Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry.
Cancer Research Communications
White, Jason A JA; Kaninjing, Ernest T ET; Adeniji, Kayode A KA; Jibrin, Paul P; Obafunwa, John O JO; Ogo, Chidiebere N CN; Mohammed, Faruk F; Popoola, Ademola A; Fatiregun, Omolara A OA; Oluwole, Olabode P OP; Karanam, Balasubramanyam B; Elhussin, Isra I; Ambs, Stefan S; Tang, Wei W; Davis, Melissa M; Polak, Paz P; Campbell, Moray J MJ; Brignole, Kathryn R KR; Rotimi, Solomon O SO; Dean-Colomb, Windy W; Odedina, Folake T FT; Martin, Damali N DN; Yates, Clayton C
Publication Date: 2022-09
Variant appearance in text: RAD51C: 790G>A; Gly264Ser; rs147241704
Genomic complexity predicts resistance to endocrine therapy and CDK4/6 inhibition in hormone receptor-positive (HR+)/HER2-negative metastatic breast cancer.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Davis, Andrew A AA; Luo, Jingqin J; Zheng, Tiantian T; Dai, Chao C; Dong, Xiaoxi X; Tan, Lu L; Suresh, Rama R; Ademuyiwa, Foluso O FO; Rigden, Caron C; Rearden, Timothy P TP; Clifton, Katherine K; Weilbaecher, Katherine K; Frith, Ashley A; Tandra, Pavankumar K PK; Summa, Tracy T; Haas, Brittney B; Thomas, Shana S; Hernandez-Aya, Leonel F LF; Peterson, Lindsay L LL; Wang, Xiaohong X; Luo, Shujun J SJ; Zhou, Kemin K; Du, Pan P; Jia, Shidong S; King, Bonnie L BL; Krishnamurthy, Jairam J; Ma, Cynthia X CX
Publication Date: 2023-01-24
Variant appearance in text: RAD51C: 790G>A; Gly264Ser
RosettaDDGPrediction for high-throughput mutational scans: from stability to binding.
Protein Science : A Publication Of The Protein Society
Sora, Valentina V; Otamendi Laspiur, Adrian A; Degn, Kristine K; Arnaudi, Matteo M; Utichi, Mattia M; Beltrame, Ludovica L; De Menezes, Dayana D; Orlandi, Matteo M; Stoltze, Ulrik Kristoffer UK; Rigina, Olga O; Sackett, Peter Wad PW; Wadt, Karin K; Schmiegelow, Kjeld K; Tiberti, Matteo M; Papaleo, Elena E
Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Prakash, Rohit R; Rawal, Yashpal Y; Sullivan, Meghan R MR; Grundy, McKenzie K MK; Bret, Hélène H; Mihalevic, Michael J MJ; Rein, Hayley L HL; Baird, Jared M JM; Darrah, Kristie K; Zhang, Fang F; Wang, Raymond R; Traina, Tiffany A TA; Radke, Marc R MR; Kaufmann, Scott H SH; Swisher, Elizabeth M EM; Guérois, Raphaël R; Modesti, Mauro M; Sung, Patrick P; Jasin, Maria M; Bernstein, Kara A KA
Response prediction in patients with gastric and esophagogastric adenocarcinoma under neoadjuvant chemotherapy using targeted gene expression analysis and next-generation sequencing in pre-therapeutic biopsies.
Journal Of Cancer Research And Clinical Oncology
Kleo, Karsten K; Jovanovic, Vladimir M VM; Arndold, Alexander A; Lehmann, Annika A; Lammert, Hedwig H; Berg, Erika E; Harloff, Hannah H; Treese, Christoph C; Hummel, Michael M; Daum, Severin S
Publication Date: 2022-03-05
Variant appearance in text: RAD51C: 790G>A; Gly264Ser; rs147241704
Integration of tumour sequencing and case-control data to assess pathogenicity of RAD51C missense variants in familial breast cancer.
Npj Breast Cancer
Lim, Belle W X BWX; Li, Na N; Rowley, Simone M SM; Thompson, Ella R ER; McInerny, Simone S; Zethoven, Magnus M; Scott, Rodney J RJ; Devereux, Lisa L; Sloan, Erica K EK; James, Paul A PA; Campbell, Ian G IG
Integration of tumour sequencing and case-control data to assess pathogenicity of RAD51C missense variants in familial breast cancer.
Npj Breast Cancer
Lim, Belle W X BWX; Li, Na N; Rowley, Simone M SM; Thompson, Ella R ER; McInerny, Simone S; Zethoven, Magnus M; Scott, Rodney J RJ; Devereux, Lisa L; Sloan, Erica K EK; James, Paul A PA; Campbell, Ian G IG
Nationwide germline whole genome sequencing of 198 consecutive pediatric cancer patients reveals a high incidence of cancer prone syndromes.
Plos Genetics
Byrjalsen, Anna A; Hansen, Thomas V O TVO; Stoltze, Ulrik K UK; Mehrjouy, Mana M MM; Barnkob, Nanna Moeller NM; Hjalgrim, Lisa L LL; Mathiasen, René R; Lautrup, Charlotte K CK; Gregersen, Pernille A PA; Hasle, Henrik H; Wehner, Peder S PS; Tuckuviene, Ruta R; Sackett, Peter Wad PW; Laspiur, Adrian O AO; Rossing, Maria M; Marvig, Rasmus L RL; Tommerup, Niels N; Olsen, Tina Elisabeth TE; Scheie, David D; Gupta, Ramneek R; Gerdes, Anne-Marie AM; Schmiegelow, Kjeld K; Wadt, Karin K
Publication Date: 2020-12
Variant appearance in text: RAD51C: 790G>A; Gly264Ser
NGS Panel Testing of Triple-Negative Breast Cancer Patients in Cyprus: A Study of BRCA-Negative Cases.
Cancers
Zanti, Maria M; Loizidou, Maria A MA; Michailidou, Kyriaki K; Pirpa, Panagiota P; Machattou, Christina C; Marcou, Yiola Y; Kyriakou, Flora F; Kakouri, Eleni E; Tanteles, George A GA; Spanou, Elena E; Spyrou, George M GM; Kyriacou, Kyriacos K; Hadjisavvas, Andreas A
Publication Date: 2020-10-27
Variant appearance in text: RAD51C: 790G>A; Gly264Ser
Upregulation of mesothelial genes in ovarian carcinoma cells is associated with an unfavorable clinical outcome and the promotion of cancer cell adhesion.
Molecular Oncology
Ojasalu, Kaire K; Brehm, Corinna C; Hartung, Kristin K; Nischak, Maximilian M; Finkernagel, Florian F; Rexin, Peter P; Nist, Andrea A; Pavlakis, Evangelos E; Stiewe, Thorsten T; Jansen, Julia M JM; Wagner, Uwe U; Gattenlöhner, Stefan S; Bräuninger, Andreas A; Müller-Brüsselbach, Sabine S; Reinartz, Silke S; Müller, Rolf R
Clustering of known low and moderate risk alleles rather than a novel recessive high-risk gene in non-BRCA1/2 sib trios affected with breast cancer.
International Journal Of Cancer
Hilbers, Florentine S FS; van 't Hof, Peter J PJ; Meijers, Caro M CM; Mei, Hailiang H; Michailidou, Kyriaki K; Dennis, Joe J; Hogervorst, Frans B L FBL; Nederlof, Petra M PM; van Asperen, Christi J CJ; Devilee, Peter P
Publication Date: 2020-11-15
Variant appearance in text: RAD51C: 790G>A; G264S; rs147241704
Criteria of the German Consortium for Hereditary Breast and Ovarian Cancer for the Classification of Germline Sequence Variants in Risk Genes for Hereditary Breast and Ovarian Cancer.
Geburtshilfe Und Frauenheilkunde
Wappenschmidt, Barbara B; Hauke, Jan J; Faust, Ulrike U; Niederacher, Dieter D; Wiesmüller, Lisa L; Schmidt, Gunnar G; Groß, Evi E; Gehrig, Andrea A; Sutter, Christian C; Ramser, Juliane J; Rump, Andreas A; Arnold, Norbert N; Meindl, Alfons A
Characterization of tumor mutation burden, PD-L1 and DNA repair genes to assess relationship to immune checkpoint inhibitors response in metastatic renal cell carcinoma.
Journal For Immunotherapy Of Cancer
Labriola, Matthew Kyle MK; Zhu, Jason J; Gupta, Rajan T RT; McCall, Shannon S; Jackson, Jennifer J; Kong, Eric F EF; White, James R JR; Cerqueira, Gustavo G; Gerding, Kelly K; Simmons, John K JK; George, Daniel D; Zhang, Tian T
Genomics of lethal prostate cancer at diagnosis and castration resistance.
The Journal Of Clinical Investigation
Mateo, Joaquin J; Seed, George G; Bertan, Claudia C; Rescigno, Pasquale P; Dolling, David D; Figueiredo, Ines I; Miranda, Susana S; Nava Rodrigues, Daniel D; Gurel, Bora B; Clarke, Matthew M; Atkin, Mark M; Chandler, Rob R; Messina, Carlo C; Sumanasuriya, Semini S; Bianchini, Diletta D; Barrero, Maialen M; Petermolo, Antonella A; Zafeiriou, Zafeiris Z; Fontes, Mariane M; Perez-Lopez, Raquel R; Tunariu, Nina N; Fulton, Ben B; Jones, Robert R; McGovern, Ursula U; Ralph, Christy C; Varughese, Mohini M; Parikh, Omi O; Jain, Suneil S; Elliott, Tony T; Sandhu, Shahneen S; Porta, Nuria N; Hall, Emma E; Yuan, Wei W; Carreira, Suzanne S; de Bono, Johann S JS
Publication Date: 2020-04-01
Variant appearance in text: RAD51C: 790G>A; G264S; rs147241704
Exome sequencing in families with chronic central serous chorioretinopathy.
Molecular Genetics & Genomic Medicine
Schellevis, Rosa L RL; van Dijk, Elon H C EHC; Breukink, Myrte B MB; Keunen, Jan E E JEE; Santen, Gijs W E GWE; Hoyng, Carel B CB; de Jong, Eiko K EK; Boon, Camiel J F CJF; den Hollander, Anneke I AI
Publication Date: 2019-04
Variant appearance in text: RAD51C: G264S; rs147241704
Spectrum and Prevalence of Pathogenic Variants in Ovarian Cancer Susceptibility Genes in a Group of 333 Patients.
Cancers
Koczkowska, Magdalena M; Krawczynska, Natalia N; Stukan, Maciej M; Kuzniacka, Alina A; Brozek, Izabela I; Sniadecki, Marcin M; Debniak, Jaroslaw J; Wydra, Dariusz D; Biernat, Wojciech W; Kozlowski, Piotr P; Limon, Janusz J; Wasag, Bartosz B; Ratajska, Magdalena M
Publication Date: 2018-11-14
Variant appearance in text: RAD51C: 790G>A; Gly264Ser; rs147241704
Pancreatic cancer as a sentinel for hereditary cancer predisposition.
Bmc Cancer
Young, Erin L EL; Thompson, Bryony A BA; Neklason, Deborah W DW; Firpo, Matthew A MA; Werner, Theresa T; Bell, Russell R; Berger, Justin J; Fraser, Alison A; Gammon, Amanda A; Koptiuch, Cathryn C; Kohlmann, Wendy K WK; Neumayer, Leigh L; Goldgar, David E DE; Mulvihill, Sean J SJ; Cannon-Albright, Lisa A LA; Tavtigian, Sean V SV
Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamous cell carcinoma.
Oncotarget
Verhagen, Caroline V M CVM; Vossen, David M DM; Borgmann, Kerstin K; Hageman, Floor F; Grénman, Reidar R; Verwijs-Janssen, Manon M; Mout, Lisanne L; Kluin, Roel J C RJC; Nieuwland, Marja M; Severson, Tesa M TM; Velds, Arno A; Kerkhoven, Ron R; O'Connor, Mark J MJ; van der Heijden, Martijn M; van Velthuysen, Marie-Louise ML; Verheij, Marcel M; Wreesmann, Volkert B VB; Wessels, Lodewyk F A LFA; van den Brekel, Michiel W M MWM; Vens, Conchita C
Identification of genetic variants for clinical management of familial colorectal tumors.
Bmc Medical Genetics
Dominguez-Valentin, Mev M; Nakken, Sigve S; Tubeuf, Hélène H; Vodak, Daniel D; Ekstrøm, Per Olaf PO; Nissen, Anke M AM; Morak, Monika M; Holinski-Feder, Elke E; Martins, Alexandra A; Møller, Pål P; Hovig, Eivind E
Publication Date: 2018-02-20
Variant appearance in text: RAD51C: 790G>A; G264S; rs147241704
Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes.
British Journal Of Cancer
Gayarre, Javier J; Martín-Gimeno, Paloma P; Osorio, Ana A; Paumard, Beatriz B; Barroso, Alicia A; Fernández, Victoria V; de la Hoya, Miguel M; Rojo, Alejandro A; Caldés, Trinidad T; Palacios, José J; Urioste, Miguel M; Benítez, Javier J; García, María J MJ
Publication Date: 2017-09-26
Variant appearance in text: RAD51C: Gly264Ser; rs147241704
Conflicting Interpretation of Genetic Variants and Cancer Risk by Commercial Laboratories as Assessed by the Prospective Registry of Multiplex Testing.
Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Balmaña, Judith J; Digiovanni, Laura L; Gaddam, Pragna P; Walsh, Michael F MF; Joseph, Vijai V; Stadler, Zsofia K ZK; Nathanson, Katherine L KL; Garber, Judy E JE; Couch, Fergus J FJ; Offit, Kenneth K; Robson, Mark E ME; Domchek, Susan M SM
Publication Date: 2016-12
Variant appearance in text: RAD51C: 790G>A; Gly264Ser
Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer.
Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Tung, Nadine N; Lin, Nancy U NU; Kidd, John J; Allen, Brian A BA; Singh, Nanda N; Wenstrup, Richard J RJ; Hartman, Anne-Renee AR; Winer, Eric P EP; Garber, Judy E JE
Publication Date: 2016-05-01
Variant appearance in text: RAD51C: 790G>A; Gly264Ser
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Song, Honglin H; Dicks, Ed E; Ramus, Susan J SJ; Tyrer, Jonathan P JP; Intermaggio, Maria P MP; Hayward, Jane J; Edlund, Christopher K CK; Conti, David D; Harrington, Patricia P; Fraser, Lindsay L; Philpott, Susan S; Anderson, Christopher C; Rosenthal, Adam A; Gentry-Maharaj, Aleksandra A; Bowtell, David D DD; Alsop, Kathryn K; Cicek, Mine S MS; Cunningham, Julie M JM; Fridley, Brooke L BL; Alsop, Jennifer J; Jimenez-Linan, Mercedes M; Høgdall, Estrid E; Høgdall, Claus K CK; Jensen, Allan A; Kjaer, Susanne Krüger SK; Lubiński, Jan J; Huzarski, Tomasz T; Jakubowska, Anna A; Gronwald, Jacek J; Poblete, Samantha S; Lele, Shashi S; Sucheston-Campbell, Lara L; Moysich, Kirsten B KB; Odunsi, Kunle K; Goode, Ellen L EL; Menon, Usha U; Jacobs, Ian J IJ; Gayther, Simon A SA; Pharoah, Paul D P PD
Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD51C status.
Scientific Reports
Cunningham, J M JM; Cicek, M S MS; Larson, N B NB; Davila, J J; Wang, C C; Larson, M C MC; Song, H H; Dicks, E M EM; Harrington, P P; Wick, M M; Winterhoff, B J BJ; Hamidi, H H; Konecny, G E GE; Chien, J J; Bibikova, M M; Fan, J-B JB; Kalli, K R KR; Lindor, N M NM; Fridley, B L BL; Pharoah, P P D PP; Goode, E L EL