Publications:

Specific Mutations in Aph1 Cause γ-Secretase Activation.

International Journal Of Molecular Sciences

Watanabe, Hikari H; Yoshida, Chika C; Hidaka, Masafumi M; Ogawa, Tomohisa T; Tomita, Taisuke T; Futai, Eugene E

Publication Date: 2022-01-03

Variant appearance in text: PS1: S438P

PubMed Link: 35008932

Variant Present in the following documents:

• Main text
• ijms-23-00507.pdf

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Specific Mutations in Aph1 Cause γ-Secretase Activation.

International Journal Of Molecular Sciences

Watanabe, Hikari H; Yoshida, Chika C; Hidaka, Masafumi M; Ogawa, Tomohisa T; Tomita, Taisuke T; Futai, Eugene E

Publication Date: 2022-01-03

Variant appearance in text: PS1: S438P

PubMed Link: 35008932

Variant Present in the following documents:

• Main text
• ijms-23-00507.pdf

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Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.

The Journal Of Biological Chemistry

Liu, Lei L; Lauro, Bianca M BM; Wolfe, Michael S MS; Selkoe, Dennis J DJ

Publication Date: 2021

Variant appearance in text: PS1: S438P

PubMed Link: 33571524

Variant Present in the following documents:

• Main text
• main.pdf

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Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Zhao, Guojun G; Liu, Zhenyi Z; Ilagan, Ma Xenia G MX; Kopan, Raphael R

Publication Date: 2010-02-03

Variant appearance in text: PS1: S438P

PubMed Link: 20130175

Variant Present in the following documents:

• Main text

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Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.

The Journal Of Biological Chemistry

Futai, Eugene E; Yagishita, Sosuke S; Ishiura, Shoichi S

Publication Date: 2009-05-08

Variant appearance in text: PS1: S438P

PubMed Link: 19254953

Variant Present in the following documents:

• 13013.pdf

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