Publications:

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Conformational Dynamics of Transmembrane Domain 3 of Presenilin 1 Is Associated with the Trimming Activity of γ-Secretase.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Cai, Tetsuo T; Morishima, Kanan K; Takagi-Niidome, Shizuka S; Tominaga, Aya A; Tomita, Taisuke T

Publication Date: 2019-10-23

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PubMed Link: 31527118

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Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Tominaga, Aya A; Cai, Tetsuo T; Takagi-Niidome, Shizuka S; Iwatsubo, Takeshi T; Tomita, Taisuke T

Publication Date: 2016-01-27

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PubMed Link: 26818522

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Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Takeo, Koji K; Tanimura, Shun S; Shinoda, Takehiro T; Osawa, Satoko S; Zahariev, Ivan Krasmirov IK; Takegami, Naoki N; Ishizuka-Katsura, Yoshiko Y; Shinya, Naoko N; Takagi-Niidome, Shizuka S; Tominaga, Aya A; Ohsawa, Noboru N; Kimura-Someya, Tomomi T; Shirouzu, Mikako M; Yokoshima, Satoshi S; Yokoyama, Shigeyuki S; Fukuyama, Tohru T; Tomita, Taisuke T; Iwatsubo, Takeshi T

Publication Date: 2014-07-22

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PubMed Link: 25009180

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Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein.

The Journal Of Biological Chemistry

Takeo, Koji K; Watanabe, Naoto N; Tomita, Taisuke T; Iwatsubo, Takeshi T

Publication Date: 2012-07-27

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PubMed Link: 22689582

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Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.

The Journal Of Biological Chemistry

Nelson, Omar O; Supnet, Charlene C; Tolia, Alexandra A; Horré, Katrien K; De Strooper, Bart B; Bezprozvanny, Ilya I

Publication Date: 2011-06-24

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PubMed Link: 21531718

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Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Takagi, Shizuka S; Tominaga, Aya A; Sato, Chihiro C; Tomita, Taisuke T; Iwatsubo, Takeshi T

Publication Date: 2010-11-24

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PubMed Link: 21106832

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The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Sato, Chihiro C; Takagi, Shizuka S; Tomita, Taisuke T; Iwatsubo, Takeshi T

Publication Date: 2008-06-11

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PubMed Link: 18550769

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Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Sato, Chihiro C; Morohashi, Yuichi Y; Tomita, Taisuke T; Iwatsubo, Takeshi T

Publication Date: 2006-11-15

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PubMed Link: 17108181

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