Publications:

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Human iPSC-Derived Neural Models for Studying Alzheimer's Disease: from Neural Stem Cells to Cerebral Organoids.

Stem Cell Reviews And Reports

Barak, Martin M; Fedorova, Veronika V; Pospisilova, Veronika V; Raska, Jan J; Vochyanova, Simona S; Sedmik, Jiri J; Hribkova, Hana H; Klimova, Hana H; Vanova, Tereza T; Bohaciakova, Dasa D

Publication Date: 2022-02

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PubMed Link: 35107767

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Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer's disease (AD) risk.

Neurobiology Of Disease

Raman, Sreedevi S; Brookhouser, Nicholas N; Brafman, David A DA

Publication Date: 2020-05

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PubMed Link: 32032733

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Recent Advances: Decoding Alzheimer's Disease With Stem Cells.

Frontiers In Aging Neuroscience

Fang, Yi Y; Gao, Ting T; Zhang, Baorong B; Pu, Jiali J

Publication Date: 2018

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PubMed Link: 29623038

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Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells.

Molecular And Cellular Neurosciences

Mungenast, Alison E AE; Siegert, Sandra S; Tsai, Li-Huei LH

Publication Date: 2016-06

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PubMed Link: 26657644

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Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

The Journal Of Biological Chemistry

Fleck, Daniel D; Voss, Matthias M; Brankatschk, Ben B; Giudici, Camilla C; Hampel, Heike H; Schwenk, Benjamin B; Edbauer, Dieter D; Fukumori, Akio A; Steiner, Harald H; Kremmer, Elisabeth E; Haug-Kröper, Martina M; Rossner, Moritz J MJ; Fluhrer, Regina R; Willem, Michael M; Haass, Christian C

Publication Date: 2016-01-01

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PubMed Link: 26574544

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Induced Pluripotent Stem Cells Derived from Alzheimer's Disease Patients: The Promise, the Hope and the Path Ahead.

Journal Of Clinical Medicine

Freude, Kristine K; Pires, Carlota C; Hyttel, Poul P; Hall, Vanessa Jane VJ

Publication Date: 2014-12-12

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PubMed Link: 26237610

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Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer's disease.

Translational Psychiatry

Honarnejad, K K; Daschner, A A; Gehring, A P AP; Szybinska, A A; Giese, A A; Kuznicki, J J; Bracher, F F; Herms, J J

Publication Date: 2014-12-16

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PubMed Link: 25514752

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Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease.

Plos One

Honarnejad, Kamran K; Daschner, Alexander A; Giese, Armin A; Zall, Andrea A; Schmidt, Boris B; Szybinska, Aleksandra A; Kuznicki, Jacek J; Herms, Jochen J

Publication Date: 2013

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PubMed Link: 24260442

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Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.

Journal Of Cellular And Molecular Medicine

Honarnejad, Kamran K; Jung, Christian K E CK; Lammich, Sven S; Arzberger, Thomas T; Kretzschmar, Hans H; Herms, Jochen J

Publication Date: 2013-02

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PubMed Link: 23379308

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• jcmm0017-0293.pdf

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Alzheimer's disease in a dish: promises and challenges of human stem cell models.

Human Molecular Genetics

Young, Jessica E JE; Goldstein, Lawrence S B LS

Publication Date: 2012-10-15

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PubMed Link: 22865875

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Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.

Molecular Brain

Lorenzen, Angela A; Samosh, Jonathan J; Vandewark, Kenneth K; Anborgh, Pieter H PH; Seah, Claudia C; Magalhaes, Ana C AC; Cregan, Sean P SP; Ferguson, Stephen S G SS; Pasternak, Stephen H SH

Publication Date: 2010-04-21

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PubMed Link: 20409323

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Klotho is a substrate for alpha-, beta- and gamma-secretase.

Febs Letters

Bloch, Laura L; Sineshchekova, Olga O; Reichenbach, Daniela D; Reiss, Karina K; Saftig, Paul P; Kuro-o, Makoto M; Kaether, Christoph C

Publication Date: 2009-10-06

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PubMed Link: 19737556

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Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity.

The Biochemical Journal

Riedle, Svenja S; Kiefel, Helena H; Gast, Daniela D; Bondong, Sandra S; Wolterink, Silke S; Gutwein, Paul P; Altevogt, Peter P

Publication Date: 2009-05-27

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PubMed Link: 19260824

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Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1.

Molecular And Cellular Biology

Tagami, Shinji S; Okochi, Masayasu M; Yanagida, Kanta K; Ikuta, Akiko A; Fukumori, Akio A; Matsumoto, Naohiko N; Ishizuka-Katsura, Yoshiko Y; Nakayama, Taisuke T; Itoh, Naohiro N; Jiang, Jingwei J; Nishitomi, Kouhei K; Kamino, Kouzin K; Morihara, Takashi T; Hashimoto, Ryota R; Tanaka, Toshihisa T; Kudo, Takashi T; Chiba, Shigeru S; Takeda, Masatoshi M

Publication Date: 2008-01

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PubMed Link: 17967888

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Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity.

Molecular And Cellular Biology

Anders, Lars L; Mertins, Philipp P; Lammich, Sven S; Murgia, Marta M; Hartmann, Dieter D; Saftig, Paul P; Haass, Christian C; Ullrich, Axel A

Publication Date: 2006-05

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PubMed Link: 16648485

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Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43.

The Biochemical Journal

Andersson, Christian X CX; Fernandez-Rodriguez, Julia J; Laos, Sirle S; Baeckström, Dan D; Haass, Christian C; Hansson, Gunnar C GC

Publication Date: 2005-04-15

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PubMed Link: 15540986

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Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

The Embo Journal

Okochi, Masayasu M; Steiner, Harald H; Fukumori, Akio A; Tanii, Hisashi H; Tomita, Taisuke T; Tanaka, Toshihisa T; Iwatsubo, Takeshi T; Kudo, Takashi T; Takeda, Masatoshi M; Haass, Christian C

Publication Date: 2002-10-15

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PubMed Link: 12374741

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Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.

The Journal Of Cell Biology

Kaether, Christoph C; Lammich, Sven S; Edbauer, Dieter D; Ertl, Michaela M; Rietdorf, Jens J; Capell, Anja A; Steiner, Harald H; Haass, Christian C

Publication Date: 2002-08-05

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PubMed Link: 12147673

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch.

Embo Reports

Sastre, M M; Steiner, H H; Fuchs, K K; Capell, A A; Multhaup, G G; Condron, M M MM; Teplow, D B DB; Haass, C C

Publication Date: 2001-09

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PubMed Link: 11520861

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