Hairy Cell Leukemia (HCL) Presenting with Joint Swelling: Case Report and Literature Review of a Rare Rheumatological Manifestation of a Hematological Disease.
Assessment of Capecitabine and Bevacizumab With or Without Atezolizumab for the Treatment of Refractory Metastatic Colorectal Cancer: A Randomized Clinical Trial.
Jama Network Open
Mettu, Niharika B NB; Ou, Fang-Shu FS; Zemla, Tyler J TJ; Halfdanarson, Thorvardur R TR; Lenz, Heinz-Josef HJ; Breakstone, Rimini A RA; Boland, Patrick M PM; Crysler, Oxana V OV; Wu, Christina C; Nixon, Andrew B AB; Bolch, Emily E; Niedzwiecki, Donna D; Elsing, Alicia A; Hurwitz, Herbert I HI; Fakih, Marwan G MG; Bekaii-Saab, Tanios T
Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response.
Nature Cancer
Poillet-Perez, Laura L; Sharp, Daniel W DW; Yang, Yang Y; Laddha, Saurabh V SV; Ibrahim, Maria M; Bommareddy, Praveen K PK; Sherrie Hu, Zhixian Z; Vieth, Joshua J; Haas, Michael M; Bosenberg, Marcus W MW; Rabinowitz, Joshua D JD; Cao, Jian J; Guan, Jun-Lin JL; Ganesan, Shridar S; Chan, Chang S CS; Mehnert, Janice M JM; Lattime, Edmund C EC; White, Eileen E
Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression.
Cancers
Proctor, Martina M; Gonzalez Cruz, Jazmina L JL; Daignault-Mill, Sheena M SM; Veitch, Margaret M; Zeng, Bijun B; Ehmann, Anna A; Sabdia, Muhammed M; Snell, Cameron C; Keane, Colm C; Dolcetti, Riccardo R; Haass, Nikolas K NK; Wells, James W JW; Gabrielli, Brian B
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.
Cell
Giampazolias, Evangelos E; Schulz, Oliver O; Lim, Kok Haw Jonathan KHJ; Rogers, Neil C NC; Chakravarty, Probir P; Srinivasan, Naren N; Gordon, Oliver O; Cardoso, Ana A; Buck, Michael D MD; Poirier, Enzo Z EZ; Canton, Johnathan J; Zelenay, Santiago S; Sammicheli, Stefano S; Moncaut, Natalia N; Varsani-Brown, Sunita S; Rosewell, Ian I; Reis E Sousa, Caetano C
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.
Cell
Giampazolias, Evangelos E; Schulz, Oliver O; Lim, Kok Haw Jonathan KHJ; Rogers, Neil C NC; Chakravarty, Probir P; Srinivasan, Naren N; Gordon, Oliver O; Cardoso, Ana A; Buck, Michael D MD; Poirier, Enzo Z EZ; Canton, Johnathan J; Zelenay, Santiago S; Sammicheli, Stefano S; Moncaut, Natalia N; Varsani-Brown, Sunita S; Rosewell, Ian I; Reis e Sousa, Caetano C
Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model.
Cancers
Qin, Shuyang S SS; Han, Booyeon J BJ; Williams, Alyssa A; Jackson, Katherine M KM; Jewell, Rachel R; Chacon, Alexander C AC; Lord, Edith M EM; Linehan, David C DC; Kim, Minsoo M; Reuben, Alexandre A; Gerber, Scott A SA; Prieto, Peter A PA
COX2 regulates senescence secretome composition and senescence surveillance through PGE2.
Cell Reports
Gonçalves, Susana S; Yin, Kelvin K; Ito, Yoko Y; Chan, Adelyne A; Olan, Ioana I; Gough, Sarah S; Cassidy, Liam L; Serrao, Eva E; Smith, Stephen S; Young, Andrew A; Narita, Masashi M; Hoare, Matthew M
Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.
Immunity
Bonavita, Eduardo E; Bromley, Christian P CP; Jonsson, Gustav G; Pelly, Victoria S VS; Sahoo, Sudhakar S; Walwyn-Brown, Katherine K; Mensurado, Sofia S; Moeini, Agrin A; Flanagan, Eimear E; Bell, Charlotte R CR; Chiang, Shih-Chieh SC; Chikkanna-Gowda, C P CP; Rogers, Neil N; Silva-Santos, Bruno B; Jaillon, Sebastien S; Mantovani, Alberto A; Reis e Sousa, Caetano C; Guerra, Nadia N; Davis, Daniel M DM; Zelenay, Santiago S
Activation of CD8+ T Cells Contributes to Antitumor Effects of CDK4/6 Inhibitors plus MEK Inhibitors.
Cancer Immunology Research
Teh, Jessica L F JLF; Erkes, Dan A DA; Cheng, Phil F PF; Tiago, Manoela M; Wilski, Nicole A NA; Field, Conroy O CO; Chervoneva, Inna I; Levesque, Mitch P MP; Xu, Xiaowei X; Dummer, Reinhard R; Aplin, Andrew E AE
Loss of testosterone impairs anti-tumor neutrophil function.
Nature Communications
Markman, Janet L JL; Porritt, Rebecca A RA; Wakita, Daiko D; Lane, Malcolm E ME; Martinon, Daisy D; Noval Rivas, Magali M; Luu, Michael M; Posadas, Edwin M EM; Crother, Timothy R TR; Arditi, Moshe M
Long-Term Programming of CD8 T Cell Immunity by Perinatal Exposure to Glucocorticoids.
Cell
Hong, Jun Young JY; Lim, Jaechul J; Carvalho, Fernando F; Cho, Jen Young JY; Vaidyanathan, Bharat B; Yu, Shuang S; Annicelli, Charles C; Ip, W K Eddie WKE; Medzhitov, Ruslan R
Siah2 control of T-regulatory cells limits anti-tumor immunity.
Nature Communications
Scortegagna, Marzia M; Hockemeyer, Kathryn K; Dolgalev, Igor I; Poźniak, Joanna J; Rambow, Florian F; Li, Yan Y; Feng, Yongmei Y; Tinoco, Roberto R; Otero, Dennis C DC; Zhang, Tongwu T; Brown, Kevin K; Bosenberg, Marcus M; Bradley, Linda M LM; Marine, Jean-Christophe JC; Aifantis, Ioannis I; Ronai, Ze'ev A ZA
LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects.
Cell Stress
Liao, Hsin-Wei HW; Garris, Christopher C; Pfirschke, Christina C; Rickelt, Steffen S; Arlauckas, Sean S; Siwicki, Marie M; Kohler, Rainer H RH; Weissleder, Ralph R; Sundvold-Gjerstad, Vibeke V; Sveinbjørnsson, Baldur B; Rekdal, Øystein Ø; Pittet, Mikael J MJ
Immunization With the CSF-470 Vaccine Plus BCG and rhGM-CSF Induced in a Cutaneous Melanoma Patient a TCRβ Repertoire Found at Vaccination Site and Tumor Infiltrating Lymphocytes That Persisted in Blood.
Frontiers In Immunology
Aris, Mariana M; Bravo, Alicia Inés AI; Garcia Alvarez, Heli Magalí HM; Carri, Ibel I; Podaza, Enrique E; Blanco, Paula Alejandra PA; Rotondaro, Cecilia C; Bentivegna, Sofia S; Nielsen, Morten M; Barrio, María Marcela MM; Mordoh, José J
The Minimal Residual Disease in Non-Hodgkin's Lymphomas: From the Laboratory to the Clinical Practice.
Frontiers In Oncology
Galimberti, Sara S; Genuardi, Elisa E; Mazziotta, Francesco F; Iovino, Lorenzo L; Morabito, Fortunato F; Grassi, Susanna S; Ciabatti, Elena E; Guerrini, Francesca F; Petrini, Mario M
Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy.
Immunity
Chow, Melvyn T MT; Ozga, Aleksandra J AJ; Servis, Rachel L RL; Frederick, Dennie T DT; Lo, Jennifer A JA; Fisher, David E DE; Freeman, Gordon J GJ; Boland, Genevieve M GM; Luster, Andrew D AD
Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy.
Nature
Di Pilato, Mauro M; Kim, Edward Y EY; Cadilha, Bruno L BL; Prüßmann, Jasper N JN; Nasrallah, Mazen N MN; Seruggia, Davide D; Usmani, Shariq M SM; Misale, Sandra S; Zappulli, Valentina V; Carrizosa, Esteban E; Mani, Vinidhra V; Ligorio, Matteo M; Warner, Ross D RD; Medoff, Benjamin D BD; Marangoni, Francesco F; Villani, Alexandra-Chloe AC; Mempel, Thorsten R TR
Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice.
Nature Communications
Li, Yan Y; Tinoco, Roberto R; Elmén, Lisa L; Segota, Igor I; Xian, Yibo Y; Fujita, Yu Y; Sahu, Avinash A; Zarecki, Raphy R; Marie, Kerrie K; Feng, Yongmei Y; Khateb, Ali A; Frederick, Dennie T DT; Ashkenazi, Shiri K SK; Kim, Hyungsoo H; Perez, Eva Guijarro EG; Day, Chi-Ping CP; Segura Muñoz, Rafael S RS; Schmaltz, Robert R; Yooseph, Shibu S; Tam, Miguel A MA; Zhang, Tongwu T; Avitan-Hersh, Emily E; Tzur, Lihi L; Roizman, Shoshana S; Boyango, Ilanit I; Bar-Sela, Gil G; Orian, Amir A; Kaufman, Randal J RJ; Bosenberg, Marcus M; Goding, Colin R CR; Baaten, Bas B; Levesque, Mitchell P MP; Dummer, Reinhard R; Brown, Kevin K; Merlino, Glenn G; Ruppin, Eytan E; Flaherty, Keith K; Ramer-Tait, Amanda A; Long, Tao T; Peterson, Scott N SN; Bradley, Linda M LM; Ronai, Ze'ev A ZA
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade.
Nature Immunology
Miller, Brian C BC; Sen, Debattama R DR; Al Abosy, Rose R; Bi, Kevin K; Virkud, Yamini V YV; LaFleur, Martin W MW; Yates, Kathleen B KB; Lako, Ana A; Felt, Kristen K; Naik, Girish S GS; Manos, Michael M; Gjini, Evisa E; Kuchroo, Juhi R JR; Ishizuka, Jeffrey J JJ; Collier, Jenna L JL; Griffin, Gabriel K GK; Maleri, Seth S; Comstock, Dawn E DE; Weiss, Sarah A SA; Brown, Flavian D FD; Panda, Arpit A; Zimmer, Margaret D MD; Manguso, Robert T RT; Hodi, F Stephen FS; Rodig, Scott J SJ; Sharpe, Arlene H AH; Haining, W Nicholas WN
Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy.
Nature Communications
Rosato, Pamela C PC; Wijeyesinghe, Sathi S; Stolley, J Michael JM; Nelson, Christine E CE; Davis, Rachel L RL; Manlove, Luke S LS; Pennell, Christopher A CA; Blazar, Bruce R BR; Chen, Clark C CC; Geller, Melissa A MA; Vezys, Vaiva V; Masopust, David D
IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin.
The Journal Of Experimental Medicine
Lane, Ryan S RS; Femel, Julia J; Breazeale, Alec P AP; Loo, Christopher P CP; Thibault, Guillaume G; Kaempf, Andy A; Mori, Motomi M; Tsujikawa, Takahiro T; Chang, Young Hwan YH; Lund, Amanda W AW
Loss of CXCR4 in Myeloid Cells Enhances Antitumor Immunity and Reduces Melanoma Growth through NK Cell and FASL Mechanisms.
Cancer Immunology Research
Yang, Jinming J; Kumar, Amrendra A; Vilgelm, Anna E AE; Chen, Sheau-Chiann SC; Ayers, Gregory D GD; Novitskiy, Sergey V SV; Joyce, Sebastian S; Richmond, Ann A
Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity.
The Journal Of Experimental Medicine
Perry, Curtis J CJ; Muñoz-Rojas, Andrés R AR; Meeth, Katrina M KM; Kellman, Laura N LN; Amezquita, Robert A RA; Thakral, Durga D; Du, Victor Y VY; Wang, Jake Xiao JX; Damsky, William W; Kuhlmann, Alexandra L AL; Sher, Joel W JW; Bosenberg, Marcus M; Miller-Jensen, Kathryn K; Kaech, Susan M SM
Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain.
Nature Communications
Singh, Manisha M; Vianden, Christina C; Cantwell, Mark J MJ; Dai, Zhimin Z; Xiao, Zhilan Z; Sharma, Meenu M; Khong, Hiep H; Jaiswal, Ashvin R AR; Faak, Faisal F; Hailemichael, Yared Y; Janssen, L M E LME; Bharadwaj, Uddalak U; Curran, Michael A MA; Diab, Adi A; Bassett, Roland L RL; Tweardy, David J DJ; Hwu, Patrick P; Overwijk, Willem W WW
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.
Nature
Manguso, Robert T RT; Pope, Hans W HW; Zimmer, Margaret D MD; Brown, Flavian D FD; Yates, Kathleen B KB; Miller, Brian C BC; Collins, Natalie B NB; Bi, Kevin K; LaFleur, Martin W MW; Juneja, Vikram R VR; Weiss, Sarah A SA; Lo, Jennifer J; Fisher, David E DE; Miao, Diana D; Van Allen, Eliezer E; Root, David E DE; Sharpe, Arlene H AH; Doench, John G JG; Haining, W Nicholas WN
STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Demaria, Olivier O; De Gassart, Aude A; Coso, Sanja S; Gestermann, Nicolas N; Di Domizio, Jeremy J; Flatz, Lukas L; Gaide, Olivier O; Michielin, Olivier O; Hwu, Patrick P; Petrova, Tatiana V TV; Martinon, Fabio F; Modlin, Robert L RL; Speiser, Daniel E DE; Gilliet, Michel M
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.
Cell
Zelenay, Santiago S; van der Veen, Annemarthe G AG; Böttcher, Jan P JP; Snelgrove, Kathryn J KJ; Rogers, Neil N; Acton, Sophie E SE; Chakravarty, Probir P; Girotti, Maria Romina MR; Marais, Richard R; Quezada, Sergio A SA; Sahai, Erik E; Reis e Sousa, Caetano C
Genetic vaccines to potentiate the effective CD103+ dendritic cell-mediated cross-priming of antitumor immunity.
Journal Of Immunology (Baltimore, Md. : 1950)
Zhang, Yi Y; Chen, Guo G; Liu, Zuqiang Z; Tian, Shenghe S; Zhang, Jiying J; Carey, Cara D CD; Murphy, Kenneth M KM; Storkus, Walter J WJ; Falo, Louis D LD; You, Zhaoyang Z
Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency.
Oncoimmunology
Zhang, Yi Y; Tian, Shenghe S; Liu, Zuqiang Z; Zhang, Jiying J; Zhang, Meili M; Bosenberg, Marcus W MW; Kedl, Ross M RM; Waldmann, Thomas A TA; Storkus, Walter J WJ; Falo, Louis D LD; You, Zhaoyang Z
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Immunity
Woo, Seng-Ryong SR; Fuertes, Mercedes B MB; Corrales, Leticia L; Spranger, Stefani S; Furdyna, Michael J MJ; Leung, Michael Y K MY; Duggan, Ryan R; Wang, Ying Y; Barber, Glen N GN; Fitzgerald, Katherine A KA; Alegre, Maria-Luisa ML; Gajewski, Thomas F TF
Effective innate and adaptive antimelanoma immunity through localized TLR7/8 activation.
Journal Of Immunology (Baltimore, Md. : 1950)
Singh, Manisha M; Khong, Hiep H; Dai, Zhimin Z; Huang, Xue-Fei XF; Wargo, Jennifer A JA; Cooper, Zachary A ZA; Vasilakos, John P JP; Hwu, Patrick P; Overwijk, Willem W WW