Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects.
Cancer Research
Ishiyama, Noboru N; O'Connor, Matthew M; Salomatov, Andrei A; Romashko, Darlene D; Thakur, Shalabh S; Mentes, Ahmet A; Hopkins, Julia F JF; Frampton, Garrett M GM; Albacker, Lee A LA; Kohlmann, Anna A; Roberts, Christopher C; Buck, Elizabeth E
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
ERBB2/HER2 mutations are transforming and therapeutically targetable in leukemia.
Leukemia
Joshi, Sunil K SK; Keck, Jamie M JM; Eide, Christopher A CA; Bottomly, Daniel D; Traer, Elie E; Tyner, Jeffrey W JW; McWeeney, Shannon K SK; Tognon, Cristina E CE; Druker, Brian J BJ
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Integrative omics analyses broaden treatment targets in human cancer.
Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
A novel, somatic, transforming mutation in the extracellular domain of Epidermal Growth Factor Receptor identified in myeloproliferative neoplasm.
Scientific Reports
Casolari, D A DA; Nguyen, T T; Butcher, C M CM; Iarossi, D G DG; Hahn, C N CN; Bray, S C SC; Neufing, P P; Parker, W T WT; Feng, J J; Maung, K Z Y KZY; Wee, A A; Vidovic, L L; Kok, C H CH; Bardy, P G PG; Branford, S S; Lewis, I D ID; Lane, S W SW; Scott, H S HS; Ross, D M DM; D'Andrea, R J RJ
Longitudinal analysis of treatment-induced genomic alterations in gliomas.
Genome Medicine
Erson-Omay, E Zeynep EZ; Henegariu, Octavian O; Omay, S Bülent SB; Harmancı, Akdes Serin AS; Youngblood, Mark W MW; Mishra-Gorur, Ketu K; Li, Jie J; Özduman, Koray K; Carrión-Grant, Geneive G; Clark, Victoria E VE; Çağlar, Caner C; Bakırcıoğlu, Mehmet M; Pamir, M Necmettin MN; Tabar, Viviane V; Vortmeyer, Alexander O AO; Bilguvar, Kaya K; Yasuno, Katsuhito K; DeAngelis, Lisa M LM; Baehring, Joachim M JM; Moliterno, Jennifer J; Günel, Murat M
HER2 as a target in invasive urothelial carcinoma.
Cancer Medicine
Bellmunt, Joaquim J; Werner, Lillian L; Bamias, Aristotle A; Fay, André P AP; Park, Rachel S RS; Riester, Markus M; Selvarajah, Shamini S; Barletta, Justine A JA; Berman, David M DM; de Muga, Silvia S; Salido, Marta M; Gallardo, Enrique E; Rojo, Federico F; Guancial, Elizabeth A EA; Bambury, Richard R; Mullane, Stephanie A SA; Choueiri, Toni K TK; Loda, Massimo M; Stack, Edward E; Rosenberg, Jonathan J
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib.
Cancer Biology & Therapy
de Martino, Michela M; Zhuang, Dazhong D; Klatte, Tobias T; Rieken, Malte M; Rouprêt, Morgan M; Xylinas, Evanguelos E; Clozel, Thomas T; Krzywinski, Martin M; Elemento, Olivier O; Shariat, Shahrokh F SF
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Greulich, Heidi H; Kaplan, Bethany B; Mertins, Philipp P; Chen, Tzu-Hsiu TH; Tanaka, Kumiko E KE; Yun, Cai-Hong CH; Zhang, Xiaohong X; Lee, Se-Hoon SH; Cho, Jeonghee J; Ambrogio, Lauren L; Liao, Rachel R; Imielinski, Marcin M; Banerji, Shantanu S; Berger, Alice H AH; Lawrence, Michael S MS; Zhang, Jinghui J; Pho, Nam H NH; Walker, Sarah R SR; Winckler, Wendy W; Getz, Gad G; Frank, David D; Hahn, William C WC; Eck, Michael J MJ; Mani, D R DR; Jaffe, Jacob D JD; Carr, Steven A SA; Wong, Kwok-Kin KK; Meyerson, Matthew M