Variant ID: 14-73640371-A-C

NM_000021.3(PSEN1):c.436A>C;(p.M146L)

This variant was identified in 804 publications

View GRCh38 version.




Publications:


A new age in understanding adult hippocampal neurogenesis in Alzheimer's disease.

Neural Regeneration Research
Hanspal, Maya A MA; Gillotin, Sébastien S
Publication Date: 2022-12

Variant appearance in text: N/A
PubMed Link: 35662190
Variant Present in the following documents:
View BVdb publication page



Impact of IL-21-associated peripheral and brain crosstalk on the Alzheimer's disease neuropathology.

Cellular And Molecular Life Sciences : Cmls
Agrawal, Sudhanshu S; Baulch, Janet E JE; Madan, Shreya S; Salah, Seher S; Cheeks, Samantha N SN; Krattli, Robert P RP; Subramanian, Veedamali S VS; Acharya, Munjal M MM; Agrawal, Anshu A
Publication Date: 2022-06-01

Variant appearance in text: PS1: M146L
PubMed Link: 35648273
Variant Present in the following documents:
  • Main text
  • 18_2022_Article_4347.pdf
View BVdb publication page



MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6 × Tg Alzheimer's Disease Model Mice.

International Journal Of Molecular Sciences
Kang, ShinWoo S; Kim, Jinho J; Lee, Sang-Yoon SY; Okamura, Nobuyuki N; Chang, Keun-A KA
Publication Date: 2022-05-14

Variant appearance in text: PS1: M146L
PubMed Link: 35628296
Variant Present in the following documents:
  • Main text
  • ijms-23-05485.pdf
View BVdb publication page



Transgenic Mouse Models of Alzheimer's Disease: An Integrative Analysis.

International Journal Of Molecular Sciences
Sanchez-Varo, Raquel R; Mejias-Ortega, Marina M; Fernandez-Valenzuela, Juan Jose JJ; Nuñez-Diaz, Cristina C; Caceres-Palomo, Laura L; Vegas-Gomez, Laura L; Sanchez-Mejias, Elisabeth E; Trujillo-Estrada, Laura L; Garcia-Leon, Juan Antonio JA; Moreno-Gonzalez, Ines I; Vizuete, Marisa M; Vitorica, Javier J; Baglietto-Vargas, David D; Gutierrez, Antonia A
Publication Date: 2022-05-12

Variant appearance in text: PS1: M146L
PubMed Link: 35628216
Variant Present in the following documents:
  • Main text
  • ijms-23-05404.pdf
View BVdb publication page



Cannabidiol Enhances Microglial Beta-Amyloid Peptide Phagocytosis and Clearance via Vanilloid Family Type 2 Channel Activation.

International Journal Of Molecular Sciences
Yang, Shaobin S; Du, Yaqin Y; Zhao, Xiaoqian X; Tang, Qi Q; Su, Wei W; Hu, Yuemeng Y; Yu, Peng P
Publication Date: 2022-05-11

Variant appearance in text: PS1: M146L
PubMed Link: 35628181
Variant Present in the following documents:
  • Main text
  • ijms-23-05367.pdf
View BVdb publication page



Olfactory Evaluation in Alzheimer's Disease Model Mice.

Brain Sciences
Zhang, Jingjing J; Zhao, Zixuan Z; Sun, Siqi S; Li, Jing J; Wang, Yu Y; Dong, Jingyin J; Yang, Su S; Lou, Yiyi Y; Yang, Jing J; Li, Weiyun W; Li, Shanshan S
Publication Date: 2022-05-06

Variant appearance in text: PS1: M146L
PubMed Link: 35624994
Variant Present in the following documents:
  • Main text
  • brainsci-12-00607.pdf
View BVdb publication page



Advances in Recapitulating Alzheimer's Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models.

Brain Sciences
Hasan, Md Fayad MF; Trushina, Eugenia E
Publication Date: 2022-04-26

Variant appearance in text: PSEN1: M146L
PubMed Link: 35624938
Variant Present in the following documents:
  • brainsci-12-00552.pdf
View BVdb publication page



Glatiramer Acetate Immunomodulation: Evidence of Neuroprotection and Cognitive Preservation.

Cells
Kasindi, Arielle A; Fuchs, Dieu-Trang DT; Koronyo, Yosef Y; Rentsendorj, Altan A; Black, Keith L KL; Koronyo-Hamaoui, Maya M
Publication Date: 2022-05-07

Variant appearance in text: PS1: M146L
PubMed Link: 35563884
Variant Present in the following documents:
  • cells-11-01578.pdf
View BVdb publication page



Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological Study.

International Journal Of Molecular Sciences
Marazuela, Paula P; Paez-Montserrat, Berta B; Bonaterra-Pastra, Anna A; Solé, Montse M; Hernández-Guillamon, Mar M
Publication Date: 2022-04-29

Variant appearance in text: PS1: M146L
PubMed Link: 35563362
Variant Present in the following documents:
  • ijms-23-04972.pdf
View BVdb publication page



High-Resolution Digital Panorama of Multiple Structures in Whole Brain of Alzheimer's Disease Mice.

Frontiers In Neuroscience
Yin, Xianzhen X; Zhang, Xiaochuan X; Zhang, Jingjing J; Yang, Weicheng W; Sun, Xian X; Zhang, Haiyan H; Gao, Zhaobing Z; Jiang, Hualiang H
Publication Date: 2022

Variant appearance in text: PS1: M146L
PubMed Link: 35516801
Variant Present in the following documents:
  • fnins-16-870520.pdf
View BVdb publication page



CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN 1 M146L mutation.

Molecular Therapy. Nucleic Acids
Konstantinidis, Evangelos E; Molisak, Agnieszka A; Perrin, Florian F; Streubel-Gallasch, Linn L; Fayad, Sarah S; Kim, Daniel Y DY; Petri, Karl K; Aryee, Martin J MJ; Aguilar, Ximena X; György, Bence B; Giedraitis, Vilmantas V; Joung, J Keith JK; Pattanayak, Vikram V; Essand, Magnus M; Erlandsson, Anna A; Berezovska, Oksana O; Ingelsson, Martin M
Publication Date: 2022-06-14

Variant appearance in text: PSEN1: M146L
PubMed Link: 35505961
Variant Present in the following documents:
  • mmc1.pdf
  • main.pdf
  • mmc2.pdf
View BVdb publication page



GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer's Disease.

Frontiers In Immunology
Islam, Jahirul J; Cho, Jung-Ah JA; Kim, Ju-Yong JY; Park, Kyung-Sun KS; Koh, Young-Jae YJ; Chung, Chu Young CY; Lee, Eun-Jae EJ; Nam, Soo Jeong SJ; Lee, Kyoungyul K; Kim, Seoung-Heon SH; Park, Sung-Hye SH; Lee, Dong Young DY; Kim, Byeong C BC; Lee, Kyung-Hwa KH; Seong, Seung-Yong SY
Publication Date: 2022

Variant appearance in text: PSEN1: M146L
PubMed Link: 35464490
Variant Present in the following documents:
  • fimmu-13-766919.pdf
View BVdb publication page



Cellular Reprogramming and Its Potential Application in Alzheimer's Disease.

Frontiers In Neuroscience
Zhou, Chao C; Ni, Wanyan W; Zhu, Taiyang T; Dong, Shuyu S; Sun, Ping P; Hua, Fang F
Publication Date: 2022

Variant appearance in text: PSEN1: M146L
PubMed Link: 35464309
Variant Present in the following documents:
  • fnins-16-884667.pdf
View BVdb publication page



Microglial Endocannabinoid Signalling in AD.

Cells
Scipioni, Lucia L; Ciaramellano, Francesca F; Carnicelli, Veronica V; Leuti, Alessandro A; Lizzi, Anna Rita AR; De Dominicis, Noemi N; Oddi, Sergio S; Maccarrone, Mauro M
Publication Date: 2022-04-06

Variant appearance in text: PSEN1: M146L
PubMed Link: 35406803
Variant Present in the following documents:
  • cells-11-01237.pdf
View BVdb publication page



AGE-TXNIP axis drives inflammation in Alzheimer's by targeting Aβ to mitochondria in microglia.

Cell Death & Disease
Sbai, Oualid O; Djelloul, Mehdi M; Auletta, Antonia A; Ieraci, Alessandro A; Vascotto, Carlo C; Perrone, L L
Publication Date: 2022-04-04

Variant appearance in text: PS1: M146L
PubMed Link: 35379773
Variant Present in the following documents:
  • 41419_2022_4758_MOESM1_ESM.pdf
View BVdb publication page



Personalized Management and Treatment of Alzheimer's Disease.

Life (Basel, Switzerland)
Cacabelos, Ramón R; Naidoo, Vinogran V; Martínez-Iglesias, Olaia O; Corzo, Lola L; Cacabelos, Natalia N; Pego, Rocío R; Carril, Juan C JC
Publication Date: 2022-03-21

Variant appearance in text: PSEN1: M146L
PubMed Link: 35330211
Variant Present in the following documents:
  • life-12-00460.pdf
View BVdb publication page



Amelioration of Experimental Autoimmune Encephalomyelitis in Alzheimer's Disease Mouse Models: A Potential Role for Aβ.

Cells
Shi, Changjie C; Cha, Jiaxue J; Gong, Junyuan J; Wang, Shaodeng S; Zeng, Peng P; Lian, Junjiang J; Zhang, Bowen B; Hua, Qiuhong Q; Lv, Jie J; Du, Changsheng C; Xie, Xin X; Zhang, Ru R
Publication Date: 2022-03-16

Variant appearance in text: PS1: M146L
PubMed Link: 35326455
Variant Present in the following documents:
  • cells-11-01004.pdf
View BVdb publication page



Meridianins Rescue Cognitive Deficits, Spine Density and Neuroinflammation in the 5xFAD Model of Alzheimer's Disease.

Frontiers In Pharmacology
Rodríguez-Urgellés, Ened E; Sancho-Balsells, Anna A; Chen, Wanqi W; López-Molina, Laura L; Ballasch, Ivan I; Del Castillo, Ignacio I; Avila, Conxita C; Alberch, Jordi J; Giralt, Albert A
Publication Date: 2022

Variant appearance in text: PS1: M146L
PubMed Link: 35281935
Variant Present in the following documents:
  • fphar-13-791666.pdf
View BVdb publication page



The Cardiac Dysfunction Caused by Metabolic Alterations in Alzheimer's Disease.

Frontiers In Cardiovascular Medicine
Murphy, Jiayuan J; Le, Tran Ngoc Van TNV; Fedorova, Julia J; Yang, Yi Y; Krause-Hauch, Meredith M; Davitt, Kayla K; Zoungrana, Linda Ines LI; Fatmi, Mohammad Kasim MK; Lesnefsky, Edward J EJ; Li, Ji J; Ren, Di D
Publication Date: 2022

Variant appearance in text: PS1: M146L
PubMed Link: 35274014
Variant Present in the following documents:
  • fcvm-09-850538.pdf
View BVdb publication page



Failure of Alzheimer's Mice Brain Resident Neural Precursor Cells in Supporting Microglia-Mediated Amyloid β Clearance.

Cells
Lachish, Marva M; Fainstein, Nina N; Ganz, Tal T; Sofer, Lihi L; Ben-Hur, Tamir T
Publication Date: 2022-03-03

Variant appearance in text: PS1: M146L
PubMed Link: 35269501
Variant Present in the following documents:
  • cells-11-00876.pdf
View BVdb publication page



Emerging Electroencephalographic Biomarkers to Improve Preclinical to Clinical Translation in Alzheimer's Disease.

Frontiers In Aging Neuroscience
Cope, Zackary A ZA; Murai, Takeshi T; Sukoff Rizzo, Stacey J SJ
Publication Date: 2022

Variant appearance in text: PSEN1: M146L
PubMed Link: 35250541
Variant Present in the following documents:
  • fnagi-14-805063.pdf
View BVdb publication page



Microglia and Astrocyte Function and Communication: What Do We Know in Humans?

Frontiers In Neuroscience
Garland, Emma F EF; Hartnell, Iain J IJ; Boche, Delphine D
Publication Date: 2022

Variant appearance in text: PSEN1: M146L
PubMed Link: 35250459
Variant Present in the following documents:
  • fnins-16-824888.pdf
View BVdb publication page



Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology.

Journal Of Neuroinflammation
Ren, Xiao X; Yao, Lingling L; Wang, YongGang Y; Mei, Lin L; Xiong, Wen-Cheng WC
Publication Date: 2022-03-02

Variant appearance in text: PSEN1: M146L
PubMed Link: 35236374
Variant Present in the following documents:
  • 12974_2022_Article_2422.pdf
View BVdb publication page



Hippocampal neurogenesis and pro-neurogenic therapies for Alzheimer's disease.

Animal Models And Experimental Medicine
Zheng, Jie J
Publication Date: 2022-02

Variant appearance in text: PS1: M146L
PubMed Link: 35229998
Variant Present in the following documents:
  • AME2-5-3.pdf
View BVdb publication page



Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis Activation.

Frontiers In Immunology
Lee, Hyun-Ju HJ; Park, Jin-Hee JH; Hoe, Hyang-Sook HS
Publication Date: 2022

Variant appearance in text: PSEN1: M146L
PubMed Link: 35222363
Variant Present in the following documents:
  • fimmu-13-749336.pdf
View BVdb publication page



Neuroimaging of Mouse Models of Alzheimer's Disease.

Biomedicines
Jullienne, Amandine A; Trinh, Michelle V MV; Obenaus, Andre A
Publication Date: 2022-01-28

Variant appearance in text: PS1: M146L
PubMed Link: 35203515
Variant Present in the following documents:
  • biomedicines-10-00305.pdf
View BVdb publication page



Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models.

Theranostics
Cai, Cui-Zan CZ; Zhuang, Xu-Xu XX; Zhu, Qi Q; Wu, Ming-Yue MY; Su, Huanxing H; Wang, Xiao-Jin XJ; Iyaswamy, Ashok A; Yue, Zhenyu Z; Wang, Qian Q; Zhang, Bin B; Xue, Yu Y; Tan, Jieqiong J; Li, Min M; He, Huanhuan H; Lu, Jia-Hong JH
Publication Date: 2022

Variant appearance in text: PSEN1: M146L
PubMed Link: 35198070
Variant Present in the following documents:
  • thnov12p1738.pdf
View BVdb publication page



Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer's disease.

Nature Communications
Sun, Qingtao Q; Zhang, Jianping J; Li, Anan A; Yao, Mei M; Liu, Guangcai G; Chen, Siqi S; Luo, Yue Y; Wang, Zhi Z; Gong, Hui H; Li, Xiangning X; Luo, Qingming Q
Publication Date: 2022-02-22

Variant appearance in text: PSEN1: M146L
PubMed Link: 35194025
Variant Present in the following documents:
  • 41467_2022_Article_28493.pdf
View BVdb publication page



Electro-Acupuncture Improve the Early Pattern Separation in Alzheimer's Disease Mice via Basal Forebrain-Hippocampus Cholinergic Neural Circuit.

Frontiers In Aging Neuroscience
Li, Long L; Li, Jianhong J; Dai, Yaling Y; Yang, Minguang M; Liang, Shengxiang S; Wang, Zhifu Z; Liu, Weilin W; Chen, Lidian L; Tao, Jing J
Publication Date: 2021

Variant appearance in text: PS1: M146L
PubMed Link: 35185516
Variant Present in the following documents:
  • fnagi-13-770948.pdf
View BVdb publication page



PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer's disease.

Genome Medicine
Tsai, Andy P AP; Dong, Chuanpeng C; Lin, Peter Bor-Chian PB; Messenger, Evan J EJ; Casali, Brad T BT; Moutinho, Miguel M; Liu, Yunlong Y; Oblak, Adrian L AL; Lamb, Bruce T BT; Landreth, Gary E GE; Bissel, Stephanie J SJ; Nho, Kwangsik K
Publication Date: 2022-02-18

Variant appearance in text: PSEN1: M146L
PubMed Link: 35180881
Variant Present in the following documents:
  • 13073_2022_Article_1022.pdf
View BVdb publication page



Editorial: The Molecular Mechanisms of Synaptic Plasticity Impairments in Alzheimer's Disease.

Frontiers In Cell And Developmental Biology
Liu, Gong-Ping GP; Lei, Peng P; Dong, Zhi-Fang ZF; Li, Shu-Peng SP
Publication Date: 2022

Variant appearance in text: PSEN1: M146L
PubMed Link: 35127687
Variant Present in the following documents:
  • Main text
  • fcell-10-832728.pdf
View BVdb publication page



Human iPSC-Derived Neural Models for Studying Alzheimer's Disease: from Neural Stem Cells to Cerebral Organoids.

Stem Cell Reviews And Reports
Barak, Martin M; Fedorova, Veronika V; Pospisilova, Veronika V; Raska, Jan J; Vochyanova, Simona S; Sedmik, Jiri J; Hribkova, Hana H; Klimova, Hana H; Vanova, Tereza T; Bohaciakova, Dasa D
Publication Date: 2022-02-02

Variant appearance in text: PSEN1: M146L
PubMed Link: 35107767
Variant Present in the following documents:
  • 12015_2021_Article_10254.pdf
View BVdb publication page



Sodium-calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer's disease.

Scientific Reports
Afewerky, Henok Kessete HK; Li, Hao H; Zhang, Tongmei T; Li, Xinyan X; Mahaman, Yacoubou Abdoul Razak YAR; Duan, Limin L; Qin, Pengwei P; Zheng, Jiequn J; Pei, Lei L; Lu, Youming Y
Publication Date: 2022-01-27

Variant appearance in text: PSEN1: M146L
PubMed Link: 35087161
Variant Present in the following documents:
  • Main text
View BVdb publication page



GlyCEST: Magnetic Resonance Imaging of Glycine-Distribution in the Normal Murine Brain and Alterations in 5xFAD Mice.

Contrast Media & Molecular Imaging
Ohno, Ken K; Ohkubo, Masaki M; Zheng, Bingwen B; Watanabe, Masaki M; Matsuda, Tsuyoshi T; Kwee, Ingrid L IL; Igarashi, Hironaka H
Publication Date: 2021

Variant appearance in text: PSEN1: M146L
PubMed Link: 35046756
Variant Present in the following documents:
  • Main text
View BVdb publication page



Cognitive enhancement and neuroprotective effects of OABL, a sesquiterpene lactone in 5xFAD Alzheimer's disease mice model.

Redox Biology
Tang, Jiang-Jiang JJ; Huang, Lan-Fang LF; Deng, Jia-Le JL; Wang, Yi-Meng YM; Guo, Cong C; Peng, Xiao-Na XN; Liu, Zhigang Z; Gao, Jin-Ming JM
Publication Date: 2022-01-08

Variant appearance in text: PSEN1: M146L
PubMed Link: 35026701
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



The Dynamics of β-Amyloid Proteoforms Accumulation in the Brain of a 5xFAD Mouse Model of Alzheimer's Disease.

International Journal Of Molecular Sciences
Bugrova, Anna E AE; Strelnikova, Polina A PA; Indeykina, Maria I MI; Kononikhin, Alexey S AS; Zakharova, Natalia V NV; Brzhozovskiy, Alexander G AG; Barykin, Evgeny P EP; Pekov, Stanislav I SI; Gavrish, Maria S MS; Babaev, Alexey A AA; Kosyreva, Anna M AM; Morozova, Anna Y AY; Degterev, Daniil A DA; Mitkevich, Vladimir A VA; Popov, Igor A IA; Makarov, Alexander A AA; Nikolaev, Evgeny N EN
Publication Date: 2021-12-21

Variant appearance in text: PSEN1: M146L
PubMed Link: 35008451
Variant Present in the following documents:
  • Main text
  • ijms-23-00027.pdf
View BVdb publication page



Microbial pathogens induce neurodegeneration in Alzheimer's disease mice: protection by microglial regulation.

Journal Of Neuroinflammation
Ganz, Tal T; Fainstein, Nina N; Elad, Amit A; Lachish, Marva M; Goldfarb, Smadar S; Einstein, Ofira O; Ben-Hur, Tamir T
Publication Date: 2022-01-06

Variant appearance in text: PS1: M146L
PubMed Link: 34991645
Variant Present in the following documents:
  • Main text
  • 12974_2021_Article_2369.pdf
View BVdb publication page



Identification of Immune Cells and Key Genes associated with Alzheimer's Disease.

International Journal Of Medical Sciences
Liu, Chenming C; Zhang, Xi X; Chai, Huazhen H; Xu, Sutong S; Liu, Qiulu Q; Luo, Yuping Y; Li, Siguang S
Publication Date: 2022

Variant appearance in text: PS1: M146L
PubMed Link: 34975305
Variant Present in the following documents:
  • ijmsv19p0112.pdf
View BVdb publication page



Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease.

Pharmaceuticals (Basel, Switzerland)
Runfola, Massimiliano M; Perni, Michele M; Yang, Xiaoting X; Marchese, Maria M; Bacci, Andrea A; Mero, Serena S; Santorelli, Filippo M FM; Polini, Beatrice B; Chiellini, Grazia G; Giuliani, Daniela D; Vilella, Antonietta A; Bodria, Martina M; Daini, Eleonora E; Vandini, Eleonora E; Rudge, Simon S; Gul, Sheraz S; Wakelam, Michale O J MOJ; Vendruscolo, Michele M; Rapposelli, Simona S
Publication Date: 2021-12-19

Variant appearance in text: PS1: M146L
PubMed Link: 34959730
Variant Present in the following documents:
  • pharmaceuticals-14-01330.pdf
View BVdb publication page



Primary Cilia Structure Is Prolonged in Enteric Neurons of 5xFAD Alzheimer's Disease Model Mice.

International Journal Of Molecular Sciences
Nguyen, Vu Thu Thuy VTT; Brücker, Lena L; Volz, Ann-Kathrin AK; Baumgärtner, Julia C JC; Dos Santos Guilherme, Malena M; Valeri, Francesco F; May-Simera, Helen H; Endres, Kristina K
Publication Date: 2021-12-17

Variant appearance in text: PS1: M146L
PubMed Link: 34948356
Variant Present in the following documents:
  • Main text
  • ijms-22-13564.pdf
View BVdb publication page



Crude Saponin from Platycodon grandiflorum Attenuates Aβ-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways.

Antioxidants (Basel, Switzerland)
Ji, Yun-Jeong YJ; Kim, Sujin S; Kim, Jwa-Jin JJ; Jang, Gwi Yeong GY; Moon, Minho M; Kim, Hyung Don HD
Publication Date: 2021-12-09

Variant appearance in text: PSEN1: M146L
PubMed Link: 34943071
Variant Present in the following documents:
  • antioxidants-10-01968.pdf
View BVdb publication page



Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis.

Cellular And Molecular Life Sciences : Cmls
Stazi, Martina M; Lehmann, Sandra S; Sakib, M Sadman MS; Pena-Centeno, Tonatiuh T; Büschgens, Luca L; Fischer, Andre A; Weggen, Sascha S; Wirths, Oliver O
Publication Date: 2021-12-16

Variant appearance in text: PSEN1: M146L
PubMed Link: 34913091
Variant Present in the following documents:
  • 18_2021_Article_4062.pdf
View BVdb publication page



Quantitative Brain Positron Emission Tomography in Female 5XFAD Alzheimer Mice: Pathological Features and Sex-Specific Alterations.

Frontiers In Medicine
Bouter, Caroline C; Irwin, Caroline C; Franke, Timon N TN; Beindorff, Nicola N; Bouter, Yvonne Y
Publication Date: 2021

Variant appearance in text: PS1: M146L
PubMed Link: 34901060
Variant Present in the following documents:
  • Main text
  • fmed-08-745064.pdf
View BVdb publication page



A Review of the Current Mammalian Models of Alzheimer's Disease and Challenges That Need to Be Overcome.

International Journal Of Molecular Sciences
Mckean, Natasha Elizabeth NE; Handley, Renee Robyn RR; Snell, Russell Grant RG
Publication Date: 2021-12-06

Variant appearance in text: PSEN1: M146L
PubMed Link: 34884970
Variant Present in the following documents:
  • Main text
  • ijms-22-13168.pdf
View BVdb publication page



Targeting MicroRNA-485-3p Blocks Alzheimer's Disease Progression.

International Journal Of Molecular Sciences
Koh, Han Seok HS; Lee, SangJoon S; Lee, Hyo Jin HJ; Min, Jae-Woong JW; Iwatsubo, Takeshi T; Teunissen, Charlotte E CE; Cho, Hyun-Jeong HJ; Ryu, Jin-Hyeob JH
Publication Date: 2021-12-04

Variant appearance in text: PS1: M146L
PubMed Link: 34884940
Variant Present in the following documents:
  • ijms-22-13136.pdf
View BVdb publication page



Magnetic Resonance Imaging in Animal Models of Alzheimer's Disease Amyloidosis.

International Journal Of Molecular Sciences
Ni, Ruiqing R
Publication Date: 2021-11-25

Variant appearance in text: PS1: M146L
PubMed Link: 34884573
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effects of transcranial ultrasound stimulation pulsed at 40 Hz on Aβ plaques and brain rhythms in 5×FAD mice.

Translational Neurodegeneration
Park, Mincheol M; Hoang, Gia Minh GM; Nguyen, Thien T; Lee, Eunkyung E; Jung, Hyun Jin HJ; Choe, Youngshik Y; Lee, Moon Hwan MH; Hwang, Jae Youn JY; Kim, Jae Gwan JG; Kim, Tae T
Publication Date: 2021-12-07

Variant appearance in text: PS1: M146L
PubMed Link: 34872618
Variant Present in the following documents:
  • Main text
  • 40035_2021_Article_274.pdf
View BVdb publication page



Systemic inflammasome activation and pyroptosis associate with the progression of amnestic mild cognitive impairment and Alzheimer's disease.

Journal Of Neuroinflammation
Rui, Wenjuan W; Xiao, Hong H; Fan, Yi Y; Ma, Zhongxuan Z; Xiao, Ming M; Li, Sheng S; Shi, Jingping J
Publication Date: 2021-12-02

Variant appearance in text: PSEN1: M146L
PubMed Link: 34856990
Variant Present in the following documents:
  • Main text
  • 12974_2021_Article_2329.pdf
View BVdb publication page



Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions.

Biomedicines
Magalhães, João Duarte JD; Fão, Lígia L; Vilaça, Rita R; Cardoso, Sandra Morais SM; Rego, Ana Cristina AC
Publication Date: 2021-11-05

Variant appearance in text: PS1: M146L
PubMed Link: 34829854
Variant Present in the following documents:
  • Main text
View BVdb publication page



Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence.

Communications Biology
Pan, Jin-Xiu JX; Sun, Dong D; Lee, Daehoon D; Xiong, Lei L; Ren, Xiao X; Guo, Hao-Han HH; Yao, Ling-Ling LL; Lu, Yuyi Y; Jung, Caroline C; Xiong, Wen-Cheng WC
Publication Date: 2021-11-25

Variant appearance in text: PSEN1: M146L
PubMed Link: 34824365
Variant Present in the following documents:
  • Main text
  • 42003_2021_Article_2843.pdf
View BVdb publication page



Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease.

Iscience
Zhang, Jie J; Gao, Feng F; Ma, Yuqian Y; Xue, Tian T; Shen, Yong Y
Publication Date: 2021-11-19

Variant appearance in text: PSEN1: M146L
PubMed Link: 34805789
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Neural Derivates of Canine Induced Pluripotent Stem Cells-Like Cells From a Mild Cognitive Impairment Dog.

Frontiers In Veterinary Science
Chandrasekaran, Abinaya A; Thomsen, Barbara Blicher BB; Agerholm, Jørgen Steen JS; Pessôa, Laís Vicari de Figueiredo LVF; Godoy Pieri, Naira Caroline NC; Sabaghidarmiyan, Vahideh V; Langley, Katarina K; Kolko, Miriam M; de Andrade, André Furugen Cesar AFC; Bressan, Fabiana Fernandes FF; Hyttel, Poul P; Berendt, Mette M; Freude, Kristine K
Publication Date: 2021

Variant appearance in text: PSEN1: M146L
PubMed Link: 34805331
Variant Present in the following documents:
  • Main text
  • fvets-08-725386.pdf
View BVdb publication page



Prostaglandin EP2 receptor antagonist ameliorates neuroinflammation in a two-hit mouse model of Alzheimer's disease.

Journal Of Neuroinflammation
Banik, Avijit A; Amaradhi, Radhika R; Lee, Daniel D; Sau, Michael M; Wang, Wenyi W; Dingledine, Raymond R; Ganesh, Thota T
Publication Date: 2021-11-20

Variant appearance in text: PS1: M146L
PubMed Link: 34801055
Variant Present in the following documents:
  • 12974_2021_Article_2297.pdf
View BVdb publication page



CD4+ effector T cells accelerate Alzheimer's disease in mice.

Journal Of Neuroinflammation
Machhi, Jatin J; Yeapuri, Pravin P; Lu, Yaman Y; Foster, Emma E; Chikhale, Rupesh R; Herskovitz, Jonathan J; Namminga, Krista L KL; Olson, Katherine E KE; Abdelmoaty, Mai Mohamed MM; Gao, Ju J; Quadros, Rolen M RM; Kiyota, Tomomi T; Jingjing, Liang L; Kevadiya, Bhavesh D BD; Wang, Xinglong X; Liu, Yutong Y; Poluektova, Larisa Y LY; Gurumurthy, Channabasavaiah B CB; Mosley, R Lee RL; Gendelman, Howard E HE
Publication Date: 2021-11-19

Variant appearance in text: PS1: M146L
PubMed Link: 34798897
Variant Present in the following documents:
  • Main text
  • 12974_2021_Article_2308.pdf
View BVdb publication page



BH3-only proteins Puma and Beclin1 regulate autophagic death in neurons in response to Amyloid-β.

Cell Death Discovery
Saha, Akash A; Saleem, Suraiya S; Paidi, Ramesh Kumar RK; Biswas, Subhas C SC
Publication Date: 2021-11-15

Variant appearance in text: PS1: M146L
PubMed Link: 34782612
Variant Present in the following documents:
  • Main text
  • 41420_2021_Article_748.pdf
View BVdb publication page



Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer's Disease and Control Mice.

Frontiers In Aging Neuroscience
den Hoedt, Sandra S; Crivelli, Simone M SM; Leijten, Frank P J FPJ; Losen, Mario M; Stevens, Jo A A JAA; Mané-Damas, Marina M; de Vries, Helga E HE; Walter, Jochen J; Mirzaian, Mina M; Sijbrands, Eric J G EJG; Aerts, Johannes M F G JMFG; Verhoeven, Adrie J M AJM; Martinez-Martinez, Pilar P; Mulder, Monique T MT
Publication Date: 2021

Variant appearance in text: PS1: M146L
PubMed Link: 34776936
Variant Present in the following documents:
  • Main text
  • fnagi-13-765252.pdf
View BVdb publication page



E2F4-Based Gene Therapy Mitigates the Phenotype of the Alzheimer's Disease Mouse Model 5xFAD.

Neurotherapeutics : The Journal Of The American Society For Experimental Neurotherapeutics
López-Sánchez, Noelia N; Garrido-García, Alberto A; Ramón-Landreau, Morgan M; Cano-Daganzo, Vanesa V; Frade, José M JM
Publication Date: 2021-11-11

Variant appearance in text: PS1: M146L
PubMed Link: 34766258
Variant Present in the following documents:
  • 13311_2021_Article_1151.pdf
View BVdb publication page



A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets.

Science Advances
Roberts, Jackson A JA; Varma, Vijay R VR; An, Yang Y; Varma, Sudhir S; Candia, Julián J; Fantoni, Giovanna G; Tiwari, Vinod V; Anerillas, Carlos C; Williamson, Andrew A; Saito, Atsushi A; Loeffler, Tina T; Schilcher, Irene I; Moaddel, Ruin R; Khadeer, Mohammed M; Lovett, Jacqueline J; Tanaka, Toshiko T; Pletnikova, Olga O; Troncoso, Juan C JC; Bennett, David A DA; Albert, Marilyn S MS; Yu, Kaiwen K; Niu, Mingming M; Haroutunian, Vahram V; Zhang, Bin B; Peng, Junmin J; Croteau, Deborah L DL; Resnick, Susan M SM; Gorospe, Myriam M; Bohr, Vilhelm A VA; Ferrucci, Luigi L; Thambisetty, Madhav M
Publication Date: 2021-11-12

Variant appearance in text: PSEN1: M146L
PubMed Link: 34757788
Variant Present in the following documents:
  • Main text
  • sciadv.abi8178.pdf
View BVdb publication page



Mindfulness intervention improves cognitive function in older adults by enhancing the level of miRNA-29c in neuron-derived extracellular vesicles.

Scientific Reports
Hashizume, Shin S; Nakano, Masako M; Kubota, Kenta K; Sato, Seiichi S; Himuro, Nobuaki N; Kobayashi, Eiji E; Takaoka, Akinori A; Fujimiya, Mineko M
Publication Date: 2021-11-08

Variant appearance in text: PS1: M146L
PubMed Link: 34750393
Variant Present in the following documents:
  • 41598_2021_Article_1318.pdf
View BVdb publication page



Microglial transcription profiles in mouse and human are driven by APOE4 and sex.

Iscience
Moser, V Alexandra VA; Workman, Michael J MJ; Hurwitz, Samantha J SJ; Lipman, Rachel M RM; Pike, Christian J CJ; Svendsen, Clive N CN
Publication Date: 2021-11-19

Variant appearance in text: PS1: M146L
PubMed Link: 34746703
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Switched Aβ43 generation in familial Alzheimer's disease with presenilin 1 mutation.

Translational Psychiatry
Kakuda, Nobuto N; Takami, Mako M; Okochi, Masayasu M; Kasuga, Kensaku K; Ihara, Yasuo Y; Ikeuchi, Takeshi T
Publication Date: 2021-11-03

Variant appearance in text: PS1: M146L
PubMed Link: 34728605
Variant Present in the following documents:
  • 41398_2021_Article_1684.pdf
View BVdb publication page



The Non-receptor Tyrosine Kinase Pyk2 in Brain Function and Neurological and Psychiatric Diseases.

Frontiers In Synaptic Neuroscience
de Pins, Benoit B; Mendes, Tiago T; Giralt, Albert A; Girault, Jean-Antoine JA
Publication Date: 2021

Variant appearance in text: PSEN1: M146L
PubMed Link: 34690733
Variant Present in the following documents:
  • Main text
View BVdb publication page



Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease.

Acta Neuropathologica Communications
Rimal, Suman S; Li, Yu Y; Vartak, Rasika R; Geng, Ji J; Tantray, Ishaq I; Li, Shuangxi S; Huh, Sungun S; Vogel, Hannes H; Glabe, Charles C; Grinberg, Lea T LT; Spina, Salvatore S; Seeley, William W WW; Guo, Su S; Lu, Bingwei B
Publication Date: 2021-10-18

Variant appearance in text: PSEN1: M146L
PubMed Link: 34663454
Variant Present in the following documents:
  • Main text
  • 40478_2021_Article_1268.pdf
View BVdb publication page



Salivary Lactoferrin Expression in a Mouse Model of Alzheimer's Disease.

Frontiers In Immunology
Antequera, Desiree D; Moneo, Diego D; Carrero, Laura L; Bartolome, Fernando F; Ferrer, Isidro I; Proctor, Gordon G; Carro, Eva E
Publication Date: 2021

Variant appearance in text: PS1: M146L
PubMed Link: 34659251
Variant Present in the following documents:
  • Main text
  • fimmu-12-749468.pdf
View BVdb publication page



Computational Interspecies Translation Between Alzheimer's Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging.

Frontiers In Neuroscience
Lee, Meelim J MJ; Wang, Chuangqi C; Carroll, Molly J MJ; Brubaker, Douglas K DK; Hyman, Bradley T BT; Lauffenburger, Douglas A DA
Publication Date: 2021

Variant appearance in text: PSEN1: M146L
PubMed Link: 34658769
Variant Present in the following documents:
  • Main text
  • fnins-15-727784.pdf
View BVdb publication page



Skeletal muscle atrophy-induced hemopexin accelerates onset of cognitive impairment in Alzheimer's disease.

Journal Of Cachexia, Sarcopenia And Muscle
Nagase, Tsukasa T; Tohda, Chihiro C
Publication Date: 2021-10-17

Variant appearance in text: PS1: M146L
PubMed Link: 34658156
Variant Present in the following documents:
  • Main text
  • JCSM-12-2199.pdf
View BVdb publication page



Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease.

Scientific Data
Forner, Stefania S; Kawauchi, Shimako S; Balderrama-Gutierrez, Gabriela G; Kramár, Enikö A EA; Matheos, Dina P DP; Phan, Jimmy J; Javonillo, Dominic I DI; Tran, Kristine M KM; Hingco, Edna E; da Cunha, Celia C; Rezaie, Narges N; Alcantara, Joshua A JA; Baglietto-Vargas, David D; Jansen, Camden C; Neumann, Jonathan J; Wood, Marcelo A MA; MacGregor, Grant R GR; Mortazavi, Ali A; Tenner, Andrea J AJ; LaFerla, Frank M FM; Green, Kim N KN
Publication Date: 2021-10-15

Variant appearance in text: PSEN1: M146L
PubMed Link: 34654824
Variant Present in the following documents:
  • Main text
  • 41597_2021_Article_1054.pdf
View BVdb publication page



HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.

Communications Biology
Tanaka, Hikari H; Kondo, Kanoh K; Fujita, Kyota K; Homma, Hidenori H; Tagawa, Kazuhiko K; Jin, Xiaocen X; Jin, Meihua M; Yoshioka, Yuki Y; Takayama, Sumire S; Masuda, Hitomi H; Tokuyama, Rie R; Nakazaki, Yukoh Y; Saito, Takashi T; Saido, Takaomi T; Murayama, Shigeo S; Ikura, Teikichi T; Ito, Nobutoshi N; Yamamori, Yu Y; Tomii, Kentaro K; Bianchi, Marco E ME; Okazawa, Hitoshi H
Publication Date: 2021-10-11

Variant appearance in text: PS1: M146L
PubMed Link: 34635772
Variant Present in the following documents:
  • Main text
  • 42003_2021_Article_2671.pdf
View BVdb publication page



Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer's disease.

Scientific Reports
Prasad, Renuka R; Jung, Hwajin H; Tan, Anderson A; Song, Yonghee Y; Moon, Sungho S; Shaker, Mohammed R MR; Sun, Woong W; Lee, Junghee J; Ryu, Hoon H; Lim, Hyun Kook HK; Jho, Eek-Hoon EH
Publication Date: 2021-10-08

Variant appearance in text: PSEN1: M146L
PubMed Link: 34625606
Variant Present in the following documents:
  • 41598_2021_Article_99562.pdf
View BVdb publication page