Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity.
Journal For Immunotherapy Of Cancer
Borodovsky, Alexandra A; Barbon, Christine M CM; Wang, Yanjun Y; Ye, Minwei M; Prickett, Laura L; Chandra, Dinesh D; Shaw, Joseph J; Deng, Nanhua N; Sachsenmeier, Kris K; Clarke, James D JD; Linghu, Bolan B; Brown, Giles A GA; Brown, James J; Congreve, Miles M; Cheng, Robert Ky RK; Dore, Andrew S AS; Hurrell, Edward E; Shao, Wenlin W; Woessner, Richard R; Reimer, Corinne C; Drew, Lisa L; Fawell, Stephen S; Schuller, Alwin G AG; Mele, Deanna A DA
Mutation of dileucine-like motifs in the human immunodeficiency virus type 1 capsid disrupts virus assembly, gag-gag interactions, gag-membrane binding, and virion maturation.
Journal Of Virology
Joshi, Anjali A; Nagashima, Kunio K; Freed, Eric O EO