Psychological Impact of Predictive Genetic Testing for Inherited Alzheimer Disease and Frontotemporal Dementia: The IT-DIAfN Protocol.
Alzheimer Disease And Associated Disorders
Galluzzi, Samantha S; Mega, Anna A; Di Fede, Giuseppe G; Muscio, Cristina C; Fascendini, Sara S; Benussi, Luisa L; Tagliavini, Fabrizio F; Frisoni, Giovanni B GB; Di Maria, Emilio E; ,
β2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7.
Journal Of Molecular Biology
Lee, Ju-Hyun JH; Wolfe, Devin M DM; Darji, Sandipkumar S; McBrayer, Mary Kate MK; Colacurcio, Daniel J DJ; Kumar, Asok A; Stavrides, Philip P; Mohan, Panaiyur S PS; Nixon, Ralph A RA
Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation.
Nature Communications
Park, Jun Sung JS; Lee, Junehawk J; Jung, Eun Sun ES; Kim, Myeong-Heui MH; Kim, Il Bin IB; Son, Hyeonju H; Kim, Sangwoo S; Kim, Sanghyeon S; Park, Young Mok YM; Mook-Jung, Inhee I; Yu, Seok Jong SJ; Lee, Jeong Ho JH
Activity-induced MEMRI cannot detect functional brain anomalies in the APPxPS1-Ki mouse model of Alzheimer's disease.
Scientific Reports
Androuin, Alexandre A; Abada, Yah-Se YS; Ly, Myriam M; Santin, Mathieu M; Petiet, Alexandra A; Epelbaum, Stéphane S; Bertrand, Anne A; Delatour, Benoît B
Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion.
Autophagy
Barbero-Camps, Elisabet E; Roca-Agujetas, Vicente V; Bartolessis, Isabel I; de Dios, Cristina C; Fernández-Checa, Jose C JC; Marí, Montserrat M; Morales, Albert A; Hartmann, Tobias T; Colell, Anna A
N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models.
Alzheimer'S Research & Therapy
Wirths, Oliver O; Walter, Susanne S; Kraus, Inga I; Klafki, Hans W HW; Stazi, Martina M; Oberstein, Timo J TJ; Ghiso, Jorge J; Wiltfang, Jens J; Bayer, Thomas A TA; Weggen, Sascha S
A genetic screen of the mutations in the Korean patients with early-onset Alzheimer's disease.
Clinical Interventions In Aging
An, Seong Soo SS; Park, Sun Ah SA; Bagyinszky, Eva E; Bae, Sun Oh SO; Kim, Yoon-Jeong YJ; Im, Ji Young JY; Park, Kyung Won KW; Park, Kee Hyung KH; Kim, Eun-Joo EJ; Jeong, Jee Hyang JH; Kim, Jong Hun JH; Han, Hyun Jeong HJ; Choi, Seong Hye SH; Kim, SangYun S
Changes in the plasma proteome at asymptomatic and symptomatic stages of autosomal dominant Alzheimer's disease.
Scientific Reports
Muenchhoff, Julia J; Poljak, Anne A; Thalamuthu, Anbupalam A; Gupta, Veer B VB; Chatterjee, Pratishtha P; Raftery, Mark M; Masters, Colin L CL; Morris, John C JC; Bateman, Randall J RJ; Fagan, Anne M AM; Martins, Ralph N RN; Sachdev, Perminder S PS
Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study.
Journal Of Alzheimer'S Disease : Jad
Chatterjee, Pratishtha P; Lim, Wei L F WL; Shui, Guanghou G; Gupta, Veer B VB; James, Ian I; Fagan, Anne M AM; Xiong, Chengjie C; Sohrabi, Hamid R HR; Taddei, Kevin K; Brown, Belinda M BM; Benzinger, Tammie T; Masters, Colin C; Snowden, Stuart G SG; Wenk, Marcus R MR; Bateman, Randall J RJ; Morris, John C JC; Martins, Ralph N RN
Genetic heterogeneity in Alzheimer disease and implications for treatment strategies.
Current Neurology And Neuroscience Reports
Ringman, John M JM; Goate, Alison A; Masters, Colin L CL; Cairns, Nigel J NJ; Danek, Adrian A; Graff-Radford, Neill N; Ghetti, Bernardino B; Morris, John C JC; ,
Mutation analysis of patients with neurodegenerative disorders using NeuroX array.
Neurobiology Of Aging
Ghani, Mahdi M; Lang, Anthony E AE; Zinman, Lorne L; Nacmias, Benedetta B; Sorbi, Sandro S; Bessi, Valentina V; Tedde, Andrea A; Tartaglia, Maria Carmela MC; Surace, Ezequiel I EI; Sato, Christine C; Moreno, Danielle D; Xi, Zhengrui Z; Hung, Rachel R; Nalls, Mike A MA; Singleton, Andrew A; St George-Hyslop, Peter P; Rogaeva, Ekaterina E
Publication Date: 2015-01
Variant appearance in text: PSEN1: M233T; rs63751024
REGION-SPECIFIC NEURON AND SYNAPSE LOSS IN THE HIPPOCAMPUS OF APPSL/PS1 KNOCK-IN MICE.
Translational Neuroscience
Brasnjevic, Ivona I; Lardenoije, Roy R; Schmitz, Christoph C; Van Der Kolk, Nicolien N; Dickstein, Dara L DL; Takahashi, Hisaaki H; Hof, Patrick R PR; Steinbusch, Harry W M HW; Rutten, Bart P F BP
Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease.
Molecular Neurodegeneration
Guzmán, Erika Avendaño EA; Bouter, Yvonne Y; Richard, Bernhard C BC; Lannfelt, Lars L; Ingelsson, Martin M; Paetau, Anders A; Verkkoniemi-Ahola, Auli A; Wirths, Oliver O; Bayer, Thomas A TA
The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease.
Molecular Neurodegeneration
Brautigam, Hannah H; Steele, John W JW; Westaway, David D; Fraser, Paul E PE; St George-Hyslop, Peter H PH; Gandy, Sam S; Hof, Patrick R PR; Dickstein, Dara L DL