ERBB2 c.1624G>A ;(p.E542K)

Variant ID: 17-37872664-G-A

NM_004448.2(ERBB2):c.1624G>A;(p.E542K)

This variant was identified in 55 publications

View GRCh38 version.




Publications:


Molecular profiling of colorectal cancer in a genetically admixed Hispanic population.

Cancer Medicine
Montes-Rodríguez, Ingrid M IM; Centeno-Girona, Hilmaris H; Rivera-Lynch, Camila C; Rivera, Noridza N; Cruz-Correa, Marcia M
Publication Date: 2023-04-11

Variant appearance in text: ERBB2: E542K
PubMed Link: 37039257
Variant Present in the following documents:
  • CAM4-12-11686-s002.xlsx, sheet 1
View BVdb publication page



Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.

Nature Communications
Sivakumar, Smruthy S; Jin, Dexter X DX; Tukachinsky, Hanna H; Murugesan, Karthikeyan K; McGregor, Kimberly K; Danziger, Natalie N; Pavlick, Dean D; Gjoerup, Ole O; Ross, Jeffrey S JS; Harmon, Robert R; Chung, Jon J; Decker, Brennan B; Dennis, Lucas L; Frampton, Garrett M GM; Molinero, Luciana L; Oesterreich, Steffi S; Venstrom, Jeffrey M JM; Oxnard, Geoffrey R GR; Hegde, Priti S PS; Sokol, Ethan S ES
Publication Date: 2022-12-05

Variant appearance in text: ERBB2: E542K
PubMed Link: 36470901
Variant Present in the following documents:
  • 41467_2022_Article_35245.pdf
View BVdb publication page



Up-front mutation detection in circulating tumor DNA by droplet digital PCR has added diagnostic value in lung cancer.

Translational Oncology
Visser, Esther E; de Kock, Remco R; Genet, Sylvia S; Borne, Ben van den BVD; Soud, Maggy Youssef-El MY; Belderbos, Huub H; Stege, Gerben G; de Saegher, Marleen M; 't Westeinde, Susan van SV; Broeren, Maarten M; Eduati, Federica F; Deiman, Birgit B; Scharnhorst, Volkher V
Publication Date: 2022-11-19

Variant appearance in text: HER2: E542K
PubMed Link: 36413862
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular characterization of acquired resistance to KRAS G12C-EGFR inhibition in colorectal cancer.

Cancer Discovery
Yaeger, Rona R; Mezzadra, Riccardo R; Sinopoli, Jenna J; Bian, Yu Y; Marasco, Michelangelo M; Kaplun, Esther E; Gao, Yijun Y; Zhao, HuiYong H; Da Cruz Paula, Arnaud A; Zhu, Yingjie Y; Chaves Perez, Almudena A; Chadalavada, Kalyani K; Tse, Edison E; Chowdhry, Sudhir S; Bowker, Sydney S; Chang, Qing Q; Qeriqi, Besnik B; Weigelt, Britta B; Nanjangud, Gouri J GJ; Berger, Michael F MF; Der-Torossian, Hirak H; Anderes, Kenna K; Socci, Nicholas D ND; Shia, Jinru J; Riely, Gregory J GJ; Murciano-Goroff, Yonina R YR; Li, Bob T BT; Christensen, James G JG; Reis-Filho, Jorge S JS; Solit, David B DB; de Stanchina, Elisa E; Lowe, Scott W SW; Rosen, Neal N; Misale, Sandra S
Publication Date: 2022-11-10

Variant appearance in text: ERBB2: E542K
PubMed Link: 36355783
Variant Present in the following documents:
  • 41.pdf
View BVdb publication page



Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.

Nature Communications
Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A
Publication Date: 2022-07-13

Variant appearance in text: ERBB2: 1624G>A; E542K
PubMed Link: 35831314
Variant Present in the following documents:
  • 41467_2022_31809_MOESM8_ESM.xlsx, sheet 3
View BVdb publication page



Fundamental immune-oncogenicity trade-offs define driver mutation fitness.

Nature
Hoyos, David D; Zappasodi, Roberta R; Schulze, Isabell I; Sethna, Zachary Z; de Andrade, Kelvin César KC; Bajorin, Dean F DF; Bandlamudi, Chaitanya C; Callahan, Margaret K MK; Funt, Samuel A SA; Hadrup, Sine R SR; Holm, Jeppe S JS; Rosenberg, Jonathan E JE; Shah, Sohrab P SP; Vázquez-García, Ignacio I; Weigelt, Britta B; Wu, Michelle M; Zamarin, Dmitriy D; Campitelli, Laura F LF; Osborne, Edward J EJ; Klinger, Mark M; Robins, Harlan S HS; Khincha, Payal P PP; Savage, Sharon A SA; Balachandran, Vinod P VP; Wolchok, Jedd D JD; Hellmann, Matthew D MD; Merghoub, Taha T; Levine, Arnold J AJ; Łuksza, Marta M; Greenbaum, Benjamin D BD
Publication Date: 2022-06

Variant appearance in text: ERBB2: E542K
PubMed Link: 35545680
Variant Present in the following documents:
  • 41586_2022_4696_MOESM1_ESM.pdf
View BVdb publication page



Next-Generation Sequencing in Lung Cancer Patients: A Comparative Approach in NSCLC and SCLC Mutational Landscapes.

Journal Of Personalized Medicine
Pop-Bica, Cecilia C; Ciocan, Cristina Alexandra CA; Braicu, Cornelia C; Haranguș, Antonia A; Simon, Marioara M; Nutu, Andreea A; Pop, Laura Ancuta LA; Slaby, Ondrej O; Atanasov, Atanas G AG; Pirlog, Radu R; Al Hajjar, Nadim N; Berindan-Neagoe, Ioana I
Publication Date: 2022-03-13

Variant appearance in text: ERBB2: 1624G>A; Glu542Lys
PubMed Link: 35330454
Variant Present in the following documents:
  • jpm-12-00453.pdf
View BVdb publication page



Establishment and application of a method of next generation sequencing of 285 genes in lung cancer based on Ion-Proton platform.

Translational Cancer Research
Chen, Yu Y; Zhang, Xu-Chao XC; Yan, Wen-Qing WQ; Guo, Wei-Bang WB; Xie, Zhi Z; Lu, Dan-Xia DX; Lv, Zhi-Yi ZY; Chen, Zhi-Hong ZH; Su, Jian J
Publication Date: 2020-07

Variant appearance in text: ERBB2: 1624G>A; E542K
PubMed Link: 35117791
Variant Present in the following documents:
  • Main text
View BVdb publication page



Organoids in Lung Cancer Management.

Frontiers In Surgery
Li, Yushi Y; Chan, Joyce W Y JWY; Lau, Rainbow W H RWH; Cheung, Winnie W Y WWY; Wong, Alissa Michelle AM; Wong, Aikha M AM; Wong, Nathalie N; Ng, Calvin Sze Hang CSH
Publication Date: 2021

Variant appearance in text: ERBB2: E542K
PubMed Link: 34957199
Variant Present in the following documents:
  • Main text
  • fsurg-08-753801.pdf
View BVdb publication page



Assessing CSF ctDNA to Improve Diagnostic Accuracy and Therapeutic Monitoring in Breast Cancer Leptomeningeal Metastasis.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Fitzpatrick, Amanda A; Iravani, Marjan M; Mills, Adam A; Childs, Lucy L; Alaguthurai, Thanussuyah T; Clifford, Angela A; Garcia-Murillas, Isaac I; Van Laere, Steven S; Dirix, Luc L; Harries, Mark M; Okines, Alicia A; Turner, Nicholas C NC; Haider, Syed S; Tutt, Andrew N J ANJ; Isacke, Clare M CM
Publication Date: 2022-03-15

Variant appearance in text: ERBB2: E542K
PubMed Link: 34921020
Variant Present in the following documents:
  • 1180.pdf
View BVdb publication page



Oncomine™ Comprehensive Assay v3 vs. Oncomine™ Comprehensive Assay Plus.

Cancers
Vestergaard, Lau K LK; Oliveira, Douglas N P DNP; Poulsen, Tim S TS; Høgdall, Claus K CK; Høgdall, Estrid V EV
Publication Date: 2021-10-18

Variant appearance in text: ERBB2: E542K
PubMed Link: 34680378
Variant Present in the following documents:
  • Main text
  • cancers-13-05230.pdf
View BVdb publication page



Immune Checkpoint Inhibitors Plus Single-Agent Chemotherapy for Advanced Non-Small-Cell Lung Cancer After Resistance to EGFR-TKI.

Frontiers In Oncology
Deng, Haiyi H; Lin, Xinqing X; Xie, Xiaohong X; Yang, Yilin Y; Wang, Liqiang L; Wu, Jianhui J; Liu, Ming M; Xie, Zhanhong Z; Qin, Yinyin Y; Zhou, Chengzhi C
Publication Date: 2021

Variant appearance in text: ERBB2: E542K
PubMed Link: 34616674
Variant Present in the following documents:
  • DataSheet_1.pdf
View BVdb publication page



Characterization of the Genomic and Immunologic Diversity of Malignant Brain Tumors through Multisector Analysis.

Cancer Discovery
Schaettler, Maximilian O MO; Richters, Megan M MM; Wang, Anthony Z AZ; Skidmore, Zachary L ZL; Fisk, Bryan B; Miller, Katherine E KE; Vickery, Tammi L TL; Kim, Albert H AH; Chicoine, Michael R MR; Osbun, Joshua W JW; Leuthardt, Eric C EC; Dowling, Joshua L JL; Zipfel, Gregory J GJ; Dacey, Ralph G RG; Lu, Hsiang-Chih HC; Johanns, Tanner M TM; Griffith, Obi L OL; Mardis, Elaine R ER; Griffith, Malachi M; Dunn, Gavin P GP
Publication Date: 2022-01

Variant appearance in text: ERBB2: 1624G>A
PubMed Link: 34610950
Variant Present in the following documents:
  • cd-21-0291_supplementary_table_4_suppst4.xlsx, sheet 74
View BVdb publication page



Comprehensive molecular profiling of pulmonary pleomorphic carcinoma.

Npj Precision Oncology
Nagano, Masaaki M; Kohsaka, Shinji S; Hayashi, Takuo T; Ueno, Toshihide T; Kojima, Shinya S; Shinozaki-Ushiku, Aya A; Morita, Shigeki S; Tsuda, Masumi M; Tanaka, Shinya S; Shinohara, Toshiya T; Omori, Yuko Y; Sugaya, Fumiko F; Kato, Hiroaki H; Narita, Yoshiaki Y; Nakajima, Jun J; Suzuki, Kenji K; Takamochi, Kazuya K; Mano, Hiroyuki H
Publication Date: 2021-06-22

Variant appearance in text: ERBB2: 1624G>A; Glu542Lys
PubMed Link: 34158601
Variant Present in the following documents:
  • 41698_2021_201_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



How to use liquid biopsies to treat patients with cancer.

Esmo Open
De Mattos-Arruda, L L; Siravegna, G G
Publication Date: 2021-04

Variant appearance in text: HER2: E542K
PubMed Link: 33647598
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Mass Spectrometry as a Highly Sensitive Method for Specific Circulating Tumor DNA Analysis in NSCLC: A Comparison Study.

Cancers
Lamy, Pierre-Jean PJ; van der Leest, Paul P; Lozano, Nicolas N; Becht, Catherine C; Duboeuf, Frédérique F; Groen, Harry J M HJM; Hilgers, Werner W; Pourel, Nicolas N; Rifaela, Naomi N; Schuuring, Ed E; Alix-Panabières, Catherine C
Publication Date: 2020-10-16

Variant appearance in text: ERBB2: 1624G>A
PubMed Link: 33081150
Variant Present in the following documents:
  • cancers-12-03002-s001.pdf
View BVdb publication page



Analytical performance evaluation of a commercial next generation sequencing liquid biopsy platform using plasma ctDNA, reference standards, and synthetic serial dilution samples derived from normal plasma.

Bmc Cancer
Verma, Suman S; Moore, Mathew W MW; Ringler, Rebecca R; Ghosal, Abhisek A; Horvath, Kyle K; Naef, Theodore T; Anvari, Sheri S; Cotter, Philip D PD; Gunn, Shelly S
Publication Date: 2020-10-01

Variant appearance in text: ERBB2: Glu542Lys
PubMed Link: 33004033
Variant Present in the following documents:
  • Main text
View BVdb publication page



Author Correction: Immunofluorescence can assess the efficacy of mTOR pathway therapeutic agent Everolimus in breast cancer models.

Scientific Reports
Kuo, Chun-Ting CT; Chen, Chen-Lin CL; Li, Chih-Chi CC; Huang, Guan-Syuan GS; Ma, Wei-Yuan WY; Hsu, Wei-Fan WF; Lin, Ching-Hung CH; Lu, Yen-Shen YS; Wo, Andrew M AM
Publication Date: 2020-08-19

Variant appearance in text: HER2: E542K
PubMed Link: 32811854
Variant Present in the following documents:
  • 41598_2020_68553_MOESM1_ESM.pdf
View BVdb publication page



Advances in the Detection Technologies and Clinical Applications of Circulating Tumor DNA in Metastatic Breast Cancer.

Cancer Management And Research
Liao, Hao H; Li, Huiping H
Publication Date: 2020

Variant appearance in text: HER2: E542K
PubMed Link: 32547192
Variant Present in the following documents:
  • Main text
  • cmar-12-3547.pdf
View BVdb publication page



Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer.

Frontiers In Oncology
Belardinilli, Francesca F; Capalbo, Carlo C; Malapelle, Umberto U; Pisapia, Pasquale P; Raimondo, Domenico D; Milanetti, Edoardo E; Yasaman, Mahdavian M; Liccardi, Carlotta C; Paci, Paola P; Sibilio, Pasquale P; Pepe, Francesco F; Bonfiglio, Caterina C; Mezi, Silvia S; Magri, Valentina V; Coppa, Anna A; Nicolussi, Arianna A; Gradilone, Angela A; Petroni, Marialaura M; Di Giulio, Stefano S; Fabretti, Francesca F; Infante, Paola P; Coni, Sonia S; Canettieri, Gianluca G; Troncone, Giancarlo G; Giannini, Giuseppe G
Publication Date: 2020

Variant appearance in text: ERBB2: E542K
PubMed Link: 32457828
Variant Present in the following documents:
  • Table_1.xlsx, sheet 1
View BVdb publication page



Mucinous Histology, BRCA1/2 Mutations, and Elevated Tumor Mutational Burden in Colorectal Cancer.

Journal Of Oncology
Harpaz, Noa N; Gatt, Yair Eli YE; Granit, Roy Zvi RZ; Fruchtman, Hila H; Hubert, Ayala A; Grinshpun, Albert A
Publication Date: 2020

Variant appearance in text: ERBB2: 1624G>A
PubMed Link: 32377194
Variant Present in the following documents:
  • 6421205.f1.xlsx, sheet 2
View BVdb publication page



[Acquired Drug Resistance Mechanism of Osimertinib in the Targeted Therapy of Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Zhao, Zitong Z; Ni, Yu Y; Li, Li L; Xin, Tao T
Publication Date: 2020-04-20

Variant appearance in text: HER-2: E542K
PubMed Link: 32316715
Variant Present in the following documents:
  • zgfazz-23-4-274.pdf
View BVdb publication page



Comprehensive pharmacogenomic characterization of gastric cancer.

Genome Medicine
Sa, Jason K JK; Hong, Jung Yong JY; Lee, In-Kyoung IK; Kim, Ju-Sun JS; Sim, Moon-Hee MH; Kim, Ha Jung HJ; An, Ji Yeong JY; Sohn, Tae Sung TS; Lee, Joon Ho JH; Bae, Jae Moon JM; Kim, Sung S; Kim, Kyoung-Mee KM; Kim, Seung Tae ST; Park, Se Hoon SH; Park, Joon Oh JO; Lim, Ho Yeong HY; Kang, Won Ki WK; Her, Nam-Gu NG; Lee, Yeri Y; Cho, Hee Jin HJ; Shin, Yong Jae YJ; Kim, Misuk M; Koo, Harim H; Kim, Mirinae M; Seo, Yun Jee YJ; Kim, Ja Yeon JY; Choi, Min-Gew MG; Nam, Do-Hyun DH; Lee, Jeeyun J
Publication Date: 2020-02-18

Variant appearance in text: ERBB2: E542K
PubMed Link: 32070411
Variant Present in the following documents:
  • 13073_2020_717_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Combined targeting EGFR and SRC as a potential novel therapeutic approach for the treatment of triple negative breast cancer.

Therapeutic Advances In Medical Oncology
Canonici, Alexandra A; Browne, Alacoque L AL; Ibrahim, Mohamed F K MFK; Fanning, Kevin P KP; Roche, Sandra S; Conlon, Neil T NT; O'Neill, Fiona F; Meiller, Justine J; Cremona, Mattia M; Morgan, Clare C; Hennessy, Bryan T BT; Eustace, Alex J AJ; Solca, Flavio F; O'Donovan, Norma N; Crown, John J
Publication Date: 2020

Variant appearance in text: HER2: E542K
PubMed Link: 32064003
Variant Present in the following documents:
  • Main text
  • 10.1177_1758835919897546.pdf
View BVdb publication page



Comprehensive assessment of HER2 alteration in a colorectal cancer cohort: from next-generation sequencing to clinical significance.

Cancer Management And Research
Yeh, Yu-Min YM; Lee, Chun-Hui CH; Chen, Shang-Hung SH; Lee, Chung-Ta CT; Chen, Yi-Lin YL; Lin, Bo-Wen BW; Lin, Shao-Chieh SC; Chan, Ren-Hao RH; Lee, Jenq-Chang JC; Shen, Meng-Ru MR; Lin, Peng-Chan PC
Publication Date: 2019

Variant appearance in text: HER2: E542K
PubMed Link: 31692488
Variant Present in the following documents:
  • cmar-11-7867.pdf
View BVdb publication page



Surface Plasmon Resonance for Biomarker Detection: Advances in Non-invasive Cancer Diagnosis.

Frontiers In Chemistry
Bellassai, Noemi N; D'Agata, Roberta R; Jungbluth, Vanessa V; Spoto, Giuseppe G
Publication Date: 2019

Variant appearance in text: HER2: E542K
PubMed Link: 31448267
Variant Present in the following documents:
  • Main text
  • fchem-07-00570.pdf
View BVdb publication page



Comprehensive validation of liquid-based cytology specimens for next-generation sequencing in cancer genome analysis.

Plos One
Akahane, Toshiaki T; Yamaguchi, Tomomi T; Kato, Yasutaka Y; Yokoyama, Seiya S; Hamada, Taiji T; Nishida, Yukari Y; Higashi, Michiyo M; Nishihara, Hiroshi H; Suzuki, Shinsuke S; Ueno, Shinichi S; Tanimoto, Akihide A
Publication Date: 2019

Variant appearance in text: ERBB2: Glu542Lys
PubMed Link: 31199826
Variant Present in the following documents:
  • Main text
  • pone.0217724.pdf
View BVdb publication page



Incidence and distribution of UroSEEK gene panel in a multi-institutional cohort of bladder urothelial carcinoma.

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc
Eich, Marie-Lisa ML; Rodriguez Pena, Maria Del Carmen MDC; Springer, Simeon U SU; Taheri, Diana D; Tregnago, Aline C AC; Salles, Daniela C DC; Bezerra, Stephania Martins SM; Cunha, Isabela W IW; Fujita, Kazutoshi K; Ertoy, Dilek D; Bivalacqua, Trinity J TJ; Tomasetti, Cristian C; Papadopoulos, Nickolas N; Kinzler, Ken W KW; Vogelstein, Bert B; Netto, George J GJ
Publication Date: 2019-10

Variant appearance in text: ERBB2: E542K
PubMed Link: 31028363
Variant Present in the following documents:
  • NIHMS1525315-supplement-2.xlsx, sheet 1
View BVdb publication page



Peptide-nanoparticle conjugates: a next generation of diagnostic and therapeutic platforms?

Nano Convergence
Jeong, Woo-Jin WJ; Bu, Jiyoon J; Kubiatowicz, Luke J LJ; Chen, Stephanie S SS; Kim, YoungSoo Y; Hong, Seungpyo S
Publication Date: 2018-12-12

Variant appearance in text: HER2: E542K
PubMed Link: 30539365
Variant Present in the following documents:
  • Main text
  • 40580_2018_Article_170.pdf
View BVdb publication page



Dynamic changes of circulating tumour DNA in surgical lung cancer patients: protocol for a prospective observational study.

Bmj Open
Chen, Kezhong K; Zhao, Heng H; Yang, Fan F; Hui, Bengang B; Wang, Tianyang T; Wang, Lieu Tu LT; Shi, Yanbin Y; Wang, Jun J
Publication Date: 2018-02-06

Variant appearance in text: ERBB2: E542K
PubMed Link: 29437753
Variant Present in the following documents:
  • Main text
  • bmjopen-2017-019012.pdf
View BVdb publication page



Whole exome sequencing for determination of tumor mutation load in liquid biopsy from advanced cancer patients.

Plos One
Koeppel, Florence F; Blanchard, Steven S; Jovelet, Cécile C; Genin, Bérengère B; Marcaillou, Charles C; Martin, Emmanuel E; Rouleau, Etienne E; Solary, Eric E; Soria, Jean-Charles JC; André, Fabrice F; Lacroix, Ludovic L
Publication Date: 2017

Variant appearance in text: ERBB2: Glu542Lys
PubMed Link: 29161279
Variant Present in the following documents:
  • Main text
  • pone.0188174.pdf
View BVdb publication page



Insights from animal models of bladder cancer: recent advances, challenges, and opportunities.

Oncotarget
John, Bincy Anu BA; Said, Neveen N
Publication Date: 2017-08-22

Variant appearance in text: ERBB2: E542K
PubMed Link: 28915710
Variant Present in the following documents:
  • Main text
  • oncotarget-08-57766.pdf
View BVdb publication page



Predicting clinical benefit from everolimus in patients with advanced solid tumors, the CPCT-03 study.

Oncotarget
Weeber, Fleur F; Cirkel, Geert A GA; Hoogstraat, Marlous M; Bins, Sander S; Gadellaa-van Hooijdonk, Christa G M CGM; Ooft, Salo S; van Werkhoven, Erik E; Willems, Stefan M SM; van Stralen, Marijn M; Veldhuis, Wouter B WB; Besselink, Nicolle J M NJM; Horlings, Hugo M HM; Steeghs, Neeltje N; de Jonge, Maja J MJ; Langenberg, Marlies H G MHG; Wessels, Lodewyk F A LFA; Cuppen, Edwin P J G EPJG; Schellens, J H JH; Sleijfer, Stefan S; Lolkema, Martijn P MP; Voest, Emile E EE
Publication Date: 2017-08-15

Variant appearance in text: ERBB2: E542K
PubMed Link: 28903445
Variant Present in the following documents:
  • oncotarget-08-55582-s002.xlsx, sheet 1
View BVdb publication page



Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate.

Esmo Open
Ree, Anne Hansen AH; Russnes, Hege G HG; Heinrich, Daniel D; Dueland, Svein S; Boye, Kjetil K; Nygaard, Vigdis V; Silwal-Pandit, Laxmi L; Østrup, Olga O; Hovig, Eivind E; Nygaard, Vegard V; Rødland, Einar A EA; Nakken, Sigve S; Øien, Janne T JT; Johansen, Christin C; Bergheim, Inger R IR; Skarpeteig, Veronica V; Sathermugathevan, Menaka M; Sauer, Torill T; Lund-Iversen, Marius M; Beiske, Klaus K; Nasser, Salah S; Julsrud, Lars L; Reisse, Claudius H CH; Ruud, Espen A EA; Flørenes, Vivi Ann VA; Hagene, Kirsten T KT; Aas, Eline E; Lurås, Hilde H; Johnsen-Soriano, Siv S; Geitvik, Gry A GA; Lingjærde, Ole Christian OC; Børresen-Dale, Anne-Lise AL; Mælandsmo, Gunhild M GM; Flatmark, Kjersti K
Publication Date: 2017

Variant appearance in text: ERBB2: E542K
PubMed Link: 28761742
Variant Present in the following documents:
  • esmoopen-2017-000158supp002.pdf
View BVdb publication page



Clinical implications of genomic profiles in metastatic breast cancer with a focus on TP53 and PIK3CA, the most frequently mutated genes.

Oncotarget
Kim, Ji-Yeon JY; Lee, Eunjin E; Park, Kyunghee K; Park, Woong-Yang WY; Jung, Hae Hyun HH; Ahn, Jin Seok JS; Im, Young-Hyuck YH; Park, Yeon Hee YH
Publication Date: 2017-04-25

Variant appearance in text: HER2: E542K
PubMed Link: 28427202
Variant Present in the following documents:
  • oncotarget-08-27997-s002.xlsx, sheet 3
View BVdb publication page



Gold Nanoparticle Based Platforms for Circulating Cancer Marker Detection.

Nanotheranostics
Huang, Xiaohua X; O'Connor, Ryan R; Kwizera, Elyahb Allie EA
Publication Date: 2017

Variant appearance in text: HER2: E542K
PubMed Link: 28217434
Variant Present in the following documents:
  • Main text
View BVdb publication page



Third-generation epidermal growth factor receptor-tyrosine kinase inhibitors in T790M-positive non-small cell lung cancer: review on emerged mechanisms of resistance.

Translational Lung Cancer Research
Minari, Roberta R; Bordi, Paola P; Tiseo, Marcello M
Publication Date: 2016-12

Variant appearance in text: HER2: E542K
PubMed Link: 28149764
Variant Present in the following documents:
  • Main text
View BVdb publication page



Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines.

Journal Of Cancer Research And Clinical Oncology
Kneissl, Julia J; Hartmann, Anja A; Pfarr, Nicole N; Erlmeier, Franziska F; Lorber, Thomas T; Keller, Simone S; Zwingenberger, Gwen G; Weichert, Wilko W; Luber, Birgit B
Publication Date: 2017-04

Variant appearance in text: HER2: E542K
PubMed Link: 27933395
Variant Present in the following documents:
  • Main text
  • 432_2016_Article_2308.pdf
View BVdb publication page



Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas.

Journal Of Radiation Research
Showler, Kaye K; Nishimura, Mayumi M; Daino, Kazuhiro K; Imaoka, Tatsuhiko T; Nishimura, Yukiko Y; Morioka, Takamitsu T; Blyth, Benjamin J BJ; Kokubo, Toshiaki T; Takabatake, Masaru M; Fukuda, Maki M; Moriyama, Hitomi H; Kakinuma, Shizuko S; Fukushi, Masahiro M; Shimada, Yoshiya Y
Publication Date: 2017-03-01

Variant appearance in text: HER2: E542K
PubMed Link: 27738081
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular analysis of a male breast cancer patient with prolonged stable disease under mTOR/PI3K inhibitors BEZ235/everolimus.

Cold Spring Harbor Molecular Case Studies
Brannon, A Rose AR; Frizziero, Melissa M; Chen, David D; Hummel, Jennifer J; Gallo, Jorge J; Riester, Markus M; Patel, Parul P; Cheung, Wing W; Morrissey, Michael M; Carbone, Carmine C; Cottini, Silvia S; Tortora, Giampaolo G; Melisi, Davide D
Publication Date: 2016-03

Variant appearance in text: HER2: E542K
PubMed Link: 27148582
Variant Present in the following documents:
  • Main text
  • BrannonMCS000620.pdf
View BVdb publication page



Circulating tumor DNA identified by targeted sequencing in advanced-stage non-small cell lung cancer patients.

Cancer Letters
Xu, Song S; Lou, Feng F; Wu, Yi Y; Sun, Da-Qiang DQ; Zhang, Jing-Bo JB; Chen, Wei W; Ye, Hua H; Liu, Jing-Hao JH; Wei, Sen S; Zhao, Ming-Yu MY; Wu, Wen-Jun WJ; Su, Xue-Xia XX; Shi, Rong R; Jones, Lindsey L; Huang, Xue F XF; Chen, Si-Yi SY; Chen, Jun J
Publication Date: 2016-01-28

Variant appearance in text: ERBB2: E542K
PubMed Link: 26582655
Variant Present in the following documents:
  • Main text
View BVdb publication page



Dual HER2/PIK3CA Targeting Overcomes Single-Agent Acquired Resistance in HER2-Amplified Uterine Serous Carcinoma Cell Lines In Vitro and In Vivo.

Molecular Cancer Therapeutics
Lopez, Salvatore S; Cocco, Emiliano E; Black, Jonathan J; Bellone, Stefania S; Bonazzoli, Elena E; Predolini, Federica F; Ferrari, Francesca F; Schwab, Carlton L CL; English, Diana P DP; Ratner, Elena E; Silasi, Dan-Arin DA; Azodi, Masoud M; Schwartz, Peter E PE; Terranova, Corrado C; Angioli, Roberto R; Santin, Alessandro D AD
Publication Date: 2015-11

Variant appearance in text: HER2: E542K
PubMed Link: 26333383
Variant Present in the following documents:
  • Main text
View BVdb publication page



Preclinical Efficacy of Ron Kinase Inhibitors Alone and in Combination with PI3K Inhibitors for Treatment of sfRon-Expressing Breast Cancer Patient-Derived Xenografts.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Bieniasz, Magdalena M; Radhakrishnan, Parvathi P; Faham, Najme N; De La O, Jean-Paul JP; Welm, Alana L AL
Publication Date: 2015-12-15

Variant appearance in text: HER2: E542K
PubMed Link: 26289070
Variant Present in the following documents:
  • Main text
View BVdb publication page



Lung cancer in never-smoker Asian females is driven by oncogenic mutations, most often involving EGFR.

Oncotarget
Ha, Sang Yun SY; Choi, So-Jung SJ; Cho, Jong Ho JH; Choi, Hye Joo HJ; Lee, Jinseon J; Jung, Kyungsoo K; Irwin, Darry D; Liu, Xiao X; Lira, Maruja E ME; Mao, Mao M; Kim, Hong Kwan HK; Choi, Yong Soo YS; Shim, Young Mog YM; Park, Woong Yang WY; Choi, Yoon-La YL; Kim, Jhingook J
Publication Date: 2015-03-10

Variant appearance in text: ERBB2: E542K
PubMed Link: 25760072
Variant Present in the following documents:
  • oncotarget-06-5465-s001.pdf
View BVdb publication page



Heterogeneity of PIK3CA mutational status at the single cell level in circulating tumor cells from metastatic breast cancer patients.

Molecular Oncology
Pestrin, Marta M; Salvianti, Francesca F; Galardi, Francesca F; De Luca, Francesca F; Turner, Natalie N; Malorni, Luca L; Pazzagli, Mario M; Di Leo, Angelo A; Pinzani, Pamela P
Publication Date: 2015-04

Variant appearance in text: HER2: 1624G>A
PubMed Link: 25539732
Variant Present in the following documents:
  • Main text
View BVdb publication page



Setting up a wide panel of patient-derived tumor xenografts of non-small cell lung cancer by improving the preanalytical steps.

Cancer Medicine
Ilie, Marius M; Nunes, Manoel M; Blot, Lydia L; Hofman, Véronique V; Long-Mira, Elodie E; Butori, Catherine C; Selva, Eric E; Merino-Trigo, Ana A; Vénissac, Nicolas N; Mouroux, Jérôme J; Vrignaud, Patricia P; Hofman, Paul P
Publication Date: 2015-02

Variant appearance in text: HER2: E542K
PubMed Link: 25470237
Variant Present in the following documents:
  • cam40004-0201.pdf
View BVdb publication page



Comprehensive molecular profiling of lung adenocarcinoma.

Nature
,
Publication Date: 2014-07-31

Variant appearance in text: ERBB2: E542K
PubMed Link: 25079552
Variant Present in the following documents:
  • NIHMS629713-supplement-Supllementary_information_2.xlsx, sheet 7
View BVdb publication page



Randomised proof-of-concept phase II trial comparing targeted therapy based on tumour molecular profiling vs conventional therapy in patients with refractory cancer: results of the feasibility part of the SHIVA trial.

British Journal Of Cancer
Le Tourneau, C C; Paoletti, X X; Servant, N N; Bièche, I I; Gentien, D D; Rio Frio, T T; Vincent-Salomon, A A; Servois, V V; Romejon, J J; Mariani, O O; Bernard, V V; Huppe, P P; Pierron, G G; Mulot, F F; Callens, C C; Wong, J J; Mauborgne, C C; Rouleau, E E; Reyes, C C; Henry, E E; Leroy, Q Q; Gestraud, P P; La Rosa, P P; Escalup, L L; Mitry, E E; Trédan, O O; Delord, J-P JP; Campone, M M; Goncalves, A A; Isambert, N N; Gavoille, C C; Kamal, M M
Publication Date: 2014-07-08

Variant appearance in text: HER-2: E542K
PubMed Link: 24762958
Variant Present in the following documents:
  • Main text
  • bjc2014211a.pdf
View BVdb publication page



Evaluation of PTEN loss and PIK3CA mutations and their correlation with efficacy of trastuzumab treatment in HER2-positive metastatic breast cancer: A retrospective study (KBC-SG 1001).

Molecular And Clinical Oncology
Nishimura, Reiki R; Arima, Nobuyuki N; Toyoshima, Satoshi S; Ohi, Yasuyo Y; Anan, Keisei K; Sagara, Yasuaki Y; Mitsuyama, Shoshu S; Tamura, Kazuo K
Publication Date: 2013-01

Variant appearance in text: HER2: E542K
PubMed Link: 24649121
Variant Present in the following documents:
  • Main text
View BVdb publication page



mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer.

Science Translational Medicine
Elkabets, Moshe M; Vora, Sadhna S; Juric, Dejan D; Morse, Natasha N; Mino-Kenudson, Mari M; Muranen, Taru T; Tao, Jessica J; Campos, Ana Bosch AB; Rodon, Jordi J; Ibrahim, Yasir H YH; Serra, Violeta V; Rodrik-Outmezguine, Vanessa V; Hazra, Saswati S; Singh, Sharat S; Kim, Phillip P; Quadt, Cornelia C; Liu, Manway M; Huang, Alan A; Rosen, Neal N; Engelman, Jeffrey A JA; Scaltriti, Maurizio M; Baselga, José J
Publication Date: 2013-07-31

Variant appearance in text: HER2: E542K
PubMed Link: 23903756
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of nine genomic regions of amplification in urothelial carcinoma, correlation with stage, and potential prognostic and therapeutic value.

Plos One
Chekaluk, Yvonne Y; Wu, Chin-Lee CL; Rosenberg, Jonathan J; Riester, Markus M; Dai, Qishan Q; Lin, Sharron S; Guo, Yanan Y; McDougal, W Scott WS; Kwiatkowski, David J DJ
Publication Date: 2013

Variant appearance in text: ERBB2: E542K
PubMed Link: 23593348
Variant Present in the following documents:
  • Main text
View BVdb publication page



PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib.

Bmc Cancer
Wang, Leiping L; Zhang, Qunling Q; Zhang, Jian J; Sun, Si S; Guo, Haiyi H; Jia, Zhen Z; Wang, Biyun B; Shao, Zhimin Z; Wang, Zhonghua Z; Hu, Xichun X
Publication Date: 2011-06-15

Variant appearance in text: HER2: E542K
PubMed Link: 21676217
Variant Present in the following documents:
  • Main text
  • 1471-2407-11-248.pdf
View BVdb publication page



Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1.

Acs Medicinal Chemistry Letters
Deng, Xianming X; Yang, Qingkai Q; Kwiatkowski, Nicholas N; Sim, Taebo T; McDermott, Ultan U; Settleman, Jeffrey E JE; Lee, Jiing-Dwan JD; Gray, Nathanael S NS
Publication Date: 2011-03-10

Variant appearance in text: ERBB2: E542K
PubMed Link: 21412406
Variant Present in the following documents:
  • ml100304b_si_002.pdf
View BVdb publication page



PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.

The American Journal Of Pathology
Esteva, Francisco J FJ; Guo, Hua H; Zhang, Siyuan S; Santa-Maria, Cesar C; Stone, Steven S; Lanchbury, Jerry S JS; Sahin, Aysegul A AA; Hortobagyi, Gabriel N GN; Yu, Dihua D
Publication Date: 2010-10

Variant appearance in text: HER2: E542K
PubMed Link: 20813970
Variant Present in the following documents:
  • Main text
View BVdb publication page