CD4+ CEM.NKR T-cells.

Retrovirology

Zhou, Tao T; Dang, Ying Y; Baker, Jacob J JJ; Zhou, Jiajun J; Zheng, Yong-Hui YH

Publication Date: 2012-11-07

Variant appearance in text: CD4: Q65R

PubMed Link: 23134572

Variant Present in the following documents:

• Main text
• 1742-4690-9-93.pdf

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Modulation of NKG2D-mediated cytotoxic functions of natural killer cells by viral protein R from HIV-1 primary isolates.

Journal Of Virology

Pham, Tram N Q TN; Richard, Jonathan J; Gerard, Francine C A FC; Power, Christopher C; Cohen, Éric A ÉA

Publication Date: 2011-12

Variant appearance in text: CD4: Q65R

PubMed Link: 21957298

Variant Present in the following documents:

• Main text

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Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways.

The Journal Of Biological Chemistry

Maudet, Claire C; Bertrand, Matthieu M; Le Rouzic, Erwann E; Lahouassa, Hichem H; Ayinde, Diana D; Nisole, Sébastien S; Goujon, Caroline C; Cimarelli, Andrea A; Margottin-Goguet, Florence F; Transy, Catherine C

Publication Date: 2011-07-08

Variant appearance in text: CD4: Q65R

PubMed Link: 21566118

Variant Present in the following documents:

• Main text

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HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest.

Journal Of Virology

Belzile, Jean-Philippe JP; Richard, Jonathan J; Rougeau, Nicole N; Xiao, Yong Y; Cohen, Eric A EA

Publication Date: 2010-04

Variant appearance in text: CD4: Q65R

PubMed Link: 20089662

Variant Present in the following documents:

• Main text

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Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions.

Plos One

Jacquot, Guillaume G; Le Rouzic, Erwann E; Maidou-Peindara, Priscilla P; Maizy, Marion M; Lefrère, Jean-Jacques JJ; Daneluzzi, Vincent V; Monteiro-Filho, Carlos M R CM; Hong, Duanping D; Planelles, Vicente V; Morand-Joubert, Laurence L; Benichou, Serge S

Publication Date: 2009-10-19

Variant appearance in text: CD4: Q65R

PubMed Link: 19838296

Variant Present in the following documents:

• Main text

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HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response.

Plos Pathogens

Ward, Jeffrey J; Davis, Zachary Z; DeHart, Jason J; Zimmerman, Erik E; Bosque, Alberto A; Brunetta, Enrico E; Mavilio, Domenico D; Planelles, Vicente V; Barker, Edward E

Publication Date: 2009-10

Variant appearance in text: CD4: Q65R

PubMed Link: 19798433

Variant Present in the following documents:

• Main text
• ppat.1000613.pdf

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HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system.

Virology Journal

DeHart, Jason L JL; Zimmerman, Erik S ES; Ardon, Orly O; Monteiro-Filho, Carlos M R CM; Argañaraz, Enrique R ER; Planelles, Vicente V

Publication Date: 2007-06-08

Variant appearance in text: CD4: Q65R

PubMed Link: 17559673

Variant Present in the following documents:

• Main text

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