Publications:

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p53 tetramerization: at the center of the dominant-negative effect of mutant p53.

Genes & Development

Gencel-Augusto, Jovanka J; Lozano, Guillermina G

Publication Date: 2020-09-01

Variant appearance in text: p53: L348A

PubMed Link: 32873579

Variant Present in the following documents:

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• 1128.pdf

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Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation.

International Journal Of Molecular Sciences

Cai, Bi-He BH; Chao, Chung-Faye CF; Huang, Hsiang-Chi HC; Lee, Hsueh-Yi HY; Kannagi, Reiji R; Chen, Jang-Yi JY

Publication Date: 2019-07-27

Variant appearance in text: p53: L348A

PubMed Link: 31357595

Variant Present in the following documents:

• Main text
• ijms-20-03681.pdf

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p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance.

Oncogene

Zhang, Jixiang J; Tan, Peng P; Guo, Lei L; Gong, Jing J; Ma, Jingjing J; Li, Jia J; Lee, Minjung M; Fang, Shaohai S; Jing, Ji J; Johnson, Gavin G; Sun, Deqiang D; Cao, Wen-Ming WM; Dashwood, Roderick R; Han, Leng L; Zhou, Yubin Y; Dong, Wei-Guo WG; Huang, Yun Y

Publication Date: 2019-03

Variant appearance in text: p53: L348A

PubMed Link: 30390073

Variant Present in the following documents:

• Main text
• nihms-1501648.pdf

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Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers.

Genes & Development

Katz, Chen C; Low-Calle, Ana Maria AM; Choe, Joshua H JH; Laptenko, Oleg O; Tong, David D; Joseph-Chowdhury, Jazmine-Saskya N JN; Garofalo, Francesca F; Zhu, Yan Y; Friedler, Assaf A; Prives, Carol C

Publication Date: 2018-03-01

Variant appearance in text: p53: L348A

PubMed Link: 29549180

Variant Present in the following documents:

• Main text
• 430.pdf
• supp_gad.304071.117_Supplemental_Material.pdf

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Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.

Nature Medicine

Mai, Wilson X WX; Gosa, Laura L; Daniels, Veerle W VW; Ta, Lisa L; Tsang, Jonathan E JE; Higgins, Brian B; Gilmore, W Blake WB; Bayley, Nicholas A NA; Harati, Mitra Dehghan MD; Lee, Jason T JT; Yong, William H WH; Kornblum, Harley I HI; Bensinger, Steven J SJ; Mischel, Paul S PS; Rao, P Nagesh PN; Clark, Peter M PM; Cloughesy, Timothy F TF; Letai, Anthony A; Nathanson, David A DA

Publication Date: 2017-11

Variant appearance in text: p53: L348A

PubMed Link: 29035366

Variant Present in the following documents:

• Main text
• nihms905238.pdf

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Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function.

Cell Reports

Shen, Jia J; Sheng, Xiangpeng X; Chang, Zenan Z; Wu, Qian Q; Wang, Sheng S; Xuan, Zongliang Z; Li, Dan D; Wu, Yalan Y; Shang, Yongjia Y; Kong, Xiangtao X; Yu, Long L; Li, Lin L; Ruan, Kangchen K; Hu, Hongyu H; Huang, Ying Y; Hui, Lijian L; Xie, Dong D; Wang, Fudi F; Hu, Ronggui R

Publication Date: 2014-04-10

Variant appearance in text: p53: Leu348Ala

PubMed Link: 24685134

Variant Present in the following documents:

• nihms638031.pdf

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p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1.

Molecular Biology Of The Cell

Santiago, Aleixo A; Li, Dawei D; Zhao, Lisa Y LY; Godsey, Adam A; Liao, Daiqing D

Publication Date: 2013-09

Variant appearance in text: p53: L348A

PubMed Link: 23825024

Variant Present in the following documents:

• Main text
• 2739.pdf

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Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Bista, Michal M; Freund, Stefan M SM; Fersht, Alan R AR

Publication Date: 2012-09-25

Variant appearance in text: p53: L348A

PubMed Link: 22972749

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Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.

The Embo Journal

Sun, Xiao-Xin XX; Challagundla, Kishore B KB; Dai, Mu-Shui MS

Publication Date: 2012-02-01

Variant appearance in text: p53: L348A

PubMed Link: 22124327

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p53 Oligomerization is essential for its C-terminal lysine acetylation.

The Journal Of Biological Chemistry

Itahana, Yoko Y; Ke, Hengming H; Zhang, Yanping Y

Publication Date: 2009-02-20

Variant appearance in text: p53: L348A

PubMed Link: 19106109

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Members of the S100 family bind p53 in two distinct ways.

Protein Science : A Publication Of The Protein Society

Fernandez-Fernandez, Maria Rosario MR; Rutherford, Trevor J TJ; Fersht, Alan R AR

Publication Date: 2008-10

Variant appearance in text: p53: L348A

PubMed Link: 18694925

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Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity.

Mechanisms Of Ageing And Development

Moore, Lynette L; Lu, Xiongbin X; Ghebranious, Nader N; Tyner, Stuart S; Donehower, Lawrence A LA

Publication Date: 2007

Variant appearance in text: p53: L348A

PubMed Link: 18061646

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Threading a peptide through a peptide: protein loops, rotaxanes, and knots.

Protein Science : A Publication Of The Protein Society

Blankenship, John W JW; Dawson, Philip E PE

Publication Date: 2007-07

Variant appearance in text: p53: L348A

PubMed Link: 17567748

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Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Fernandez-Fernandez, Maria Rosario MR; Veprintsev, Dmitry B DB; Fersht, Alan R AR

Publication Date: 2005-03-29

Variant appearance in text: p53: L348A

PubMed Link: 15781852

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A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assay.

Journal Of Virology

Cathomen, T T; Collete, D D; Weitzman, M D MD

Publication Date: 2000-03

Variant appearance in text: p53: L348A

PubMed Link: 10666268

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