Prevalence of Transmitted Drug-Resistance Mutations and Polymorphisms in HIV-1 Reverse Transcriptase, Protease, and gp41 Sequences Among Recent Seroconverters in Southern Poland.
Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research
Smoleń-Dzirba, Joanna J; Rosińska, Magdalena M; Kruszyński, Piotr P; Bratosiewicz-Wąsik, Jolanta J; Wojtyczka, Robert R; Janiec, Janusz J; Szetela, Bartosz B; Beniowski, Marek M; Bociąga-Jasik, Monika M; Jabłonowska, Elżbieta E; Wąsik, Tomasz J TJ; The Cascade Collaboration In EuroCoord, And A
Anti-HIV-1 activity determined by β-galactosidase activity in the multinuclear activation of an indicator assay is comparable with that by a conventional focus counting method.
Antiviral Chemistry & Chemotherapy
Miyamoto, Fusako F; Kawaji, Kumi K; Oishi, Shinya S; Fujii, Nobutaka N; Kaku, Mitsuo M; Kodama, Eiichi N EN
Resistance of human immunodeficiency virus type 1 to a third-generation fusion inhibitor requires multiple mutations in gp41 and is accompanied by a dramatic loss of gp41 function.
Journal Of Virology
Eggink, Dirk D; Bontjer, Ilja I; Langedijk, Johannes P M JP; Berkhout, Ben B; Sanders, Rogier W RW
Impact of the HIV-1 env genetic context outside HR1-HR2 on resistance to the fusion inhibitor enfuvirtide and viral infectivity in clinical isolates.
Plos One
Baatz, Franky F; Nijhuis, Monique M; Lemaire, Morgane M; Riedijk, Martiene M; Wensing, Annemarie M J AM; Servais, Jean-Yves JY; van Ham, Petra M PM; Hoepelman, Andy I M AI; Koopmans, Peter P PP; Sprenger, Herman G HG; Devaux, Carole C; Schmit, Jean-Claude JC; Perez Bercoff, Danielle D
HR-2 mutations in human immunodeficiency virus type 1 gp41 restore fusion kinetics delayed by HR-1 mutations that cause clinical resistance to enfuvirtide.
Journal Of Virology
Ray, Neelanjana N; Blackburn, Leslie A LA; Doms, Robert W RW
SC29EK, a peptide fusion inhibitor with enhanced alpha-helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtide.
Impact of human immunodeficiency virus type 1 gp41 amino acid substitutions selected during enfuvirtide treatment on gp41 binding and antiviral potency of enfuvirtide in vitro.
Journal Of Virology
Mink, M M; Mosier, S M SM; Janumpalli, S S; Davison, D D; Jin, L L; Melby, T T; Sista, P P; Erickson, J J; Lambert, D D; Stanfield-Oakley, S A SA; Salgo, M M; Cammack, N N; Matthews, T T; Greenberg, M L ML
Emergence and evolution of enfuvirtide resistance following long-term therapy involves heptad repeat 2 mutations within gp41.
Antimicrobial Agents And Chemotherapy
Xu, L L; Pozniak, A A; Wildfire, A A; Stanfield-Oakley, S A SA; Mosier, S M SM; Ratcliffe, D D; Workman, J J; Joall, A A; Myers, R R; Smit, E E; Cane, P A PA; Greenberg, M L ML; Pillay, D D