A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling.
Cancer Discovery
Romano, Gabriele G; Chen, Pei-Ling PL; Song, Ping P; McQuade, Jennifer L JL; Liang, Roger J RJ; Liu, Mingguang M; Roh, Whijae W; Duose, Dzifa Y DY; Carapeto, Fernando C L FCL; Li, Jun J; Teh, Jessica L F JLF; Aplin, Andrew E AE; Chen, Merry M; Zhang, Jianhua J; Lazar, Alexander J AJ; Davies, Michael A MA; Futreal, P Andrew PA; Amaria, Rodabe N RN; Zhang, David Y DY; Wargo, Jennifer A JA; Kwong, Lawrence N LN