TP53 c.1126T>G ;(p.S376A)

Variant ID: 17-7572983-A-C

NM_000546.5(TP53):c.1126T>G;(p.S376A)

This variant was identified in 16 publications

View GRCh38 version.




Publications:


Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH.

Open Biology
Schulte, Tim T; Panas, Marc D MD; Han, Xiao X; Williams, Lucy L; Kedersha, Nancy N; Fleck, Jonas Simon JS; Tan, Timothy J C TJC; Dopico, Xaquin Castro XC; Olsson, Anders A; Morro, Ainhoa Moliner AM; Hanke, Leo L; Nilvebrant, Johan J; Giang, Kim Anh KA; Nygren, Per-Åke PÅ; Anderson, Paul P; Achour, Adnane A; McInerney, Gerald M GM
Publication Date: 2023-05

Variant appearance in text: p53: S376A
PubMed Link: 37161291
Variant Present in the following documents:
  • rsob.220369.pdf
View BVdb publication page



CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience
Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X
Publication Date: 2022-09-16

Variant appearance in text: p53: 1126T>G
PubMed Link: 36117989
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
View BVdb publication page



Regulation of p53 by the 14-3-3 protein interaction network: new opportunities for drug discovery in cancer.

Cell Death Discovery
Falcicchio, Marta M; Ward, Jake A JA; Macip, Salvador S; Doveston, Richard G RG
Publication Date: 2020-11-16

Variant appearance in text: p53: S376A
PubMed Link: 33298896
Variant Present in the following documents:
  • Main text
  • 41420_2020_Article_362.pdf
View BVdb publication page



Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53's DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption.

Cancers
Wang, Yu-Chu YC; Huang, Jau-Ling JL; Lee, Ka-Wo KW; Lu, Hsing-Han HH; Lin, Yuan-Jen YJ; Chen, Long-Fong LF; Wang, Chung-Sheng CS; Cheng, Yun-Chiao YC; Zeng, Zih-Ting ZT; Chu, Pei-Yi PY; Lin, Chang-Shen CS
Publication Date: 2020-07-25

Variant appearance in text: p53: S376A
PubMed Link: 32722430
Variant Present in the following documents:
  • Main text
  • cancers-12-02053.pdf
View BVdb publication page



appreci8: a pipeline for precise variant calling integrating 8 tools.

Bioinformatics (Oxford, England)
Sandmann, Sarah S; Karimi, Mohsen M; de Graaf, Aniek O AO; Rohde, Christian C; Göllner, Stefanie S; Varghese, Julian J; Ernsting, Jan J; Walldin, Gunilla G; van der Reijden, Bert A BA; Müller-Tidow, Carsten C; Malcovati, Luca L; Hellström-Lindberg, Eva E; Jansen, Joop H JH; Dugas, Martin M
Publication Date: 2018-12-15

Variant appearance in text: TP53: 1126T>G; Ser376Ala
PubMed Link: 29945233
Variant Present in the following documents:
  • bty518_supplementary_data_s3.xlsx, sheet 9
View BVdb publication page



Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair.

Nucleic Acids Research
Kumar, Varun V; Fleming, Thomas T; Terjung, Stefan S; Gorzelanny, Christian C; Gebhardt, Christoffer C; Agrawal, Raman R; Mall, Marcus A MA; Ranzinger, Julia J; Zeier, Martin M; Madhusudhan, Thati T; Ranjan, Satish S; Isermann, Berend B; Liesz, Arthur A; Deshpande, Divija D; Häring, Hans-Ulrich HU; Biswas, Subrata K SK; Reynolds, Paul R PR; Hammes, Hans-Peter HP; Peperkok, Rainer R; Angel, Peter P; Herzig, Stephan S; Nawroth, Peter P PP
Publication Date: 2017-10-13

Variant appearance in text: p53: S376A
PubMed Link: 28977635
Variant Present in the following documents:
  • gkx705.pdf
View BVdb publication page



iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports
Wang, Meng M; Wei, Liping L
Publication Date: 2016-08-16

Variant appearance in text: TP53: S376A
PubMed Link: 27527004
Variant Present in the following documents:
  • srep31321-s5.xls, sheet 1
View BVdb publication page



GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics
Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J
Publication Date: 2015-07-25

Variant appearance in text: TP53: S376A
PubMed Link: 26206375
Variant Present in the following documents:
  • 12859_2015_673_MOESM1_ESM.xls, sheet 1
View BVdb publication page



Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: TP53: S376A
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



A novel potent tumour promoter aberrantly overexpressed in most human cancers.

Scientific Reports
Takahashi, Atsushi A; Tokita, Hisashi H; Takahashi, Kenzo K; Takeoka, Tomoharu T; Murayama, Kosho K; Tomotsune, Daihachiro D; Ohira, Miki M; Iwamatsu, Akihiro A; Ohara, Kazuaki K; Yazaki, Kazufumi K; Koda, Tadayuki T; Nakagawara, Akira A; Tani, Kenzaburo K
Publication Date: 2011

Variant appearance in text: p53: S376A
PubMed Link: 22355534
Variant Present in the following documents:
  • Main text
  • srep00015.pdf
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: TP53: S376A
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page



A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.

Plos Biology
van Vugt, Marcel A T M MA; Gardino, Alexandra K AK; Linding, Rune R; Ostheimer, Gerard J GJ; Reinhardt, H Christian HC; Ong, Shao-En SE; Tan, Chris S CS; Miao, Hua H; Keezer, Susan M SM; Li, Jeijin J; Pawson, Tony T; Lewis, Timothy A TA; Carr, Steven A SA; Smerdon, Stephen J SJ; Brummelkamp, Thijn R TR; Yaffe, Michael B MB
Publication Date: 2010-01-26

Variant appearance in text: p53: S376A
PubMed Link: 20126263
Variant Present in the following documents:
  • Main text
View BVdb publication page



The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53.

Plos One
Valbuena, Alberto A; Blanco, Sandra S; Vega, Francisco M FM; Lazo, Pedro A PA
Publication Date: 2008-07-09

Variant appearance in text: p53: S376A
PubMed Link: 18612383
Variant Present in the following documents:
  • Main text
  • pone.0002649.pdf
View BVdb publication page



Phosphorylation at carboxyl-terminal S373 and S375 residues and 14-3-3 binding are not required for mouse p53 function.

Neoplasia (New York, N.Y.)
Lee, Ming Kei MK; Sabapathy, Kanaga K
Publication Date: 2007-09

Variant appearance in text: p53: S376A
PubMed Link: 17898864
Variant Present in the following documents:
  • Main text
View BVdb publication page



Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta.

Molecular And Cellular Biology
Pluquet, Olivier O; Qu, Li-Ke LK; Baltzis, Dionissios D; Koromilas, Antonis E AE
Publication Date: 2005-11

Variant appearance in text: p53: S376A
PubMed Link: 16227590
Variant Present in the following documents:
  • Main text
View BVdb publication page



Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.

Genes & Development
Qu, LiKe L; Huang, Shirley S; Baltzis, Dionissios D; Rivas-Estilla, Ana-Maria AM; Pluquet, Olivier O; Hatzoglou, Maria M; Koumenis, Costas C; Taya, Yoichi Y; Yoshimura, Akihiko A; Koromilas, Antonis E AE
Publication Date: 2004-02-01

Variant appearance in text: p53: S376A
PubMed Link: 14744935
Variant Present in the following documents:
  • Main text
View BVdb publication page