Publications:

Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation.

Embo Reports

Trambauer, Johannes J; Rodríguez Sarmiento, Rosa María RM; Fukumori, Akio A; Feederle, Regina R; Baumann, Karlheinz K; Steiner, Harald H

Publication Date: 2020-01-07

Variant appearance in text: PS1: G382A

PubMed Link: 31762188

Variant Present in the following documents:

• Main text
• EMBR-21-e47996-s010.pdf
• EMBR-21-e47996-s008.pdf
• EMBR-21-e47996.pdf
• EMBR-21-e47996-s005.pdf
• EMBR-21-e47996-s002.pdf

View BVdb publication page

Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease.

Oncotarget

Grigorenko, Anastasia P AP; Moliaka, Youri K YK; Plotnikova, Olga V OV; Smirnov, Alexander A; Nikishina, Vera A VA; Goltsov, Andrey Y AY; Gusev, Fedor F; Andreeva, Tatiana V TV; Nelson, Omar O; Bezprozvanny, Ilya I; Rogaev, Evgeny I EI

Publication Date: 2017-10-10

Variant appearance in text: PSEN1: G382A

PubMed Link: 29137240

Variant Present in the following documents:

• Main text
• oncotarget-08-82006-s001.pdf
• oncotarget-08-82006.pdf

View BVdb publication page

Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds.

The Journal Of Biological Chemistry

Kretner, Benedikt B; Fukumori, Akio A; Gutsmiedl, Amelie A; Page, Richard M RM; Luebbers, Thomas T; Galley, Guido G; Baumann, Karlheinz K; Haass, Christian C; Steiner, Harald H

Publication Date: 2011-04-29

Variant appearance in text: PS1: G382A

PubMed Link: 21357415

Variant Present in the following documents:

• Main text

View BVdb publication page

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Sato, Chihiro C; Morohashi, Yuichi Y; Tomita, Taisuke T; Iwatsubo, Takeshi T

Publication Date: 2006-11-15

Variant appearance in text: PS1: G382A

PubMed Link: 17108181

Variant Present in the following documents:

• Main text

View BVdb publication page