Publications:

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FTO Inhibits Epithelial Ovarian Cancer Progression by Destabilising SNAI1 mRNA through IGF2BP2.

Cancers

Sun, Meige M; Zhang, Xiaocui X; Bi, Fangfang F; Wang, Dandan D; Zhou, Xin X; Li, Xiao X; Yang, Qing Q

Publication Date: 2022-10-25

Variant appearance in text: FTO: D233A

PubMed Link: 36358640

Variant Present in the following documents:

• Main text
• cancers-14-05218.pdf

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Mutant NPM1-Regulated FTO-Mediated m6A Demethylation Promotes Leukemic Cell Survival via PDGFRB/ERK Signaling Axis.

Frontiers In Oncology

Xiao, Qiaoling Q; Lei, Li L; Ren, Jun J; Peng, Meixi M; Jing, Yipei Y; Jiang, Xueke X; Huang, Junpeng J; Tao, Yonghong Y; Lin, Can C; Yang, Jing J; Sun, Minghui M; Tang, Lisha L; Wei, Xingyu X; Yang, Zailin Z; Zhang, Ling L

Publication Date: 2022

Variant appearance in text: FTO: D233A

PubMed Link: 35211409

Variant Present in the following documents:

• Main text
• fonc-12-817584.pdf

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FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner.

Journal Of Experimental & Clinical Cancer Research : Cr

Huang, Jiapeng J; Sun, Wei W; Wang, Zhihong Z; Lv, Chengzhou C; Zhang, Ting T; Zhang, Dalin D; Dong, Wenwu W; Shao, Liang L; He, Liang L; Ji, Xiaoyu X; Zhang, Ping P; Zhang, Hao H

Publication Date: 2022-01-28

Variant appearance in text: FTO: D233A

PubMed Link: 35090515

Variant Present in the following documents:

• Main text
• 13046_2022_Article_2254.pdf

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FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner.

Journal Of Experimental & Clinical Cancer Research : Cr

Huang, Jiapeng J; Sun, Wei W; Wang, Zhihong Z; Lv, Chengzhou C; Zhang, Ting T; Zhang, Dalin D; Dong, Wenwu W; Shao, Liang L; He, Liang L; Ji, Xiaoyu X; Zhang, Ping P; Zhang, Hao H

Publication Date: 2022-01-28

Variant appearance in text: FTO: D233A

PubMed Link: 35090515

Variant Present in the following documents:

• Main text
• 13046_2022_Article_2254.pdf

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Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice.

Nature Communications

Liu, Shu S; Xiu, Jianbo J; Zhu, Caiyun C; Meng, Kexin K; Li, Chen C; Han, Rongrong R; Du, Tingfu T; Li, Lanlan L; Xu, Lingdan L; Liu, Renjie R; Zhu, Wanwan W; Shen, Yan Y; Xu, Qi Q

Publication Date: 2021-11-26

Variant appearance in text: FTO: D233A

PubMed Link: 34836959

Variant Present in the following documents:

• Main text
• 41467_2021_Article_27044.pdf

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Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice.

Nature Communications

Liu, Shu S; Xiu, Jianbo J; Zhu, Caiyun C; Meng, Kexin K; Li, Chen C; Han, Rongrong R; Du, Tingfu T; Li, Lanlan L; Xu, Lingdan L; Liu, Renjie R; Zhu, Wanwan W; Shen, Yan Y; Xu, Qi Q

Publication Date: 2021-11-26

Variant appearance in text: FTO: D233A

PubMed Link: 34836959

Variant Present in the following documents:

• Main text
• 41467_2021_Article_27044.pdf

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m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling.

Molecular Therapy. Nucleic Acids

Zeng, Juan J; Zhang, Heying H; Tan, Yonggang Y; Wang, Zhe Z; Li, Yunwei Y; Yang, Xianghong X

Publication Date: 2021-09-03

Variant appearance in text: FTO: D233A

PubMed Link: 34484859

Variant Present in the following documents:

• main.pdf
• mmc2.pdf

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FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.

Oncogene

Ruan, Dan-Yun DY; Li, Ting T; Wang, Ying-Nan YN; Meng, Qi Q; Li, Yang Y; Yu, Kai K; Wang, Min M; Lin, Jin-Fei JF; Luo, Li-Zhi LZ; Wang, De-Shen DS; Lin, Jun-Zhong JZ; Bai, Long L; Liu, Ze-Xian ZX; Zhao, Qi Q; Wu, Xiang-Yuan XY; Ju, Huai-Qiang HQ; Xu, Rui-Hua RH

Publication Date: 2021-08

Variant appearance in text: FTO: D233A

PubMed Link: 34218271

Variant Present in the following documents:

• 41388_2021_Article_1916.pdf

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FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.

Oncogene

Ruan, Dan-Yun DY; Li, Ting T; Wang, Ying-Nan YN; Meng, Qi Q; Li, Yang Y; Yu, Kai K; Wang, Min M; Lin, Jin-Fei JF; Luo, Li-Zhi LZ; Wang, De-Shen DS; Lin, Jun-Zhong JZ; Bai, Long L; Liu, Ze-Xian ZX; Zhao, Qi Q; Wu, Xiang-Yuan XY; Ju, Huai-Qiang HQ; Xu, Rui-Hua RH

Publication Date: 2021-08

Variant appearance in text: FTO: D233A

PubMed Link: 34218271

Variant Present in the following documents:

• 41388_2021_Article_1916.pdf

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Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.

Frontiers In Cardiovascular Medicine

Ma, Dong D; Liu, Xiao X; Zhang, Jin-Jin JJ; Zhao, Jun-Jian JJ; Xiong, Yan-Jie YJ; Chang, Quan Q; Wang, Hong-Yan HY; Su, Peng P; Meng, Jia J; Zhao, Yong-Bo YB

Publication Date: 2020

Variant appearance in text: FTO: D233A

PubMed Link: 33330653

Variant Present in the following documents:

• Main text
• fcvm-07-592550.pdf

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Correction to: The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells.

Cancer Cell International

Zou, Dongling D; Dong, Lei L; Li, Chenying C; Yin, Zhe Z; Rao, Shuan S; Zhou, Qi Q

Publication Date: 2020

Variant appearance in text: FTO: D233A

PubMed Link: 32884446

Variant Present in the following documents:

• 12935_2020_Article_1473.pdf

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The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Xiao, Yiren Y; Thakkar, Kaushik N KN; Zhao, Hongjuan H; Broughton, James J; Li, Yang Y; Seoane, Jose A JA; Diep, Anh N AN; Metzner, Thomas J TJ; von Eyben, Rie R; Dill, David L DL; Brooks, James D JD; Curtis, Christina C; Leppert, John T JT; Ye, Jiangbin J; Peehl, Donna M DM; Giaccia, Amato J AJ; Sinha, Subarna S; Rankin, Erinn B EB

Publication Date: 2020-09-01

Variant appearance in text: FTO: D233A

PubMed Link: 32817424

Variant Present in the following documents:

• Main text

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The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells.

Cancer Cell International

Zou, Dongling D; Dong, Lei L; Li, Chenying C; Yin, Zhe Z; Rao, Shuan S; Zhou, Qi Q

Publication Date: 2019

Variant appearance in text: FTO: D233A

PubMed Link: 31827395

Variant Present in the following documents:

• Main text
• 12935_2019_Article_1045.pdf

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Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates.

Nature Chemical Biology

Liu, Xiao-Min XM; Zhou, Jun J; Mao, Yuanhui Y; Ji, Quanquan Q; Qian, Shu-Bing SB

Publication Date: 2019-09

Variant appearance in text: FTO: D233A

PubMed Link: 31383972

Variant Present in the following documents:

• Main text
• nihms-1532702.pdf

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N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1α signalling axis.

Journal Of Cellular And Molecular Medicine

Zhuang, Changshui C; Zhuang, Chengle C; Luo, Xiaomin X; Huang, Xinbo X; Yao, Lv L; Li, Jianfa J; Li, Yawen Y; Xiong, Tiefu T; Ye, Jing J; Zhang, Fangting F; Gui, Yaoting Y

Publication Date: 2019-03

Variant appearance in text: FTO: D233A

PubMed Link: 30648791

Variant Present in the following documents:

• Main text
• JCMM-23-2163.pdf

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N6-methyladenine RNA modification and cancers.

American Journal Of Cancer Research

Wu, Xia X; Sang, Lina L; Gong, Yuping Y

Publication Date: 2018

Variant appearance in text: FTO: D233A

PubMed Link: 30416848

Variant Present in the following documents:

• Main text

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N6-methyladenosine links RNA metabolism to cancer progression.

Cell Death & Disease

Dai, Dongjun D; Wang, Hanying H; Zhu, Liyuan L; Jin, Hongchuan H; Wang, Xian X

Publication Date: 2018-01-26

Variant appearance in text: FTO: D233A

PubMed Link: 29374143

Variant Present in the following documents:

• Main text
• 41419_2017_Article_129.pdf

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R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.

Cell

Su, Rui R; Dong, Lei L; Li, Chenying C; Nachtergaele, Sigrid S; Wunderlich, Mark M; Qing, Ying Y; Deng, Xiaolan X; Wang, Yungui Y; Weng, Xiaocheng X; Hu, Chao C; Yu, Mengxia M; Skibbe, Jennifer J; Dai, Qing Q; Zou, Dongling D; Wu, Tong T; Yu, Kangkang K; Weng, Hengyou H; Huang, Huilin H; Ferchen, Kyle K; Qin, Xi X; Zhang, Bin B; Qi, Jun J; Sasaki, Atsuo T AT; Plas, David R DR; Bradner, James E JE; Wei, Minjie M; Marcucci, Guido G; Jiang, Xi X; Mulloy, James C JC; Jin, Jie J; He, Chuan C; Chen, Jianjun J

Publication Date: 2018-01-11

Variant appearance in text: FTO: D233A

PubMed Link: 29249359

Variant Present in the following documents:

• Main text

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N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing.

Nucleic Acids Research

Bartosovic, Marek M; Molares, Helena Covelo HC; Gregorova, Pavlina P; Hrossova, Dominika D; Kudla, Grzegorz G; Vanacova, Stepanka S

Publication Date: 2017-11-02

Variant appearance in text: FTO: D233A

PubMed Link: 28977517

Variant Present in the following documents:

• Main text
• gkx778.pdf

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FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.

Cancer Cell

Li, Zejuan Z; Weng, Hengyou H; Su, Rui R; Weng, Xiaocheng X; Zuo, Zhixiang Z; Li, Chenying C; Huang, Huilin H; Nachtergaele, Sigrid S; Dong, Lei L; Hu, Chao C; Qin, Xi X; Tang, Lichun L; Wang, Yungui Y; Hong, Gia-Ming GM; Huang, Hao H; Wang, Xiao X; Chen, Ping P; Gurbuxani, Sandeep S; Arnovitz, Stephen S; Li, Yuanyuan Y; Li, Shenglai S; Strong, Jennifer J; Neilly, Mary Beth MB; Larson, Richard A RA; Jiang, Xi X; Zhang, Pumin P; Jin, Jie J; He, Chuan C; Chen, Jianjun J

Publication Date: 2017-01-09

Variant appearance in text: FTO: D233A

PubMed Link: 28017614

Variant Present in the following documents:

• Main text

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NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation.

The Embo Journal

Haag, Sara S; Sloan, Katherine E KE; Ranjan, Namit N; Warda, Ahmed S AS; Kretschmer, Jens J; Blessing, Charlotte C; Hübner, Benedikt B; Seikowski, Jan J; Dennerlein, Sven S; Rehling, Peter P; Rodnina, Marina V MV; Höbartner, Claudia C; Bohnsack, Markus T MT

Publication Date: 2016-10-04

Variant appearance in text: FTO: D233A

PubMed Link: 27497299

Variant Present in the following documents:

• Main text
• EMBJ-35-2104.pdf

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Fat mass and obesity-associated (FTO) protein interacts with CaMKII and modulates the activity of CREB signaling pathway.

Human Molecular Genetics

Lin, Li L; Hales, Chadwick M CM; Garber, Kathryn K; Jin, Peng P

Publication Date: 2014-06-15

Variant appearance in text: FTO: D233A

PubMed Link: 24488767

Variant Present in the following documents:

• Main text

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Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites.

Dna Repair

Müller, Tina A TA; Meek, Katheryn K; Hausinger, Robert P RP

Publication Date: 2010-01-02

Variant appearance in text: FTO: D233A

PubMed Link: 19959401

Variant Present in the following documents:

• Main text

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