Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.
Nature Communications
Sivakumar, Smruthy S; Jin, Dexter X DX; Tukachinsky, Hanna H; Murugesan, Karthikeyan K; McGregor, Kimberly K; Danziger, Natalie N; Pavlick, Dean D; Gjoerup, Ole O; Ross, Jeffrey S JS; Harmon, Robert R; Chung, Jon J; Decker, Brennan B; Dennis, Lucas L; Frampton, Garrett M GM; Molinero, Luciana L; Oesterreich, Steffi S; Venstrom, Jeffrey M JM; Oxnard, Geoffrey R GR; Hegde, Priti S PS; Sokol, Ethan S ES
Up-front mutation detection in circulating tumor DNA by droplet digital PCR has added diagnostic value in lung cancer.
Translational Oncology
Visser, Esther E; de Kock, Remco R; Genet, Sylvia S; Borne, Ben van den BVD; Soud, Maggy Youssef-El MY; Belderbos, Huub H; Stege, Gerben G; de Saegher, Marleen M; 't Westeinde, Susan van SV; Broeren, Maarten M; Eduati, Federica F; Deiman, Birgit B; Scharnhorst, Volkher V
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Nature Communications
Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A
Fundamental immune-oncogenicity trade-offs define driver mutation fitness.
Nature
Hoyos, David D; Zappasodi, Roberta R; Schulze, Isabell I; Sethna, Zachary Z; de Andrade, Kelvin César KC; Bajorin, Dean F DF; Bandlamudi, Chaitanya C; Callahan, Margaret K MK; Funt, Samuel A SA; Hadrup, Sine R SR; Holm, Jeppe S JS; Rosenberg, Jonathan E JE; Shah, Sohrab P SP; Vázquez-García, Ignacio I; Weigelt, Britta B; Wu, Michelle M; Zamarin, Dmitriy D; Campitelli, Laura F LF; Osborne, Edward J EJ; Klinger, Mark M; Robins, Harlan S HS; Khincha, Payal P PP; Savage, Sharon A SA; Balachandran, Vinod P VP; Wolchok, Jedd D JD; Hellmann, Matthew D MD; Merghoub, Taha T; Levine, Arnold J AJ; Łuksza, Marta M; Greenbaum, Benjamin D BD
Next-Generation Sequencing in Lung Cancer Patients: A Comparative Approach in NSCLC and SCLC Mutational Landscapes.
Journal Of Personalized Medicine
Pop-Bica, Cecilia C; Ciocan, Cristina Alexandra CA; Braicu, Cornelia C; Haranguș, Antonia A; Simon, Marioara M; Nutu, Andreea A; Pop, Laura Ancuta LA; Slaby, Ondrej O; Atanasov, Atanas G AG; Pirlog, Radu R; Al Hajjar, Nadim N; Berindan-Neagoe, Ioana I
Publication Date: 2022-03-13
Variant appearance in text: ERBB2: 1624G>A; Glu542Lys
Li, Yushi Y; Chan, Joyce W Y JWY; Lau, Rainbow W H RWH; Cheung, Winnie W Y WWY; Wong, Alissa Michelle AM; Wong, Aikha M AM; Wong, Nathalie N; Ng, Calvin Sze Hang CSH
Assessing CSF ctDNA to Improve Diagnostic Accuracy and Therapeutic Monitoring in Breast Cancer Leptomeningeal Metastasis.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Fitzpatrick, Amanda A; Iravani, Marjan M; Mills, Adam A; Childs, Lucy L; Alaguthurai, Thanussuyah T; Clifford, Angela A; Garcia-Murillas, Isaac I; Van Laere, Steven S; Dirix, Luc L; Harries, Mark M; Okines, Alicia A; Turner, Nicholas C NC; Haider, Syed S; Tutt, Andrew N J ANJ; Isacke, Clare M CM
Characterization of the Genomic and Immunologic Diversity of Malignant Brain Tumors through Multisector Analysis.
Cancer Discovery
Schaettler, Maximilian O MO; Richters, Megan M MM; Wang, Anthony Z AZ; Skidmore, Zachary L ZL; Fisk, Bryan B; Miller, Katherine E KE; Vickery, Tammi L TL; Kim, Albert H AH; Chicoine, Michael R MR; Osbun, Joshua W JW; Leuthardt, Eric C EC; Dowling, Joshua L JL; Zipfel, Gregory J GJ; Dacey, Ralph G RG; Lu, Hsiang-Chih HC; Johanns, Tanner M TM; Griffith, Obi L OL; Mardis, Elaine R ER; Griffith, Malachi M; Dunn, Gavin P GP
Mass Spectrometry as a Highly Sensitive Method for Specific Circulating Tumor DNA Analysis in NSCLC: A Comparison Study.
Cancers
Lamy, Pierre-Jean PJ; van der Leest, Paul P; Lozano, Nicolas N; Becht, Catherine C; Duboeuf, Frédérique F; Groen, Harry J M HJM; Hilgers, Werner W; Pourel, Nicolas N; Rifaela, Naomi N; Schuuring, Ed E; Alix-Panabières, Catherine C
Analytical performance evaluation of a commercial next generation sequencing liquid biopsy platform using plasma ctDNA, reference standards, and synthetic serial dilution samples derived from normal plasma.
Bmc Cancer
Verma, Suman S; Moore, Mathew W MW; Ringler, Rebecca R; Ghosal, Abhisek A; Horvath, Kyle K; Naef, Theodore T; Anvari, Sheri S; Cotter, Philip D PD; Gunn, Shelly S
Comprehensive pharmacogenomic characterization of gastric cancer.
Genome Medicine
Sa, Jason K JK; Hong, Jung Yong JY; Lee, In-Kyoung IK; Kim, Ju-Sun JS; Sim, Moon-Hee MH; Kim, Ha Jung HJ; An, Ji Yeong JY; Sohn, Tae Sung TS; Lee, Joon Ho JH; Bae, Jae Moon JM; Kim, Sung S; Kim, Kyoung-Mee KM; Kim, Seung Tae ST; Park, Se Hoon SH; Park, Joon Oh JO; Lim, Ho Yeong HY; Kang, Won Ki WK; Her, Nam-Gu NG; Lee, Yeri Y; Cho, Hee Jin HJ; Shin, Yong Jae YJ; Kim, Misuk M; Koo, Harim H; Kim, Mirinae M; Seo, Yun Jee YJ; Kim, Ja Yeon JY; Choi, Min-Gew MG; Nam, Do-Hyun DH; Lee, Jeeyun J
Combined targeting EGFR and SRC as a potential novel therapeutic approach for the treatment of triple negative breast cancer.
Therapeutic Advances In Medical Oncology
Canonici, Alexandra A; Browne, Alacoque L AL; Ibrahim, Mohamed F K MFK; Fanning, Kevin P KP; Roche, Sandra S; Conlon, Neil T NT; O'Neill, Fiona F; Meiller, Justine J; Cremona, Mattia M; Morgan, Clare C; Hennessy, Bryan T BT; Eustace, Alex J AJ; Solca, Flavio F; O'Donovan, Norma N; Crown, John J
Predicting clinical benefit from everolimus in patients with advanced solid tumors, the CPCT-03 study.
Oncotarget
Weeber, Fleur F; Cirkel, Geert A GA; Hoogstraat, Marlous M; Bins, Sander S; Gadellaa-van Hooijdonk, Christa G M CGM; Ooft, Salo S; van Werkhoven, Erik E; Willems, Stefan M SM; van Stralen, Marijn M; Veldhuis, Wouter B WB; Besselink, Nicolle J M NJM; Horlings, Hugo M HM; Steeghs, Neeltje N; de Jonge, Maja J MJ; Langenberg, Marlies H G MHG; Wessels, Lodewyk F A LFA; Cuppen, Edwin P J G EPJG; Schellens, J H JH; Sleijfer, Stefan S; Lolkema, Martijn P MP; Voest, Emile E EE
Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate.
Esmo Open
Ree, Anne Hansen AH; Russnes, Hege G HG; Heinrich, Daniel D; Dueland, Svein S; Boye, Kjetil K; Nygaard, Vigdis V; Silwal-Pandit, Laxmi L; Østrup, Olga O; Hovig, Eivind E; Nygaard, Vegard V; Rødland, Einar A EA; Nakken, Sigve S; Øien, Janne T JT; Johansen, Christin C; Bergheim, Inger R IR; Skarpeteig, Veronica V; Sathermugathevan, Menaka M; Sauer, Torill T; Lund-Iversen, Marius M; Beiske, Klaus K; Nasser, Salah S; Julsrud, Lars L; Reisse, Claudius H CH; Ruud, Espen A EA; Flørenes, Vivi Ann VA; Hagene, Kirsten T KT; Aas, Eline E; Lurås, Hilde H; Johnsen-Soriano, Siv S; Geitvik, Gry A GA; Lingjærde, Ole Christian OC; Børresen-Dale, Anne-Lise AL; Mælandsmo, Gunhild M GM; Flatmark, Kjersti K
Molecular analysis of a male breast cancer patient with prolonged stable disease under mTOR/PI3K inhibitors BEZ235/everolimus.
Cold Spring Harbor Molecular Case Studies
Brannon, A Rose AR; Frizziero, Melissa M; Chen, David D; Hummel, Jennifer J; Gallo, Jorge J; Riester, Markus M; Patel, Parul P; Cheung, Wing W; Morrissey, Michael M; Carbone, Carmine C; Cottini, Silvia S; Tortora, Giampaolo G; Melisi, Davide D
Dual HER2/PIK3CA Targeting Overcomes Single-Agent Acquired Resistance in HER2-Amplified Uterine Serous Carcinoma Cell Lines In Vitro and In Vivo.
Molecular Cancer Therapeutics
Lopez, Salvatore S; Cocco, Emiliano E; Black, Jonathan J; Bellone, Stefania S; Bonazzoli, Elena E; Predolini, Federica F; Ferrari, Francesca F; Schwab, Carlton L CL; English, Diana P DP; Ratner, Elena E; Silasi, Dan-Arin DA; Azodi, Masoud M; Schwartz, Peter E PE; Terranova, Corrado C; Angioli, Roberto R; Santin, Alessandro D AD
Preclinical Efficacy of Ron Kinase Inhibitors Alone and in Combination with PI3K Inhibitors for Treatment of sfRon-Expressing Breast Cancer Patient-Derived Xenografts.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Bieniasz, Magdalena M; Radhakrishnan, Parvathi P; Faham, Najme N; De La O, Jean-Paul JP; Welm, Alana L AL
Lung cancer in never-smoker Asian females is driven by oncogenic mutations, most often involving EGFR.
Oncotarget
Ha, Sang Yun SY; Choi, So-Jung SJ; Cho, Jong Ho JH; Choi, Hye Joo HJ; Lee, Jinseon J; Jung, Kyungsoo K; Irwin, Darry D; Liu, Xiao X; Lira, Maruja E ME; Mao, Mao M; Kim, Hong Kwan HK; Choi, Yong Soo YS; Shim, Young Mog YM; Park, Woong Yang WY; Choi, Yoon-La YL; Kim, Jhingook J
Heterogeneity of PIK3CA mutational status at the single cell level in circulating tumor cells from metastatic breast cancer patients.
Molecular Oncology
Pestrin, Marta M; Salvianti, Francesca F; Galardi, Francesca F; De Luca, Francesca F; Turner, Natalie N; Malorni, Luca L; Pazzagli, Mario M; Di Leo, Angelo A; Pinzani, Pamela P
Setting up a wide panel of patient-derived tumor xenografts of non-small cell lung cancer by improving the preanalytical steps.
Cancer Medicine
Ilie, Marius M; Nunes, Manoel M; Blot, Lydia L; Hofman, Véronique V; Long-Mira, Elodie E; Butori, Catherine C; Selva, Eric E; Merino-Trigo, Ana A; Vénissac, Nicolas N; Mouroux, Jérôme J; Vrignaud, Patricia P; Hofman, Paul P
Randomised proof-of-concept phase II trial comparing targeted therapy based on tumour molecular profiling vs conventional therapy in patients with refractory cancer: results of the feasibility part of the SHIVA trial.
British Journal Of Cancer
Le Tourneau, C C; Paoletti, X X; Servant, N N; Bièche, I I; Gentien, D D; Rio Frio, T T; Vincent-Salomon, A A; Servois, V V; Romejon, J J; Mariani, O O; Bernard, V V; Huppe, P P; Pierron, G G; Mulot, F F; Callens, C C; Wong, J J; Mauborgne, C C; Rouleau, E E; Reyes, C C; Henry, E E; Leroy, Q Q; Gestraud, P P; La Rosa, P P; Escalup, L L; Mitry, E E; Trédan, O O; Delord, J-P JP; Campone, M M; Goncalves, A A; Isambert, N N; Gavoille, C C; Kamal, M M
Evaluation of PTEN loss and PIK3CA mutations and their correlation with efficacy of trastuzumab treatment in HER2-positive metastatic breast cancer: A retrospective study (KBC-SG 1001).
Identification of nine genomic regions of amplification in urothelial carcinoma, correlation with stage, and potential prognostic and therapeutic value.
Plos One
Chekaluk, Yvonne Y; Wu, Chin-Lee CL; Rosenberg, Jonathan J; Riester, Markus M; Dai, Qishan Q; Lin, Sharron S; Guo, Yanan Y; McDougal, W Scott WS; Kwiatkowski, David J DJ
PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.
The American Journal Of Pathology
Esteva, Francisco J FJ; Guo, Hua H; Zhang, Siyuan S; Santa-Maria, Cesar C; Stone, Steven S; Lanchbury, Jerry S JS; Sahin, Aysegul A AA; Hortobagyi, Gabriel N GN; Yu, Dihua D