Publications:

Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.

The Journal Of Biological Chemistry

Liu, Lei L; Lauro, Bianca M BM; Wolfe, Michael S MS; Selkoe, Dennis J DJ

Publication Date: 2021

Variant appearance in text: PS1: F441L

PubMed Link: 33571524

Variant Present in the following documents:

• Main text
• main.pdf

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Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.

The Journal Of Biological Chemistry

Futai, Eugene E; Yagishita, Sosuke S; Ishiura, Shoichi S

Publication Date: 2009-05-08

Variant appearance in text: PS1: F441L

PubMed Link: 19254953

Variant Present in the following documents:

• 13013.pdf

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