Publications:

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BRCA1 transports the DNA damage signal for CDDP-induced centrosome amplification through the centrosomal Aurora A.

Cancer Science

Qi, Huicheng H; Kikuchi, Megumi M; Yoshino, Yuki Y; Fang, Zhenzhou Z; Ohashi, Kazune K; Gotoh, Takato T; Ideta, Ryo R; Ui, Ayako A; Endo, Shino S; Otsuka, Kei K; Shindo, Norihisa N; Gonda, Kohsuke K; Ishioka, Chikashi C; Miki, Yoshio Y; Iwabuchi, Tokuro T; Chiba, Natsuko N

Publication Date: 2022-09-09

Variant appearance in text: BRCA1: S1524A

PubMed Link: 36082621

Variant Present in the following documents:

• Main text
• CAS-113-4230.pdf

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Understanding and predicting the functional consequences of missense mutations in BRCA1 and BRCA2.

Scientific Reports

Aljarf, Raghad R; Shen, Mengyuan M; Pires, Douglas E V DEV; Ascher, David B DB

Publication Date: 2022-06-21

Variant appearance in text: BRCA1: S1524A

PubMed Link: 35729312

Variant Present in the following documents:

• 41598_2022_13508_MOESM2_ESM.xlsx, sheet 1

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An integrative model for the comprehensive classification of BRCA1 and BRCA2 variants of uncertain clinical significance.

Npj Genomic Medicine

Iversen, Edwin S ES; Lipton, Gary G; Hart, Steven N SN; Lee, Kun Y KY; Hu, Chunling C; Polley, Eric C EC; Pesaran, Tina T; Yussuf, Amal A; LaDuca, Holly H; Chao, Elizabeth E; Karam, Rachid R; Goldgar, David E DE; Couch, Fergus J FJ; Monteiro, Alvaro N A ANA

Publication Date: 2022-06-03

Variant appearance in text: BRCA1: S1524A

PubMed Link: 35665744

Variant Present in the following documents:

• 41525_2022_302_MOESM3_ESM.xlsx, sheet 1
• 41525_2022_302_MOESM3_ESM.xlsx, sheet 5
• 41525_2022_Article_302.pdf

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BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ.

Open Biology

Bunch, Heeyoun H; Jeong, Jaehyeon J; Kang, Keunsoo K; Jo, Doo Sin DS; Cong, Anh T Q ATQ; Kim, Deukyeong D; Kim, Donguk D; Cho, Dong-Hyung DH; Lee, You Mie YM; Chen, Benjamin P C BPC; Schellenberg, Matthew J MJ; Calderwood, Stuart K SK

Publication Date: 2021-10

Variant appearance in text: BRCA1: S1524A

PubMed Link: 34610268

Variant Present in the following documents:

• Main text
• rsob.210221.pdf

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Prediction of the functional impact of missense variants in BRCA1 and BRCA2 with BRCA-ML.

Npj Breast Cancer

Hart, Steven N SN; Polley, Eric C EC; Shimelis, Hermella H; Yadav, Siddhartha S; Couch, Fergus J FJ

Publication Date: 2020

Variant appearance in text: BRCA1: 4570T>G; Ser1524Ala

PubMed Link: 32377563

Variant Present in the following documents:

• 41523_2020_159_MOESM3_ESM.xlsx, sheet 1

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Comprehensive annotation of BRCA1 and BRCA2 missense variants by functionally validated sequence-based computational prediction models.

Genetics In Medicine : Official Journal Of The American College Of Medical Genetics

Hart, Steven N SN; Hoskin, Tanya T; Shimelis, Hermela H; Moore, Raymond M RM; Feng, Bingjian B; Thomas, Abigail A; Lindor, Noralane M NM; Polley, Eric C EC; Goldgar, David E DE; Iversen, Edwin E; Monteiro, Alvaro N A ANA; Suman, Vera J VJ; Couch, Fergus J FJ

Publication Date: 2019-01

Variant appearance in text: BRCA1: S1524A

PubMed Link: 29884841

Variant Present in the following documents:

• NIHMS953431-supplement-Table_S2.xls, sheet 1

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Unsolved mystery: the role of BRCA1 in DNA end-joining.

Journal Of Radiation Research

Saha, Janapriya J; Davis, Anthony J AJ

Publication Date: 2016-08

Variant appearance in text: BRCA1: S1524A

PubMed Link: 27170701

Variant Present in the following documents:

• Main text
• rrw032.pdf

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Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining.

Oncotarget

Beckta, Jason M JM; Dever, Seth M SM; Gnawali, Nisha N; Khalil, Ashraf A; Sule, Amrita A; Golding, Sarah E SE; Rosenberg, Elizabeth E; Narayanan, Aarthi A; Kehn-Hall, Kylene K; Xu, Bo B; Povirk, Lawrence F LF; Valerie, Kristoffer K

Publication Date: 2015-09-29

Variant appearance in text: BRCA1: S1524A

PubMed Link: 26320175

Variant Present in the following documents:

• Main text

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BRCA1 functions as a novel transcriptional cofactor in HIV-1 infection.

Virology Journal

Guendel, Irene I; Meltzer, Beatrix W BW; Baer, Alan A; Dever, Seth M SM; Valerie, Kristoffer K; Guo, Jia J; Wu, Yuntao Y; Kehn-Hall, Kylene K

Publication Date: 2015-03-06

Variant appearance in text: BRCA1: S1524A

PubMed Link: 25879655

Variant Present in the following documents:

• Main text
• 12985_2015_Article_266.pdf

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Probing structure-function relationships in missense variants in the carboxy-terminal region of BRCA1.

Plos One

Carvalho, Renato S RS; Abreu, Renata B V RB; Velkova, Aneliya A; Marsillac, Sylvia S; Rodarte, Renato S RS; Suarez-Kurtz, Guilherme G; Iversen, Edwin S ES; Monteiro, Alvaro N A AN; Carvalho, Marcelo A MA

Publication Date: 2014

Variant appearance in text: BRCA1: Ser1524Ala

PubMed Link: 24845084

Variant Present in the following documents:

• Main text
• pone.0097766.pdf

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BAF complexes facilitate decatenation of DNA by topoisomerase IIα.

Nature

Dykhuizen, Emily C EC; Hargreaves, Diana C DC; Miller, Erik L EL; Cui, Kairong K; Korshunov, Andrey A; Kool, Marcel M; Pfister, Stefan S; Cho, Yoon-Jae YJ; Zhao, Keji K; Crabtree, Gerald R GR

Publication Date: 2013-05-30

Variant appearance in text: BRCA1: S1524A

PubMed Link: 23698369

Variant Present in the following documents:

• nihms463906.pdf

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Links between genome integrity and BRCA1 tumor suppression.

Trends In Biochemical Sciences

Li, Mischa L ML; Greenberg, Roger A RA

Publication Date: 2012-10

Variant appearance in text: BRCA1: S1524A

PubMed Link: 22836122

Variant Present in the following documents:

• Main text

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Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of γ-H2AX and DNA damage responses in Huntington's disease.

Molecular Neurobiology

Jeon, Gye Sun GS; Kim, Ki Yoon KY; Hwang, Yu Jin YJ; Jung, Min-Kyung MK; An, Sungkwan S; Ouchi, Mutsuko M; Ouchi, Toru T; Kowall, Neil N; Lee, Junghee J; Ryu, Hoon H

Publication Date: 2012-06

Variant appearance in text: BRCA1: S1524A

PubMed Link: 22580959

Variant Present in the following documents:

• Main text

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The cellular response to DNA damage: a focus on MDC1 and its interacting proteins.

Nucleus (Austin, Tex.)

Coster, Gideon G; Goldberg, Michal M

Publication Date: 2010

Variant appearance in text: BRCA1: S1524A

PubMed Link: 21326949

Variant Present in the following documents:

• Main text

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Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations.

The Journal Of Clinical Investigation

Chang, Suhwan S; Biswas, Kajal K; Martin, Betty K BK; Stauffer, Stacey S; Sharan, Shyam K SK

Publication Date: 2009-10

Variant appearance in text: BRCA1: S1524A

PubMed Link: 19770520

Variant Present in the following documents:

• Main text

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Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner.

Cancer Research

Fan, Saijun S; Meng, Qinghui Q; Saha, Tapas T; Sarkar, Fazlul H FH; Rosen, Eliot M EM

Publication Date: 2009-08-01

Variant appearance in text: BRCA1: S1524A

PubMed Link: 19622773

Variant Present in the following documents:

• Main text

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Topoisomerase IIalpha controls the decatenation checkpoint.

Nature Cell Biology

Luo, Kuntian K; Yuan, Jian J; Chen, Junjie J; Lou, Zhenkun Z

Publication Date: 2009-02

Variant appearance in text: BRCA1: S1524A

PubMed Link: 19098900

Variant Present in the following documents:

• Main text

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