ERBB2 c.1978G>C ;(p.G660R)

Variant ID: 17-37879603-G-C

NM_004448.2(ERBB2):c.1978G>C;(p.G660R)

This variant was identified in 11 publications

View GRCh38 version.




Publications:


Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications
Boström, Martin M; Larsson, Erik E
Publication Date: 2022-11-17

Variant appearance in text: ERBB2: G660R
PubMed Link: 36396655
Variant Present in the following documents:
  • 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics
Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q
Publication Date: 2022-11-04

Variant appearance in text: ERBB2: 1978G>C; Gly660Arg
PubMed Link: 36333792
Variant Present in the following documents:
  • 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Efficacy and Resistance of Afatinib in Chinese Non-Small Cell Lung Cancer Patients With HER2 Alterations: A Multicenter Retrospective Study.

Frontiers In Oncology
Song, Zhengbo Z; Lv, Dongqing D; Chen, Shiqing S; Huang, Jianhui J; Wang, Liping L; Xu, Shuguang S; Chen, Huafei H; Wang, Guoqiang G; Lin, Quan Q
Publication Date: 2021

Variant appearance in text: HER2: G660R
PubMed Link: 34026634
Variant Present in the following documents:
  • Main text
  • fonc-11-657283.pdf
View BVdb publication page



Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations.

Oncotarget
Joshi, Asim A; Mishra, Rohit R; Desai, Sanket S; Chandrani, Pratik P; Kore, Hitesh H; Sunder, Roma R; Hait, Supriya S; Iyer, Prajish P; Trivedi, Vaishakhi V; Choughule, Anuradha A; Noronha, Vanita V; Joshi, Amit A; Patil, Vijay V; Menon, Nandini N; Kumar, Rajiv R; Prabhash, Kumar K; Dutt, Amit A
Publication Date: 2021-03-16

Variant appearance in text: ERBB2: G660R
PubMed Link: 33796225
Variant Present in the following documents:
  • oncotarget-12-578-s003.xlsx, sheet 1
View BVdb publication page



mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.

Cell Reports
Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM
Publication Date: 2020-06-23

Variant appearance in text: ERBB2: G660R
PubMed Link: 32579932
Variant Present in the following documents:
  • mmc5.xlsx, sheet 3
View BVdb publication page



Clinical and molecular characteristics of Chinese non-small cell lung cancer patients with ERBB2 transmembrane domain mutations.

Molecular Oncology
Fan, Yun Y; Qiu, Jinrong J; Yu, Ruoying R; Cao, Ran R; Chen, Xiaoxi X; Ou, Qiuxiang Q; Wu, Xue X; Shao, Yang W YW; Nagasaka, Misako M; Zhang, Jiexia J; Ou, Sai-Hong Ignatius SI
Publication Date: 2020-08

Variant appearance in text: HER2: G660R
PubMed Link: 32478891
Variant Present in the following documents:
  • Main text
  • MOL2-14-1731.pdf
View BVdb publication page



Response to Afatinib in a Patient with Non-Small Cell Lung Cancer Harboring HER2 R896G Mutation: A Case Report.

Oncotargets And Therapy
Lin, Ling L; Ge, Hongfei H; Yan, Zhengqing Z; Wang, Guoqiang G; Wu, Xiaomai X; Lv, Dongqing D
Publication Date: 2019

Variant appearance in text: HER2: G660R
PubMed Link: 31849493
Variant Present in the following documents:
  • Main text
  • ott-12-10897.pdf
View BVdb publication page



In the literature: December 2018.

Esmo Open
Gambardella, Valentina V; Fleitas, Tania T; Cervantes, Andrés A
Publication Date: 2018

Variant appearance in text: HER2: G660R
PubMed Link: 30559980
Variant Present in the following documents:
  • Main text
  • esmoopen-2018-000468.pdf
View BVdb publication page



Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations.

Cancer Cell
Pahuja, Kanika Bajaj KB; Nguyen, Thong T TT; Jaiswal, Bijay S BS; Prabhash, Kumar K; Thaker, Tarjani M TM; Senger, Kate K; Chaudhuri, Subhra S; Kljavin, Noelyn M NM; Antony, Aju A; Phalke, Sameer S; Kumar, Prasanna P; Mravic, Marco M; Stawiski, Eric W EW; Vargas, Derek D; Durinck, Steffen S; Gupta, Ravi R; Khanna-Gupta, Arati A; Trabucco, Sally E SE; Sokol, Ethan S ES; Hartmaier, Ryan J RJ; Singh, Ashish A; Chougule, Anuradha A; Trivedi, Vaishakhi V; Dutt, Amit A; Patil, Vijay V; Joshi, Amit A; Noronha, Vanita V; Ziai, James J; Banavali, Sripad D SD; Ramprasad, Vedam V; DeGrado, William F WF; Bueno, Raphael R; Jura, Natalia N; Seshagiri, Somasekar S
Publication Date: 2018-11-12

Variant appearance in text: HER2: G660R
PubMed Link: 30449325
Variant Present in the following documents:
  • Main text
View BVdb publication page



Afatinib as first-line treatment for advanced lung adenocarcinoma patients harboring HER2 mutation: A case report and review of the literature.

Thoracic Cancer
Shi, Yuequan Y; Wang, Mengzhao M
Publication Date: 2018-12

Variant appearance in text: HER2: G660R
PubMed Link: 30379401
Variant Present in the following documents:
  • Main text
  • TCA-9-1788.pdf
View BVdb publication page



Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Cell Reports
Way, Gregory P GP; Sanchez-Vega, Francisco F; La, Konnor K; Armenia, Joshua J; Chatila, Walid K WK; Luna, Augustin A; Sander, Chris C; Cherniack, Andrew D AD; Mina, Marco M; Ciriello, Giovanni G; Schultz, Nikolaus N; , ; Sanchez, Yolanda Y; Greene, Casey S CS
Publication Date: 2018-04-03

Variant appearance in text: ERBB2: Gly660Arg
PubMed Link: 29617658
Variant Present in the following documents:
  • NIHMS958974-supplement-6.xlsx, sheet 1
View BVdb publication page