Detrimental NFKB1 missense variants affecting the Rel-homology domain of p105/p50.
Frontiers In Immunology
Fliegauf, Manfred M; Kinnunen, Matias M; Posadas-Cantera, Sara S; Camacho-Ordonez, Nadezhda N; Abolhassani, Hassan H; Alsina, Laia L; Atschekzei, Faranaz F; Bogaert, Delfien J DJ; Burns, Siobhan O SO; Church, Joseph A JA; Dückers, Gregor G; Freeman, Alexandra F AF; Hammarström, Lennart L; Hanitsch, Leif Gunnar LG; Kerre, Tessa T; Kobbe, Robin R; Sharapova, Svetlana O SO; Siepermann, Kathrin K; Speckmann, Carsten C; Steiner, Sophie S; Verma, Nisha N; Walter, Jolan E JE; Westermann-Clark, Emma E; Goldacker, Sigune S; Warnatz, Klaus K; Varjosalo, Markku M; Grimbacher, Bodo B
CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Clement, Mathew M; Knezevic, Lea L; Dockree, Tamsin T; McLaren, James E JE; Ladell, Kristin K; Miners, Kelly L KL; Llewellyn-Lacey, Sian S; Rubina, Anzelika A; Francis, Ore O; Cole, David K DK; Sewell, Andrew K AK; Bridgeman, John S JS; Price, David A DA; van den Berg, Hugo A HA; Wooldridge, Linda L
Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph.
Nature Communications
van de Sandt, C E CE; Clemens, E B EB; Grant, E J EJ; Rowntree, L C LC; Sant, S S; Halim, H H; Crowe, J J; Cheng, A C AC; Kotsimbos, T C TC; Richards, M M; Miller, A A; Tong, S Y C SYC; Rossjohn, J J; Nguyen, T H O THO; Gras, S S; Chen, W W; Kedzierska, K K
Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.
Nature Communications
Zhao, Xiang X; Sankaran, Shvetha S; Yap, Jiawei J; Too, Chien Tei CT; Ho, Zi Zong ZZ; Dolton, Garry G; Legut, Mateusz M; Ren, Ee Chee EC; Sewell, Andrew K AK; Bertoletti, Antonio A; MacAry, Paul A PA; Brzostek, Joanna J; Gascoigne, Nicholas R J NRJ
CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.
Immunology And Cell Biology
Dockree, Tamsin T; Holland, Christopher J CJ; Clement, Mathew M; Ladell, Kristin K; McLaren, James E JE; van den Berg, Hugo A HA; Gostick, Emma E; L Miners, Kelly K; Llewellyn-Lacey, Sian S; Bridgeman, John S JS; Man, Stephen S; Bailey, Mick M; Burrows, Scott R SR; Price, David A DA; Wooldridge, Linda L
Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain.
Immunity
Beal, Allison M AM; Anikeeva, Nadia N; Varma, Rajat R; Cameron, Thomas O TO; Vasiliver-Shamis, Gaia G; Norris, Philip J PJ; Dustin, Michael L ML; Sykulev, Yuri Y
Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region.
European Journal Of Immunology
Wooldridge, Linda L; Lissina, Anna A; Vernazza, Jonathan J; Gostick, Emma E; Laugel, Bruno B; Hutchinson, Sarah L SL; Mirza, Fareed F; Dunbar, P Rod PR; Boulter, Jonathan M JM; Glick, Meir M; Cerundolo, Vincenzo V; van den Berg, Hugo A HA; Price, David A DA; Sewell, Andrew K AK
Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface.
The Journal Of Biological Chemistry
Wooldridge, Linda L; van den Berg, Hugo A HA; Glick, Meir M; Gostick, Emma E; Laugel, Bruno B; Hutchinson, Sarah L SL; Milicic, Anita A; Brenchley, Jason M JM; Douek, Daniel C DC; Price, David A DA; Sewell, Andrew K AK