Publications:

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FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences.

Food Technology And Biotechnology

Popović, Ana-Marija AM; Huđek Turković, Ana A; Žuna, Kristina K; Bačun-Družina, Višnja V; Rubelj, Ivica I; Matovinović, Martina M

Publication Date: 2023-03

Variant appearance in text: FTO: R316Q

PubMed Link: 37200795

Variant Present in the following documents:

• Main text
• FTB-61-14.pdf

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In silico profiling of nonsynonymous SNPs of fat mass and obesity-associated gene: possible impacts on the treatment of non-alcoholic fatty liver disease.

Lipids In Health And Disease

Patnaik, Damini D; Jena, Atala Bihari AB; Kerry, Rout George RG; Duttaroy, Asim K AK

Publication Date: 2023-01-30

Variant appearance in text: FTO: R316Q; rs121918214

PubMed Link: 36717943

Variant Present in the following documents:

• Main text
• 12944_2023_Article_1782.pdf

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Down-regulated m6A reader FTO destabilizes PHF1 that triggers enhanced stemness capacity and tumor progression in lung adenocarcinoma.

Cell Death Discovery

Ning, Jinfeng J; Wang, Fengjiao F; Bu, Jianlong J; Zhu, Kaibin K; Liu, Wei W

Publication Date: 2022-08-09

Variant appearance in text: FTO: R316Q

PubMed Link: 35945194

Variant Present in the following documents:

• Main text
• 41420_2022_Article_1125.pdf

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Comprehensive mutations analyses of FTO (fat mass and obesity-associated gene) and their effects on FTO's substrate binding implicated in obesity.

Frontiers In Nutrition

Kumar, Rakesh R; Ningombam, Somorjit Singh SS; Kumar, Rahul R; Goel, Harsh H; Gogia, Ajay A; Khurana, Sachin S; Deo, S V S SVS; Mathur, Sandeep S; Tanwar, Pranay P

Publication Date: 2022

Variant appearance in text: FTO: R316Q

PubMed Link: 35923209

Variant Present in the following documents:

• Main text
• fnut-09-852944.pdf

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Analysis of coding variants in the human FTO gene from the gnomAD database.

Plos One

Souza Junior, Mauro Lúcio Ferreira MLF; de Sousa, Jaime Viana JV; Guerreiro, João Farias JF

Publication Date: 2022

Variant appearance in text: FTO: Arg316Gln

PubMed Link: 34990463

Variant Present in the following documents:

• Main text
• pone.0248610.pdf

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Analysis of coding variants in the human FTO gene from the gnomAD database.

Plos One

Souza Junior, Mauro Lúcio Ferreira MLF; de Sousa, Jaime Viana JV; Guerreiro, João Farias JF

Publication Date: 2022

Variant appearance in text: FTO: Arg316Gln

PubMed Link: 34990463

Variant Present in the following documents:

• Main text
• pone.0248610.pdf

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The RNA N6-Methyladenosine Demethylase FTO Promotes Head and Neck Squamous Cell Carcinoma Proliferation and Migration by Increasing CTNNB1.

International Journal Of General Medicine

Zhang, Yu Y; Chen, Lixiao L; Wu, Xiaoliang X; Sun, Zhenfeng Z; Wang, Fei F; Wang, Baoxin B; Dong, Pin P

Publication Date: 2021

Variant appearance in text: FTO: R316Q

PubMed Link: 34853532

Variant Present in the following documents:

• Main text
• ijgm-14-8785.pdf

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The detection and functions of RNA modification m6A based on m6A writers and erasers.

The Journal Of Biological Chemistry

Zhang, Wei W; Qian, Yang Y; Jia, Guifang G

Publication Date: 2021-08

Variant appearance in text: FTO: R316Q

PubMed Link: 34280435

Variant Present in the following documents:

• Main text
• main.pdf

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FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.

Oncogene

Ruan, Dan-Yun DY; Li, Ting T; Wang, Ying-Nan YN; Meng, Qi Q; Li, Yang Y; Yu, Kai K; Wang, Min M; Lin, Jin-Fei JF; Luo, Li-Zhi LZ; Wang, De-Shen DS; Lin, Jun-Zhong JZ; Bai, Long L; Liu, Ze-Xian ZX; Zhao, Qi Q; Wu, Xiang-Yuan XY; Ju, Huai-Qiang HQ; Xu, Rui-Hua RH

Publication Date: 2021-08

Variant appearance in text: FTO: R316Q

PubMed Link: 34218271

Variant Present in the following documents:

• Main text
• 41388_2021_Article_1916.pdf

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FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis.

Oncogene

Ruan, Dan-Yun DY; Li, Ting T; Wang, Ying-Nan YN; Meng, Qi Q; Li, Yang Y; Yu, Kai K; Wang, Min M; Lin, Jin-Fei JF; Luo, Li-Zhi LZ; Wang, De-Shen DS; Lin, Jun-Zhong JZ; Bai, Long L; Liu, Ze-Xian ZX; Zhao, Qi Q; Wu, Xiang-Yuan XY; Ju, Huai-Qiang HQ; Xu, Rui-Hua RH

Publication Date: 2021-08

Variant appearance in text: FTO: R316Q

PubMed Link: 34218271

Variant Present in the following documents:

• Main text
• 41388_2021_Article_1916.pdf

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Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.

Nature Communications

Cui, Yan-Hong YH; Yang, Seungwon S; Wei, Jiangbo J; Shea, Christopher R CR; Zhong, Wen W; Wang, Fang F; Shah, Palak P; Kibriya, Muhammad G MG; Cui, Xiaolong X; Ahsan, Habibul H; He, Chuan C; He, Yu-Ying YY

Publication Date: 2021-04-12

Variant appearance in text: FTO: R316Q

PubMed Link: 33846348

Variant Present in the following documents:

• Main text
• 41467_2021_Article_22469.pdf

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Context-Dependent Roles of RNA Modifications in Stress Responses and Diseases.

International Journal Of Molecular Sciences

Wilkinson, Emma E; Cui, Yan-Hong YH; He, Yu-Ying YY

Publication Date: 2021-02-16

Variant appearance in text: FTO: R316Q

PubMed Link: 33669361

Variant Present in the following documents:

• Main text
• ijms-22-01949.pdf

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Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder.

Molecular Psychiatry

Jia, Xiaoming X; Goes, Fernando S FS; Locke, Adam E AE; Palmer, Duncan D; Wang, Weiqing W; Cohen-Woods, Sarah S; Genovese, Giulio G; Jackson, Anne U AU; Jiang, Chen C; Kvale, Mark M; Mullins, Niamh N; Nguyen, Hoang H; Pirooznia, Mehdi M; Rivera, Margarita M; Ruderfer, Douglas M DM; Shen, Ling L; Thai, Khanh K; Zawistowski, Matthew M; Zhuang, Yongwen Y; Abecasis, Gonçalo G; Akil, Huda H; Bergen, Sarah S; Burmeister, Margit M; Chapman, Sinéad S; DelaBastide, Melissa M; Juréus, Anders A; Kang, Hyun Min HM; Kwok, Pui-Yan PY; Li, Jun Z JZ; Levy, Shawn E SE; Monson, Eric T ET; Moran, Jennifer J; Sobell, Janet J; Watson, Stanley S; Willour, Virginia V; Zöllner, Sebastian S; Adolfsson, Rolf R; Blackwood, Douglas D; Boehnke, Michael M; Breen, Gerome G; Corvin, Aiden A; Craddock, Nick N; DiFlorio, Arianna A; Hultman, Christina M CM; Landen, Mikael M; Lewis, Cathryn C; McCarroll, Steven A SA; Richard McCombie, W W; McGuffin, Peter P; McIntosh, Andrew A; McQuillin, Andrew A; Morris, Derek D; Myers, Richard M RM; O'Donovan, Michael M; Ophoff, Roel R; Boks, Marco M; Kahn, Rene R; Ouwehand, Willem W; Owen, Michael M; Pato, Carlos C; Pato, Michele M; Posthuma, Danielle D; Potash, James B JB; Reif, Andreas A; Sklar, Pamela P; Smoller, Jordan J; Sullivan, Patrick F PF; Vincent, John J; Walters, James J; Neale, Benjamin B; Purcell, Shaun S; Risch, Neil N; Schaefer, Catherine C; Stahl, Eli A EA; Zandi, Peter P PP; Scott, Laura J LJ

Publication Date: 2021-09

Variant appearance in text: FTO: R316Q

PubMed Link: 33483695

Variant Present in the following documents:

• 41380_2020_1006_MOESM2_ESM.xlsx, sheet 3

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Roles of HIF and 2-Oxoglutarate-Dependent Dioxygenases in Controlling Gene Expression in Hypoxia.

Cancers

Frost, Julianty J; Frost, Mark M; Batie, Michael M; Jiang, Hao H; Rocha, Sonia S

Publication Date: 2021-01-19

Variant appearance in text: FTO: 947G>A; R316Q

PubMed Link: 33477877

Variant Present in the following documents:

• cancers-13-00350-s001.pdf

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Intracellular and tissue specific expression of FTO protein in pig: changes with age, energy intake and metabolic status.

Scientific Reports

Ferenc, Karolina K; Pilžys, Tomaš T; Garbicz, Damian D; Marcinkowski, Michał M; Skorobogatov, Oleksandr O; Dylewska, Małgorzata M; Gajewski, Zdzisław Z; Grzesiuk, Elżbieta E; Zabielski, Romuald R

Publication Date: 2020-08-03

Variant appearance in text: FTO: R316Q

PubMed Link: 32747736

Variant Present in the following documents:

• Main text
• 41598_2020_Article_69856.pdf

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Posttranscriptional modification of messenger RNAs in eukaryotes.

Molecular Biology

Laptev, I G IG; Golovina, A Ya AY; Sergiev, P V PV; Dontsova, O A OA

Publication Date: 2015

Variant appearance in text: FTO: R316Q

PubMed Link: 32214475

Variant Present in the following documents:

• 11008_2015_Article_6736.pdf

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Optimizing clinical exome design and parallel gene-testing for recessive genetic conditions in preconception carrier screening: Translational research genomic data from 14,125 exomes.

Plos Genetics

Capalbo, Antonio A; Valero, Roberto Alonso RA; Jimenez-Almazan, Jorge J; Pardo, Pere Mir PM; Fabiani, Marco M; Jiménez, David D; Simon, Carlos C; Rodriguez, Julio Martin JM

Publication Date: 2019-10

Variant appearance in text: FTO: 947G>A; rs121918214

PubMed Link: 31589614

Variant Present in the following documents:

• pgen.1008409.s001.xlsx, sheet 1

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m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.

Nature Communications

Yang, Seungwon S; Wei, Jiangbo J; Cui, Yan-Hong YH; Park, Gayoung G; Shah, Palak P; Deng, Yu Y; Aplin, Andrew E AE; Lu, Zhike Z; Hwang, Seungmin S; He, Chuan C; He, Yu-Ying YY

Publication Date: 2019-06-25

Variant appearance in text: FTO: R316Q

PubMed Link: 31239444

Variant Present in the following documents:

• 41467_2019_10669_MOESM1_ESM.pdf

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The Genetic Basis of Metabolic Disease.

Cell

Barroso, Inês I; McCarthy, Mark I MI

Publication Date: 2019-03-21

Variant appearance in text: FTO: R316Q

PubMed Link: 30901536

Variant Present in the following documents:

• Main text

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Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting.

American Journal Of Human Genetics

Wright, Caroline F CF; West, Ben B; Tuke, Marcus M; Jones, Samuel E SE; Patel, Kashyap K; Laver, Thomas W TW; Beaumont, Robin N RN; Tyrrell, Jessica J; Wood, Andrew R AR; Frayling, Timothy M TM; Hattersley, Andrew T AT; Weedon, Michael N MN

Publication Date: 2019-02-07

Variant appearance in text: FTO: R316Q; rs121918214

PubMed Link: 30665703

Variant Present in the following documents:

• mmc3.xlsx, sheet 1

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A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N 6-methyladenosine demethylase activity in cells.

Chemical Science

Cheong, Adeline A; Low, Joanne J A JJA; Lim, Andrea A; Yen, Paul M PM; Woon, Esther C Y ECY

Publication Date: 2018-09-28

Variant appearance in text: FTO: R316Q

PubMed Link: 30288236

Variant Present in the following documents:

• Main text

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m6A RNA modification controls autophagy through upregulating ULK1 protein abundance.

Cell Research

Jin, Shouheng S; Zhang, Xiya X; Miao, Yanyan Y; Liang, Puping P; Zhu, Kaiyu K; She, Yuanchu Y; Wu, Yaoxing Y; Liu, Di-Ao DA; Huang, Junjiu J; Ren, Jian J; Cui, Jun J

Publication Date: 2018-09

Variant appearance in text: FTO: R316Q

PubMed Link: 30046135

Variant Present in the following documents:

• Main text

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Utility and limitations of exome sequencing as a genetic diagnostic tool for children with hearing loss.

Genetics In Medicine : Official Journal Of The American College Of Medical Genetics

Sheppard, Sarah S; Biswas, Sawona S; Li, Mindy H MH; Jayaraman, Vijayakumar V; Slack, Ian I; Romasko, Edward J EJ; Sasson, Ariella A; Brunton, Joshua J; Rajagopalan, Ramakrishnan R; Sarmady, Mahdi M; Abrudan, Jenica L JL; Jairam, Sowmya S; DeChene, Elizabeth T ET; Ying, Xiahoan X; Choi, Jiwon J; Wilkens, Alisha A; Raible, Sarah E SE; Scarano, Maria I MI; Santani, Avni A; Pennington, Jeffrey W JW; Luo, Minjie M; Conlin, Laura K LK; Devkota, Batsal B; Dulik, Matthew C MC; Spinner, Nancy B NB; Krantz, Ian D ID

Publication Date: 2018-12

Variant appearance in text: FTO: 947G>A

PubMed Link: 29907799

Variant Present in the following documents:

• 41436_2018_4_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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FTO demethylase activity is essential for normal bone growth and bone mineralization in mice.

Biochimica Et Biophysica Acta. Molecular Basis Of Disease

Sachse, Gregor G; Church, Chris C; Stewart, Michelle M; Cater, Heather H; Teboul, Lydia L; Cox, Roger D RD; Ashcroft, Frances M FM

Publication Date: 2018-03

Variant appearance in text: FTO: R316Q

PubMed Link: 29203346

Variant Present in the following documents:

• Main text

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Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty.

The Journal Of Clinical Endocrinology And Metabolism

Howard, Sasha R SR; Guasti, Leonardo L; Poliandri, Ariel A; David, Alessia A; Cabrera, Claudia P CP; Barnes, Michael R MR; Wehkalampi, Karoliina K; O'Rahilly, Stephen S; Aiken, Catherine E CE; Coll, Anthony P AP; Ma, Marcella M; Rimmington, Debra D; Yeo, Giles S H GSH; Dunkel, Leo L

Publication Date: 2018-02-01

Variant appearance in text: FTO: R316Q

PubMed Link: 29161441

Variant Present in the following documents:

• Main text

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Exogenous Expressions of FTO Wild-Type and R316Q Mutant Proteins Caused an Increase in HNRPK Levels in 3T3-L1 Cells as Demonstrated by DIGE Analysis.

Biomed Research International

Guzel, Nil N; Kasap, Murat M; Kanli, Aylin A; Akpinar, Gurler G; Gulkac, M Dogan MD; Karaosmanoglu, Kubra K

Publication Date: 2017

Variant appearance in text: FTO: R316Q

PubMed Link: 28555196

Variant Present in the following documents:

• Main text

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Complex Relationship between Obesity and the Fat Mass and Obesity Locus.

International Journal Of Biological Sciences

Yang, Qingyun Q; Xiao, Tiancun T; Guo, Jiao J; Su, Zhengquan Z

Publication Date: 2017

Variant appearance in text: FTO: R316Q

PubMed Link: 28539834

Variant Present in the following documents:

• Main text
• ijbsv13p0615.pdf

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The RNA Modification N6-methyladenosine and Its Implications in Human Disease.

Genomics, Proteomics & Bioinformatics

Batista, Pedro J PJ

Publication Date: 2017-06

Variant appearance in text: FTO: R316Q

PubMed Link: 28533023

Variant Present in the following documents:

• Main text

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A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP.

Journal Of Human Genetics

Çağlayan, Ahmet O AO; Tüysüz, Beyhan B; Coşkun, Süleyman S; Quon, Jennifer J; Harmancı, Akdes S AS; Baranoski, Jacob F JF; Baran, Burçin B; Erson-Omay, E Zeynep EZ; Henegariu, Octavian O; Mane, Shrikant M SM; Bilgüvar, Kaya K; Yasuno, Katsuhito K; Günel, Murat M

Publication Date: 2016-05

Variant appearance in text: FTO: R316Q

PubMed Link: 26740239

Variant Present in the following documents:

• Main text
• nihms742086.pdf

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Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases.

Journal Of Translational Medicine

Melnik, Bodo C BC

Publication Date: 2015-12-21

Variant appearance in text: FTO: R316Q

PubMed Link: 26691922

Variant Present in the following documents:

• Main text

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The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation.

Plos One

Zhang, Meizi M; Zhang, Ying Y; Ma, Jun J; Guo, Feima F; Cao, Qian Q; Zhang, Yu Y; Zhou, Bin B; Chai, Jijie J; Zhao, Wenqing W; Zhao, Renbin R

Publication Date: 2015

Variant appearance in text: FTO: R316Q

PubMed Link: 26218273

Variant Present in the following documents:

• Main text

View BVdb publication page

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: FTO: R316Q

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 1

View BVdb publication page

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FTO influences adipogenesis by regulating mitotic clonal expansion.

Nature Communications

Merkestein, Myrte M; Laber, Samantha S; McMurray, Fiona F; Andrew, Daniel D; Sachse, Gregor G; Sanderson, Jeremy J; Li, Mengdi M; Usher, Samuel S; Sellayah, Dyan D; Ashcroft, Frances M FM; Cox, Roger D RD

Publication Date: 2015-04-17

Variant appearance in text: FTO: R316Q

PubMed Link: 25881961

Variant Present in the following documents:

• Main text

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Pharmacological inhibition of FTO.

Plos One

McMurray, Fiona F; Demetriades, Marina M; Aik, WeiShen W; Merkestein, Myrte M; Kramer, Holger H; Andrew, Daniel S DS; Scudamore, Cheryl L CL; Hough, Tertius A TA; Wells, Sara S; Ashcroft, Frances M FM; McDonough, Michael A MA; Schofield, Christopher J CJ; Cox, Roger D RD

Publication Date: 2015

Variant appearance in text: FTO: R316Q

PubMed Link: 25830347

Variant Present in the following documents:

• Main text

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Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation.

Iucrj

Dong, Cheng C; Zhang, Heng H; Xu, Chao C; Arrowsmith, Cheryl H CH; Min, Jinrong J

Publication Date: 2014-11-01

Variant appearance in text: FTO: R316Q

PubMed Link: 25485134

Variant Present in the following documents:

• Main text
• m-01-00540.pdf

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Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm.

Bioscience Reports

Gulati, Pawan P; Avezov, Edward E; Ma, Marcella M; Antrobus, Robin R; Lehner, Paul P; O'Rahilly, Stephen S; Yeo, Giles S H GS

Publication Date: 2014-10-22

Variant appearance in text: FTO: R316Q

PubMed Link: 25242086

Variant Present in the following documents:

• Main text
• bsr034e144.pdf

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EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.

Frontiers In Genetics

Namjou, Bahram B; Keddache, Mehdi M; Marsolo, Keith K; Wagner, Michael M; Lingren, Todd T; Cobb, Beth B; Perry, Cassandra C; Kennebeck, Stephanie S; Holm, Ingrid A IA; Li, Rongling R; Crimmins, Nancy A NA; Martin, Lisa L; Solti, Imre I; Kohane, Isaac S IS; Harley, John B JB

Publication Date: 2013

Variant appearance in text: FTO: R316Q

PubMed Link: 24348519

Variant Present in the following documents:

• Main text
• fgene-04-00268.pdf

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Is genetic testing of value in predicting and treating obesity?

North Carolina Medical Journal

Ng, Maggie C Y MC; Bowden, Donald W DW

Publication Date: 2013

Variant appearance in text: FTO: Arg316Gln

PubMed Link: 24316784

Variant Present in the following documents:

• Main text

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The bigger picture of FTO: the first GWAS-identified obesity gene.

Nature Reviews. Endocrinology

Loos, Ruth J F RJ; Yeo, Giles S H GS

Publication Date: 2014-01

Variant appearance in text: FTO: R316Q

PubMed Link: 24247219

Variant Present in the following documents:

• Main text

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Uncovering the biology of FTO.

Molecular Metabolism

Yeo, Giles S H GS; O'Rahilly, Stephen S

Publication Date: 2012

Variant appearance in text: FTO: R316Q

PubMed Link: 24024116

Variant Present in the following documents:

• Main text

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The biology of FTO: from nucleic acid demethylase to amino acid sensor.

Diabetologia

Gulati, Pawan P; Yeo, Giles S H GS

Publication Date: 2013-10

Variant appearance in text: FTO: R316Q

PubMed Link: 23896822

Variant Present in the following documents:

• Main text

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Screening for coding variants in FTO and SH2B1 genes in Chinese patients with obesity.

Plos One

Zheng, Zhaojing Z; Hong, Li L; Huang, Xiaodong X; Yang, Peirong P; Li, Juan J; Ding, Yu Y; Yao, Ru-En RE; Geng, Juan J; Shen, Yongnian Y; Shen, Yiping Y; Fu, Qihua Q; Yu, Yongguo Y

Publication Date: 2013

Variant appearance in text: FTO: R316Q

PubMed Link: 23825611

Variant Present in the following documents:

• Main text

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The genetics of human obesity.

Annals Of The New York Academy Of Sciences

Xia, Qianghua Q; Grant, Struan F A SF

Publication Date: 2013-04

Variant appearance in text: FTO: R316Q

PubMed Link: 23360386

Variant Present in the following documents:

• Main text
• nyas1281-0178.pdf

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Role for the obesity-related FTO gene in the cellular sensing of amino acids.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Gulati, Pawan P; Cheung, Man Ka MK; Antrobus, Robin R; Church, Chris D CD; Harding, Heather P HP; Tung, Yi-Chun Loraine YC; Rimmington, Debra D; Ma, Marcella M; Ron, David D; Lehner, Paul J PJ; Ashcroft, Frances M FM; Cox, Roger D RD; Coll, Anthony P AP; O'Rahilly, Stephen S; Yeo, Giles S H GS

Publication Date: 2013-02-12

Variant appearance in text: FTO: R316Q

PubMed Link: 23359686

Variant Present in the following documents:

• Main text

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Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.

Plos Genetics

McMurray, Fiona F; Church, Chris D CD; Larder, Rachel R; Nicholson, George G; Wells, Sara S; Teboul, Lydia L; Tung, Y C Loraine YC; Rimmington, Debra D; Bosch, Fatima F; Jimenez, Veronica V; Yeo, Giles S H GS; O'Rahilly, Stephen S; Ashcroft, Frances M FM; Coll, Anthony P AP; Cox, Roger D RD

Publication Date: 2013

Variant appearance in text: FTO: R316Q

PubMed Link: 23300482

Variant Present in the following documents:

• Main text

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DNA repair by reversal of DNA damage.

Cold Spring Harbor Perspectives In Biology

Yi, Chengqi C; He, Chuan C

Publication Date: 2013-01-01

Variant appearance in text: FTO: Arg316Gln

PubMed Link: 23284047

Variant Present in the following documents:

• Main text

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Reversible RNA adenosine methylation in biological regulation.

Trends In Genetics : Tig

Jia, Guifang G; Fu, Ye Y; He, Chuan C

Publication Date: 2013-02

Variant appearance in text: FTO: R316Q

PubMed Link: 23218460

Variant Present in the following documents:

• Main text

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FTO Biology and Obesity: Why Do a Billion of Us Weigh 3 kg More?

Frontiers In Endocrinology

Cheung, Man-Ka Marcella MK; Yeo, Giles S H GS

Publication Date: 2011

Variant appearance in text: FTO: R316Q

PubMed Link: 22649359

Variant Present in the following documents:

• Main text

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N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

Nature Chemical Biology

Jia, Guifang G; Fu, Ye Y; Zhao, Xu X; Dai, Qing Q; Zheng, Guanqun G; Yang, Ying Y; Yi, Chengqi C; Lindahl, Tomas T; Pan, Tao T; Yang, Yun-Gui YG; He, Chuan C

Publication Date: 2011-10-16

Variant appearance in text: FTO: R316Q

PubMed Link: 22002720

Variant Present in the following documents:

• Main text
• nihms316493.pdf
• NIHMS316493-supplement-1.pdf

View BVdb publication page

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Overexpression of Fto leads to increased food intake and results in obesity.

Nature Genetics

Church, Chris C; Moir, Lee L; McMurray, Fiona F; Girard, Christophe C; Banks, Gareth T GT; Teboul, Lydia L; Wells, Sara S; Brüning, Jens C JC; Nolan, Patrick M PM; Ashcroft, Frances M FM; Cox, Roger D RD

Publication Date: 2010-12

Variant appearance in text: FTO: R316Q

PubMed Link: 21076408

Variant Present in the following documents:

• Main text
• ukmss-32984.pdf

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