Publications:

Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer.

Biomolecules

Zhang, Shengliang S; Carlsen, Lindsey L; Hernandez Borrero, Liz L; Seyhan, Attila A AA; Tian, Xiaobing X; El-Deiry, Wafik S WS

Publication Date: 2022-04-06

Variant appearance in text: p53: N268R

PubMed Link: 35454137

Variant Present in the following documents:

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• biomolecules-12-00548.pdf

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A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells.

Oncotarget

Paulmurugan, Ramasamy R; Afjei, Rayhaneh R; Sekar, Thillai V TV; Babikir, Husam A HA; Massoud, Tarik F TF

Publication Date: 2018-04-20

Variant appearance in text: p53: N268R

PubMed Link: 29765555

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Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53.

Cancer Research

Zhang, Shengliang S; Zhou, Lanlan L; Hong, Bo B; van den Heuvel, A Pieter J AP; Prabhu, Varun V VV; Warfel, Noel A NA; Kline, Christina Leah B CL; Dicker, David T DT; Kopelovich, Levy L; El-Deiry, Wafik S WS

Publication Date: 2015-09-15

Variant appearance in text: p53: N268R

PubMed Link: 26294215

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SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53.

The Journal Of Biological Chemistry

Demma, Mark M; Maxwell, Eugene E; Ramos, Robert R; Liang, Lianzhu L; Li, Cheng C; Hesk, David D; Rossman, Randall R; Mallams, Alan A; Doll, Ronald R; Liu, Ming M; Seidel-Dugan, Cynthia C; Bishop, W Robert WR; Dasmahapatra, Bimalendu B

Publication Date: 2010-04-02

Variant appearance in text: p53: N268R

PubMed Link: 20124408

Variant Present in the following documents:

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