Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23
Variant appearance in text: FBN1: 3662G>A; Cys1221Tyr
Comprehensive functional genomic analyses link APC somatic mutation and mRNA-miRNA networks to the clinical outcome of stage-III colorectal cancer patients.
Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm.
Nature Genetics
Doyle, Alexander J AJ; Doyle, Jefferson J JJ; Bessling, Seneca L SL; Maragh, Samantha S; Lindsay, Mark E ME; Schepers, Dorien D; Gillis, Elisabeth E; Mortier, Geert G; Homfray, Tessa T; Sauls, Kimberly K; Norris, Russell A RA; Huso, Nicholas D ND; Leahy, Dan D; Mohr, David W DW; Caulfield, Mark J MJ; Scott, Alan F AF; Destrée, Anne A; Hennekam, Raoul C RC; Arn, Pamela H PH; Curry, Cynthia J CJ; Van Laer, Lut L; McCallion, Andrew S AS; Loeys, Bart L BL; Dietz, Harry C HC