Publications:

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Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.

Cell Reports

Liu, Hongqi H; Feng, Xizhi X; Ennis, Kelli N KN; Behrmann, Catherine A CA; Sarma, Pranjal P; Jiang, Tony T TT; Kofuji, Satoshi S; Niu, Liang L; Stratton, Yiwen Y; Thomas, Hala Elnakat HE; Yoon, Sang-Oh SO; Sasaki, Atsuo T AT; Plas, David R DR

Publication Date: 2017-02-28

Variant appearance in text: TSC2: T389E

PubMed Link: 28249155

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• Main text

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PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition.

Cancer Cell

Castel, Pau P; Ellis, Haley H; Bago, Ruzica R; Toska, Eneda E; Razavi, Pedram P; Carmona, F Javier FJ; Kannan, Srinivasaraghavan S; Verma, Chandra S CS; Dickler, Maura M; Chandarlapaty, Sarat S; Brogi, Edi E; Alessi, Dario R DR; Baselga, José J; Scaltriti, Maurizio M

Publication Date: 2016-08-08

Variant appearance in text: TSC2: T389E

PubMed Link: 27451907

Variant Present in the following documents:

• mmc2.pdf

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The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation.

Current Biology : Cb

Csibi, Alfredo A; Lee, Gina G; Yoon, Sang-Oh SO; Tong, Haoxuan H; Ilter, Didem D; Elia, Ilaria I; Fendt, Sarah-Maria SM; Roberts, Thomas M TM; Blenis, John J

Publication Date: 2014-10-06

Variant appearance in text: TSC2: T389E

PubMed Link: 25220053

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Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination.

The Journal Of Biological Chemistry

Xu, Xinsong X; Keshwani, Malik M; Meyer, Kathleen K; Sarikas, Antonio A; Taylor, Susan S; Pan, Zhen-Qiang ZQ

Publication Date: 2012-11-23

Variant appearance in text: TSC2: T389E

PubMed Link: 23045529

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The crosstalk of mTOR/S6K1 and Hedgehog pathways.

Cancer Cell

Wang, Yan Y; Ding, Qingqing Q; Yen, Chia-Jui CJ; Xia, Weiya W; Izzo, Julie G JG; Lang, Jing-Yu JY; Li, Chia-Wei CW; Hsu, Jennifer L JL; Miller, Stephanie A SA; Wang, Xuemei X; Lee, Dung-Fang DF; Hsu, Jung-Mao JM; Huo, Longfei L; Labaff, Adam M AM; Liu, Dongping D; Huang, Tzu-Hsuan TH; Lai, Chien-Chen CC; Tsai, Fuu-Jen FJ; Chang, Wei-Chao WC; Chen, Chung-Hsuan CH; Wu, Tsung-Teh TT; Buttar, Navtej S NS; Wang, Kenneth K KK; Wu, Yun Y; Wang, Huamin H; Ajani, Jaffer J; Hung, Mien-Chie MC

Publication Date: 2012-03-20

Variant appearance in text: TSC2: T389E

PubMed Link: 22439934

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Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Shin, Sejeong S; Wolgamott, Laura L; Yu, Yonghao Y; Blenis, John J; Yoon, Sang-Oh SO

Publication Date: 2011-11-22

Variant appearance in text: TSC2: T389E

PubMed Link: 22065737

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mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells.

The Journal Of Biological Chemistry

Liu, Jianyu J; Stevens, Payton D PD; Gao, Tianyan T

Publication Date: 2011-02-25

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PubMed Link: 21177869

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mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Molecular And Cellular Biology

Julien, Louis-Andre LA; Carriere, Audrey A; Moreau, Julie J; Roux, Philippe P PP

Publication Date: 2010-02

Variant appearance in text: TSC2: T389E

PubMed Link: 19995915

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mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E.

Molecular And Cellular Biology

Fingar, Diane C DC; Richardson, Celeste J CJ; Tee, Andrew R AR; Cheatham, Lynn L; Tsou, Christina C; Blenis, John J

Publication Date: 2004-01

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PubMed Link: 14673156

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