CD4 c.226C>G ;(p.L76V)

Variant ID: 12-6923319-C-G

NM_000616.4(CD4):c.226C>G;(p.L76V)

This variant was identified in 79 publications

View GRCh38 version.




Publications:


Understanding drug resistance patterns across different classes of antiretrovirals used in HIV-1-infected treatment-Naïve and experienced patients in Mumbai, India.

Indian Journal Of Sexually Transmitted Diseases And Aids
Harjani, Raj Gurubuxrai RG; Iyer, Asha Krishnaraj AK; Chaurasia, Ankita A
Publication Date: 2022

Variant appearance in text: CD4: L76V
PubMed Link: 36743113
Variant Present in the following documents:
  • Main text
View BVdb publication page



Evaluation of treatment simplification strategies in patients living with HIV with multi-drug resistance.

Therapeutic Advances In Infectious Disease
Harris, Taylor N TN; Buscemi, Lindsey R LR
Publication Date: 2023

Variant appearance in text: CD4: L76V
PubMed Link: 36699503
Variant Present in the following documents:
  • Main text
  • 10.1177_20499361221149869.pdf
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A Case Report of Multiclass HIV Drug-Resistance After an Inappropriate Switch of ARVs with Persistent Unsuppressed Viral Load.

Journal Of The International Association Of Providers Of Aids Care
Kakubu, Mireille A Mpalang MAM; Kalonji, Mukebayi M; Katoto, Patrick D M C PDMC
Publication Date: 2022

Variant appearance in text: CD4: L76V
PubMed Link: 35854413
Variant Present in the following documents:
  • Main text
View BVdb publication page



A Low Level of Darunavir Resistance-Associated Mutation Emergence in Patients With Virological Failure During Long-term Use of Darunavir in People With HIV. The ANRS CO3 Aquitaine Cohort.

Open Forum Infectious Diseases
Chaussade, Hélène H; Tumiotto, Camille C; Le Marec, Fabien F; Leleux, Olivier O; Lefèvre, Lucile L; Lazaro, Estibaliz E; Lafon, Marie-Edith ME; Nyamankolly, Elsa E; Duffau, Pierre P; Neau, Didier D; Bellecave, Pantxika P; Bonnet, Fabrice F
Publication Date: 2020-12

Variant appearance in text: CD4: L76V
PubMed Link: 33409332
Variant Present in the following documents:
  • Main text
  • ofaa567.pdf
View BVdb publication page



First case of Dolutegravir and Darunavir/r multi drug-resistant HIV-1 in Cameroon following exposure to Raltegravir: lessons and implications in the era of transition to Dolutegravir-based regimens.

Antimicrobial Resistance And Infection Control
Fokam, Joseph J; Takou, Desire D; Semengue, Ezechiel Ngoufack Jagni ENJ; Teto, Georges G; Beloumou, Grace G; Dambaya, Beatrice B; Santoro, Maria-Mercedes MM; Mossiang, Leonella L; Billong, Serge Clotaire SC; Cham, Fatim F; Sosso, Samuel Martin SM; Temgoua, Edith Saounde ES; Nanfack, Aubin Joseph AJ; Moudourou, Sylvie S; Kamgaing, Nelly N; Kamgaing, Rachel R; Ngako Pamen, Joelle Nounouce JN; Etame, Mireille Mpoudi Ngole MMN; Bissek, Anne-Cecile Z-K AZ; Elat, Jean-Bosco N JN; Moussi, Emmanuel Eben EE; Colizzi, Vittorio V; Perno, Carlo-Federico CF; Ndjolo, Alexis A; ,
Publication Date: 2020-08-26

Variant appearance in text: CD4: L76V
PubMed Link: 32843050
Variant Present in the following documents:
  • Main text
  • 13756_2020_Article_799.pdf
View BVdb publication page



The role of mutations at codons 32, 47, 54, and 90 in HIV-1 protease flap dynamics.

Discoveries (Craiova, Romania)
Chordia, Poorvi P; Dewdney, Tamaria G TG; Keusch, Bradley B; Kuiper, Benjamin D BD; Ross, Kyla K; Kovari, Iulia A IA; MacArthur, Rodger R; Salimnia, Hossein H; Kovari, Ladislau C LC
Publication Date: 2014-12-31

Variant appearance in text: CD4: L76V
PubMed Link: 32309558
Variant Present in the following documents:
  • Main text
  • discoveries-02-027.pdf
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Efficacy and Safety of Raltegravir-Based Dual Therapy in AIDS Patients: A Meta-Analysis of Randomized Controlled Trials.

Frontiers In Pharmacology
Huang, Yinqiu Y; Huang, Xiaojie X; Chen, Hui H; Wu, Hao H; Chen, Yaokai Y
Publication Date: 2019

Variant appearance in text: CD4: L76V
PubMed Link: 31749699
Variant Present in the following documents:
  • Main text
View BVdb publication page



2018 update to the HIV-TRePS system: the development of new computational models to predict HIV treatment outcomes, with or without a genotype, with enhanced usability for low-income settings.

The Journal Of Antimicrobial Chemotherapy
Revell, Andrew D AD; Wang, Dechao D; Perez-Elias, Maria-Jesus MJ; Wood, Robin R; Cogill, Dolphina D; Tempelman, Hugo H; Hamers, Raph L RL; Reiss, Peter P; van Sighem, Ard I AI; Rehm, Catherine A CA; Pozniak, Anton A; Montaner, Julio S G JSG; Lane, H Clifford HC; Larder, Brendan A BA; ,
Publication Date: 2018-08-01

Variant appearance in text: CD4: L76V
PubMed Link: 29889249
Variant Present in the following documents:
  • Main text
View BVdb publication page



Highlighting the crucial role of Hangzhou in HIV-1 transmission among men who have sex with men in Zhejiang, China.

Scientific Reports
Zhang, Jiafeng J; Guo, Zhihong Z; Pan, Xiaohong X; Zhang, Wenjun W; Yang, Jiezhe J; Ding, Xiaobei X; Xu, Yun Y; Xia, Yan Y; Jiang, Jianmin J
Publication Date: 2017-10-24

Variant appearance in text: CD4: L76V
PubMed Link: 29066776
Variant Present in the following documents:
  • Main text
View BVdb publication page



Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation.

Plos One
Paredes, Roger R; Tzou, Philip L PL; van Zyl, Gert G; Barrow, Geoff G; Camacho, Ricardo R; Carmona, Sergio S; Grant, Philip M PM; Gupta, Ravindra K RK; Hamers, Raph L RL; Harrigan, P Richard PR; Jordan, Michael R MR; Kantor, Rami R; Katzenstein, David A DA; Kuritzkes, Daniel R DR; Maldarelli, Frank F; Otelea, Dan D; Wallis, Carole L CL; Schapiro, Jonathan M JM; Shafer, Robert W RW
Publication Date: 2017

Variant appearance in text: CD4: L76V
PubMed Link: 28753637
Variant Present in the following documents:
  • Main text
  • pone.0181357.pdf
View BVdb publication page



Antiviral Activity, Safety, and Exposure-Response Relationships of GSK3532795, a Second-Generation Human Immunodeficiency Virus Type 1 Maturation Inhibitor, Administered as Monotherapy or in Combination With Atazanavir With or Without Ritonavir in a Phase 2a Randomized, Dose-Ranging, Controlled Trial (AI468002).

Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America
Hwang, Carey C; Schürmann, Dirk D; Sobotha, Christian C; Boffito, Marta M; Sevinsky, Heather H; Ray, Neelanjana N; Ravindran, Palanikumar P; Xiao, Hong H; Keicher, Christian C; Hüser, Andreas A; Krystal, Mark M; Dicker, Ira B IB; Grasela, Dennis D; Lataillade, Max M
Publication Date: 2017-08-01

Variant appearance in text: CD4: L76V
PubMed Link: 28369211
Variant Present in the following documents:
  • Main text
View BVdb publication page



High levels of virological failure with major genotypic resistance mutations in HIV-1-infected children after 5 years of care according to WHO-recommended 1st-line and 2nd-line antiretroviral regimens in the Central African Republic: A cross-sectional study.

Medicine
Mossoro-Kpinde, Christian Diamant CD; Gody, Jean-Chrysostome JC; Mboumba Bouassa, Ralph-Sydney RS; Mbitikon, Olivia O; Jenabian, Mohammad-Ali MA; Robin, Leman L; Matta, Mathieu M; Zeitouni, Kamal K; Longo, Jean De Dieu JD; Costiniuk, Cecilia C; Grésenguet, Gérard G; Touré Kane, Ndèye Coumba NC; Bélec, Laurent L
Publication Date: 2017-03

Variant appearance in text: CD4: L76V
PubMed Link: 28272247
Variant Present in the following documents:
  • medi-96-e6282.pdf
View BVdb publication page



Trends and predictors of HIV-1 acquired drug resistance in Minas Gerais, Brazil: 2002-2012.

The Brazilian Journal Of Infectious Diseases : An Official Publication Of The Brazilian Society Of Infectious Diseases
Duani, Helena H; Aleixo, Agdemir Waleria AW; Tupinambás, Unaí U
Publication Date: 2017

Variant appearance in text: CD4: L76V
PubMed Link: 28017554
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Therapeutic Drug Monitoring of Lopinavir in HIV-Infected Children on Second-Line Antiretroviral Therapy in Asia.

Therapeutic Drug Monitoring
Aurpibul, Linda L; Teerananchai, Sirinya S; Prasitsuebsai, Wasana W; Sudjaritruk, Tavitiya T; Kosalaraksa, Pope P; Kurniati, Nia N; Truong, Khanh Huu KH; Do, Viet Chau VC; Nguyen, Lam Van LV; Chokephaibulkit, Kulkanya K; Singtoroj, Thida T; Kerr, Stephen J SJ
Publication Date: 2016-12

Variant appearance in text: CD4: L76V
PubMed Link: 27749514
Variant Present in the following documents:
  • Main text
View BVdb publication page



An update to the HIV-TRePS system: the development and evaluation of new global and local computational models to predict HIV treatment outcomes, with or without a genotype.

The Journal Of Antimicrobial Chemotherapy
Revell, Andrew D AD; Wang, Dechao D; Wood, Robin R; Morrow, Carl C; Tempelman, Hugo H; Hamers, Raph L RL; Reiss, Peter P; van Sighem, Ard I AI; Nelson, Mark M; Montaner, Julio S G JS; Lane, H Clifford HC; Larder, Brendan A BA; ,
Publication Date: 2016-10

Variant appearance in text: CD4: L76V
PubMed Link: 27330070
Variant Present in the following documents:
  • Main text
View BVdb publication page



Raltegravir in second-line antiretroviral therapy in resource-limited settings (SELECT): a randomised, phase 3, non-inferiority study.

The Lancet. Hiv
La Rosa, Alberto M AM; Harrison, Linda J LJ; Taiwo, Babafemi B; Wallis, Carole L CL; Zheng, Lu L; Kim, Peter P; Kumarasamy, Nagalingeswaran N; Hosseinipour, Mina C MC; Jarocki, Bernadette B; Mellors, John W JW; Collier, Ann C AC; ,
Publication Date: 2016-06

Variant appearance in text: CD4: Leu76Val
PubMed Link: 27240787
Variant Present in the following documents:
  • Main text
View BVdb publication page



Model-Based Analysis of Unbound Lopinavir Pharmacokinetics in HIV-Infected Pregnant Women Supports Standard Dosing in the Third Trimester.

Cpt: Pharmacometrics & Systems Pharmacology
Chen, J J; Malone, S S; Prince, H M A HM; Patterson, K B KB; Dumond, J B JB
Publication Date: 2016-03

Variant appearance in text: CD4: L76V
PubMed Link: 27069778
Variant Present in the following documents:
  • PSP4-5-147.pdf
View BVdb publication page



Evaluating the role of atazanavir/cobicistat and darunavir/cobicistat fixed-dose combinations for the treatment of HIV-1 infection.

Hiv/Aids (Auckland, N.Z.)
Crutchley, Rustin D RD; Guduru, Rakesh C RC; Cheng, Amy M AM
Publication Date: 2016

Variant appearance in text: CD4: L76V
PubMed Link: 27022304
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effectiveness of Ritonavir-Boosted Protease Inhibitor Monotherapy in Clinical Practice Even with Previous Virological Failures to Protease Inhibitor-Based Regimens.

Plos One
López-Cortés, Luis F LF; Castaño, Manuel A MA; López-Ruz, Miguel A MA; Rios-Villegas, María J MJ; Hernández-Quero, José J; Merino, Dolores D; Jiménez-Aguilar, Patricia P; Marquez-Solero, Manuel M; Terrón-Pernía, Alberto A; Tellez-Pérez, Francisco F; Viciana, Pompeyo P; Orihuela-Cañadas, Francisco F; Palacios-Baena, Zaira Z; Vinuesa-Garcia, David D; Fajardo-Pico, Jose M JM; Romero-Palacios, Alberto A; Ojeda-Burgos, Guillermo G; Pasquau-Liaño, Juan J
Publication Date: 2016

Variant appearance in text: CD4: L76V
PubMed Link: 26872331
Variant Present in the following documents:
  • Main text
View BVdb publication page



High prevalence of PI resistance in patients failing second-line ART in Vietnam.

The Journal Of Antimicrobial Chemotherapy
Thao, Vu Phuong VP; Quang, Vo Minh VM; Day, Jeremy N JN; Chinh, Nguyen Tran NT; Shikuma, Cecilia M CM; Farrar, Jeremy J; Van Vinh Chau, Nguyen N; Thwaites, Guy E GE; Dunstan, Sarah J SJ; Le, Thuy T
Publication Date: 2016-03

Variant appearance in text: CD4: L76V
PubMed Link: 26661398
Variant Present in the following documents:
  • Main text
View BVdb publication page



Cobicistat-boosted darunavir in HIV-1-infected adults: week 48 results of a Phase IIIb, open-label single-arm trial.

Aids Research And Therapy
Tashima, Karen K; Crofoot, Gordon G; Tomaka, Frank L FL; Kakuda, Thomas N TN; Brochot, Anne A; Van de Casteele, Tom T; Opsomer, Magda M; Garner, William W; Margot, Nicolas N; Custodio, Joseph M JM; Fordyce, Marshall W MW; Szwarcberg, Javier J
Publication Date: 2014

Variant appearance in text: CD4: L76V
PubMed Link: 25926858
Variant Present in the following documents:
  • Main text
View BVdb publication page



Drug susceptibility to etravirine and darunavir among Human Immunodeficiency Virus Type 1-derived pseudoviruses in treatment-experienced patients with HIV/AIDS in South Korea.

Virology Journal
Kwon, Oh-Kyung OK; Kim, Sung Soon SS; Rhee, Jee Eun JE; Kee, Mee-Kyung MK; Park, Mina M; Oh, Hye-Ri HR; Choi, Ju-Yeon JY
Publication Date: 2015-04-09

Variant appearance in text: CD4: L76V
PubMed Link: 25879840
Variant Present in the following documents:
  • Main text
View BVdb publication page



A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape.

Retrovirology
Kløverpris, Henrik N HN; Cole, David K DK; Fuller, Anna A; Carlson, Jonathan J; Beck, Konrad K; Schauenburg, Andrea J AJ; Rizkallah, Pierre J PJ; Buus, Søren S; Sewell, Andrew K AK; Goulder, Philip P
Publication Date: 2015-02-20

Variant appearance in text: CD4: L76V
PubMed Link: 25808313
Variant Present in the following documents:
  • Main text
  • 12977_2015_Article_149.pdf
View BVdb publication page



Virologic failure among children taking lopinavir/ritonavir-containing first-line antiretroviral therapy in South Africa.

The Pediatric Infectious Disease Journal
Meyers, Tammy T; Sawry, Shobna S; Wong, Jessica Y JY; Moultrie, Harry H; Pinillos, Francoise F; Fairlie, Lee L; van Zyl, Gert G
Publication Date: 2015-02

Variant appearance in text: CD4: L76V
PubMed Link: 25741970
Variant Present in the following documents:
  • Main text
View BVdb publication page



Viral envelope is a major determinant of enhanced fitness of a multidrug-resistant HIV-1 variant.

Journal Of Acquired Immune Deficiency Syndromes (1999)
Mohri, Hiroshi H; Prada, Nicole N; Markowitz, Martin M
Publication Date: 2015-04-15

Variant appearance in text: CD4: L76V
PubMed Link: 25622054
Variant Present in the following documents:
  • Main text
View BVdb publication page



Prevalence of transmitted HIV-1 antiretroviral resistance among patients initiating antiretroviral therapy in Brazil: a surveillance study using dried blood spots.

Journal Of The International Aids Society
de Moraes Soares, Celina M P CM; Vergara, Tania R C TR; Brites, Carlos C; Brito, Jose D U JD; Grinberg, Gorki G; Caseiro, Marcos M MM; Correa, Carlos C; Suffert, Theodoro A TA; Pereira, Flavio R FR; Camargo, Michelle M; Janini, Luiz M LM; Komninakis, Shirley S; Sucupira, Maria C A MC; Diaz, Ricardo S RS
Publication Date: 2014

Variant appearance in text: CD4: L76V
PubMed Link: 25249214
Variant Present in the following documents:
  • Main text
  • JIAS-17-19042.pdf
View BVdb publication page



Transmitted antiretroviral drug resistance in the men who have sex with men HIV patient cohort, Beijing, China, 2008-2011.

Viral Immunology
Dai, Lili L; Li, Ning N; Wei, Feili F; Li, Jingyun J; Liu, Yongjian Y; Xia, Wei W; Zhang, Tong T; Guo, Caiping C; Wang, Wen W; Schwartz, Stanley A SA; Mahajan, Supriya D SD; Hsiao, Chiu-Bin CB; Wu, Hao H
Publication Date: 2014-10

Variant appearance in text: CD4: L76V
PubMed Link: 25084305
Variant Present in the following documents:
  • Main text
View BVdb publication page



Trends and correlates of HIV-1 resistance among subjects failing an antiretroviral treatment over the 2003-2012 decade in Italy.

Bmc Infectious Diseases
Franzetti, Marco M; Violin, Michela M; Antinori, Andrea A; De Luca, Andrea A; Ceccherini-Silberstein, Francesca F; Gianotti, Nicola N; Torti, Carlo C; Bonora, Stefano S; Zazzi, Maurizio M; Balotta, Claudia C
Publication Date: 2014-07-18

Variant appearance in text: CD4: L76V
PubMed Link: 25037229
Variant Present in the following documents:
  • Main text
View BVdb publication page



Drug resistance among newly diagnosed HIV-infected children in the era of more efficacious antiretroviral prophylaxis.

Aids (London, England)
Kuhn, Louise L; Hunt, Gillian G; Technau, Karl-Günter KG; Coovadia, Ashraf A; Ledwaba, Johanna J; Pickerill, Sam S; Penazzato, Martina M; Bertagnolio, Silvia S; Mellins, Claude A CA; Black, Vivian V; Morris, Lynn L; Abrams, Elaine J EJ
Publication Date: 2014-07-17

Variant appearance in text: CD4: L76V
PubMed Link: 24785949
Variant Present in the following documents:
  • Main text
View BVdb publication page



Natural polymorphisms and unusual mutations in HIV-1 protease with potential antiretroviral resistance: a bioinformatic analysis.

Bmc Bioinformatics
Mata-Munguía, Carlos C; Escoto-Delgadillo, Martha M; Torres-Mendoza, Blanca B; Flores-Soto, Mario M; Vázquez-Torres, Mildred M; Gálvez-Gastelum, Francisco F; Viniegra-Osorio, Arturo A; Castillero-Manzano, Marcelo M; Vázquez-Valls, Eduardo E
Publication Date: 2014-03-15

Variant appearance in text: CD4: L76V
PubMed Link: 24629078
Variant Present in the following documents:
  • Main text
View BVdb publication page



Comparable long-term efficacy of Lopinavir/Ritonavir and similar drug-resistance profiles in different HIV-1 subtypes.

Plos One
Grossman, Zehava Z; Schapiro, Jonathan M JM; Levy, Itzchak I; Elbirt, Daniel D; Chowers, Michal M; Riesenberg, Klaris K; Olstein-Pops, Karen K; Shahar, Eduardo E; Istomin, Valery V; Asher, Ilan I; Gottessman, Bat-Sheva BS; Shemer, Yonat Y; Elinav, Hila H; Hassoun, Gamal G; Rosenberg, Shira S; Averbuch, Diana D; Machleb-Guri, Keren K; Kra-Oz, Zipi Z; Radian-Sade, Sara S; Rudich, Hagit H; Ram, Daniela D; Maayan, Shlomo S; Agmon-Levin, Nancy N; Sthoeger, Zev Z
Publication Date: 2014

Variant appearance in text: CD4: L76V
PubMed Link: 24475093
Variant Present in the following documents:
  • Main text
  • pone.0086239.pdf
View BVdb publication page



Increasing trends in primary NNRTI resistance among newly HIV-1-diagnosed individuals in Buenos Aires, Argentina.

Journal Of The International Aids Society
Rodriguez-Rodrigues, Nahuel N; Duran, Adriana A; Bouzas, María Belen MB; Zapiola, Ines I; Vila, Marcelo M; Indyk, Debbie D; Bissio, Emiliano E; Salomon, Horacio H; Dilernia, Dario A DA
Publication Date: 2013-10-03

Variant appearance in text: CD4: L76V
PubMed Link: 24093951
Variant Present in the following documents:
  • Main text
View BVdb publication page



Trends in Genotypic HIV-1 Antiretroviral Resistance between 2006 and 2012 in South African Patients Receiving First- and Second-Line Antiretroviral Treatment Regimens.

Plos One
Van Zyl, Gert U GU; Liu, Tommy F TF; Claassen, Mathilda M; Engelbrecht, Susan S; de Oliveira, Tulio T; Preiser, Wolfgang W; Wood, Natasha T NT; Travers, Simon S; Shafer, Robert W RW
Publication Date: 2013

Variant appearance in text: CD4: L76V
PubMed Link: 23840622
Variant Present in the following documents:
  • Main text
View BVdb publication page



Virologic response, early HIV-1 decay, and maraviroc pharmacokinetics with the nucleos(t)ide-free regimen of maraviroc plus darunavir/ritonavir in a pilot study.

Journal Of Acquired Immune Deficiency Syndromes (1999)
Taiwo, Babafemi B; Acosta, Edward P EP; Ryscavage, Patrick P; Berzins, Baiba B; Lu, Darlene D; Lalezari, Jay J; Castro, Jose J; Adeyemi, Oluwatoyin O; Kuritzkes, Daniel R DR; Eron, Joseph J JJ; Tsibris, Athe A; Swindells, Susan S
Publication Date: 2013-10-01

Variant appearance in text: CD4: L76V
PubMed Link: 23797691
Variant Present in the following documents:
  • Main text
View BVdb publication page



Incidence and associated factors of HIV drug resistance in Chinese HIV-infected patients receiving antiretroviral treatment.

Plos One
Xing, Hui H; Wang, Xia X; Liao, Lingjie L; Ma, Yanling Y; Su, Bin B; Fu, Jihua J; He, Jianmei J; Chen, Lin L; Pan, Xiaohong X; Dong, Yonghui Y; Liu, Wei W; Hsi, Jenny H JH; Yang, Liting L; Ruan, Yuhua Y; Shao, Yiming Y
Publication Date: 2013

Variant appearance in text: CD4: L76V
PubMed Link: 23638072
Variant Present in the following documents:
  • Main text
View BVdb publication page



Differential impact of resistance-associated mutations to protease inhibitors and nonnucleoside reverse transcriptase inhibitors on HIV-1 replication capacity.

Aids Research And Human Retroviruses
Hsieh, Szu-Min SM; Pan, Sung-Ching SC; Chang, Sui-Yuan SY; Hung, Chien-Ching CC; Sheng, Wang-Huei WH; Chen, Mao-Yuan MY; Chang, Shan-Chwen SC
Publication Date: 2013-08

Variant appearance in text: CD4: L76V
PubMed Link: 23594266
Variant Present in the following documents:
  • Main text
View BVdb publication page



The design of single-arm clinical trials of combination antiretroviral regimens for treatment-naive HIV-infected patients.

Aids Research And Human Retroviruses
Zheng, Lu L; Rosenkranz, Susan L SL; Taiwo, Babafemi B; Para, Michael F MF; Eron, Joseph J JJ; Hughes, Michael D MD
Publication Date: 2013-04

Variant appearance in text: CD4: L76V
PubMed Link: 23228206
Variant Present in the following documents:
  • Main text
View BVdb publication page



Collinearity of protease mutations in HIV-1 samples with high-level protease inhibitor class resistance.

The Journal Of Antimicrobial Chemotherapy
Babrzadeh, Farbod F; Varghese, Vici V; Pacold, Mary M; Liu, Tommy F TF; Nyrén, Pål P; Schiffer, Celia C; Fessel, W Jeffrey WJ; Shafer, Robert W RW
Publication Date: 2013-02

Variant appearance in text: CD4: L76V
PubMed Link: 23085775
Variant Present in the following documents:
  • Main text
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Darunavir is a good third-line antiretroviral agent for HIV type 1-infected patients failing second-line protease inhibitor-based regimens in South India.

Aids Research And Human Retroviruses
Saravanan, Shanmugam S; Madhavan, Vidya V; Balakrishnan, Pachamuthu P; Smith, Davey M DM; Solomon, Sunil Suhas SS; Sivamalar, Sathasivam S; Poongulali, Selvamuthu S; Kumarasamy, Nagalingeswaran N; Schooley, Robert T RT; Solomon, Suniti S; Kantor, Rami R
Publication Date: 2013-03

Variant appearance in text: CD4: L76V
PubMed Link: 23045961
Variant Present in the following documents:
  • Main text
View BVdb publication page



Protease-Mediated Maturation of HIV: Inhibitors of Protease and the Maturation Process.

Molecular Biology International
Adamson, Catherine S CS
Publication Date: 2012

Variant appearance in text: CD4: L76V
PubMed Link: 22888428
Variant Present in the following documents:
  • Main text
  • MBI2012-604261.pdf
View BVdb publication page



Transmitted antiretroviral drug resistance in newly HIV-infected and untreated patients in Ségou and Bamako, Mali.

Aids Research And Human Retroviruses
Maiga, Almoustapha Issiaka AI; Fofana, Djeneba Bocar DB; Maiga, Aichatou Chehy AC; Diallo, Fodie F; Ait-Arkoub, Zaina Z; Daou, Fatoumata F; Cisse, Mamadou M; Sarro, Yaya Dit Sadio YD; Oumar, Aboubacar Alassane AA; Sylla, Aliou A; Katlama, Christine C; Taiwo, Babafemi B; Murphy, Robert R; Tounkara, Anatole A; Marcelin, Anne-Genevieve AG; Calvez, Vincent V
Publication Date: 2013-01

Variant appearance in text: CD4: L76V
PubMed Link: 22823755
Variant Present in the following documents:
  • Main text
View BVdb publication page



Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix.

Retrovirology
Kuo, Lillian S LS; Baugh, Laura L LL; Denial, Sarah J SJ; Watkins, Richard L RL; Liu, Mingjie M; Garcia, J Victor JV; Foster, John L JL
Publication Date: 2012-05-31

Variant appearance in text: CD4: L76V
PubMed Link: 22651890
Variant Present in the following documents:
  • Main text
View BVdb publication page



Transmitted drug resistance and phylogenetic relationships among acute and early HIV-1-infected individuals in New York City.

Journal Of Acquired Immune Deficiency Syndromes (1999)
Castor, Delivette D; Low, Andrea A; Evering, Teresa T; Karmon, Sharon S; Davis, Brandi B; Figueroa, Amir A; LaMar, Melissa M; Garmon, Donald D; Mehandru, Saurabh S; Markowitz, Martin M
Publication Date: 2012-09-01

Variant appearance in text: CD4: L76V
PubMed Link: 22592583
Variant Present in the following documents:
  • Main text
View BVdb publication page



Impact of low-level-viremia on HIV-1 drug-resistance evolution among antiretroviral treated-patients.

Plos One
Delaugerre, Constance C; Gallien, Sébastien S; Flandre, Philippe P; Mathez, Dominique D; Amarsy, Rishma R; Ferret, Samuel S; Timsit, Julie J; Molina, Jean-Michel JM; de Truchis, Pierre P
Publication Date: 2012

Variant appearance in text: CD4: L76V
PubMed Link: 22590588
Variant Present in the following documents:
  • Main text
View BVdb publication page



Substantial multiclass transmitted drug resistance and drug-relevant polymorphisms among treatment-naïve behaviorally HIV-infected youth.

Aids Patient Care And Stds
Agwu, Allison L AL; Bethel, James J; Hightow-Weidman, Lisa B LB; Sleasman, John W JW; Wilson, Craig M CM; Rudy, Bret B; Kapogiannis, Bill G BG; ,
Publication Date: 2012-04

Variant appearance in text: CD4: L76V
PubMed Link: 22563607
Variant Present in the following documents:
  • Main text
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Low prevalence of transmitted drug resistance in patients newly diagnosed with HIV-1 infection in Sweden 2003-2010.

Plos One
Karlsson, Annika A; Björkman, Per P; Bratt, Göran G; Ekvall, Håkan H; Gisslén, Magnus M; Sönnerborg, Anders A; Mild, Mattias M; Albert, Jan J
Publication Date: 2012

Variant appearance in text: CD4: L76V
PubMed Link: 22448246
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Viremia and HIV-1 drug resistance mutations among patients receiving second-line highly active antiretroviral therapy in Chennai, Southern India.

Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America
Saravanan, Shanmugam S; Vidya, Madhavan M; Balakrishnan, Pachamuthu P; Kantor, Rami R; Solomon, Sunil S SS; Katzenstein, David D; Kumarasamy, Nagalingeswaran N; Yeptomi, Tokugha T; Sivamalar, Sathasivam S; Rifkin, Samara S; Mayer, Kenneth H KH; Solomon, Suniti S
Publication Date: 2012-04

Variant appearance in text: CD4: L76V
PubMed Link: 22323567
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Role of darunavir in the management of HIV infection.

Hiv/Aids (Auckland, N.Z.)
Lascar, R Monica RM; Benn, Paul P
Publication Date: 2009

Variant appearance in text: CD4: L76V
PubMed Link: 22096377
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It is time to consider third-line options in antiretroviral-experienced paediatric patients?

Journal Of The International Aids Society
Zyl, Gert U van GU; Rabie, Helena H; Nuttall, James J JJ; Cotton, Mark F MF
Publication Date: 2011-11-15

Variant appearance in text: CD4: L76V
PubMed Link: 22085598
Variant Present in the following documents:
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  • 1758-2652-14-55.pdf
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Polymorphism in Gag gene cleavage sites of HIV-1 non-B subtype and virological outcome of a first-line lopinavir/ritonavir single drug regimen.

Plos One
Ghosn, Jade J; Delaugerre, Constance C; Flandre, Philippe P; Galimand, Julie J; Cohen-Codar, Isabelle I; Raffi, François F; Delfraissy, Jean-François JF; Rouzioux, Christine C; Chaix, Marie-Laure ML
Publication Date: 2011

Variant appearance in text: CD4: L76V
PubMed Link: 21949754
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Efficacy of a nucleoside-sparing regimen of darunavir/ritonavir plus raltegravir in treatment-naive HIV-1-infected patients (ACTG A5262).

Aids (London, England)
Taiwo, Babafemi B; Zheng, Lu L; Gallien, Sebastien S; Matining, Roy M RM; Kuritzkes, Daniel R DR; Wilson, Cara C CC; Berzins, Baiba I BI; Acosta, Edward P EP; Bastow, Barbara B; Kim, Peter S PS; Eron, Joseph J JJ; ,
Publication Date: 2011-11-13

Variant appearance in text: CD4: L76V
PubMed Link: 21857490
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Drug resistance and coreceptor usage in HIV type 1 subtype C-infected children initiating or failing highly active antiretroviral therapy in South Africa.

Aids Research And Human Retroviruses
Green, Taryn N TN; Archary, Mohendran M; Gordon, Michelle L ML; Padayachi, Nagavelli N; Lie, Yolanda Y; Anton, Elizabeth D ED; Reeves, Jacqueline D JD; Grobler, Anneke A; Bobat, Raziya R; Coovadia, Hoosen H; Ndung'u, Thumbi T
Publication Date: 2012-04

Variant appearance in text: CD4: L76V
PubMed Link: 21819257
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Loss of protease dimerization inhibition activity of darunavir is associated with the acquisition of resistance to darunavir by HIV-1.

Journal Of Virology
Koh, Yasuhiro Y; Aoki, Manabu M; Danish, Matthew L ML; Aoki-Ogata, Hiromi H; Amano, Masayuki M; Das, Debananda D; Shafer, Robert W RW; Ghosh, Arun K AK; Mitsuya, Hiroaki H
Publication Date: 2011-10

Variant appearance in text: CD4: L76V
PubMed Link: 21813613
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Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa.

Aids Research And Treatment
Wallis, Carole L CL; Mellors, John W JW; Venter, Willem D F WD; Sanne, Ian I; Stevens, Wendy W
Publication Date: 2011

Variant appearance in text: CD4: L76V
PubMed Link: 21490784
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The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir: is there a clinical advantage?

Aids Research And Therapy
Wiesmann, Frank F; Vachta, Jan J; Ehret, Robert R; Walter, Hauke H; Kaiser, Rolf R; Stürmer, Martin M; Tappe, André A; Däumer, Martin M; Berg, Thomas T; Naeth, Gudrun G; Braun, Patrick P; Knechten, Heribert H
Publication Date: 2011-02-13

Variant appearance in text: CD4: L76V
PubMed Link: 21314993
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Positive impact of HIV-1 gag cleavage site mutations on the virological response to darunavir boosted with ritonavir.

Antimicrobial Agents And Chemotherapy
Larrouy, Lucile L; Lambert-Niclot, Sidonie S; Charpentier, Charlotte C; Fourati, Slim S; Visseaux, Benoit B; Soulié, Cathia C; Wirden, Marc M; Katlama, Christine C; Yeni, Patrick P; Brun-Vézinet, Françoise F; Calvez, Vincent V; Marcelin, Anne-Geneviève AG; Descamps, Diane D
Publication Date: 2011-04

Variant appearance in text: CD4: L76V
PubMed Link: 21282435
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Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C.

Viruses
Margeridon-Thermet, Severine S; Shafer, Robert W RW
Publication Date: 2010-12-01

Variant appearance in text: CD4: L76V
PubMed Link: 21243082
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Role of tipranavir in treatment of patients with multidrug-resistant HIV.

Therapeutics And Clinical Risk Management
Courter, Joshua D JD; Teevan, Colleen J CJ; Li, Michael H MH; Girotto, Jennifer E JE; Salazar, Juan C JC
Publication Date: 2010-10-05

Variant appearance in text: CD4: L76V
PubMed Link: 20957134
Variant Present in the following documents:
  • Main text
  • tcrm-6-431.pdf
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Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi.

Aids Research And Human Retroviruses
Bansode, Vijay V; Drebert, Zuzanna J ZJ; Travers, Simon A A SA; Banda, Emmanuel E; Molesworth, Anna A; Crampin, Amelia A; Ngwira, Bagrey B; French, Neil N; Glynn, Judith R JR; McCormack, Grace P GP
Publication Date: 2011-04

Variant appearance in text: CD4: L76V
PubMed Link: 20950147
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Prevalence of transmitted drug resistance and impact of transmitted resistance on treatment success in the German HIV-1 Seroconverter Cohort.

Plos One
Bartmeyer, Barbara B; Kuecherer, Claudia C; Houareau, Claudia C; Werning, Johanna J; Keeren, Kathrin K; Somogyi, Sybille S; Kollan, Christian C; Jessen, Heiko H; Dupke, Stephan S; Hamouda, Osamah O; ,
Publication Date: 2010-10-07

Variant appearance in text: CD4: L76V
PubMed Link: 20949104
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Incidence of HIV type 1 infection, antiretroviral drug resistance, and molecular characterization in newly diagnosed individuals in Argentina: A Global Fund Project.

Aids Research And Human Retroviruses
Pando, M A MA; Gómez-Carrillo, M M; Vignoles, M M; Rubio, A E AE; dos Ramos Farias, M S MS; Vila, M M; Rossi, D D; Ralón, G G; Marone, R R; Reynaga, E E; Sosa, J J; Torres, O O; Maestri, M M; Avila, M M MM; Salomón, H H
Publication Date: 2011-01

Variant appearance in text: CD4: L76V
PubMed Link: 20860532
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In vitro selection of highly darunavir-resistant and replication-competent HIV-1 variants by using a mixture of clinical HIV-1 isolates resistant to multiple conventional protease inhibitors.

Journal Of Virology
Koh, Yasuhiro Y; Amano, Masayuki M; Towata, Tomomi T; Danish, Matthew M; Leshchenko-Yashchuk, Sofiya S; Das, Debananda D; Nakayama, Maki M; Tojo, Yasushi Y; Ghosh, Arun K AK; Mitsuya, Hiroaki H
Publication Date: 2010-11

Variant appearance in text: CD4: L76V
PubMed Link: 20810732
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Drug resistance mutations in HIV-infected patients in the Spanish drug resistance database failing tipranavir and darunavir therapy.

Antimicrobial Agents And Chemotherapy
Poveda, Eva E; Anta, Lourdes L; Blanco, José Luis JL; Casado, José Luis JL; Gutiérrez, Félix F; García, Federico F; Gómez-Sirvent, Juan Luis JL; Iribarren, José Antonio JA; Soriano, Vincent V; de Mendoza, Carmen C; ,
Publication Date: 2010-07

Variant appearance in text: CD4: L76V
PubMed Link: 20479204
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Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo.

Antimicrobial Agents And Chemotherapy
Delelis, Olivier O; Thierry, Sylvain S; Subra, Frédéric F; Simon, Françoise F; Malet, Isabelle I; Alloui, Chakib C; Sayon, Sophie S; Calvez, Vincent V; Deprez, Eric E; Marcelin, Anne-Geneviève AG; Tchertanov, Luba L; Mouscadet, Jean-François JF
Publication Date: 2010-01

Variant appearance in text: CD4: L76V
PubMed Link: 19901095
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Protease inhibitor resistance analysis in the MONARK trial comparing first-line lopinavir-ritonavir monotherapy to lopinavir-ritonavir plus zidovudine and lamivudine triple therapy.

Antimicrobial Agents And Chemotherapy
Delaugerre, Constance C; Flandre, Philippe P; Chaix, Marie Laure ML; Ghosn, Jade J; Raffi, François F; Dellamonica, Pierre P; Jaeger, H H; Shürmann, D D; Cohen-Codar, Isabelle I; Van, Philippe Ngo PN; Norton, Michael M; Taburet, Anne-Marie AM; Delfraissy, Jean-François JF; Rouzioux, Christine C; ,
Publication Date: 2009-07

Variant appearance in text: CD4: L76V
PubMed Link: 19451297
Variant Present in the following documents:
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Role of atazanavir in the treatment of HIV infection.

Therapeutics And Clinical Risk Management
Rivas, Pablo P; Morello, Judit J; Garrido, Carolina C; Rodríguez-Nóvoa, Sonia S; Soriano, Vincent V
Publication Date: 2009-02

Variant appearance in text: CD4: L76V
PubMed Link: 19436623
Variant Present in the following documents:
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Virological response to highly active antiretroviral therapy in patients infected with human immunodeficiency virus type 2 (HIV-2) and in patients dually infected with HIV-1 and HIV-2 in the Gambia and emergence of drug-resistant variants.

Journal Of Clinical Microbiology
Jallow, Sabelle S; Alabi, Abraham A; Sarge-Njie, Ramu R; Peterson, Kevin K; Whittle, Hilton H; Corrah, Tumani T; Jaye, Assan A; Cotten, Matthew M; Vanham, Guido G; McConkey, Samuel J SJ; Rowland-Jones, Sarah S; Janssens, Wouter W
Publication Date: 2009-07

Variant appearance in text: CD4: L76V
PubMed Link: 19420165
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Efficacy and safety of darunavir and etravirine in an antiretroviral multi-experienced youth with vertically HIV-1 infection.

European Journal Of Medical Research
Rosso, Raffaella R; Bernardini, C C; Bruzzone, B B; Secondo, G G; Icardi, G G; Viscoli, C C; Di Biagio, A A
Publication Date: 2009-03-17

Variant appearance in text: CD4: L76V
PubMed Link: 19380285
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Both a protective and a deleterious role for the L76V mutation.

Antimicrobial Agents And Chemotherapy
Tartaglia, Alessandra A; Saracino, Annalisa A; Monno, Laura L; Tinelli, Carmine C; Angarano, Gioacchino G
Publication Date: 2009-04

Variant appearance in text: CD4: L76V
PubMed Link: 19299521
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Envelope coreceptor tropism, drug resistance, and viral evolution among subtype C HIV-1-infected individuals receiving nonsuppressive antiretroviral therapy.

Journal Of Acquired Immune Deficiency Syndromes (1999)
Kassaye, Seble S; Johnston, Elizabeth E; McColgan, Bryan B; Kantor, Rami R; Zijenah, Lynn L; Katzenstein, David D
Publication Date: 2009-01-01

Variant appearance in text: CD4: L76V
PubMed Link: 19295330
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Combating HIV resistance - focus on darunavir.

Therapeutics And Clinical Risk Management
Tremblay, Cécile L CL
Publication Date: 2008-08

Variant appearance in text: CD4: L76V
PubMed Link: 19209258
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Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir.

Aids Reviews
Lefebvre, Eric E; Schiffer, Celia A CA
Publication Date: 2008

Variant appearance in text: CD4: L76V
PubMed Link: 18820715
Variant Present in the following documents:
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