TP53 c.1048_1049delinsGC ;(p.L350A)

Variant ID: 17-7573978-AG-GC

NM_000546.5(TP53):c.1048_1049delinsGC;(p.L350A)

This variant was identified in 6 publications

View GRCh38 version.




Publications:


The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses.

Frontiers In Cell And Developmental Biology
Cui, Danrui D; Qu, Ruirui R; Liu, Dian D; Xiong, Xiufang X; Liang, Tingbo T; Zhao, Yongchao Y
Publication Date: 2021

Variant appearance in text: p53: L350A
PubMed Link: 34869377
Variant Present in the following documents:
  • Main text
  • fcell-09-775507.pdf
View BVdb publication page



Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.

Nature Medicine
Mai, Wilson X WX; Gosa, Laura L; Daniels, Veerle W VW; Ta, Lisa L; Tsang, Jonathan E JE; Higgins, Brian B; Gilmore, W Blake WB; Bayley, Nicholas A NA; Harati, Mitra Dehghan MD; Lee, Jason T JT; Yong, William H WH; Kornblum, Harley I HI; Bensinger, Steven J SJ; Mischel, Paul S PS; Rao, P Nagesh PN; Clark, Peter M PM; Cloughesy, Timothy F TF; Letai, Anthony A; Nathanson, David A DA
Publication Date: 2017-11

Variant appearance in text: p53: L350A
PubMed Link: 29035366
Variant Present in the following documents:
  • Main text
  • nihms905238.pdf
View BVdb publication page



Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function.

Cell Reports
Shen, Jia J; Sheng, Xiangpeng X; Chang, Zenan Z; Wu, Qian Q; Wang, Sheng S; Xuan, Zongliang Z; Li, Dan D; Wu, Yalan Y; Shang, Yongjia Y; Kong, Xiangtao X; Yu, Long L; Li, Lin L; Ruan, Kangchen K; Hu, Hongyu H; Huang, Ying Y; Hui, Lijian L; Xie, Dong D; Wang, Fudi F; Hu, Ronggui R
Publication Date: 2014-04-10

Variant appearance in text: p53: Leu350Ala
PubMed Link: 24685134
Variant Present in the following documents:
  • nihms638031.pdf
View BVdb publication page



A novel function for p53: regulation of growth cone motility through interaction with Rho kinase.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Qin, Qingyu Q; Baudry, Michel M; Liao, Guanghong G; Noniyev, Albert A; Galeano, James J; Bi, Xiaoning X
Publication Date: 2009-04-22

Variant appearance in text: p53: L350A
PubMed Link: 19386914
Variant Present in the following documents:
  • Main text
View BVdb publication page



Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity.

Mechanisms Of Ageing And Development
Moore, Lynette L; Lu, Xiongbin X; Ghebranious, Nader N; Tyner, Stuart S; Donehower, Lawrence A LA
Publication Date: 2007

Variant appearance in text: p53: L350A
PubMed Link: 18061646
Variant Present in the following documents:
  • Main text
View BVdb publication page



Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.

Genes & Development
Qu, LiKe L; Huang, Shirley S; Baltzis, Dionissios D; Rivas-Estilla, Ana-Maria AM; Pluquet, Olivier O; Hatzoglou, Maria M; Koumenis, Costas C; Taya, Yoichi Y; Yoshimura, Akihiko A; Koromilas, Antonis E AE
Publication Date: 2004-02-01

Variant appearance in text: p53: L350A
PubMed Link: 14744935
Variant Present in the following documents:
  • Main text
View BVdb publication page