TP53 c.854A>C ;(p.E285A)

Variant ID: 17-7577084-T-G

NM_000546.5(TP53):c.854A>C;(p.E285A)

This variant was identified in 16 publications

View GRCh38 version.




Publications:


CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience
Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X
Publication Date: 2022-09-16

Variant appearance in text: p53: 854A>C
PubMed Link: 36117989
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
View BVdb publication page



The landscape of driver mutations in cutaneous squamous cell carcinoma.

Npj Genomic Medicine
Chang, Darwin D; Shain, A Hunter AH
Publication Date: 2021-07-16

Variant appearance in text: TP53: E285A
PubMed Link: 34272401
Variant Present in the following documents:
  • 41525_2021_226_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases.

Scientific Reports
Magraner-Pardo, Lorena L; Laskowski, Roman A RA; Pons, Tirso T; Thornton, Janet M JM
Publication Date: 2021-07-12

Variant appearance in text: TP53: 854A>C; E285A
PubMed Link: 34253785
Variant Present in the following documents:
  • 41598_2021_93715_MOESM2_ESM.xlsx, sheet 10
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: TP53: 854A>C; E285A
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.

Oncogene
Luiken, Sarah S; Fraas, Angelika A; Bieg, Matthias M; Sugiyanto, Raisatun R; Goeppert, Benjamin B; Singer, Stephan S; Ploeger, Carolin C; Warsow, Gregor G; Marquardt, Jens U JU; Sticht, Carsten C; De La Torre, Carolina C; Pusch, Stefan S; Mehrabi, Arianeb A; Gretz, Norbert N; Schlesner, Matthias M; Eils, Roland R; Schirmacher, Peter P; Longerich, Thomas T; Roessler, Stephanie S
Publication Date: 2020-04

Variant appearance in text: TP53: 854A>C
PubMed Link: 32055024
Variant Present in the following documents:
  • 41388_2020_1198_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: TP53: E285A
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients.

Bmc Cancer
Koyama, Takahiko T; Rhrissorrakrai, Kahn K; Parida, Laxmi L
Publication Date: 2019-02-01

Variant appearance in text: TP53: 854A>C; E285A
PubMed Link: 30709382
Variant Present in the following documents:
  • 12885_2019_5313_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports
Wang, Meng M; Wei, Liping L
Publication Date: 2016-08-16

Variant appearance in text: TP53: E285A
PubMed Link: 27527004
Variant Present in the following documents:
  • srep31321-s5.xls, sheet 1
View BVdb publication page



GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics
Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J
Publication Date: 2015-07-25

Variant appearance in text: TP53: E285A
PubMed Link: 26206375
Variant Present in the following documents:
  • 12859_2015_673_MOESM1_ESM.xls, sheet 1
View BVdb publication page



Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: TP53: E285A
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Delivery of a monomeric p53 subdomain with mitochondrial targeting signals from pro-apoptotic Bak or Bax.

Pharmaceutical Research
Matissek, Karina J KJ; Okal, Abood A; Mossalam, Mohanad M; Lim, Carol S CS
Publication Date: 2014-09

Variant appearance in text: p53: E285A
PubMed Link: 24633417
Variant Present in the following documents:
  • Main text
View BVdb publication page



ESR1 ligand-binding domain mutations in hormone-resistant breast cancer.

Nature Genetics
Toy, Weiyi W; Shen, Yang Y; Won, Helen H; Green, Bradley B; Sakr, Rita A RA; Will, Marie M; Li, Zhiqiang Z; Gala, Kinisha K; Fanning, Sean S; King, Tari A TA; Hudis, Clifford C; Chen, David D; Taran, Tetiana T; Hortobagyi, Gabriel G; Greene, Geoffrey G; Berger, Michael M; Baselga, José J; Chandarlapaty, Sarat S
Publication Date: 2013-12

Variant appearance in text: TP53: E285A
PubMed Link: 24185512
Variant Present in the following documents:
  • NIHMS531250-supplement-2.xlsx, sheet 1
View BVdb publication page



Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins.

The Journal Of Cell Biology
Sideridou, Maria M; Zakopoulou, Roubini R; Evangelou, Konstantinos K; Liontos, Michalis M; Kotsinas, Athanassios A; Rampakakis, Emmanouil E; Gagos, Sarantis S; Kahata, Kaoru K; Grabusic, Kristina K; Gkouskou, Kalliopi K; Trougakos, Ioannis P IP; Kolettas, Evangelos E; Georgakilas, Alexandros G AG; Volarevic, Sinisa S; Eliopoulos, Aristides G AG; Zannis-Hadjopoulos, Maria M; Moustakas, Aristidis A; Gorgoulis, Vassilis G VG
Publication Date: 2011-12-26

Variant appearance in text: p53: E285A
PubMed Link: 22201124
Variant Present in the following documents:
  • Main text
  • JCB_201108121.pdf
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: TP53: E285A
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page



Molecular basis of Pirh2-mediated p53 ubiquitylation.

Nature Structural & Molecular Biology
Sheng, Yi Y; Laister, Rob C RC; Lemak, Alexander A; Wu, Bin B; Tai, Elizabeth E; Duan, Shili S; Lukin, Jonathan J; Sunnerhagen, Maria M; Srisailam, Sampath S; Karra, Murthy M; Benchimol, Sam S; Arrowsmith, Cheryl H CH
Publication Date: 2008-12

Variant appearance in text: p53: E285A
PubMed Link: 19043414
Variant Present in the following documents:
  • Main text
View BVdb publication page



Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain.

The Journal Of Biological Chemistry
Pietsch, E Christine EC; Perchiniak, Erin E; Canutescu, Adrian A AA; Wang, Guoli G; Dunbrack, Roland L RL; Murphy, Maureen E ME
Publication Date: 2008-07-25

Variant appearance in text: p53: E285A
PubMed Link: 18524770
Variant Present in the following documents:
  • Main text
View BVdb publication page