Mechanistic Insight from Preclinical Models of Parkinson's Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy.
International Journal Of Molecular Sciences
Delgado-Minjares, Karen M KM; Martinez-Fong, Daniel D; Martínez-Dávila, Irma A IA; Bañuelos, Cecilia C; Gutierrez-Castillo, M E ME; Blanco-Alvarez, Víctor Manuel VM; Cardenas-Aguayo, Maria-Del-Carmen MD; Luna-Muñoz, José J; Pacheco-Herrero, Mar M; Soto-Rojas, Luis O LO
Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells.
Scientific Reports
Thirstrup, Kenneth K; Dächsel, Justus C JC; Oppermann, Felix S FS; Williamson, Douglas S DS; Smith, Garrick P GP; Fog, Karina K; Christensen, Kenneth V KV
Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons.
Plos One
Qureshi, Hamid Y HY; Han, Dong D; MacDonald, Ryen R; Paudel, Hemant K HK
Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease.
Brain : A Journal Of Neurology
Tönges, Lars L; Frank, Tobias T; Tatenhorst, Lars L; Saal, Kim A KA; Koch, Jan C JC; Szego, Éva M ÉM; Bähr, Mathias M; Weishaupt, Jochen H JH; Lingor, Paul P
Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element.
International Journal Of Molecular Sciences
Olivares, David D; Huang, Xudong X; Branden, Lars L; Greig, Nigel H NH; Rogers, Jack T JT