Publications:

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p53 tetramerization: at the center of the dominant-negative effect of mutant p53.

Genes & Development

Gencel-Augusto, Jovanka J; Lozano, Guillermina G

Publication Date: 2020-09-01

Variant appearance in text: p53: L330A

PubMed Link: 32873579

Variant Present in the following documents:

• Main text
• 1128.pdf

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Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers.

Genes & Development

Katz, Chen C; Low-Calle, Ana Maria AM; Choe, Joshua H JH; Laptenko, Oleg O; Tong, David D; Joseph-Chowdhury, Jazmine-Saskya N JN; Garofalo, Francesca F; Zhu, Yan Y; Friedler, Assaf A; Prives, Carol C

Publication Date: 2018-03-01

Variant appearance in text: p53: L330A

PubMed Link: 29549180

Variant Present in the following documents:

• Main text
• 430.pdf
• supp_gad.304071.117_Supplemental_Material.pdf

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: TP53: L330A

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

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Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.

Plos Pathogens

Sato, Yoshitaka Y; Kamura, Takumi T; Shirata, Noriko N; Murata, Takayuki T; Kudoh, Ayumi A; Iwahori, Satoko S; Nakayama, Sanae S; Isomura, Hiroki H; Nishiyama, Yukihiro Y; Tsurumi, Tatsuya T

Publication Date: 2009-07

Variant appearance in text: p53: L330A

PubMed Link: 19649319

Variant Present in the following documents:

• Main text
• ppat.1000530.pdf

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Parallel analysis of tetramerization domain mutants of the human p53 protein using PCR colonies.

Genomic Medicine

Merritt, Joshua J; Roberts, Kim G KG; Butz, James A JA; Edwards, Jeremy S JS

Publication Date: 2007

Variant appearance in text: p53: Leu330Ala

PubMed Link: 18923936

Variant Present in the following documents:

• Main text

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Unfolding, aggregation, and amyloid formation by the tetramerization domain from mutant p53 associated with lung cancer.

Biochemistry

Higashimoto, Yuichiro Y; Asanomi, Yuya Y; Takakusagi, Satoru S; Lewis, Marc S MS; Uosaki, Kohei K; Durell, Stewart R SR; Anderson, Carl W CW; Appella, Ettore E; Sakaguchi, Kazuyasu K

Publication Date: 2006-02-14

Variant appearance in text: p53: L330A

PubMed Link: 16460008

Variant Present in the following documents:

• Main text

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