The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.
Nature Structural & Molecular Biology
Mateos-Gomez, Pedro A PA; Kent, Tatiana T; Deng, Sarah K SK; McDevitt, Shane S; Kashkina, Ekaterina E; Hoang, Trung M TM; Pomerantz, Richard T RT; Sfeir, Agnel A
Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks.
Molecular Cell
Wyatt, David W DW; Feng, Wanjuan W; Conlin, Michael P MP; Yousefzadeh, Matthew J MJ; Roberts, Steven A SA; Mieczkowski, Piotr P; Wood, Richard D RD; Gupta, Gaorav P GP; Ramsden, Dale A DA