Understanding drug resistance patterns across different classes of antiretrovirals used in HIV-1-infected treatment-Naïve and experienced patients in Mumbai, India.
Indian Journal Of Sexually Transmitted Diseases And Aids
A Low Level of Darunavir Resistance-Associated Mutation Emergence in Patients With Virological Failure During Long-term Use of Darunavir in People With HIV. The ANRS CO3 Aquitaine Cohort.
First case of Dolutegravir and Darunavir/r multi drug-resistant HIV-1 in Cameroon following exposure to Raltegravir: lessons and implications in the era of transition to Dolutegravir-based regimens.
The role of mutations at codons 32, 47, 54, and 90 in HIV-1 protease flap dynamics.
Discoveries (Craiova, Romania)
Chordia, Poorvi P; Dewdney, Tamaria G TG; Keusch, Bradley B; Kuiper, Benjamin D BD; Ross, Kyla K; Kovari, Iulia A IA; MacArthur, Rodger R; Salimnia, Hossein H; Kovari, Ladislau C LC
2018 update to the HIV-TRePS system: the development of new computational models to predict HIV treatment outcomes, with or without a genotype, with enhanced usability for low-income settings.
The Journal Of Antimicrobial Chemotherapy
Revell, Andrew D AD; Wang, Dechao D; Perez-Elias, Maria-Jesus MJ; Wood, Robin R; Cogill, Dolphina D; Tempelman, Hugo H; Hamers, Raph L RL; Reiss, Peter P; van Sighem, Ard I AI; Rehm, Catherine A CA; Pozniak, Anton A; Montaner, Julio S G JSG; Lane, H Clifford HC; Larder, Brendan A BA; ,
Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation.
Plos One
Paredes, Roger R; Tzou, Philip L PL; van Zyl, Gert G; Barrow, Geoff G; Camacho, Ricardo R; Carmona, Sergio S; Grant, Philip M PM; Gupta, Ravindra K RK; Hamers, Raph L RL; Harrigan, P Richard PR; Jordan, Michael R MR; Kantor, Rami R; Katzenstein, David A DA; Kuritzkes, Daniel R DR; Maldarelli, Frank F; Otelea, Dan D; Wallis, Carole L CL; Schapiro, Jonathan M JM; Shafer, Robert W RW
Antiviral Activity, Safety, and Exposure-Response Relationships of GSK3532795, a Second-Generation Human Immunodeficiency Virus Type 1 Maturation Inhibitor, Administered as Monotherapy or in Combination With Atazanavir With or Without Ritonavir in a Phase 2a Randomized, Dose-Ranging, Controlled Trial (AI468002).
Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America
Hwang, Carey C; Schürmann, Dirk D; Sobotha, Christian C; Boffito, Marta M; Sevinsky, Heather H; Ray, Neelanjana N; Ravindran, Palanikumar P; Xiao, Hong H; Keicher, Christian C; Hüser, Andreas A; Krystal, Mark M; Dicker, Ira B IB; Grasela, Dennis D; Lataillade, Max M
High levels of virological failure with major genotypic resistance mutations in HIV-1-infected children after 5 years of care according to WHO-recommended 1st-line and 2nd-line antiretroviral regimens in the Central African Republic: A cross-sectional study.
Medicine
Mossoro-Kpinde, Christian Diamant CD; Gody, Jean-Chrysostome JC; Mboumba Bouassa, Ralph-Sydney RS; Mbitikon, Olivia O; Jenabian, Mohammad-Ali MA; Robin, Leman L; Matta, Mathieu M; Zeitouni, Kamal K; Longo, Jean De Dieu JD; Costiniuk, Cecilia C; Grésenguet, Gérard G; Touré Kane, Ndèye Coumba NC; Bélec, Laurent L
An update to the HIV-TRePS system: the development and evaluation of new global and local computational models to predict HIV treatment outcomes, with or without a genotype.
The Journal Of Antimicrobial Chemotherapy
Revell, Andrew D AD; Wang, Dechao D; Wood, Robin R; Morrow, Carl C; Tempelman, Hugo H; Hamers, Raph L RL; Reiss, Peter P; van Sighem, Ard I AI; Nelson, Mark M; Montaner, Julio S G JS; Lane, H Clifford HC; Larder, Brendan A BA; ,
Raltegravir in second-line antiretroviral therapy in resource-limited settings (SELECT): a randomised, phase 3, non-inferiority study.
The Lancet. Hiv
La Rosa, Alberto M AM; Harrison, Linda J LJ; Taiwo, Babafemi B; Wallis, Carole L CL; Zheng, Lu L; Kim, Peter P; Kumarasamy, Nagalingeswaran N; Hosseinipour, Mina C MC; Jarocki, Bernadette B; Mellors, John W JW; Collier, Ann C AC; ,
Effectiveness of Ritonavir-Boosted Protease Inhibitor Monotherapy in Clinical Practice Even with Previous Virological Failures to Protease Inhibitor-Based Regimens.
Plos One
López-Cortés, Luis F LF; Castaño, Manuel A MA; López-Ruz, Miguel A MA; Rios-Villegas, María J MJ; Hernández-Quero, José J; Merino, Dolores D; Jiménez-Aguilar, Patricia P; Marquez-Solero, Manuel M; Terrón-Pernía, Alberto A; Tellez-Pérez, Francisco F; Viciana, Pompeyo P; Orihuela-Cañadas, Francisco F; Palacios-Baena, Zaira Z; Vinuesa-Garcia, David D; Fajardo-Pico, Jose M JM; Romero-Palacios, Alberto A; Ojeda-Burgos, Guillermo G; Pasquau-Liaño, Juan J
High prevalence of PI resistance in patients failing second-line ART in Vietnam.
The Journal Of Antimicrobial Chemotherapy
Thao, Vu Phuong VP; Quang, Vo Minh VM; Day, Jeremy N JN; Chinh, Nguyen Tran NT; Shikuma, Cecilia M CM; Farrar, Jeremy J; Van Vinh Chau, Nguyen N; Thwaites, Guy E GE; Dunstan, Sarah J SJ; Le, Thuy T
Cobicistat-boosted darunavir in HIV-1-infected adults: week 48 results of a Phase IIIb, open-label single-arm trial.
Aids Research And Therapy
Tashima, Karen K; Crofoot, Gordon G; Tomaka, Frank L FL; Kakuda, Thomas N TN; Brochot, Anne A; Van de Casteele, Tom T; Opsomer, Magda M; Garner, William W; Margot, Nicolas N; Custodio, Joseph M JM; Fordyce, Marshall W MW; Szwarcberg, Javier J
Drug susceptibility to etravirine and darunavir among Human Immunodeficiency Virus Type 1-derived pseudoviruses in treatment-experienced patients with HIV/AIDS in South Korea.
Virology Journal
Kwon, Oh-Kyung OK; Kim, Sung Soon SS; Rhee, Jee Eun JE; Kee, Mee-Kyung MK; Park, Mina M; Oh, Hye-Ri HR; Choi, Ju-Yeon JY
A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape.
Retrovirology
Kløverpris, Henrik N HN; Cole, David K DK; Fuller, Anna A; Carlson, Jonathan J; Beck, Konrad K; Schauenburg, Andrea J AJ; Rizkallah, Pierre J PJ; Buus, Søren S; Sewell, Andrew K AK; Goulder, Philip P
Prevalence of transmitted HIV-1 antiretroviral resistance among patients initiating antiretroviral therapy in Brazil: a surveillance study using dried blood spots.
Journal Of The International Aids Society
de Moraes Soares, Celina M P CM; Vergara, Tania R C TR; Brites, Carlos C; Brito, Jose D U JD; Grinberg, Gorki G; Caseiro, Marcos M MM; Correa, Carlos C; Suffert, Theodoro A TA; Pereira, Flavio R FR; Camargo, Michelle M; Janini, Luiz M LM; Komninakis, Shirley S; Sucupira, Maria C A MC; Diaz, Ricardo S RS
Trends and correlates of HIV-1 resistance among subjects failing an antiretroviral treatment over the 2003-2012 decade in Italy.
Bmc Infectious Diseases
Franzetti, Marco M; Violin, Michela M; Antinori, Andrea A; De Luca, Andrea A; Ceccherini-Silberstein, Francesca F; Gianotti, Nicola N; Torti, Carlo C; Bonora, Stefano S; Zazzi, Maurizio M; Balotta, Claudia C
Drug resistance among newly diagnosed HIV-infected children in the era of more efficacious antiretroviral prophylaxis.
Aids (London, England)
Kuhn, Louise L; Hunt, Gillian G; Technau, Karl-Günter KG; Coovadia, Ashraf A; Ledwaba, Johanna J; Pickerill, Sam S; Penazzato, Martina M; Bertagnolio, Silvia S; Mellins, Claude A CA; Black, Vivian V; Morris, Lynn L; Abrams, Elaine J EJ
Natural polymorphisms and unusual mutations in HIV-1 protease with potential antiretroviral resistance: a bioinformatic analysis.
Bmc Bioinformatics
Mata-Munguía, Carlos C; Escoto-Delgadillo, Martha M; Torres-Mendoza, Blanca B; Flores-Soto, Mario M; Vázquez-Torres, Mildred M; Gálvez-Gastelum, Francisco F; Viniegra-Osorio, Arturo A; Castillero-Manzano, Marcelo M; Vázquez-Valls, Eduardo E
Trends in Genotypic HIV-1 Antiretroviral Resistance between 2006 and 2012 in South African Patients Receiving First- and Second-Line Antiretroviral Treatment Regimens.
Plos One
Van Zyl, Gert U GU; Liu, Tommy F TF; Claassen, Mathilda M; Engelbrecht, Susan S; de Oliveira, Tulio T; Preiser, Wolfgang W; Wood, Natasha T NT; Travers, Simon S; Shafer, Robert W RW
Virologic response, early HIV-1 decay, and maraviroc pharmacokinetics with the nucleos(t)ide-free regimen of maraviroc plus darunavir/ritonavir in a pilot study.
Journal Of Acquired Immune Deficiency Syndromes (1999)
Taiwo, Babafemi B; Acosta, Edward P EP; Ryscavage, Patrick P; Berzins, Baiba B; Lu, Darlene D; Lalezari, Jay J; Castro, Jose J; Adeyemi, Oluwatoyin O; Kuritzkes, Daniel R DR; Eron, Joseph J JJ; Tsibris, Athe A; Swindells, Susan S
Differential impact of resistance-associated mutations to protease inhibitors and nonnucleoside reverse transcriptase inhibitors on HIV-1 replication capacity.
Darunavir is a good third-line antiretroviral agent for HIV type 1-infected patients failing second-line protease inhibitor-based regimens in South India.
Aids Research And Human Retroviruses
Saravanan, Shanmugam S; Madhavan, Vidya V; Balakrishnan, Pachamuthu P; Smith, Davey M DM; Solomon, Sunil Suhas SS; Sivamalar, Sathasivam S; Poongulali, Selvamuthu S; Kumarasamy, Nagalingeswaran N; Schooley, Robert T RT; Solomon, Suniti S; Kantor, Rami R
Transmitted drug resistance and phylogenetic relationships among acute and early HIV-1-infected individuals in New York City.
Journal Of Acquired Immune Deficiency Syndromes (1999)
Castor, Delivette D; Low, Andrea A; Evering, Teresa T; Karmon, Sharon S; Davis, Brandi B; Figueroa, Amir A; LaMar, Melissa M; Garmon, Donald D; Mehandru, Saurabh S; Markowitz, Martin M
Efficacy of a nucleoside-sparing regimen of darunavir/ritonavir plus raltegravir in treatment-naive HIV-1-infected patients (ACTG A5262).
Aids (London, England)
Taiwo, Babafemi B; Zheng, Lu L; Gallien, Sebastien S; Matining, Roy M RM; Kuritzkes, Daniel R DR; Wilson, Cara C CC; Berzins, Baiba I BI; Acosta, Edward P EP; Bastow, Barbara B; Kim, Peter S PS; Eron, Joseph J JJ; ,
Drug resistance and coreceptor usage in HIV type 1 subtype C-infected children initiating or failing highly active antiretroviral therapy in South Africa.
Aids Research And Human Retroviruses
Green, Taryn N TN; Archary, Mohendran M; Gordon, Michelle L ML; Padayachi, Nagavelli N; Lie, Yolanda Y; Anton, Elizabeth D ED; Reeves, Jacqueline D JD; Grobler, Anneke A; Bobat, Raziya R; Coovadia, Hoosen H; Ndung'u, Thumbi T
Loss of protease dimerization inhibition activity of darunavir is associated with the acquisition of resistance to darunavir by HIV-1.
Journal Of Virology
Koh, Yasuhiro Y; Aoki, Manabu M; Danish, Matthew L ML; Aoki-Ogata, Hiromi H; Amano, Masayuki M; Das, Debananda D; Shafer, Robert W RW; Ghosh, Arun K AK; Mitsuya, Hiroaki H
Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa.
Aids Research And Treatment
Wallis, Carole L CL; Mellors, John W JW; Venter, Willem D F WD; Sanne, Ian I; Stevens, Wendy W
The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir: is there a clinical advantage?
Aids Research And Therapy
Wiesmann, Frank F; Vachta, Jan J; Ehret, Robert R; Walter, Hauke H; Kaiser, Rolf R; Stürmer, Martin M; Tappe, André A; Däumer, Martin M; Berg, Thomas T; Naeth, Gudrun G; Braun, Patrick P; Knechten, Heribert H
Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi.
Aids Research And Human Retroviruses
Bansode, Vijay V; Drebert, Zuzanna J ZJ; Travers, Simon A A SA; Banda, Emmanuel E; Molesworth, Anna A; Crampin, Amelia A; Ngwira, Bagrey B; French, Neil N; Glynn, Judith R JR; McCormack, Grace P GP
Incidence of HIV type 1 infection, antiretroviral drug resistance, and molecular characterization in newly diagnosed individuals in Argentina: A Global Fund Project.
Aids Research And Human Retroviruses
Pando, M A MA; Gómez-Carrillo, M M; Vignoles, M M; Rubio, A E AE; dos Ramos Farias, M S MS; Vila, M M; Rossi, D D; Ralón, G G; Marone, R R; Reynaga, E E; Sosa, J J; Torres, O O; Maestri, M M; Avila, M M MM; Salomón, H H
In vitro selection of highly darunavir-resistant and replication-competent HIV-1 variants by using a mixture of clinical HIV-1 isolates resistant to multiple conventional protease inhibitors.
Journal Of Virology
Koh, Yasuhiro Y; Amano, Masayuki M; Towata, Tomomi T; Danish, Matthew M; Leshchenko-Yashchuk, Sofiya S; Das, Debananda D; Nakayama, Maki M; Tojo, Yasushi Y; Ghosh, Arun K AK; Mitsuya, Hiroaki H
Drug resistance mutations in HIV-infected patients in the Spanish drug resistance database failing tipranavir and darunavir therapy.
Antimicrobial Agents And Chemotherapy
Poveda, Eva E; Anta, Lourdes L; Blanco, José Luis JL; Casado, José Luis JL; Gutiérrez, Félix F; García, Federico F; Gómez-Sirvent, Juan Luis JL; Iribarren, José Antonio JA; Soriano, Vincent V; de Mendoza, Carmen C; ,
Protease inhibitor resistance analysis in the MONARK trial comparing first-line lopinavir-ritonavir monotherapy to lopinavir-ritonavir plus zidovudine and lamivudine triple therapy.
Antimicrobial Agents And Chemotherapy
Delaugerre, Constance C; Flandre, Philippe P; Chaix, Marie Laure ML; Ghosn, Jade J; Raffi, François F; Dellamonica, Pierre P; Jaeger, H H; Shürmann, D D; Cohen-Codar, Isabelle I; Van, Philippe Ngo PN; Norton, Michael M; Taburet, Anne-Marie AM; Delfraissy, Jean-François JF; Rouzioux, Christine C; ,
Virological response to highly active antiretroviral therapy in patients infected with human immunodeficiency virus type 2 (HIV-2) and in patients dually infected with HIV-1 and HIV-2 in the Gambia and emergence of drug-resistant variants.
Journal Of Clinical Microbiology
Jallow, Sabelle S; Alabi, Abraham A; Sarge-Njie, Ramu R; Peterson, Kevin K; Whittle, Hilton H; Corrah, Tumani T; Jaye, Assan A; Cotten, Matthew M; Vanham, Guido G; McConkey, Samuel J SJ; Rowland-Jones, Sarah S; Janssens, Wouter W
Envelope coreceptor tropism, drug resistance, and viral evolution among subtype C HIV-1-infected individuals receiving nonsuppressive antiretroviral therapy.
Journal Of Acquired Immune Deficiency Syndromes (1999)
Kassaye, Seble S; Johnston, Elizabeth E; McColgan, Bryan B; Kantor, Rami R; Zijenah, Lynn L; Katzenstein, David D