The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis.
Circulation Research
Karamanavi, Elisavet E; McVey, David G DG; van der Laan, Sander W SW; Stanczyk, Paulina J PJ; Morris, Gavin E GE; Wang, Yifan Y; Yang, Wei W; Chan, Kenneth K; Poston, Robin N RN; Luo, Jun J; Zhou, Xinmiao X; Gong, Peng P; Jones, Peter D PD; Cao, Junjun J; Kostogrys, Renata B RB; Webb, Tom R TR; Pasterkamp, Gerard G; Yu, Haojie H; Xiao, Qingzhong Q; Greer, Peter A PA; Stringer, Emma J EJ; Samani, Nilesh J NJ; Ye, Shu S
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.
Scientific Reports
Gaddis, Nathan N; Mathur, Ravi R; Marks, Jesse J; Zhou, Linran L; Quach, Bryan B; Waldrop, Alex A; Levran, Orna O; Agrawal, Arpana A; Randesi, Matthew M; Adelson, Miriam M; Jeffries, Paul W PW; Martin, Nicholas G NG; Degenhardt, Louisa L; Montgomery, Grant W GW; Wetherill, Leah L; Lai, Dongbing D; Bucholz, Kathleen K; Foroud, Tatiana T; Porjesz, Bernice B; Runarsdottir, Valgerdur V; Tyrfingsson, Thorarinn T; Einarsson, Gudmundur G; Gudbjartsson, Daniel F DF; Webb, Bradley Todd BT; Crist, Richard C RC; Kranzler, Henry R HR; Sherva, Richard R; Zhou, Hang H; Hulse, Gary G; Wildenauer, Dieter D; Kelty, Erin E; Attia, John J; Holliday, Elizabeth G EG; McEvoy, Mark M; Scott, Rodney J RJ; Schwab, Sibylle G SG; Maher, Brion S BS; Gruza, Richard R; Kreek, Mary Jeanne MJ; Nelson, Elliot C EC; Thorgeirsson, Thorgeir T; Stefansson, Kari K; Berrettini, Wade H WH; Gelernter, Joel J; Edenberg, Howard J HJ; Bierut, Laura L; Hancock, Dana B DB; Johnson, Eric Otto EO
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.
Molecular Psychiatry
Deak, Joseph D JD; Zhou, Hang H; Galimberti, Marco M; Levey, Daniel F DF; Wendt, Frank R FR; Sanchez-Roige, Sandra S; Hatoum, Alexander S AS; Johnson, Emma C EC; Nunez, Yaira Z YZ; Demontis, Ditte D; Børglum, Anders D AD; Rajagopal, Veera M VM; Jennings, Mariela V MV; Kember, Rachel L RL; Justice, Amy C AC; Edenberg, Howard J HJ; Agrawal, Arpana A; Polimanti, Renato R; Kranzler, Henry R HR; Gelernter, Joel J
Evidence for Shared Genetic Aetiology Between Schizophrenia, Cardiometabolic, and Inflammation-Related Traits: Genetic Correlation and Colocalization Analyses.
Schizophrenia Bulletin Open
Perry, Benjamin I BI; Bowker, Nicholas N; Burgess, Stephen S; Wareham, Nicholas J NJ; Upthegrove, Rachel R; Jones, Peter B PB; Langenberg, Claudia C; Khandaker, Golam M GM
Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors.
Translational Psychiatry
Torgersen, Kristin K; Bahrami, Shahram S; Frei, Oleksandr O; Shadrin, Alexey A; Connell, Kevin S O' KSO; Smeland, Olav B OB; Munkhaugen, John J; Djurovic, Srdjan S; Dammen, Toril T; Andreassen, Ole A OA
Germline Genetic Variants of Viral Entry and Innate Immunity May Influence Susceptibility to SARS-CoV-2 Infection: Toward a Polygenic Risk Score for Risk Stratification.
Frontiers In Immunology
Grolmusz, Vince Kornél VK; Bozsik, Anikó A; Papp, János J; Patócs, Attila A
Cardiovascular risk factor mediation of the effects of education and Genetic Risk Score on cardiovascular disease: a prospective observational cohort study of the Framingham Heart Study.
Bmj Open
Powell, Katie L KL; Stephens, Sebastien R SR; Stephens, Alexandre S AS
Tissue Proteases and Immune Responses: Influencing Factors of COVID-19 Severity and Mortality.
Pathogens (Basel, Switzerland)
Mulinari Turin de Oliveira, Natália N; Fernandes da Silva Figueiredo, Isabella I; Cristine Malaquias da Silva, Liziane L; Sauruk da Silva, Karien K; Regis Bueno, Laryssa L; Barbosa da Luz, Bruna B; Rita Corso, Cláudia C; de Paula Werner, Maria Fernanda MF; Soares Fernandes, Elizabeth E; Maria-Ferreira, Daniele D
Association between HindIII (rs320) variant in the lipoprotein lipase gene and the presence of coronary artery disease and stroke among the Saudi population.
Saudi Journal Of Biological Sciences
Bogari, Neda M NM; Aljohani, Ashwag A; Dannoun, Anas A; Elkhateeb, Osama O; Porqueddu, Masimo M; Amin, Amr A AA; Bogari, Dema N DN; Taher, Mohiuddin M MM; Buba, Faruk F; Allam, Reem M RM; Bogari, Mustafa N MN; Alamanni, Francesco F
Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies.
Scientific Reports
Shadrina, Alexandra S AS; Shashkova, Tatiana I TI; Torgasheva, Anna A AA; Sharapov, Sodbo Z SZ; Klarić, Lucija L; Pakhomov, Eugene D ED; Alexeev, Dmitry G DG; Wilson, James F JF; Tsepilov, Yakov A YA; Joshi, Peter K PK; Aulchenko, Yurii S YS
FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease-Associated Genetic Variant and Influences Monocyte Transendothelial Migration.
Journal Of The American Heart Association
Yang, Xu X; Yang, Wei W; McVey, David G DG; Zhao, Guojun G; Hu, Jinfu J; Poston, Robin N RN; Ren, Meixia M; Willeit, Karin K; Coassin, Stefan S; Willeit, Johann J; Webb, Thomas R TR; Samani, Nilesh J NJ; Mayr, Manuel M; Kiechl, Stefan S; Ye, Shu S
Genome-wide association study of medication-use and associated disease in the UK Biobank.
Nature Communications
Wu, Yeda Y; Byrne, Enda M EM; Zheng, Zhili Z; Kemper, Kathryn E KE; Yengo, Loic L; Mallett, Andrew J AJ; Yang, Jian J; Visscher, Peter M PM; Wray, Naomi R NR
FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.
Arteriosclerosis, Thrombosis, And Vascular Biology
Yakala, Gopala K GK; Cabrera-Fuentes, Hector A HA; Crespo-Avilan, Gustavo E GE; Rattanasopa, Chutima C; Burlacu, Alexandrina A; George, Benjamin L BL; Anand, Kaviya K; Mayan, David Castaño DC; Corlianò, Maria M; Hernández-Reséndiz, Sauri S; Wu, Zihao Z; Schwerk, Anne M K AMK; Tan, Amberlyn L J ALJ; Trigueros-Motos, Laia L; Chèvre, Raphael R; Chua, Tricia T; Kleemann, Robert R; Liehn, Elisa A EA; Hausenloy, Derek J DJ; Ghosh, Sujoy S; Singaraja, Roshni R RR
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances.
Elife
Timmers, Paul Rhj PR; Mounier, Ninon N; Lall, Kristi K; Fischer, Krista K; Ning, Zheng Z; Feng, Xiao X; Bretherick, Andrew D AD; Clark, David W DW; , ; Shen, Xia X; Esko, Tõnu T; Kutalik, Zoltán Z; Wilson, James F JF; Joshi, Peter K PK
Novel risk genes identified in a genome-wide association study for coronary artery disease in patients with type 1 diabetes.
Cardiovascular Diabetology
Charmet, Romain R; Duffy, Seamus S; Keshavarzi, Sareh S; Gyorgy, Beata B; Marre, Michel M; Rossing, Peter P; McKnight, Amy Jayne AJ; Maxwell, Alexander P AP; Ahluwalia, Tarun Veer Singh TVS; Paterson, Andrew D AD; Trégouët, David-Alexandre DA; Hadjadj, Samy S
Human longevity: 25 genetic loci associated in 389,166 UK biobank participants.
Aging
Pilling, Luke C LC; Kuo, Chia-Ling CL; Sicinski, Kamil K; Tamosauskaite, Jone J; Kuchel, George A GA; Harries, Lorna W LW; Herd, Pamela P; Wallace, Robert R; Ferrucci, Luigi L; Melzer, David D
Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy.
Plos Genetics
Byars, Sean G SG; Huang, Qin Qin QQ; Gray, Lesley-Ann LA; Bakshi, Andrew A; Ripatti, Samuli S; Abraham, Gad G; Stearns, Stephen C SC; Inouye, Michael M
ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice.
Mediators Of Inflammation
Weerasekera, Lakshini L; Rudnicka, Caroline C; Sang, Qing-Xiang QX; Curran, Joanne E JE; Johnson, Matthew P MP; Moses, Eric K EK; Göring, Harald H H HH; Blangero, John J; Hricova, Jana J; Schlaich, Markus M; Matthews, Vance B VB
Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.
Journal Of The American College Of Cardiology
Webb, Thomas R TR; Erdmann, Jeanette J; Stirrups, Kathleen E KE; Stitziel, Nathan O NO; Masca, Nicholas G D NG; Jansen, Henning H; Kanoni, Stavroula S; Nelson, Christopher P CP; Ferrario, Paola G PG; König, Inke R IR; Eicher, John D JD; Johnson, Andrew D AD; Hamby, Stephen E SE; Betsholtz, Christer C; Ruusalepp, Arno A; Franzén, Oscar O; Schadt, Eric E EE; Björkegren, Johan L M JL; Weeke, Peter E PE; Auer, Paul L PL; Schick, Ursula M UM; Lu, Yingchang Y; Zhang, He H; Dube, Marie-Pierre MP; Goel, Anuj A; Farrall, Martin M; Peloso, Gina M GM; Won, Hong-Hee HH; Do, Ron R; van Iperen, Erik E; Kruppa, Jochen J; Mahajan, Anubha A; Scott, Robert A RA; Willenborg, Christina C; Braund, Peter S PS; van Capelleveen, Julian C JC; Doney, Alex S F AS; Donnelly, Louise A LA; Asselta, Rosanna R; Merlini, Pier A PA; Duga, Stefano S; Marziliano, Nicola N; Denny, Josh C JC; Shaffer, Christian C; El-Mokhtari, Nour Eddine NE; Franke, Andre A; Heilmann, Stefanie S; Hengstenberg, Christian C; Hoffmann, Per P; Holmen, Oddgeir L OL; Hveem, Kristian K; Jansson, Jan-Håkan JH; Jöckel, Karl-Heinz KH; Kessler, Thorsten T; Kriebel, Jennifer J; Laugwitz, Karl L KL; Marouli, Eirini E; Martinelli, Nicola N; McCarthy, Mark I MI; Van Zuydam, Natalie R NR; Meisinger, Christa C; Esko, Tõnu T; Mihailov, Evelin E; Escher, Stefan A SA; Alver, Maris M; Moebus, Susanne S; Morris, Andrew D AD; Virtamo, Jarma J; Nikpay, Majid M; Olivieri, Oliviero O; Provost, Sylvie S; AlQarawi, Alaa A; Robertson, Neil R NR; Akinsansya, Karen O KO; Reilly, Dermot F DF; Vogt, Thomas F TF; Yin, Wu W; Asselbergs, Folkert W FW; Kooperberg, Charles C; Jackson, Rebecca D RD; Stahl, Eli E; Müller-Nurasyid, Martina M; Strauch, Konstantin K; Varga, Tibor V TV; Waldenberger, Melanie M; , ; Zeng, Lingyao L; Chowdhury, Rajiv R; Salomaa, Veikko V; Ford, Ian I; Jukema, J Wouter JW; Amouyel, Philippe P; Kontto, Jukka J; , ; Nordestgaard, Børge G BG; Ferrières, Jean J; Saleheen, Danish D; Sattar, Naveed N; Surendran, Praveen P; Wagner, Aline A; Young, Robin R; Howson, Joanna M M JM; Butterworth, Adam S AS; Danesh, John J; Ardissino, Diego D; Bottinger, Erwin P EP; Erbel, Raimund R; Franks, Paul W PW; Girelli, Domenico D; Hall, Alistair S AS; Hovingh, G Kees GK; Kastrati, Adnan A; Lieb, Wolfgang W; Meitinger, Thomas T; Kraus, William E WE; Shah, Svati H SH; McPherson, Ruth R; Orho-Melander, Marju M; Melander, Olle O; Metspalu, Andres A; Palmer, Colin N A CN; Peters, Annette A; Rader, Daniel J DJ; Reilly, Muredach P MP; Loos, Ruth J F RJ; Reiner, Alex P AP; Roden, Dan M DM; Tardif, Jean-Claude JC; Thompson, John R JR; Wareham, Nicholas J NJ; Watkins, Hugh H; Willer, Cristen J CJ; Samani, Nilesh J NJ; Schunkert, Heribert H; Deloukas, Panos P; Kathiresan, Sekar S; ,
Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association.
Circulation
Benjamin, Emelia J EJ; Blaha, Michael J MJ; Chiuve, Stephanie E SE; Cushman, Mary M; Das, Sandeep R SR; Deo, Rajat R; de Ferranti, Sarah D SD; Floyd, James J; Fornage, Myriam M; Gillespie, Cathleen C; Isasi, Carmen R CR; Jiménez, Monik C MC; Jordan, Lori Chaffin LC; Judd, Suzanne E SE; Lackland, Daniel D; Lichtman, Judith H JH; Lisabeth, Lynda L; Liu, Simin S; Longenecker, Chris T CT; Mackey, Rachel H RH; Matsushita, Kunihiro K; Mozaffarian, Dariush D; Mussolino, Michael E ME; Nasir, Khurram K; Neumar, Robert W RW; Palaniappan, Latha L; Pandey, Dilip K DK; Thiagarajan, Ravi R RR; Reeves, Mathew J MJ; Ritchey, Matthew M; Rodriguez, Carlos J CJ; Roth, Gregory A GA; Rosamond, Wayne D WD; Sasson, Comilla C; Towfighi, Amytis A; Tsao, Connie W CW; Turner, Melanie B MB; Virani, Salim S SS; Voeks, Jenifer H JH; Willey, Joshua Z JZ; Wilkins, John T JT; Wu, Jason Hy JH; Alger, Heather M HM; Wong, Sally S SS; Muntner, Paul P; ,
Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies.
Genome Biology
Joehanes, Roby R; Zhang, Xiaoling X; Huan, Tianxiao T; Yao, Chen C; Ying, Sai-Xia SX; Nguyen, Quang Tri QT; Demirkale, Cumhur Yusuf CY; Feolo, Michael L ML; Sharopova, Nataliya R NR; Sturcke, Anne A; Schäffer, Alejandro A AA; Heard-Costa, Nancy N; Chen, Han H; Liu, Po-Ching PC; Wang, Richard R; Woodhouse, Kimberly A KA; Tanriverdi, Kahraman K; Freedman, Jane E JE; Raghavachari, Nalini N; Dupuis, Josée J; Johnson, Andrew D AD; O'Donnell, Christopher J CJ; Levy, Daniel D; Munson, Peter J PJ
Variant Discovery and Fine Mapping of Genetic Loci Associated with Blood Pressure Traits in Hispanics and African Americans.
Plos One
Franceschini, Nora N; Carty, Cara L CL; Lu, Yingchang Y; Tao, Ran R; Sung, Yun Ju YJ; Manichaikul, Ani A; Haessler, Jeff J; Fornage, Myriam M; Schwander, Karen K; Zubair, Niha N; Bien, Stephanie S; Hindorff, Lucia A LA; Guo, Xiuqing X; Bielinski, Suzette J SJ; Ehret, Georg G; Kaufman, Joel D JD; Rich, Stephen S SS; Carlson, Christopher S CS; Bottinger, Erwin P EP; North, Kari E KE; Rao, D C DC; Chakravarti, Aravinda A; Barrett, Paula Q PQ; Loos, Ruth J F RJ; Buyske, Steven S; Kooperberg, Charles C
Coronary Artery Calcification and Rheumatoid Arthritis: Lack of Relationship to Risk Alleles for Coronary Artery Disease in the General Population.
Arthritis & Rheumatology (Hoboken, N.J.)
Ferraz-Amaro, Iván I; Winchester, Robert R; Gregersen, Peter K PK; Reynolds, Richard J RJ; Wasko, Mary Chester MC; Oeser, Anette A; Chung, Cecilia P CP; Stein, C Michael CM; Giles, Jon T JT; Bathon, Joan M JM