ERBB2 c.2305G>C ;(p.D769H)

Variant ID: 17-37880261-G-C

NM_004448.2(ERBB2):c.2305G>C;(p.D769H)

This variant was identified in 130 publications

View GRCh38 version.




Publications:


Mechanisms of neratinib resistance in HER2-mutant metastatic breast cancer.

Cancer Drug Resistance (Alhambra, Calif.)
Eli, Lisa D LD; Kavuri, Shyam M SM
Publication Date: 2022

Variant appearance in text: HER2: D769H
PubMed Link: 36627899
Variant Present in the following documents:
  • cdr-5-4-873.pdf
View BVdb publication page



Trastuzumab combined with irinotecan in patients with HER2-positive metastatic colorectal cancer: A phase II single-arm study and exploratory biomarker analysis.

Cancer Research And Treatment
Xu, Ting T; Wang, Xicheng X; Xin, Ying Y; Wang, Zhenghang Z; Gong, Jifang J; Zhang, Xiaotian X; Li, Yanyan Y; Ji, Congcong C; Sun, Yu Y; Zhao, Feilong F; Huang, Depei D; Bai, Yuezong Y; Li, Jian J; Shen, Lin L
Publication Date: 2022-12-23

Variant appearance in text: HER2: D769H
PubMed Link: 36550683
Variant Present in the following documents:
  • Main text
  • crt-2022-1058.pdf
View BVdb publication page



An EGFR L858R mutation identified in 1862 Chinese NSCLC patients can be a promising neoantigen vaccine therapeutic strategy.

Frontiers In Immunology
Lin, Jing J; Liu, Jun J; Hao, Shi-Guang SG; Lan, Bin B; Zheng, Xiao-Bin XB; Xiong, Jia-Ni JN; Zhang, Ying-Qian YQ; Gao, Xuan X; Chen, Chuan-Ben CB; Chen, Ling L; Huang, Yu-Fang YF; Luo, Hong H; Yi, Yu-Ting YT; Yi, Xin X; Lu, Jian-Ping JP; Zheng, Xiong-Wei XW; Chen, Gang G; Wang, Xue-Feng XF; Chen, Yu Y
Publication Date: 2022

Variant appearance in text: ERBB2: 2305G>C; D769H
PubMed Link: 36505399
Variant Present in the following documents:
  • Table_2.xlsx, sheet 3
  • Table_2.xlsx, sheet 2
View BVdb publication page



Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications
Boström, Martin M; Larsson, Erik E
Publication Date: 2022-11-17

Variant appearance in text: ERBB2: D769H
PubMed Link: 36396655
Variant Present in the following documents:
  • 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics
Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q
Publication Date: 2022-11-04

Variant appearance in text: N/A
PubMed Link: 36333792
Variant Present in the following documents:
View BVdb publication page



Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract.

Cancer Communications (London, England)
Wu, Huanwen H; Yu, Zicheng Z; Liu, Yueping Y; Guo, Lei L; Teng, Lianghong L; Guo, Lingchuan L; Liang, Li L; Wang, Jing J; Gao, Jie J; Li, Ruiyu R; Yang, Ling L; Nie, Xiu X; Su, Dan D; Liang, Zhiyong Z
Publication Date: 2022-10-20

Variant appearance in text: ERBB2: 2305G>C; D769H; rs121913468
PubMed Link: 36264285
Variant Present in the following documents:
  • CAC2-42-1367-s002.xlsx, sheet 3
View BVdb publication page



A single arm phase Ib/II trial of first-line pembrolizumab, trastuzumab and chemotherapy for advanced HER2-positive gastric cancer.

Nature Communications
Lee, Choong-Kun CK; Rha, Sun Young SY; Kim, Hyo Song HS; Jung, Minkyu M; Kang, Beodeul B; Che, Jingmin J; Kwon, Woo Sun WS; Park, Sejung S; Bae, Woo Kyun WK; Koo, Dong-Hoe DH; Shin, Su-Jin SJ; Kim, Hyunki H; Jeung, Hei-Cheul HC; Zang, Dae Young DY; Lee, Sang Kil SK; Nam, Chung Mo CM; Chung, Hyun Cheol HC
Publication Date: 2022-10-12

Variant appearance in text: ERBB2: D769H
PubMed Link: 36224176
Variant Present in the following documents:
  • Main text
  • 41467_2022_Article_33267.pdf
View BVdb publication page



Improving prediction of response to neoadjuvant treatment in patients with breast cancer by combining liquid biopsies with multiparametric MRI: protocol of the LIMA study - a multicentre prospective observational cohort study.

Bmj Open
Janssen, Liselore M LM; Suelmann, Britt B M BBM; Elias, Sjoerd G SG; Janse, Markus H A MHA; van Diest, Paul J PJ; van der Wall, Elsken E; Gilhuijs, Kenneth G A KGA
Publication Date: 2022-09-20

Variant appearance in text: ERBB2: D769H
PubMed Link: 36127090
Variant Present in the following documents:
  • bmjopen-2022-061334supp001.pdf
  • bmjopen-2022-061334.draft_revisions.pdf
  • bmjopen-2022-061334.reviewer_comments.pdf
View BVdb publication page



Comprehensive genomic profiling of Finnish lung adenocarcinoma cohort reveals high clinical actionability and SMARCA4 altered tumors with variable histology and poor prognosis.

Neoplasia (New York, N.Y.)
Talvitie, Eva-Maria EM; Liljeroos, Lassi L; Vilhonen, Heikki H; Orte, Katri K; Leivo, Ilmo I; Kallajoki, Markku M; Taimen, Pekka P
Publication Date: 2022-10

Variant appearance in text: ERBB2: Asp769His
PubMed Link: 35964518
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Molecular Landscape of ERBB2 Alterations in 14,956 Solid Tumors.

Pathology Oncology Research : Por
Wang, Hao H; Miao, Ji J; Wen, Yazhou Y; Xia, Xihua X; Chen, Yanan Y; Huang, Mengli M; Chen, Shiqing S; Zhao, Zhengyi Z; Zhang, Yuzi Y; Chen, Chunzhu C; Zhu, Xinhua X
Publication Date: 2022

Variant appearance in text: ERBB2: D769H
PubMed Link: 35911441
Variant Present in the following documents:
  • Main text
  • pore-28-1610360.pdf
View BVdb publication page



Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.

Nature Communications
Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A
Publication Date: 2022-07-13

Variant appearance in text: ERBB2: 2305G>C; Asp769His; rs121913468
PubMed Link: 35831314
Variant Present in the following documents:
  • 41467_2022_31809_MOESM8_ESM.xlsx, sheet 3
View BVdb publication page



Poziotinib Inhibits HER2-Mutant-Driven Therapeutic Resistance and Multiorgan Metastasis in Breast Cancer.

Cancer Research
Kalra, Rashi R; Chen, Ching Hui CH; Wang, Junkai J; Salam, Ahmad Bin AB; Dobrolecki, Lacey E LE; Lewis, Alaina A; Sallas, Christina C; Yates, Clayton C CC; Gutierrez, Carolina C; Karanam, Balasubramanyam B; Anurag, Meenakshi M; Lim, Bora B; Ellis, Matthew J MJ; Kavuri, Shyam M SM
Publication Date: 2022-08-16

Variant appearance in text: HER2: D769H
PubMed Link: 35736563
Variant Present in the following documents:
  • Main text
  • 2928.pdf
View BVdb publication page



Construction and validation of an immunoediting-based optimized neoantigen load (ioTNL) model to predict the response and prognosis of immune checkpoint therapy in various cancers.

Aging
Su, Xiaofan X; Jin, Haoxuan H; Wang, Jiaqian J; Lu, Huiping H; Gu, Tiantian T; Gao, Zhibo Z; Li, Manxiang M
Publication Date: 2022-05-25

Variant appearance in text: ERBB2: 2305G>C; D769H
PubMed Link: 35613927
Variant Present in the following documents:
  • aging-14-204101-s004.xlsx, sheet 1
View BVdb publication page



Molecular landscape of TP53 mutations in breast cancer and their utility for predicting the response to HER-targeted therapy in HER2 amplification-positive and HER2 mutation-positive amplification-negative patients.

Cancer Medicine
Liu, Binliang B; Yi, Zongbi Z; Guan, Yanfang Y; Ouyang, Quchang Q; Li, Chunxiao C; Guan, Xiuwen X; Lv, Dan D; Li, Lixi L; Zhai, Jingtong J; Qian, Haili H; Xu, Binghe B; Ma, Fei F; Zeng, Yixin Y
Publication Date: 2022-07

Variant appearance in text: ERBB2: 2305G>C; D769H
PubMed Link: 35393784
Variant Present in the following documents:
  • CAM4-11-2767-s001.xlsx, sheet 1
View BVdb publication page



Evaluation of the Clinical Utility of Genomic Profiling to Inform Selection of Clinical Trial Therapy in Salivary Gland Cancer.

Cancers
Rack, Samuel S; Feeney, Laura L; Hapuarachi, Brindley B; Adderley, Helen H; Woodhouse, Laura L; Betts, Guy G; Burghel, George J GJ; Harrington, Kevin J KJ; Metcalf, Robert R
Publication Date: 2022-02-23

Variant appearance in text: ERBB2: 2305G>C
PubMed Link: 35267442
Variant Present in the following documents:
  • cancers-14-01133.pdf
View BVdb publication page



Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research
Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL
Publication Date: 2022-05

Variant appearance in text: ERBB2: D769H
PubMed Link: 35229492
Variant Present in the following documents:
  • PCMR-35-369-s003.xlsx, sheet 12
View BVdb publication page



The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: ERBB2: Asp769His
PubMed Link: 35221333
Variant Present in the following documents:
  • 43018_2022_332_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Disease characterization in liquid biopsy from HER2-mutated, non-amplified metastatic breast cancer patients treated with neratinib.

Npj Breast Cancer
Shishido, Stephanie N SN; Masson, Rahul R; Xu, Liya L; Welter, Lisa L; Prabakar, Rishvanth Kaliappan RK; D' Souza, Anishka A; Spicer, Darcy D; Kang, Irene I; Jayachandran, Priya P; Hicks, James J; Lu, Janice J; Kuhn, Peter P
Publication Date: 2022-02-18

Variant appearance in text: ERBB2: D769H
PubMed Link: 35181666
Variant Present in the following documents:
  • 41523_2022_390_MOESM1_ESM.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: ERBB2: D769H
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Clinical Utility of Liquid Biopsy-Based Actionable Mutations Detected via ddPCR.

Biomedicines
Palacín-Aliana, Irina I; García-Romero, Noemí N; Asensi-Puig, Adrià A; Carrión-Navarro, Josefa J; González-Rumayor, Víctor V; Ayuso-Sacido, Ángel Á
Publication Date: 2021-07-28

Variant appearance in text: HER2: D769H
PubMed Link: 34440110
Variant Present in the following documents:
  • Main text
View BVdb publication page



Dissecting the biological heterogeneity of HER2-positive breast cancer.

Breast (Edinburgh, Scotland)
Schettini, Francesco F; Prat, Aleix A
Publication Date: 2021-10

Variant appearance in text: HER2: D769H
PubMed Link: 34392185
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology
Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN
Publication Date: 2021

Variant appearance in text: ERBB2: D769H
PubMed Link: 34113354
Variant Present in the following documents:
  • Table_1.xlsx, sheet 4
  • Table_1.xlsx, sheet 2
  • Table_1.xlsx, sheet 3
View BVdb publication page



Tumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients.

Genome Medicine
Tsui, Dana W Y DWY; Cheng, Michael L ML; Shady, Maha M; Yang, Julie L JL; Stephens, Dennis D; Won, Helen H; Srinivasan, Preethi P; Huberman, Kety K; Meng, Fanli F; Jing, Xiaohong X; Patel, Juber J; Hasan, Maysun M; Johnson, Ian I; Gedvilaite, Erika E; Houck-Loomis, Brian B; Socci, Nicholas D ND; Selcuklu, S Duygu SD; Seshan, Venkatraman E VE; Zhang, Hongxin H; Chakravarty, Debyani D; Zehir, Ahmet A; Benayed, Ryma R; Arcila, Maria M; Ladanyi, Marc M; Funt, Samuel A SA; Feldman, Darren R DR; Li, Bob T BT; Razavi, Pedram P; Rosenberg, Jonathan J; Bajorin, Dean D; Iyer, Gopa G; Abida, Wassim W; Scher, Howard I HI; Rathkopf, Dana D; Viale, Agnes A; Berger, Michael F MF; Solit, David B DB
Publication Date: 2021-05-31

Variant appearance in text: ERBB2: D769H
PubMed Link: 34059130
Variant Present in the following documents:
  • 13073_2021_898_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Genomic profile of advanced breast cancer in circulating tumour DNA.

Nature Communications
Kingston, Belinda B; Cutts, Rosalind J RJ; Bye, Hannah H; Beaney, Matthew M; Walsh-Crestani, Giselle G; Hrebien, Sarah S; Swift, Claire C; Kilburn, Lucy S LS; Kernaghan, Sarah S; Moretti, Laura L; Wilkinson, Katie K; Wardley, Andrew M AM; Macpherson, Iain R IR; Baird, Richard D RD; Roylance, Rebecca R; Reis-Filho, Jorge S JS; Hubank, Michael M; Faull, Iris I; Banks, Kimberly C KC; Lanman, Richard B RB; Garcia-Murillas, Isaac I; Bliss, Judith M JM; Ring, Alistair A; Turner, Nicholas C NC
Publication Date: 2021-04-23

Variant appearance in text: HER2: D769H
PubMed Link: 33893289
Variant Present in the following documents:
  • Main text
View BVdb publication page



Comprehensive omic characterization of breast cancer in Mexican-Hispanic women.

Nature Communications
Romero-Cordoba, Sandra L SL; Salido-Guadarrama, Ivan I; Rebollar-Vega, Rosa R; Bautista-Piña, Veronica V; Dominguez-Reyes, Carlos C; Tenorio-Torres, Alberto A; Villegas-Carlos, Felipe F; Fernández-López, Juan C JC; Uribe-Figueroa, Laura L; Alfaro-Ruiz, Luis L; Hidalgo-Miranda, Alfredo A
Publication Date: 2021-04-14

Variant appearance in text: ERBB2: D769H
PubMed Link: 33854067
Variant Present in the following documents:
  • 41467_2021_22478_MOESM8_ESM.xlsx, sheet 5
View BVdb publication page



Early plasma circulating tumor DNA (ctDNA) changes predict response to first-line pembrolizumab-based therapy in non-small cell lung cancer (NSCLC).

Journal For Immunotherapy Of Cancer
Ricciuti, Biagio B; Jones, Greg G; Severgnini, Mariano M; Alessi, Joao V JV; Recondo, Gonzalo G; Lawrence, Marissa M; Forshew, Tim T; Lydon, Christine C; Nishino, Mizuki M; Cheng, Michael M; Awad, Mark M
Publication Date: 2021-03

Variant appearance in text: HER2: D769H
PubMed Link: 33771889
Variant Present in the following documents:
  • Main text
  • jitc-2020-001504.pdf
  • jitc-2020-001504supp002.pdf
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: ERBB2: 2305G>C; D769H
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



Partial Response to Pyrotinib Plus Capecitabine in an Advanced Breast Cancer Patient with HER2 Amplification and R157W Mutation After Anti-HER2 Treatment: A Case Report and Literature Review.

Oncotargets And Therapy
Qu, Yanchun Y; Liu, Yufeng Y; Ding, Kailin K; Li, Yong Y; Hong, Xiaoyu X; Zhang, Haibo H
Publication Date: 2021

Variant appearance in text: HER2: D769H
PubMed Link: 33688205
Variant Present in the following documents:
  • Main text
  • ott-14-1581.pdf
View BVdb publication page



Molecular Biomarkers for Contemporary Therapies in Hormone Receptor-Positive Breast Cancer.

Genes
Freelander, Allegra A; Brown, Lauren J LJ; Parker, Andrew A; Segara, Davendra D; Portman, Neil N; Lau, Brandon B; Lim, Elgene E
Publication Date: 2021-02-17

Variant appearance in text: HER2: Asp769His
PubMed Link: 33671468
Variant Present in the following documents:
  • Main text
  • genes-12-00285.pdf
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: ERBB2: 2305G>C; D769H
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
  • 41467_2020_20162_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Predictive Biomarkers for Immune Checkpoint Inhibitors in Metastatic Breast Cancer.

Cancer Medicine
Sivapiragasam, Abirami A; Ashok Kumar, Prashanth P; Sokol, Ethan S ES; Albacker, Lee A LA; Killian, Jonathan K JK; Ramkissoon, Shakti H SH; Huang, Richard S P RSP; Severson, Eric A EA; Brown, Charlotte A CA; Danziger, Natalie N; McGregor, Kimberly K; Ross, Jeffrey S JS
Publication Date: 2021-01

Variant appearance in text: ERBB2: D769H
PubMed Link: 33314633
Variant Present in the following documents:
  • CAM4-10-53-s003.xlsx, sheet 1
  • CAM4-10-53-s002.xlsx, sheet 1
View BVdb publication page



Distinct mutation profiles between primary bladder cancer and circulating tumor cells warrant the use of circulating tumors cells as cellular resource for mutation follow-up.

Bmc Cancer
Kim, Tae-Min TM; Yoo, Jin-Seon JS; Moon, Hyong Woo HW; Hur, Kyung Jae KJ; Choi, Jin Bong JB; Hong, Sung-Hoo SH; Lee, Ji Youl JY; Ha, U-Syn US
Publication Date: 2020-12-07

Variant appearance in text: ERBB2: D769H
PubMed Link: 33287735
Variant Present in the following documents:
  • 12885_2020_7684_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Tyrosine Kinase Receptors in Oncology.

International Journal Of Molecular Sciences
Esteban-Villarrubia, Jorge J; Soto-Castillo, Juan José JJ; Pozas, Javier J; San Román-Gil, María M; Orejana-Martín, Inmaculada I; Torres-Jiménez, Javier J; Carrato, Alfredo A; Alonso-Gordoa, Teresa T; Molina-Cerrillo, Javier J
Publication Date: 2020-11-12

Variant appearance in text: HER2: D769H
PubMed Link: 33198314
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular landscape and efficacy of HER2-targeted therapy in patients with HER2-mutated metastatic breast cancer.

Npj Breast Cancer
Yi, Zongbi Z; Rong, Guohua G; Guan, Yanfang Y; Li, Jin J; Chang, Lianpeng L; Li, Hui H; Liu, Binliang B; Wang, Wenna W; Guan, Xiuwen X; Ouyang, Quchang Q; Li, Lixi L; Zhai, Jingtong J; Li, Chunxiao C; Li, Lifeng L; Xia, Xuefeng X; Yang, Ling L; Qian, Haili H; Yi, Xin X; Xu, Binghe B; Ma, Fei F
Publication Date: 2020

Variant appearance in text: HER2: D769H
PubMed Link: 33145402
Variant Present in the following documents:
  • Main text
  • 41523_2020_Article_201.pdf
  • 41523_2020_201_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports
Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O
Publication Date: 2020-10-13

Variant appearance in text: rs121913468
PubMed Link: 33051506
Variant Present in the following documents:
  • 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Identifying ERBB2 Activating Mutations in HER2-Negative Breast Cancer: Clinical Impact of Institute-Wide Genomic Testing and Enrollment in Matched Therapy Trials.

Jco Precision Oncology
Exman, Pedro P; Garrido-Castro, Ana C AC; Hughes, Melissa E ME; Freedman, Rachel A RA; Li, Tianyu T; Trippa, Lorenzo L; Bychkovsky, Brittany L BL; Barroso-Sousa, Romualdo R; Di Lascio, Simona S; Mackichan, Colin C; Lloyd, Max R MR; Krevalin, Max M; Cerami, Ethan E; Merrill, Margaret S MS; Santiago, Rebecca R; Crowley, Lindsey L; Kuhnly, Nicole N; Files, Janet J; Lindeman, Neal I NI; MacConaill, Laura E LE; Kumari, Priti P; Tolaney, Sara M SM; Krop, Ian E IE; Bose, Ron R; Johnson, Bruce E BE; Ma, Cynthia X CX; Dillon, Deborah A DA; Winer, Eric P EP; Wagle, Nikhil N; Lin, Nancy U NU
Publication Date: 2019

Variant appearance in text: ERBB2: D769H
PubMed Link: 32923853
Variant Present in the following documents:
  • Main text
View BVdb publication page



HER2 Exon 20 Insertion Mutations in Lung Adenocarcinoma: Case Series and Response to Pyrotinib.

Frontiers In Oncology
Zhang, Xinyong X; Lv, Jialin J; Wu, Yuhua Y; Qin, Na N; Ma, Li L; Li, Xi X; Nong, Jingying J; Zhang, Hui H; Zhang, Quan Q; Yang, Xinjie X; Shi, Huibo H; Wang, Jinghui J; Zhang, Shucai S
Publication Date: 2020

Variant appearance in text: HER2: D769H
PubMed Link: 32850330
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets.

Breast Cancer Research : Bcr
Kurozumi, Sasagu S; Alsaleem, Mansour M; Monteiro, Cíntia J CJ; Bhardwaj, Kartikeya K; Joosten, Stacey E P SEP; Fujii, Takaaki T; Shirabe, Ken K; Green, Andrew R AR; Ellis, Ian O IO; Rakha, Emad A EA; Mongan, Nigel P NP; Heery, David M DM; Zwart, Wilbert W; Oesterreich, Steffi S; Johnston, Simon J SJ
Publication Date: 2020-08-11

Variant appearance in text: HER2: D769H
PubMed Link: 32782013
Variant Present in the following documents:
  • Main text
View BVdb publication page



Oncogenic mutations within the β3-αC loop of EGFR/ERBB2/BRAF/MAP2K1 predict response to therapies.

Molecular Genetics & Genomic Medicine
Zhang, Biao B; Chen, Yongsheng Y; Dai, Pingping P; Yu, Haoda H; Ma, Jianhui J; Chen, Chen C; Zhang, Yan Y; Guan, Yanfang Y; Chen, Rongrong R; Liu, Tao T; Wang, Jiayin J; Yang, Ling L; Yi, Xin X; Xia, Xuefeng X; Ma, Haitao H
Publication Date: 2020-10

Variant appearance in text: ERBB2: D769H
PubMed Link: 32757330
Variant Present in the following documents:
  • Main text
View BVdb publication page



Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine
Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y
Publication Date: 2020-08-01

Variant appearance in text: ERBB2: D769H
PubMed Link: 32738923
Variant Present in the following documents:
  • 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Molecular subtyping and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer: the FUTURE trial.

Cell Research
Jiang, Yi-Zhou YZ; Liu, Yin Y; Xiao, Yi Y; Hu, Xin X; Jiang, Lin L; Zuo, Wen-Jia WJ; Ma, Ding D; Ding, Jiahan J; Zhu, Xiaoyu X; Zou, Jianjun J; Verschraegen, Claire C; Stover, Daniel G DG; Kaklamani, Virginia V; Wang, Zhong-Hua ZH; Shao, Zhi-Ming ZM
Publication Date: 2021-02

Variant appearance in text: rs121913468
PubMed Link: 32719455
Variant Present in the following documents:
  • 41422_2020_375_MOESM12_ESM.xlsx, sheet 1
View BVdb publication page



ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications.

Journal Of Clinical Medicine
Jin, Wook W
Publication Date: 2020-07-16

Variant appearance in text: ERBB2: D769H
PubMed Link: 32708604
Variant Present in the following documents:
  • Main text
  • jcm-09-02255.pdf
View BVdb publication page



Comparable cancer-relevant mutation profiles in synchronous ductal carcinoma in situ and invasive breast cancer.

Cancer Reports (Hoboken, N.J.)
Bergholtz, Helga H; Kumar, Surendra S; Wärnberg, Fredrik F; Lüders, Torben T; Kristensen, Vessela V; Sørlie, Therese T
Publication Date: 2020-06

Variant appearance in text: ERBB2: D769H
PubMed Link: 32671987
Variant Present in the following documents:
  • Main text
  • CNR2-3-e1248-s003.xlsx, sheet 1
View BVdb publication page



Breast Cancer With a HER2 IHC2+ and FISH HER2/CEP17 Ratio ≥2.0 and an Average HER2 Gene Copy Number <4.0 per Tumor Cell: HER2 mRNA Overexpression Is a Rare Event.

Frontiers In Oncology
Liu, Yuanyuan Y; Wu, Shafei S; Shi, Xiaohua X; Mao, Feng F; Zeng, Xuan X
Publication Date: 2020

Variant appearance in text: HER2: D769H
PubMed Link: 32637359
Variant Present in the following documents:
  • Main text
  • fonc-10-00985.pdf
View BVdb publication page



mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.

Cell Reports
Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM
Publication Date: 2020-06-23

Variant appearance in text: ERBB2: D769H
PubMed Link: 32579932
Variant Present in the following documents:
  • mmc5.xlsx, sheet 3
View BVdb publication page



Landscape of drug-resistance mutations in kinase regulatory hotspots.

Briefings In Bioinformatics
Kim, Pora P; Li, Hanyang H; Wang, Junmei J; Zhao, Zhongming Z
Publication Date: 2021-05-20

Variant appearance in text: ERBB2: D769H
PubMed Link: 32510566
Variant Present in the following documents:
  • Main text
View BVdb publication page



Phase and context shape the function of composite oncogenic mutations.

Nature
Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS
Publication Date: 2020-06

Variant appearance in text: ERBB2: D769H
PubMed Link: 32461694
Variant Present in the following documents:
  • NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2
View BVdb publication page