Publications:

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Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.

Nature Communications

Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A

Publication Date: 2022-07-13

Variant appearance in text: TP53: 1109A>G

PubMed Link: 35831314

Variant Present in the following documents:

• 41467_2022_31809_MOESM8_ESM.xlsx, sheet 3

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Deciphering the acetylation code of p53 in transcription regulation and tumor suppression.

Oncogene

Xia, Zhangchuan Z; Kon, Ning N; Gu, Alyssa P AP; Tavana, Omid O; Gu, Wei W

Publication Date: 2022-05

Variant appearance in text: p53: K370R

PubMed Link: 35487975

Variant Present in the following documents:

• nihms-1800386.pdf

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Dysfunction of X-linked inhibitor of apoptosis protein (XIAP) triggers neuropathological processes via altered p53 activity in Huntington's disease.

Progress In Neurobiology

Hyeon, Seung Jae SJ; Park, Jinyoung J; Yoo, Junsang J; Kim, Su-Hyun SH; Hwang, Yu Jin YJ; Kim, Seung-Chan SC; Liu, Tian T; Shim, Hyun Soo HS; Kim, Yunha Y; Cho, Yakdol Y; Woo, Jiwan J; Kim, Key-Sun KS; Myers, Richard H RH; Ryu, Hannah L HL; Kowall, Neil W NW; Song, Eun Joo EJ; Hwang, Eun Mi EM; Seo, Hyemyung H; Lee, Junghee J; Ryu, Hoon H

Publication Date: 2021-09

Variant appearance in text: p53: K370R

PubMed Link: 34166773

Variant Present in the following documents:

• Main text

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mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.

Genes & Development

Kon, Ning N; Ou, Yang Y; Wang, Shang-Jui SJ; Li, Huan H; Rustgi, Anil K AK; Gu, Wei W

Publication Date: 2021-01-01

Variant appearance in text: p53: K370R

PubMed Link: 33303641

Variant Present in the following documents:

• Main text
• 59.pdf

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Regulating tumor suppressor genes: post-translational modifications.

Signal Transduction And Targeted Therapy

Chen, Ling L; Liu, Shuang S; Tao, Yongguang Y

Publication Date: 2020-06-10

Variant appearance in text: p53: K370R

PubMed Link: 32532965

Variant Present in the following documents:

• Main text
• 41392_2020_Article_196.pdf

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p53 β-hydroxybutyrylation attenuates p53 activity.

Cell Death & Disease

Liu, Kun K; Li, Fangzhou F; Sun, Qianqian Q; Lin, Ning N; Han, Haichao H; You, Kaiqiang K; Tian, Feng F; Mao, Zebin Z; Li, Tingting T; Tong, Tanjun T; Geng, Meiyu M; Zhao, Yingming Y; Gu, Wei W; Zhao, Wenhui W

Publication Date: 2019-03-11

Variant appearance in text: p53: K370R

PubMed Link: 30858356

Variant Present in the following documents:

• Main text
• 41419_2019_Article_1463.pdf

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appreci8: a pipeline for precise variant calling integrating 8 tools.

Bioinformatics (Oxford, England)

Sandmann, Sarah S; Karimi, Mohsen M; de Graaf, Aniek O AO; Rohde, Christian C; Göllner, Stefanie S; Varghese, Julian J; Ernsting, Jan J; Walldin, Gunilla G; van der Reijden, Bert A BA; Müller-Tidow, Carsten C; Malcovati, Luca L; Hellström-Lindberg, Eva E; Jansen, Joop H JH; Dugas, Martin M

Publication Date: 2018-12-15

Variant appearance in text: TP53: 1109A>G; Lys370Arg

PubMed Link: 29945233

Variant Present in the following documents:

• bty518_supplementary_data_s4.xlsx, sheet 9
• bty518_supplementary_data_s3.xlsx, sheet 9

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G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1.

Theranostics

Zhang, Jie J; Wang, Yafang Y; Shen, Yanyan Y; He, Pengxing P; Ding, Jian J; Chen, Yi Y

Publication Date: 2018

Variant appearance in text: p53: K370R

PubMed Link: 29774081

Variant Present in the following documents:

• Main text
• thnov08p2884.pdf

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USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells.

Nature Communications

Padmanabhan, Achuth A; Candelaria, Nicholes N; Wong, Kwong-Kwok KK; Nikolai, Bryan C BC; Lonard, David M DM; O'Malley, Bert W BW; Richards, JoAnne S JS

Publication Date: 2018-03-28

Variant appearance in text: p53: K370R

PubMed Link: 29593334

Variant Present in the following documents:

• 41467_2018_3599_MOESM1_ESM.pdf
• 41467_2018_3599_MOESM2_ESM.pdf

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Germ-line and somatic EPHA2 coding variants in lens aging and cataract.

Plos One

Bennett, Thomas M TM; M'Hamdi, Oussama O; Hejtmancik, J Fielding JF; Shiels, Alan A

Publication Date: 2017

Variant appearance in text: TP53: K370R

PubMed Link: 29267365

Variant Present in the following documents:

• pone.0189881.s008.xlsx, sheet 1

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The interplay between epigenetic changes and the p53 protein in stem cells.

Genes & Development

Levine, Arnold J AJ; Berger, Shelley L SL

Publication Date: 2017-06-15

Variant appearance in text: p53: K370R

PubMed Link: 28765161

Variant Present in the following documents:

• Main text
• 1195.pdf

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The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein.

Trends In Biochemical Sciences

Laptenko, Oleg O; Tong, David R DR; Manfredi, James J; Prives, Carol C

Publication Date: 2016-12

Variant appearance in text: p53: K370R

PubMed Link: 27669647

Variant Present in the following documents:

• Main text

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Lysine methylation represses p53 activity in teratocarcinoma cancer cells.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Zhu, Jiajun J; Dou, Zhixun Z; Sammons, Morgan A MA; Levine, Arnold J AJ; Berger, Shelley L SL

Publication Date: 2016-08-30

Variant appearance in text: p53: K370R

PubMed Link: 27535933

Variant Present in the following documents:

• Main text

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: TP53: K370R

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

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The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain.

Molecular Cell

Laptenko, Oleg O; Shiff, Idit I; Freed-Pastor, Will W; Zupnick, Andrew A; Mattia, Melissa M; Freulich, Ella E; Shamir, Inbal I; Kadouri, Noam N; Kahan, Tamar T; Manfredi, James J; Simon, Itamar I; Prives, Carol C

Publication Date: 2015-03-19

Variant appearance in text: p53: K370R

PubMed Link: 25794615

Variant Present in the following documents:

• Main text

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The selective activation of p53 target genes regulated by SMYD2 in BIX-01294 induced autophagy-related cell death.

Plos One

Fan, Jia-Dong JD; Lei, Pin-Ji PJ; Zheng, Jun-Yi JY; Wang, Xiang X; Li, Shangze S; Liu, Huan H; He, Yi-Lei YL; Wang, Zhao-Ning ZN; Wei, Gang G; Zhang, Xiaodong X; Li, Lian-Yun LY; Wu, Min M

Publication Date: 2015

Variant appearance in text: p53: K370R

PubMed Link: 25562686

Variant Present in the following documents:

• Main text
• pone.0116782.pdf

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p53 degradation by a coronavirus papain-like protease suppresses type I interferon signaling.

The Journal Of Biological Chemistry

Yuan, Lin L; Chen, Zhongbin Z; Song, Shanshan S; Wang, Shan S; Tian, Chunyan C; Xing, Guichun G; Chen, Xiaojuan X; Xiao, Zhi-Xiong ZX; He, Fuchu F; Zhang, Lingqiang L

Publication Date: 2015-01-30

Variant appearance in text: p53: K370R

PubMed Link: 25505178

Variant Present in the following documents:

• Main text

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: TP53: K370R

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

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Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Drosten, Matthias M; Sum, Eleanor Y M EY; Lechuga, Carmen G CG; Simón-Carrasco, Lucía L; Jacob, Harrys K C HK; García-Medina, Raquel R; Huang, Sidong S; Beijersbergen, Roderick L RL; Bernards, Rene R; Barbacid, Mariano M

Publication Date: 2014-10-21

Variant appearance in text: p53: K370R

PubMed Link: 25288756

Variant Present in the following documents:

• Main text

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Illuminating p53 function in cancer with genetically engineered mouse models.

Seminars In Cell & Developmental Biology

Garcia, Patty B PB; Attardi, Laura D LD

Publication Date: 2014-03

Variant appearance in text: p53: K370R

PubMed Link: 24394915

Variant Present in the following documents:

• Main text

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The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption.

The Journal Of Biological Chemistry

Ono, Wakana W; Hayashi, Yuki Y; Yokoyama, Wataru W; Kuroda, Takao T; Kishimoto, Hiroyuki H; Ito, Ichiaki I; Kimura, Keiji K; Akaogi, Kensuke K; Waku, Tsuyoshi T; Yanagisawa, Junn J

Publication Date: 2014-02-21

Variant appearance in text: p53: K370R

PubMed Link: 24375404

Variant Present in the following documents:

• Main text

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RNA content in the nucleolus alters p53 acetylation via MYBBP1A.

The Embo Journal

Kuroda, Takao T; Murayama, Akiko A; Katagiri, Naohiro N; Ohta, Yu-mi YM; Fujita, Etsuko E; Masumoto, Hiroshi H; Ema, Masatsugu M; Takahashi, Satoru S; Kimura, Keiji K; Yanagisawa, Junn J

Publication Date: 2011-03-16

Variant appearance in text: p53: K370R

PubMed Link: 21297583

Variant Present in the following documents:

• Main text

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p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response.

Oncogene

Song, L L; Gao, M M; Dong, W W; Hu, M M; Li, J J; Shi, X X; Hao, Y Y; Li, Y Y; Huang, C C

Publication Date: 2011-03-17

Variant appearance in text: p53: Lys370Arg

PubMed Link: 21057544

Variant Present in the following documents:

• Main text

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Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies.

Journal Of Virology

Pennella, Mario A MA; Liu, Yue Y; Woo, Jennifer L JL; Kim, Chongwoo A CA; Berk, Arnold J AJ

Publication Date: 2010-12

Variant appearance in text: p53: K370R

PubMed Link: 20861261

Variant Present in the following documents:

• Main text

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Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation.

Molecular And Cellular Biology

Rodriguez, M S MS; Desterro, J M JM; Lain, S S; Lane, D P DP; Hay, R T RT

Publication Date: 2000-11

Variant appearance in text: p53: K370R

PubMed Link: 11046142

Variant Present in the following documents:

• Main text

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