Comparative analysis of EpCAM high-expressing and low-expressing circulating tumour cells with regard to their clonal relationship and clinical value.
British Journal Of Cancer
Franken, André A; Kraemer, Annika A; Sicking, Alicia A; Watolla, Meike M; Rivandi, Mahdi M; Yang, Liwen L; Warfsmann, Jens J; Polzer, Bernhard M BM; Friedl, Thomas W P TWP; Meier-Stiegen, Franziska F; Stoecklein, Nikolas H NH; Dayan, Davut D; Riethdorf, Sabine S; Mueller, Volkmar V; Pantel, Klaus K; Koch, André A; Hartkopf, Andreas D AD; Krawczyk, Natalia N; Ruckhaeberle, Eugen E; Niederacher, Dieter D; Fehm, Tanja T; Neubauer, Hans H
USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K.
Molecular Oncology
Prieto-Garcia, Cristian C; Hartmann, Oliver O; Reissland, Michaela M; Braun, Fabian F; Bozkurt, Süleyman S; Pahor, Nikolett N; Fuss, Carmina C; Schirbel, Andreas A; Schülein-Völk, Christina C; Buchberger, Alexander A; Calzado Canale, Marco A MA; Rosenfeldt, Mathias M; Dikic, Ivan I; Münch, Christian C; Diefenbacher, Markus E ME
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy.
Cancer Discovery
Song, Kyung W KW; Edgar, Kyle A KA; Hanan, Emily J EJ; Hafner, Marc M; Oeh, Jason J; Merchant, Mark M; Sampath, Deepak D; Nannini, Michelle A MA; Hong, Rebecca R; Phu, Lilian L; Forrest, William F WF; Stawiski, Eric E; Schmidt, Stephen S; Endres, Nicholas N; Guan, Jane J; Wallin, Jeffrey J JJ; Cheong, Jonathan J; Plise, Emile G EG; Lewis Phillips, Gail D GD; Salphati, Laurent L; Heffron, Timothy P TP; Olivero, Alan G AG; Malek, Shiva S; Staben, Steven T ST; Kirkpatrick, Donald S DS; Dey, Anwesha A; Friedman, Lori S LS
Mass Spectrometry as a Highly Sensitive Method for Specific Circulating Tumor DNA Analysis in NSCLC: A Comparison Study.
Cancers
Lamy, Pierre-Jean PJ; van der Leest, Paul P; Lozano, Nicolas N; Becht, Catherine C; Duboeuf, Frédérique F; Groen, Harry J M HJM; Hilgers, Werner W; Pourel, Nicolas N; Rifaela, Naomi N; Schuuring, Ed E; Alix-Panabières, Catherine C
Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer care.
Npj Genomic Medicine
Rennert, Hanna H; Eng, Kenneth K; Zhang, Tuo T; Tan, Adrian A; Xiang, Jenny J; Romanel, Alessandro A; Kim, Robert R; Tam, Wayne W; Liu, Yen-Chun YC; Bhinder, Bhavneet B; Cyrta, Joanna J; Beltran, Himisha H; Robinson, Brian B; Mosquera, Juan Miguel JM; Fernandes, Helen H; Demichelis, Francesca F; Sboner, Andrea A; Kluk, Michael M; Rubin, Mark A MA; Elemento, Olivier O
Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer.
Acs Chemical Biology
Terai, Hideki H; Tan, Li L; Beauchamp, Ellen M EM; Hatcher, John M JM; Liu, Qingsong Q; Meyerson, Matthew M; Gray, Nathanael S NS; Hammerman, Peter S PS
Revealing the Molecular Portrait of Triple Negative Breast Tumors in an Understudied Population through Omics Analysis of Formalin-Fixed and Paraffin-Embedded Tissues.
Plos One
Vaca-Paniagua, Felipe F; Alvarez-Gomez, Rosa María RM; Maldonado-Martínez, Hector Aquiles HA; Pérez-Plasencia, Carlos C; Fragoso-Ontiveros, Veronica V; Lasa-Gonsebatt, Federico F; Herrera, Luis Alonso LA; Cantú, David D; Bargallo-Rocha, Enrique E; Mohar, Alejandro A; Durand, Geoffroy G; Forey, Nathalie N; Voegele, Catherine C; Vallée, Maxime M; Le Calvez-Kelm, Florence F; McKay, James J; Ardin, Maude M; Villar, Stéphanie S; Zavadil, Jiri J; Olivier, Magali M
PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity, prognostic impact and incidence of prior malignancies.
Oncotarget
Scheffler, Matthias M; Bos, Marc M; Gardizi, Masyar M; König, Katharina K; Michels, Sebastian S; Fassunke, Jana J; Heydt, Carina C; Künstlinger, Helen H; Ihle, Michaela M; Ueckeroth, Frank F; Albus, Kerstin K; Serke, Monika M; Gerigk, Ulrich U; Schulte, Wolfgang W; Töpelt, Karin K; Nogova, Lucia L; Zander, Thomas T; Engel-Riedel, Walburga W; Stoelben, Erich E; Ko, Yon-Dschun YD; Randerath, Winfried W; Kaminsky, Britta B; Panse, Jens J; Becker, Carolin C; Hellmich, Martin M; Merkelbach-Bruse, Sabine S; Heukamp, Lukas C LC; Büttner, Reinhard R; Wolf, Jürgen J
Randomised proof-of-concept phase II trial comparing targeted therapy based on tumour molecular profiling vs conventional therapy in patients with refractory cancer: results of the feasibility part of the SHIVA trial.
British Journal Of Cancer
Le Tourneau, C C; Paoletti, X X; Servant, N N; Bièche, I I; Gentien, D D; Rio Frio, T T; Vincent-Salomon, A A; Servois, V V; Romejon, J J; Mariani, O O; Bernard, V V; Huppe, P P; Pierron, G G; Mulot, F F; Callens, C C; Wong, J J; Mauborgne, C C; Rouleau, E E; Reyes, C C; Henry, E E; Leroy, Q Q; Gestraud, P P; La Rosa, P P; Escalup, L L; Mitry, E E; Trédan, O O; Delord, J-P JP; Campone, M M; Goncalves, A A; Isambert, N N; Gavoille, C C; Kamal, M M