Publications:

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Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model.

Nature Communications

Lordén, Gema G; Wozniak, Jacob M JM; Doré, Kim K; Dozier, Lara E LE; Cates-Gatto, Chelsea C; Patrick, Gentry N GN; Gonzalez, David J DJ; Roberts, Amanda J AJ; Tanzi, Rudolph E RE; Newton, Alexandra C AC

Publication Date: 2022-11-23

Variant appearance in text: rs34406842

PubMed Link: 36418293

Variant Present in the following documents:

• Main text
• 41467_2022_34679_MOESM1_ESM.pdf
• 41467_2022_34679_MOESM3_ESM.pdf
• 41467_2022_Article_34679.pdf
• 41467_2022_34679_MOESM2_ESM.pdf

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Targeting Protein Kinase C for Cancer Therapy.

Cancers

He, Sijia S; Li, Qi Q; Huang, Qian Q; Cheng, Jin J

Publication Date: 2022-02-22

Variant appearance in text: PKCα: M489V

PubMed Link: 35267413

Variant Present in the following documents:

• cancers-14-01104.pdf

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SMAP is a pipeline for sample matching in proteogenomics.

Nature Communications

Li, Ling L; Niu, Mingming M; Erickson, Alyssa A; Luo, Jie J; Rowbotham, Kincaid K; Guo, Kai K; Huang, He H; Li, Yuxin Y; Jiang, Yi Y; Hur, Junguk J; Liu, Chunyu C; Peng, Junmin J; Wang, Xusheng X

Publication Date: 2022-02-08

Variant appearance in text: PRKCA: M489V

PubMed Link: 35136070

Variant Present in the following documents:

• 41467_2022_28411_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

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Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?

Neuronal Signaling

Lordén, Gema G; Newton, Alexandra C AC

Publication Date: 2021-12

Variant appearance in text: PKCα: M489V

PubMed Link: 34737895

Variant Present in the following documents:

• Main text
• ns-05-ns20210036C.pdf

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Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Callender, Julia A JA; Yang, Yimin Y; Lordén, Gema G; Stephenson, Natalie L NL; Jones, Alexander C AC; Brognard, John J; Newton, Alexandra C AC

Publication Date: 2018-06-12

Variant appearance in text: PKCα: M489V

PubMed Link: 29844158

Variant Present in the following documents:

• Main text

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Protein kinase C: perfectly balanced.

Critical Reviews In Biochemistry And Molecular Biology

Newton, Alexandra C AC

Publication Date: 2018-04

Variant appearance in text: PKCα: M489V

PubMed Link: 29513138

Variant Present in the following documents:

• Main text

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Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment.

Scientific Reports

Chen, Xiaowei Sylvia XS; Reader, Rose H RH; Hoischen, Alexander A; Veltman, Joris A JA; Simpson, Nuala H NH; Francks, Clyde C; Newbury, Dianne F DF; Fisher, Simon E SE

Publication Date: 2017-04-25

Variant appearance in text: PRKCA: M489V; rs34406842

PubMed Link: 28440294

Variant Present in the following documents:

• srep46105-s2.xls, sheet 8

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Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.

Science Signaling

Alfonso, Stephanie I SI; Callender, Julia A JA; Hooli, Basavaraj B; Antal, Corina E CE; Mullin, Kristina K; Sherman, Mathew A MA; Lesné, Sylvain E SE; Leitges, Michael M; Newton, Alexandra C AC; Tanzi, Rudolph E RE; Malinow, Roberto R

Publication Date: 2016-05-10

Variant appearance in text: PKCα: M489V; rs34406842

PubMed Link: 27165780

Variant Present in the following documents:

• Main text

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Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One

Holehouse, Alex S AS; Naegle, Kristen M KM

Publication Date: 2015

Variant appearance in text: rs34406842

PubMed Link: 26659599

Variant Present in the following documents:

• pone.0144692.s002.xlsx, sheet 1

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: PRKCA: M489V

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 1

View BVdb publication page

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