Publications:

MAP4K3 inhibits Sirtuin-1 to repress the LKB1-AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex.

Life Science Alliance

Branch, Mary Rose MR; Hsu, Cynthia L CL; Ohnishi, Kohta K; Shen, Wen-Chuan WC; Lee, Elian E; Meisenhelder, Jill J; Winborn, Brett B; Sopher, Bryce L BL; Taylor, J Paul JP; Hunter, Tony T; La Spada, Albert R AR

Publication Date: 2023-08

Variant appearance in text: TSC2: S1387A

PubMed Link: 37221017

Variant Present in the following documents:

• LSA-2022-01525_review_history.pdf

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Alexander, Angela A; Cai, Sheng-Li SL; Kim, Jinhee J; Nanez, Adrian A; Sahin, Mustafa M; MacLean, Kirsteen H KH; Inoki, Ken K; Guan, Kun-Liang KL; Shen, Jianjun J; Person, Maria D MD; Kusewitt, Donna D; Mills, Gordon B GB; Kastan, Michael B MB; Walker, Cheryl Lyn CL

Publication Date: 2010-03-02

Variant appearance in text: TSC2: S1387A

PubMed Link: 20160076

Variant Present in the following documents:

• Main text

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