Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer.
Cancer Epidemiology
Yang, Baiyu B; Thrift, Aaron P AP; Figueiredo, Jane C JC; Jenkins, Mark A MA; Schumacher, Fredrick R FR; Conti, David V DV; Lin, Yi Y; Win, Aung Ko AK; Limburg, Paul J PJ; Berndt, Sonja I SI; Brenner, Hermann H; Chan, Andrew T AT; Chang-Claude, Jenny J; Hoffmeister, Michael M; Hudson, Thomas J TJ; Marchand, Loïc Le LL; Newcomb, Polly A PA; Slattery, Martha L ML; White, Emily E; Peters, Ulrike U; Casey, Graham G; Campbell, Peter T PT
Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index.
Frontiers In Genetics
Cronin, Robert M RM; Field, Julie R JR; Bradford, Yuki Y; Shaffer, Christian M CM; Carroll, Robert J RJ; Mosley, Jonathan D JD; Bastarache, Lisa L; Edwards, Todd L TL; Hebbring, Scott J SJ; Lin, Simon S; Hindorff, Lucia A LA; Crane, Paul K PK; Pendergrass, Sarah A SA; Ritchie, Marylyn D MD; Crawford, Dana C DC; Pathak, Jyotishman J; Bielinski, Suzette J SJ; Carrell, David S DS; Crosslin, David R DR; Ledbetter, David H DH; Carey, David J DJ; Tromp, Gerard G; Williams, Marc S MS; Larson, Eric B EB; Jarvik, Gail P GP; Peissig, Peggy L PL; Brilliant, Murray H MH; McCarty, Catherine A CA; Chute, Christopher G CG; Kullo, Iftikhar J IJ; Bottinger, Erwin E; Chisholm, Rex R; Smith, Maureen E ME; Roden, Dan M DM; Denny, Joshua C JC
Low copy number of the salivary amylase gene predisposes to obesity.
Nature Genetics
Falchi, Mario M; El-Sayed Moustafa, Julia Sarah JS; Takousis, Petros P; Pesce, Francesco F; Bonnefond, Amélie A; Andersson-Assarsson, Johanna C JC; Sudmant, Peter H PH; Dorajoo, Rajkumar R; Al-Shafai, Mashael Nedham MN; Bottolo, Leonardo L; Ozdemir, Erdal E; So, Hon-Cheong HC; Davies, Robert W RW; Patrice, Alexandre A; Dent, Robert R; Mangino, Massimo M; Hysi, Pirro G PG; Dechaume, Aurélie A; Huyvaert, Marlène M; Skinner, Jane J; Pigeyre, Marie M; Caiazzo, Robert R; Raverdy, Violeta V; Vaillant, Emmanuel E; Field, Sarah S; Balkau, Beverley B; Marre, Michel M; Visvikis-Siest, Sophie S; Weill, Jacques J; Poulain-Godefroy, Odile O; Jacobson, Peter P; Sjostrom, Lars L; Hammond, Christopher J CJ; Deloukas, Panos P; Sham, Pak Chung PC; McPherson, Ruth R; Lee, Jeannette J; Tai, E Shyong ES; Sladek, Robert R; Carlsson, Lena M S LM; Walley, Andrew A; Eichler, Evan E EE; Pattou, Francois F; Spector, Timothy D TD; Froguel, Philippe P
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.
Plos Genetics
Avery, Christy L CL; He, Qianchuan Q; North, Kari E KE; Ambite, Jose L JL; Boerwinkle, Eric E; Fornage, Myriam M; Hindorff, Lucia A LA; Kooperberg, Charles C; Meigs, James B JB; Pankow, James S JS; Pendergrass, Sarah A SA; Psaty, Bruce M BM; Ritchie, Marylyn D MD; Rotter, Jerome I JI; Taylor, Kent D KD; Wilkens, Lynne R LR; Heiss, Gerardo G; Lin, Dan Yu DY
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.
Plos Genetics
Scuteri, Angelo A; Sanna, Serena S; Chen, Wei-Min WM; Uda, Manuela M; Albai, Giuseppe G; Strait, James J; Najjar, Samer S; Nagaraja, Ramaiah R; Orrú, Marco M; Usala, Gianluca G; Dei, Mariano M; Lai, Sandra S; Maschio, Andrea A; Busonero, Fabio F; Mulas, Antonella A; Ehret, Georg B GB; Fink, Ashley A AA; Weder, Alan B AB; Cooper, Richard S RS; Galan, Pilar P; Chakravarti, Aravinda A; Schlessinger, David D; Cao, Antonio A; Lakatta, Edward E; Abecasis, Gonçalo R GR