Polyclonal Broadly Neutralizing Antibody Activity Characterized by CD4 Binding Site and V3-Glycan Antibodies in a Subset of HIV-1 Virus Controllers.
Frontiers In Immunology
Nyanhete, Tinashe E TE; Edwards, Robert J RJ; LaBranche, Celia C CC; Mansouri, Katayoun K; Eaton, Amanda A; Dennison, S Moses SM; Saunders, Kevin O KO; Goodman, Derrick D; Janowska, Katarzyna K; Spreng, Rachel L RL; Zhang, Lu L; Mudrak, Sarah V SV; Hope, Thomas J TJ; Hora, Bhavna B; Bradley, Todd T; Georgiev, Ivelin S IS; Montefiori, David C DC; Acharya, Priyamvada P; Tomaras, Georgia D GD
CD4+ T Cells Are Dispensable for Induction of Broad Heterologous HIV Neutralizing Antibodies in Rhesus Macaques.
Frontiers In Immunology
Sarkar, Sanghita S; Spencer, David A DA; Barnette, Philip P; Pandey, Shilpi S; Sutton, William F WF; Basu, Madhubanti M; Burch, Reuben E RE; Cleveland, John D JD; Rosenberg, Alexander F AF; Rangel-Moreno, Javier J; Keefer, Michael C MC; Hessell, Ann J AJ; Haigwood, Nancy L NL; Kobie, James J JJ
Potent Induction of Envelope-Specific Antibody Responses by Virus-Like Particle Immunogens Based on HIV-1 Envelopes from Patients with Early Broadly Neutralizing Responses.
Journal Of Virology
Beltran-Pavez, Carolina C; Bontjer, Ilja I; Gonzalez, Nuria N; Pernas, Maria M; Merino-Mansilla, Alberto A; Olvera, Alex A; Miro, Jose M JM; Brander, Christian C; Alcami, Jose J; Sanders, Rogier W RW; Sanchez-Merino, Victor V; Yuste, Eloisa E
Potent Induction of Envelope-Specific Antibody Responses by Virus-Like Particle (VLP) Immunogens Based on HIV-1 Envelopes from Patients with Early Broadly Neutralizing Responses.
Journal Of Virology
Beltran-Pavez, Carolina C; Bontjer, Ilja I; Gonzalez, Nuria N; Pernas, Maria M; Merino-Mansilla, Alberto A; Olvera, Alex A; Miro, Jose M JM; Brander, Christian C; Alcami, Jose J; Sanders, Rogier W RW; Sanchez-Merino, Victor V; Yuste, Eloisa E
Broadly neutralizing antibody responses in the longitudinal primary HIV-1 infection Short Pulse Anti-Retroviral Therapy at Seroconversion cohort.
Aids (London, England)
Granger, Luke A LA; Huettner, Isabella I; Debeljak, Franka F; Kaleebu, Pontiano P; Schechter, Mauro M; Tambussi, Giuseppe G; Weber, Jonathan J; Miro, Jose M JM; Phillips, Rodney R; Babiker, Abdel A; Cooper, David A DA; Fisher, Martin M; Ramjee, Gita G; Fidler, Sarah S; Frater, John J; Fox, Julie J; Doores, Katie J KJ
Cross Type Neutralizing Antibodies Detected in a Unique HIV-2 Infected Individual From India.
Frontiers In Immunology
Vidyavijayan, K K KK; Cheedarala, Narayanaiah N; Babu, Hemalatha H; Precilla, Lucia K LK; Sathyamurthi, Pattabiraman P; Chandrasekaran, Padmapriyadarsini P; Murugavel, Kailapuri G KG; Swaminathan, Soumya S; Tripathy, Srikanth P SP; Hanna, Luke Elizabeth LE
Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier.
Immunity
Bonsignori, Mattia M; Scott, Eric E; Wiehe, Kevin K; Easterhoff, David D; Alam, S Munir SM; Hwang, Kwan-Ki KK; Cooper, Melissa M; Xia, Shi-Mao SM; Zhang, Ruijun R; Montefiori, David C DC; Henderson, Rory R; Nie, Xiaoyan X; Kelsoe, Garnett G; Moody, M Anthony MA; Chen, Xuejun X; Joyce, M Gordon MG; Kwong, Peter D PD; Connors, Mark M; Mascola, John R JR; McGuire, Andrew T AT; Stamatatos, Leonidas L; Medina-Ramírez, Max M; Sanders, Rogier W RW; Saunders, Kevin O KO; Kepler, Thomas B TB; Haynes, Barton F BF
Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors.
Plos One
González, Nuria N; McKee, Krisha K; Lynch, Rebecca M RM; Georgiev, Ivelin S IS; Jimenez, Laura L; Grau, Eulalia E; Yuste, Eloísa E; Kwong, Peter D PD; Mascola, John R JR; Alcamí, José J
Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.
Nature Communications
Williams, Wilton B WB; Zhang, Jinsong J; Jiang, Chuancang C; Nicely, Nathan I NI; Fera, Daniela D; Luo, Kan K; Moody, M Anthony MA; Liao, Hua-Xin HX; Alam, S Munir SM; Kepler, Thomas B TB; Ramesh, Akshaya A; Wiehe, Kevin K; Holland, James A JA; Bradley, Todd T; Vandergrift, Nathan N; Saunders, Kevin O KO; Parks, Robert R; Foulger, Andrew A; Xia, Shi-Mao SM; Bonsignori, Mattia M; Montefiori, David C DC; Louder, Mark M; Eaton, Amanda A; Santra, Sampa S; Scearce, Richard R; Sutherland, Laura L; Newman, Amanda A; Bouton-Verville, Hilary H; Bowman, Cindy C; Bomze, Howard H; Gao, Feng F; Marshall, Dawn J DJ; Whitesides, John F JF; Nie, Xiaoyan X; Kelsoe, Garnett G; Reed, Steven G SG; Fox, Christopher B CB; Clary, Kim K; Koutsoukos, Marguerite M; Franco, David D; Mascola, John R JR; Harrison, Stephen C SC; Haynes, Barton F BF; Verkoczy, Laurent L
Broad and potent cross clade neutralizing antibodies with multiple specificities in the plasma of HIV-1 subtype C infected individuals.
Scientific Reports
Cheedarla, Narayanaiah N; Precilla, K Lucia KL; Babu, Hemalatha H; Vijayan, K K Vidya KKV; Ashokkumar, Manickam M; Chandrasekaran, Padmapriyadarsini P; Kailasam, Nandagopal N; Sundaramurthi, Jagadish Chandrabose JC; Swaminathan, Soumya S; Buddolla, Viswanath V; Vaniambadi, S Kalyanaraman SK; Ramanathan, V D VD; Hanna, Luke Elizabeth LE
Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.
Plos Pathogens
Easterhoff, David D; Moody, M Anthony MA; Fera, Daniela D; Cheng, Hao H; Ackerman, Margaret M; Wiehe, Kevin K; Saunders, Kevin O KO; Pollara, Justin J; Vandergrift, Nathan N; Parks, Rob R; Kim, Jerome J; Michael, Nelson L NL; O'Connell, Robert J RJ; Excler, Jean-Louis JL; Robb, Merlin L ML; Vasan, Sandhya S; Rerks-Ngarm, Supachai S; Kaewkungwal, Jaranit J; Pitisuttithum, Punnee P; Nitayaphan, Sorachai S; Sinangil, Faruk F; Tartaglia, James J; Phogat, Sanjay S; Kepler, Thomas B TB; Alam, S Munir SM; Liao, Hua-Xin HX; Ferrari, Guido G; Seaman, Michael S MS; Montefiori, David C DC; Tomaras, Georgia D GD; Harrison, Stephen C SC; Haynes, Barton F BF
Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques.
Jci Insight
Luo, Kan K; Liao, Hua-Xin HX; Zhang, Ruijun R; Easterhoff, David D; Wiehe, Kevin K; Gurley, Thaddeus C TC; Armand, Lawrence C LC; Allen, Ashley A AA; Von Holle, Tarra A TA; Marshall, Dawn J DJ; Whitesides, John F JF; Pritchett, Jamie J; Foulger, Andrew A; Hernandez, Giovanna G; Parks, Robert R; Lloyd, Krissey E KE; Stolarchuk, Christina C; Sawant, Sheetal S; Peel, Jessica J; Yates, Nicole L NL; Dunford, Erika E; Arora, Sabrina S; Wang, Amy A; Bowman, Cindy M CM; Sutherland, Laura L LL; Scearce, Richard M RM; Xia, Shi-Mao SM; Bonsignori, Mattia M; Pollara, Justin J; Edwards, R Whitney RW; Santra, Sampa S; Letvin, Norman L NL; Tartaglia, James J; Francis, Donald D; Sinangil, Faruk F; Lee, Carter C; Kaewkungwal, Jaranit J; Nitayaphan, Sorachai S; Pitisuttithum, Punnee P; Rerks-Ngarm, Supachai S; Michael, Nelson L NL; Kim, Jerome H JH; Alam, S Munir SM; Vandergrift, Nathan A NA; Ferrari, Guido G; Montefiori, David C DC; Tomaras, Georgia D GD; Haynes, Barton F BF; Moody, M Anthony MA
Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.
Immunity
Huang, Jinghe J; Kang, Byong H BH; Ishida, Elise E; Zhou, Tongqing T; Griesman, Trevor T; Sheng, Zizhang Z; Wu, Fan F; Doria-Rose, Nicole A NA; Zhang, Baoshan B; McKee, Krisha K; O'Dell, Sijy S; Chuang, Gwo-Yu GY; Druz, Aliaksandr A; Georgiev, Ivelin S IS; Schramm, Chaim A CA; Zheng, Anqi A; Joyce, M Gordon MG; Asokan, Mangaiarkarasi M; Ransier, Amy A; Darko, Sam S; Migueles, Stephen A SA; Bailer, Robert T RT; Louder, Mark K MK; Alam, S Munir SM; Parks, Robert R; Kelsoe, Garnett G; Von Holle, Tarra T; Haynes, Barton F BF; Douek, Daniel C DC; Hirsch, Vanessa V; Seaman, Michael S MS; Shapiro, Lawrence L; Mascola, John R JR; Kwong, Peter D PD; Connors, Mark M
An HIV-1 Env-Antibody Complex Focuses Antibody Responses to Conserved Neutralizing Epitopes.
Journal Of Immunology (Baltimore, Md. : 1950)
Chen, Yajing Y; Wilson, Richard R; O'Dell, Sijy S; Guenaga, Javier J; Feng, Yu Y; Tran, Karen K; Chiang, Chi-I CI; Arendt, Heather E HE; DeStefano, Joanne J; Mascola, John R JR; Wyatt, Richard T RT; Li, Yuxing Y
Repeated Vaccination of Cows with HIV Env gp140 during Subsequent Pregnancies Elicits and Sustains an Enduring Strong Env-Binding and Neutralising Antibody Response.
Plos One
Heydarchi, Behnaz B; Center, Rob J RJ; Gonelli, Christopher C; Muller, Brian B; Mackenzie, Charlene C; Khoury, Georges G; Lichtfuss, Marit M; Rawlin, Grant G; Purcell, Damian F J DF
Detection of Broadly Neutralizing Activity within the First Months of HIV-1 Infection.
Journal Of Virology
Sanchez-Merino, V V; Fabra-Garcia, A A; Gonzalez, N N; Nicolas, D D; Merino-Mansilla, A A; Manzardo, C C; Ambrosioni, J J; Schultz, A A; Meyerhans, A A; Mascola, J R JR; Gatell, J M JM; Alcami, J J; Miro, J M JM; Yuste, E E
Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces a Robust Immunoglobulin A Isotype B Cell Response in Breast Milk.
Journal Of Virology
Nelson, Cody S CS; Pollara, Justin J; Kunz, Erika L EL; Jeffries, Thomas L TL; Duffy, Ryan R; Beck, Charles C; Stamper, Lisa L; Wang, Minyue M; Shen, Xiaoying X; Pickup, David J DJ; Staats, Herman F HF; Hudgens, Michael G MG; Kepler, Thomas B TB; Montefiori, David C DC; Moody, M Anthony MA; Tomaras, Georgia D GD; Liao, Hua-Xin HX; Haynes, Barton F BF; Ferrari, Guido G; Fouda, Genevieve G A GGA; Permar, Sallie R SR
An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.
The Journal Of Clinical Investigation
Bonsignori, Mattia M; Wiehe, Kevin K; Grimm, Sebastian K SK; Lynch, Rebecca R; Yang, Guang G; Kozink, Daniel M DM; Perrin, Florence F; Cooper, Abby J AJ; Hwang, Kwan-Ki KK; Chen, Xi X; Liu, Mengfei M; McKee, Krisha K; Parks, Robert J RJ; Eudailey, Joshua J; Wang, Minyue M; Clowse, Megan M; Criscione-Schreiber, Lisa G LG; Moody, M Anthony MA; Ackerman, Margaret E ME; Boyd, Scott D SD; Gao, Feng F; Kelsoe, Garnett G; Verkoczy, Laurent L; Tomaras, Georgia D GD; Liao, Hua-Xin HX; Kepler, Thomas B TB; Montefiori, David C DC; Mascola, John R JR; Haynes, Barton F BF
Immune focusing and enhanced neutralization induced by HIV-1 gp140 chemical cross-linking.
Journal Of Virology
Schiffner, T T; Kong, L L; Duncan, C J A CJ; Back, J W JW; Benschop, J J JJ; Shen, X X; Huang, P S PS; Stewart-Jones, G B GB; DeStefano, J J; Seaman, M S MS; Tomaras, G D GD; Montefiori, D C DC; Schief, W R WR; Sattentau, Q J QJ
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
Nature
Liao, Hua-Xin HX; Lynch, Rebecca R; Zhou, Tongqing T; Gao, Feng F; Alam, S Munir SM; Boyd, Scott D SD; Fire, Andrew Z AZ; Roskin, Krishna M KM; Schramm, Chaim A CA; Zhang, Zhenhai Z; Zhu, Jiang J; Shapiro, Lawrence L; , ; Mullikin, James C JC; Gnanakaran, S S; Hraber, Peter P; Wiehe, Kevin K; Kelsoe, Garnett G; Yang, Guang G; Xia, Shi-Mao SM; Montefiori, David C DC; Parks, Robert R; Lloyd, Krissey E KE; Scearce, Richard M RM; Soderberg, Kelly A KA; Cohen, Myron M; Kamanga, Gift G; Louder, Mark K MK; Tran, Lillian M LM; Chen, Yue Y; Cai, Fangping F; Chen, Sheri S; Moquin, Stephanie S; Du, Xiulian X; Joyce, M Gordon MG; Srivatsan, Sanjay S; Zhang, Baoshan B; Zheng, Anqi A; Shaw, George M GM; Hahn, Beatrice H BH; Kepler, Thomas B TB; Korber, Bette T M BT; Kwong, Peter D PD; Mascola, John R JR; Haynes, Barton F BF
The development of CD4 binding site antibodies during HIV-1 infection.
Journal Of Virology
Lynch, Rebecca M RM; Tran, Lillian L; Louder, Mark K MK; Schmidt, Stephen D SD; Cohen, Myron M; , ; Dersimonian, Rebecca R; Euler, Zelda Z; Gray, Elin S ES; Abdool Karim, Salim S; Kirchherr, Jennifer J; Montefiori, David C DC; Sibeko, Sengeziwe S; Soderberg, Kelly K; Tomaras, Georgia G; Yang, Zhi-Yong ZY; Nabel, Gary J GJ; Schuitemaker, Hanneke H; Morris, Lynn L; Haynes, Barton F BF; Mascola, John R JR